ライフサイエンスコーパス: spiral ganglion

1 ocalizes to inner ear sensory hair cells and spiral ganglion.

2 ibular end organs as well as in cells of the spiral ganglion.

3 n hair cells and postnatal expression in the spiral ganglion.

4 that compose approximately 95% of the adult spiral ganglion.

5 ar and cochlear sensory epithelia and to the spiral ganglions.

6 through anatomically distinct populations of spiral ganglion afferent neurons.

7 t on their postsynaptic targets, the type II spiral ganglion afferents.

8 may set the "address" of neurons within the spiral ganglion, allowing them to elaborate the appropri

9 uitment into both the sensory epithelium and spiral ganglion and also resulted in diminished survival

10 iring activity has been observed in immature spiral ganglion and brain-stem neurons and is likely to

11 fluorescent protein provided observation of spiral ganglion and cochlear nucleus neurons to facilita

12 of the dysfunctional Kcnq4_v3 variant in the spiral ganglion and inner hair cells in the basal hook r

13 tly complementary expression patterns in the spiral ganglion and its nearby region, the spiral limbus

14 f Tg-mtTFB1 mice implicated apoptosis in the spiral ganglion and stria vascularis because of mitochon

15 By P10, these fibers had reached the spiral ganglion and were projecting toward the organ of

16 cellular proteins within the organ of Corti, spiral ganglion, and stria vascularis, which are known t

17 is sufficient to attract leukocytes into the spiral ganglion, and that fractalkine signaling plays a

18 the cochlear epithelium and the main body of spiral ganglion, and the neurites of mispositioned SGNs

19 ditory maturation, and further implicate the spiral ganglion as a potential controlling centre in thi

20 andardized locations along the length of the spiral ganglion, as determined from serial reconstructio

21 his principle also applies to neurons of the spiral ganglion, as evidenced by distinctly different fi

22 dditional dimension of complexity within the spiral ganglion beyond that currently categorized.

23 ive degeneration includes hair cells and the spiral ganglion, but the brain itself is spared despite

24 ed macrophages were also observed within the spiral ganglion, but their numbers remained elevated for

25 bular and cochlear sensory epithelia and the spiral ganglion - by measuring electrophysiological prop

26 Spiral ganglion cell (SGC) degeneration was prevented du

27 The spatial distribution of spiral ganglion cell loss correlated with the pattern of

28 s unclear how these topologic differences in spiral ganglion cell morphology and density emerge durin

29 ans of a cochlear implant requires a healthy spiral ganglion cell population.

30 Spiral ganglion cell somata were also labeled as early a

31 The difference in symmetry of spiral ganglion cell survival between the two groups was

32 In contrast, spiral ganglion cell survival was bilaterally symmetric

33 In the absence of chronic stimulation, spiral ganglion cell survival was relatively symmetric i

34 f unilateral chronic electrical stimulation, spiral ganglion cell survival was significantly greater

35 Electrical stimulation (ES) of spiral ganglion cells (SGCs) has been shown to enhance t

36 The remaining spiral ganglion cells (type IIs) are unmyelinated and co

37 Spiral ganglion cells acquire action potential-generatin

38 Our injections also transduced 10% of spiral ganglion cells and a much larger fraction of thei

39 gous knockout mice were examined for loss of spiral ganglion cells and eighth nerve fibers.

40 crodissected immature (postnatal days 10-13) spiral ganglion cells and outer hair cells but not inner

41 stane was increased in the stria vascularis, spiral ganglion cells and the organ of Corti.

42 (postnatal days 10-13) inner hair cells and spiral ganglion cells but not outer hair cells.

43 In the cochlea, nNOS was identified in spiral ganglion cells by using nicotinamide adenine dinu

44 In mammals, the size and number of spiral ganglion cells can vary significantly along the l

45 knockout mice also had a significant loss of spiral ganglion cells compared with 2-month-old wild-typ

46 The onset of diaphorase expression in the spiral ganglion cells corresponds to a critical period o

47 t postnatal week, the total number of gerbil spiral ganglion cells decreased significantly by 27%, wi

48 ls in both sexes as well as small savings of spiral ganglion cells in females and inner hair cells in

49 Nerve fibers from spiral ganglion cells in the middle turn extended to inn

50 he electrical responsiveness of BDNF-treated spiral ganglion cells is preserved during this period as

51 strikingly, significant degeneration of the spiral ganglion cells of the auditory nerve.

52 hat mGluR7 is expressed in hair cells and in spiral ganglion cells of the inner ear.

53 D4 was detected in spiral ganglion cells only.

54 in-3 (NT-3) or its receptor, TrkC, lose many spiral ganglion cells predominantly in the basal turn of

55 ations of cells within the organ of Corti or spiral ganglion cells rather than a mixed population of

56 We have shown that cochlear spiral ganglion cells secrete OPG at high levels and lac

57 ssed survival of primary auditory afferents (spiral ganglion cells) in systemically deafened guinea p

58 zable organ of Corti, presented >90% loss of spiral ganglion cells, and displayed marked structural a

59 esholds and the loss of outer hair cells and spiral ganglion cells, but not with the loss of inner ha

60 cilia and a base-apex loss of hair cells and spiral ganglion cells, were consistent with the observed

61 ubsequent degeneration of the hair cells and spiral ganglion cells.

62 expression in cochlear outer hair cells and spiral ganglion cells.

63 during early development and in cells of the spiral ganglion during early development and adulthood.

64 various functional domains (organ of Corti, spiral ganglion, etc.) by LCM.

65 To understand the determinants of spiral ganglion function, we characterized the NT-3 conc

66 e type II proximal, radial process, near the spiral ganglion, in agreement with the high voltage thre

67 The spiral ganglion is a compelling model system to examine

68 PLZF immunoreactivity is present in the spiral ganglion, lateral wall of the cochlea, and organ

69 thods to co-culture neural stem cell-derived spiral ganglion-like neurons (ScNs) and mouse auditory c

70 ocalize with the Schwann cell marker Krox20, spiral ganglion marker NF200, nor glial fibrillary acidi

71 Dissociated spiral ganglion neuron (SGN) cell cultures and organ of

72 analog), and membrane depolarization promote spiral ganglion neuron (SGN) survival in vitro in an add

73 the ability to seal the reticular lamina and spiral ganglion neuron counts are normal, a key requirem

74 n experiments to examine the role of Sox2 in spiral ganglion neuron formation.

75 Prph((-/-)) mice lacked type II spiral ganglion neuron innervation of the outer hair cel

76 Spiral ganglion neuron responses to depolarizing current

77 membrane level were investigated on isolated spiral ganglion neuron somata from guinea-pigs by whole-

78 ons between BDNF and NT-3 may be crucial for spiral ganglion neuron survival during the final stages

79 ed two broad electrophysiological classes of spiral ganglion neuron that differ in their rate of acco

80 -clamp recordings were made from mouse basal spiral ganglion neurons (postnatal day 5) exposed to dif

81 broblast growth factor 8 (FGF8) in mammalian spiral ganglion neurons (SGN) neurite outgrowth has not

82 Optogenetic stimulation of spiral ganglion neurons (SGNs) activated the auditory pa

83 romoting stimulus for cultured postnatal rat spiral ganglion neurons (SGNs) and that depolarization p

84 f espins to a large proportion of rat type I spiral ganglion neurons (SGNs) and their projections to

85 Spiral ganglion neurons (SGNs) are postsynaptic to hair

86 Type II spiral ganglion neurons (SGNs) are small caliber, unmyel

87 The mammalian spiral ganglion neurons (SGNs) are specialzed bipolar ne

88 ng loss have long suggested that survival of spiral ganglion neurons (SGNs) depends on trophic suppor

89 Mammalian cochlear spiral ganglion neurons (SGNs) encode sound with microse

90 development of periphery auditory circuits, spiral ganglion neurons (SGNs) extend their neurites to

91 Peripheral axons from auditory spiral ganglion neurons (SGNs) form an elaborate series

92 oss, involves degeneration of hair cells and spiral ganglion neurons (SGNs) from basal to apical coch

93 and neuromodulators, has been identified on spiral ganglion neurons (SGNs) in the inner ear; however

94 s known about the fate of efferent fibers or spiral ganglion neurons (SGNs) in this model.

95 he exception of humans, the somata of type I spiral ganglion neurons (SGNs) of most mammalian species

96 Degeneration of the spiral ganglion neurons (SGNs) of the auditory nerve occ

97 Spiral ganglion neurons (SGNs) play a key role in hearin

98 Spiral ganglion neurons (SGNs) receive input from cochle

99 Spiral ganglion neurons (SGNs) relay acoustic code from

100 Spiral ganglion neurons (SGNs) require both pre- and pos

101 synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) that carry acoustic infor

102 For sounds of a given frequency, spiral ganglion neurons (SGNs) with different thresholds

103 c) contributes to the proper organization of spiral ganglion neurons (SGNs) within the Rosenthal's ca

104 Such injury can also lead to degeneration of spiral ganglion neurons (SGNs), but this occurs over a p

105 complementary coding by functionally diverse spiral ganglion neurons (SGNs), each changing activity o

106 Loss of spiral ganglion neurons (SGNs), the primary sensory rela

107 eloping murine cochlea, where two classes of spiral ganglion neurons (SGNs), type I and type II, navi

108 We found that NRG1 is expressed by spiral ganglion neurons (SGNs), whereas erbB2 and erbB3

109 the radiation beam was directed towards the spiral ganglion neurons (SGNs), whereas little responses

110 y cells in the cochlea, i.e., hair cells and spiral ganglion neurons (SGNs), with a focus on their to

111 bursts of action potentials in postsynaptic spiral ganglion neurons (SGNs).

112 stroy hair cells, the sole afferent input to spiral ganglion neurons (SGNs).

113 ed into a mini-burst of action potentials in spiral ganglion neurons (SGNs).

114 eripheral auditory fibers (PAFs) and loss of spiral ganglion neurons (SGNs).

115 cells directly in the sensory epithelium or spiral ganglion neurons (SGNs).

116 mechanosensory hair cells (HCs) and afferent spiral ganglion neurons (SGNs).

117 IHCs), and was lacking from the postsynaptic spiral ganglion neurons (SGNs).

118 -profoundly deaf by electrically stimulating spiral ganglion neurons (SGNs).

119 transmit auditory information faithfully to spiral ganglion neurons (SGNs).

120 ed for rapid transmission from hair cells to spiral ganglion neurons (SGNs).

121 the sensory hair cells and their associated spiral ganglion neurons (SGNs).

122 and also resulted in diminished survival of spiral ganglion neurons after hair cell death.

123 he role of these pathways in the survival of spiral ganglion neurons after noise exposure and during

124 ived neural precursor cells and later in the spiral ganglion neurons along with Neurog1 and NeuroD1,

125 show that alpha2delta3 mRNA is expressed in spiral ganglion neurons and auditory brainstem nuclei an

126 nt of glucocorticoids in age-related loss of spiral ganglion neurons and extensive studies in the cen

127 reduced age-related apoptotic cell death of spiral ganglion neurons and hair cells in the cochlea, a

128 n binaural transduction of inner hair cells, spiral ganglion neurons and vestibular hair cells.

129 Furthermore, spiral ganglion neurons are absent in cochleae from Sox2

130 Inner hair cells, auditory synapses and spiral ganglion neurons are all present after noise expo

131 iously that the intrinsic firing features of spiral ganglion neurons are influenced by brain-derived

132 ir cells, whereas delta1 is expressed in all spiral ganglion neurons as well as in their satellite gl

133 the apex and in inner hair cells as well as spiral ganglion neurons at the base.

134 es also suggest that intrinsic properties of spiral ganglion neurons can contribute to the characteri

135 Type I and type II spiral ganglion neurons convey auditory information from

136 h that the electrophysiological phenotype of spiral ganglion neurons depends critically on the precis

137 Spiral ganglion neurons exhibit spontaneous activity at

138 In the NT-3 mutant, almost normal numbers of spiral ganglion neurons form, but fiber outgrowth to the

139 Type I spiral ganglion neurons have a unique role relative to o

140 In addition, Egr2; Atoh1(CKO) mice lose spiral ganglion neurons in the cochlea and AAN neurons d

141 reduces the spontaneous activity of IHCs and spiral ganglion neurons in the developing cochlea and pr

142 indicating that these features characterize spiral ganglion neurons in the fully developed ear.

143 d the peripheral processes of their afferent spiral ganglion neurons in the mouse lasts for 5 days po

144 g properties and ion channel distribution of spiral ganglion neurons in the murine cochlea.

145 the electrophysiological features of murine spiral ganglion neurons in vitro at a time when recordin

146 and within the type I and type II classes of spiral ganglion neurons is necessary to appreciate their

147 F1 and apoptosis in the stria vascularis and spiral ganglion neurons of the inner ear, and progressiv

148 In the cochlea, spiral ganglion neurons play a critical role in hearing

149 These results suggest that spiral ganglion neurons possess electrophysiological mec

150 In vivo recordings from postsynaptic spiral ganglion neurons showed a use-dependent reduction

151 3 (NT-3) synergistically enhance survival of spiral ganglion neurons such that simultaneous exposure

152 nnervation of the inner hair cells by type I spiral ganglion neurons was normal.

153 not due to a loss of cochlear hair cells or spiral ganglion neurons, both of which normally express

154 information is conveyed into the CNS via the spiral ganglion neurons, cells that possess distinctive

155 ner ear was immunolocalized predominantly to spiral ganglion neurons, indicating that DFNB86 deafness

156 no evident pathology among supporting cells, spiral ganglion neurons, or cells of the cochlear latera

157 ral aspects of the cochlea are innervated by spiral ganglion neurons, presumably under the tropic inf

158 a three-neuron pathway consisting of type I spiral ganglion neurons, reflex interneurons in the coch

159 physical properties of the auditory neurons (spiral ganglion neurons, SGNs) stimulated in electrical

160 xpression of TMC1 protein in the hair cells, spiral ganglion neurons, supporting cells, and stria lig

161 In spiral ganglion neurons, the primary afferents in the co

162 ia vascularis and was also detectable in the spiral ganglion neurons.

163 t, transmission, and output functions of the spiral ganglion neurons.

164 Cx30 labeling was seen in the hair cells and spiral ganglion neurons.

165 g the length of the mouse organ of Corti and spiral ganglion neurons.

166 ncentration dependence and mode of action on spiral ganglion neurons.

167 sion toward the apex in inner hair cells and spiral ganglion neurons.

168 characteristic firing features of postnatal spiral ganglion neurons.

169 synapse between the inner hair cells and the spiral ganglion neurons.

170 ecificity in vitro for both mouse and gerbil spiral ganglion neurons.

171 encoding of sound onset in the postsynaptic spiral ganglion neurons.

172 wave I latency, consistent with apoptosis of spiral ganglion neurons.

173 n both embryonic SAG neurons and adult mouse spiral ganglion neurons.

174 ong-term function of auditory hair cells and spiral ganglion neurons.

175 Selective loss of TrkC neurons in the spiral ganglion of Brn3a(-/-) cochlea leads to an innerv

176 al, labeling a small cluster of cells in the spiral ganglion of each cochlea.

177 ular injections of Neurobiotin (NB) into the spiral ganglion of the basal cochlea.

178 indicate that the tonotopic organization of spiral ganglion projections to the cochlear nucleus is a

179 To understand better the sophistication of spiral ganglion response properties, we compared somatic

180 vating the organ of Corti originate from the spiral ganglion, roughly 95% of which innervate exclusiv

181 e found in microdissected organ of Corti and spiral ganglion samples.

182 Morphometric evaluation of spiral ganglion (SG) cell somata within Rosenthal's cana

183 Proper structural organization of spiral ganglion (SG) innervation is crucial for normal h

184 In the cochlea, spiral ganglion (SG) neuron survival is strongly depende

185 Postnatal development and survival of spiral ganglion (SG) neurons depend on both neural activ

186 tion was seen in satellite cells surrounding spiral ganglion (SG) neurons from postnatal month 1 onwa

187 hlear implant promotes increased survival of spiral ganglion (SG) neurons in animals deafened early i

188 , we found that (1) ASIC2 was present in the spiral ganglion (SG) neurons in the adult cochlea and th

189 Most spiral ganglion (SG) neurons in the middle and basal tur

190 on of the auditory sensory hair cells or the spiral ganglion (SG) neurons that innervate the hair cel

191 wann cells myelinating the soma and fiber of spiral ganglion (SG) neurons.

192 own to interact with EphA4, are expressed by spiral ganglion (SG) neurons.

193 und information from the ear to the brain by spiral ganglion (SG) neurons.

194 tory nerve projections from the cat cochlear spiral ganglion (SG) to the cochlear nucleus (CN).

195 ment in the auditory pathway, neurons in the spiral ganglion shape the initial coding of sound stimul

196 toward autoimmune hearing loss, ototoxicity, spiral ganglion survival, and genetic forms of hearing l

197 t of the rat AN projecting from the cochlear spiral ganglion to brainstem cochlear nuclei.

198 ned intact with the corresponding portion of spiral ganglion to investigate excitotoxic damage to IHC

199 opment of the tonotopic projections from the spiral ganglion to the cochlear nucleus during the perio

200 all sectors (300-500 microm) of the cochlear spiral ganglion, to study the projections of auditory ne

201 t, hearing loss and damage in hair cells and spiral ganglion was determined by noise-induced oxidativ

202 PLP1(+) glial cells from the spiral ganglion were identified as neural progenitors, w