ライフサイエンスコーパス: splice variant

1 ncreased signaling and characterizes a GPR56 splice variant.

2 Factor H levels, especially carriers of the splice variant.

3 e production of PKC betaII and the VEGF 165b splice variant.

4 died, because it has been considered a minor splice variant.

5 use brain, with ClC-3c being the predominant splice variant.

6 ulin and of its muscle-specific metavinculin splice variant.

7 nt systems via expression of different ClC-3 splice variants.

8 WERING LOCUS M-beta (FLM-beta) and FLM-delta splice variants.

9 might be exploited to target specific CXCR3 splice variants.

10 eptor gene OPRM1 creates multiple C-terminal splice variants.

11 nduced changes in the levels of SRSF2 3' UTR splice variants.

12 own to repress translation of specific SRSF2 splice variants.

13 ng a set of 6TM truncated mu-opioid receptor splice variants.

14 distinct modes of targeting of the two K-Ras splice variants.

15 has four isoforms (PDE4A-D) with at least 25 splice variants.

16 is known about miRNA regulation of the OPRM1 splice variants.

17 tially due to the increased expression of AR splice variants.

18 macological targeting of individual receptor splice variants.

19 a context-dependent algorithm for selecting splice variants.

20 different genes, alternative promoters, and splice variants.

21 vel expression of the transporters and their splice variants.

22 of mRNA encoding different IGF-1 alternative splicing variants.

23 ncluding expression of AR gene mutations and splicing variants.

24 ull-length AR (twofold, P < 0.05) and the AR splice variants 1 (threefold, P < 0.05) and 7 (threefold

25 rcise-induced expression of total BDNF, BDNF splice variants 1, 2, 4, 6 and fibronectin type III doma

26 exonic mutation c.3538G>A causes 3 in-frame splicing variants (23del, 26del, and 23/26del) which can

27 ndent cell migration but did not affect RAGE splice variant 4 cell migration.

28 We further show that human CDKN1A mRNA splice variant 4 is preferentially translated following

29 pression of the splice variant of RAGE (RAGE splice variant 4), which is resistant to ectodomain shed

30 y showed that detection of androgen receptor splice variant 7 (AR-V7) in circulating tumor cells (CTC

31 mine if pretherapy nuclear androgen-receptor splice variant 7 (AR-V7) protein expression and localiza

32 AR splice variant 7 (AR-V7, also termed AR3) is the most ab

33 transcripts including the androgen-receptor splice variant 7 in a cohort of prostate cancer patients

34 The androgen-receptor isoform encoded by splice variant 7 lacks the ligand-binding domain, which

35 thesized that detection of androgen-receptor splice variant 7 messenger RNA (AR-V7) in circulating tu

36 usly that the detection of androgen receptor splice variant-7 (AR-V7) mRNA in circulating tumor cells

37 otype and coexistence of more than one TNNT2 splicing variant (90.5% GG v 41.7% GA/AA; P = .005).

38 CD33 generates two splice variants: a full-length CD33M transcript produced

39 eceptor-deficient mouse that lacks all Oprm1 splice variants, ablating mu-opioid activity in these an

40 These results show that CXCR3 splice variants activate different signaling pathways an

41 gene expression analysis for RBM20-dependent splice variants affected sarcomeric (TTN and LDB3) and c

42 full-length transcript and the most frequent splice variants (AID-DeltaE4a, AID-DeltaE) were detected

43 (LHY) and CIRCADIAN CLOCK ASSOCIATED1 (CCA1) splice variants, among other alternatively spliced trans

44 greater amounts of a non-coding Neurog3 mRNA splice variant and had fewer Neurog3/Insm1 co-expressing

45 Isradipine inhibition was splice variant and isoform dependent, with a 5- to 11-fo

46 y transcript has three potential alternative splice variants and cell-type specific expression result

47 we describe examples of these CKD-associated splice variants and ideas on how to manipulate them for

48 be gathered from this database for different splice variants and ncRNAs, such as microRNAs and lincRN

49 n of functional IFNlambda4 through noncoding splice variants and nonfunctional protein isoforms.

50 e results in reduced bimodality of all hTERT splice variants and significant upregulation of alpha sp

51 ology of ligand binding to CXCR3 alternative splice variants and their downstream signaling pathways

52 d as a soluble form generated by alternative splice variants and/or by shedding.

53 s with novel transcription initiation sites, spliced variants and alternative polyadenylation sites.

54 odifications, amino acid variants, alternate splicing variants and protein cleavage patterns.

55 sequencing-based RNA-seq is able to identify splicing variants and single nucleotide variants in one

56 Quiescent LNEPs activate a DeltaNp63 (a p63 splice variant) and cytokeratin 5 remodelling program af

57 urrent depends on the species of origin, the splice variant, and the concentration of the purinergic

58 identified including indels, stop-gain/loss, splice variants, and recurrent gene variants indicative

59 se to somatic copy number amplifications, AR splice-variants, and steroid treatment.

60 both full-length androgen receptor (fAR) and splice variant AR (AR-V7) to inhibit AR transcriptional

61 ealed that miR-124 directly downregulated AR splice variants AR-V4 and V7 along with EZH2 and Src, on

62 y and protein levels of both full-length and splice-variant AR.

63 course of development, including in abnormal splice variants (AR-SV)-driven advanced stage castration

64 R-FL) and constitutively active truncated AR splice variants (AR-Vs).

65 ility to repress the expression of AR or its splice variant, AR-V7.

66 ing to upregulation of the androgen receptor splice variant AR3 which has been shown to play a role i

67 use cerebellum revealed that thousands of RE splice variants are associated with translating ribosome

68 static to sic-3, indicating the LHY and CCA1 splice variants are needed for sic-3 circadian clock phe

69 ctivated states, and the differences between splice variants are occluded by antiepileptic drugs that

70 SRSF2 splice variants are then stabilized by caffeine-mediated

71 mechanisms including resurgence of AR and AR splice variant (ARV) signaling.

72 In contrast, the microtubule-interacting splice variant ARv567 was sensitive to taxane-induced mi

73 at two clinically relevant androgen receptor splice variants, ARv567 and ARv7, differentially associa

74 Androgen receptor splicing variants (ARVs) that lack the ligand-binding do

75 findings highlight the importance of an MDM2 splice variant as a critical modifier of both p53-depend

76 same pattern of 5' untranslated region (UTR) splice variants as the transgenic mice and the human can

77 Ps may control expression of AR-V7 and other splice variants as well as their downstream functions in

78 rotein fragments from two different human CT splice variants, as predicted from SCA6 patients, in PCs

79 n transcript isoforms, including length- and splice variants, as well as between overlapping polycist

80 ly inhibits ASIC1a, but has no effect on the splice variant ASIC1b.

81 ve: ASIC2a is activated by acid, whereas its splice variant ASIC2b is not.

82 e differential expression of two alternative splice variants (ASV), which differ in length and in the

83 microheterogeneity with numerous alternative splice variants (ASVs) and post-translational modificati

84 ubunit, long and short Cav1.3 alpha1-subunit splice variants; beta3/alpha2delta1).

85 The betaE' splice variant bound more weakly than alpha, showing tha

86 It differs from the adult CaV1.1a splice variant by the exclusion of exon 29 coding for 19

87 We identified a GABRG2 splice variant (c.549-3T>G) in 2 unrelated patients as w

88 ternate 5'-splice donor sites, to yield five splice variants (canine mda-7sv1, canine mda-7sv2, canin

89 te RNA processing of caspase-9 generates the splice variants caspase 9a (C9a) and caspase 9b (C9b).

90 Like the adult splice variant CaV1.1a, the embryonic CaV1.1e variant fu

91 rom the aberrant expression of the embryonic splice variant CaV1.1e in the skeletal muscles of myoton

92 ength CaV1.3L and two C-terminally truncated splice variants (CaV1.342A and CaV1.343S) and their modu

93 derived from mice expressing different CD44 splice variants (Cd44(+/+), Cd44(-/-), Cd44(s/s), or Cd4

94 ified compound heterozygosity for a maternal splicing variant (chr5:60195556, NM_000082:c.618-2A > G)

95 genome, assemble transcripts including novel splice variants, compute the abundance of these transcri

96 CRs), Oprm1 also produces a set of truncated splice variants containing only six transmembrane domain

97 The fibronectin-splicing variant containing extra domain A (Fn-EDA) is p

98 pended on glycolysis, which controlled Foxp3 splicing variants containing exon 2 (Foxp3-E2) through t

99 Our data predict that Cav1.2 and Cav1.3 splice variants contribute differentially to Ca(2+) load

100 sults demonstrate that the production of DCC splice variants controlled by NOVA has a crucial functio

101 nt splicing products and loss of canonically spliced variants correlate with stage and progression in

102 median expression level, 92-98% of observed splice variants correspond to errors.

103 Both CXCL10 and CXCL11 activated splice variant CXCR3A.

104 The dopamine D2 receptor has two splice variants, D2S (Short) and D2L (Long).

105 Molecular manipulations of CPEB2 splice variants demonstrated a key role for this RNA spl

106 d that expression of alpha6 integrin and its splice variants differs between epithelial and mesenchym

107 Here, we evaluated the role of PKCdeltaI splice variant during adipogenesis.

108 splasin A (EDA) is produced as 2 full-length splice variants, EDA1 and EDA2, that bind to EDA recepto

109 racting partners represent contribution from splicing variants, emphasizing the importance of isoform

110 Furthermore, we identified splice variants encoding distinct nuclear and cytoplasmi

111 s in The Cancer Genome Atlas to analyze TP53 splice variant expression.

112 Chronic alcohol exposure can change splice variant expression.

113 hout exon 2 revealed that both groups of FIR splice variants facilitate tumor-supporting effects.

114 t confirm that the 15-kDa protein is a novel splice variant form of TREM-1 (TREM-1sv).

115 xpression of the constitutively-active AR-V7 splice variant generated by AR cryptic exon 3b inclusion

116 MDM2-ALT1, the major splice variant generated, is known to activate the p53 p

117 or drug target, has a highly conserved minor splice variant, GRgamma, which differs by a single argin

118 the splicing event is highly conserved, one splice variant has been selectively removed from Nav1.1

119 A plethora of splice variants have been implicated in CKDs as well.

120 ile mutations in MST1R are rare, alternative splice variants have been previously reported in epithel

121 eptor agonists at the two most abundant hH3R splice variants (hH3R445 and hH3R365) across seven signa

122 e, we provide mechanistic insight that FGFR3 splice variants IIIb and IIIc impact considerably on the

123 ), and replicated previous associations of a splice variant in APOC3 (rs138326449) with triglycerides

124 gest causal roles for these genes, as does a splice variant in SLC16A8.

125 isoform of CaMKII is the predominant nuclear splice variant in the adult heart and regulates cardiomy

126 une diseases or measuring the ratios of mRNA splice variants in cancer stem cells.

127 uantitative technologies for monitoring mRNA splice variants in cells.

128 es is cancer, many reports detail pathogenic splice variants in diseases ranging from neuromuscular d

129 Using PCR approaches we have identified two splice variants in human tissues, which we have named MT

130 ging can be used to detect and quantify mRNA splice variants in living cells.

131 modifications act on the p53 protein and its splice variants in stem and progenitor cells to silence

132 concentrations for the different IGF-1 mRNA splice variants in the cohort of tissues by employing su

133 We identified LSR splice variants in the colon carcinoma cell line HCT116

134 rease in the numbers of established damaging splice variants in these genes.

135 that 72% of multiexon genes express multiple splice variants in this single tissue.

136 functional properties of epithelial-specific splice variants in vivo.

137 5[C] are associated with expression of CASP8 splice variants in which sequences from intron 8 are ret

138 of SCN5A cardiac sodium (Na(+)) channel mRNA splice variants in white blood cells (WBCs) with risk of

139 , 37 base pairs upstream from an alternative splicing variant in NDUFAF6 chr8:96046951 A > G; rs74395

140 This indicated that there are short splicing variants in addition to GABAB receptor subunit

141 Analysis of TNNT2 splicing variants in healthy human hearts suggested an a

142 Together our data indicate that splicing variants in WDR35, and possibly in other IFT-A

143 In this report we describe pathogenic splicing variants in WDR35, encoding retrograde intrafla

144 We previously identified TRAILshort, a TRAIL splice variant, in HIV-infected patients and characteriz

145 c glycine receptor channels, including their splice variants, in the same cellular expression system

146 sed expression of an exon 10-skipped CYP24A1 splice variant; in a minigene model the latter was atten

147 relin, receptors and the recently discovered splicing variant In1-ghrelin, in human normal pituitarie

148 Androgen receptor (AR) splice variants including AR-V7 function as constitutive

149 The splice variant is detected in 73% of xenografts derived

150 by SCN1A, the increased availability of one splice variant is detrimental.

151 rovide converging evidence indicating that a splice variant isoform of the Acbd7 mRNA is expressed an

152 arkedly reduce the activity of wild-type and splice variant isoforms of AR at submicromolar doses.

153 Transcript levels for pan-ErbB4, four ErbB4 splicing variants (JM-a, JM-b, CYT-1, CYT-2), parvalbumi

154 Here we report that one of the K-Ras splice variants, K-Ras4a, is subject to lysine fatty acy

155 One of these novel PTP1B variants, a splice variant lacking exon 6 (PTP1BDelta6), was found e

156 in exon 11 of BRCA1 express a BRCA1-Delta11q splice variant lacking the majority of exon 11.

157 though SRPK1 readily phosphorylates RS2 in a splice variant lacking the N-terminal RS domain (Tra2bet

158 Identification of splice variants lacking a signal peptide suggests the ex

159 Recent reports highlight the emergence of AR splice variants lacking the LBD that can arise during di

160 constitutively active androgen receptor (AR) splice variants lacking the ligand-binding domain.

161 neffective or where constitutively active AR splice variants, lacking the LBD, become overexpressed.

162 we identify biallelic mutations in PIEZO1 (a splicing variant leading to early truncation and a non-s

163 ed lens epithelium-derived growth factor p75 splicing variant (LEDGF), which is a reader protein of H

164 e found that FKBP65 forms complexes with LH2 splice variants LH2A and LH2B but not with LH1 and LH3.

165 onal activity and constitutive activity of a splice variant-like AR.

166 e kinase (PK) over its constitutively active splice variant M1 isoform is considered critical for aer

167 estigated the relationship between macroH2A1 splice variants, macroH2A1.1 and macroH2A1.2, and liver

168 Moreover, AR splice variants may preclude patients with advanced dise

169 es the generation of the proapoptotic, short splicing variant (MCL1-S) and diminishes the antiapoptot

170 However, a fraction of splice variants might correspond to spurious transcripts

171 erns, we hypothesized that these WBC-derived splice variants might further stratify patients with HF

172 However, a LDAH alternative-splicing variant missing 90 amino acids at C-terminus do

173 Here we demonstrated that a truncated 6TM splice variant, mMOR-1G, can rescue IBNtxA analgesia in

174 ially deleterious (nonsynonymous, stop-gain, splice) variants (n = 2,398 for EA; n = 1,693 for AA) an

175 competes with both HGF/SF and its truncated splice variant NK1 for MET binding, despite the location

176 s to quantify any human protein and numerous spliced variants, non-synonymous mutations, and post-tra

177 These full-length and KIDINS220 splice variants occur at precise moments in cortical, hi

178 In human cells, C-Ala is also a splice variant of AlaRS.

179 Vertebrates have evolved a neuron-specific splice variant of C-Src, N1-Src, which differs from C-Sr

180 In parallel, we found that a specific splice variant of canine CNGA3 removes a region of the p

181 Here we identified in rodents a splice variant of CaV1.2 channel, named CaV1.2e21+22, th

182 w that the resurgence of a specific neonatal splice variant of CaV1.2 channels in adult heart under s

183 ing to increased expression of a mesenchymal splice variant of CD44 and a more invasive phenotype.

184 echanism featuring translation of a specific splice variant of CDKN1A that facilitates G1 arrest and

185 CaV1.1e is the voltage-gated calcium channel splice variant of embryonic skeletal muscle.

186 g the production of the extra domain-B (EDB) splice variant of fibronectin (FN), a hallmark of tumor

187 The dominant alternative splice variant of human IL-36beta mRNA was isoform 2, wh

188 utamine to glutamate, as catalyzed by GAC, a splice variant of kidney-type glutaminase (GLS).

189 In this study we describe a splice variant of Lcp2 that reduced the amount of wild-t

190 the formation of MDM2-ALT1, a stress-induced splice variant of MDM2, even under normal conditions.

191 Previous studies in mice identified a splice variant of MTP with an alternate first exon.

192 anism that requires superoxide and a nuclear splice variant of NADPH oxidase.

193 d haplotype likely reintroduced an ancestral splice variant of OAS1 encoding a more active protein, s

194 Here we describe rPGRP-LC, an alternative splice variant of PGRP-LC that selectively dampens immun

195 -/-) mice, which lack the NH2-amino terminal splice variant of PTEN, were unable to eradicate Pseudom

196 Ectopic expression of the splice variant of RAGE (RAGE splice variant 4), which is

197 The presence of the neuronal-specific N1-Src splice variant of the C-Src tyrosine kinase is conserved

198 pe of splicing usually gives rise to a minor splice variant of the endogenous gene and in silico anal

199 e investigated the signaling regulation of a splice variant of the estrogen receptor, namely estrogen

200 The first is a splice variant of the ProTalpha gene, known as isoform C

201 sst5TMD4, a splice variant of the sst5 gene, is overexpressed and as

202 to increased expression of an antiangiogenic splice variant of VEGF-A.

203 These findings demonstrate that splice variants of a single receptor gene can regulate s

204 Examination of splice variants of Ca(V)2.2, containing either exon 37a

205 three transcription start sites and several splice variants of ChemR23 in both monocytes and macroph

206 RT-PCR in mouse brain, we detected two novel splice variants of Htt that lacked the 111-bp exon 29 (H

207 Splice variants of human MTP have not been reported.

208 Several splice variants of IgE exist in human plasma, including

209 In this study we identified short splice variants of KV10.1 resulting from exon-skipping e

210 k, we report the identification of two novel splice variants of Md1, which are expressed at similar l

211 resistance in C. finmarchicus, we identified splice variants of NaVs that were predicted to be toxin

212 ula densa expresses alpha-, beta-, and gamma-splice variants of neuronal nitric oxide synthase 1 (NOS

213 The splice variants of NOTCH2 and FLT3 resulted from complet

214 AA-enriched splice variants of PIK3CD, FGFR3, TSC2 and RASGRP2 contr

215 and temporal distribution of three selected splice variants of the breast cancer susceptibility gene

216 unknown stoichiometry of the three different splice variants of the capsid protein in adeno-associate

217 Our results show that the different splice variants of the CTs differentially distribute wit

218 Here, we characterized novel splice variants of the cytoplasmic C-terminal domain of

219 Splice variants of the mu opioid receptor (MOR), which m

220 ioids may be possible by targeting truncated splice variants of the mu-opioid receptor.

221 We found that four splice variants of the peptidase inhibitor 16 (PI16) mRN

222 for the H3R; further, it is unknown whether splice variants of the same receptor engender the same o

223 tic cells, where they constitutively express splice variants of the tumor antigen (TAg) gene.

224 nique on the localization of NMD-insensitive splice variants of two Arabidopsis thaliana genes, RS2Z3

225 this study we analyzed whether NGT and both splice variants of UGT (UGT1 and UGT2) are able to inter

226 taining the stress-regulated exon (STREX), a splice-variant of the alpha-subunit that displays altere

227 l cells and promoted cell death, a truncated spliced variant of Bnip3 mRNA deleted for exon 3 (Bnip3D

228 These cells either contained a novel spliced variant of the L1 mRNAs that bypassed the suppre

229 ctions between brain-expressed alternatively spliced variants of ASD risk factors.

230 of fusion proteins in plants, we show that a splicing variant of AtGLR3.5 targets the inner mitochond

231 ernative splicing of SCN5A mRNA and that the splicing variant of SCN5A produced in DM presents a redu

232 d downregulation of a short alternative mRNA splicing variant of the methyl-CpG binding domain 2 gene

233 In addition, novel alternative splicing variants of three neuropeptide genes (allatosta

234 allow us to investigate the effects of this splice variant on the progression of tumorigenesis.

235 r in exons 1 or 2 and therefore, render both splice variants oncogenic.

236 ing, the method found three cryptic intronic splice variants (one known and two experimentally verifi

237 Akt3 is expressed as two alternatively spliced variants, one of which lacks the key regulatory

238 Expression of the short splice variants or deletion of the C-terminal PDZ-bindin

239 at are not due to gene fusions, multiple RNA splice variants or pleiotropic effects.

240 ween the large number of active and inactive splice variants, or gain-of-function and loss-of-functio

241 mble the naturally occurring alternative p53 splice variant, p53-psi.

242 tor co-activator 1 alpha (PGC1alpha) and its splice variant PGC1alpha4 increase skeletal muscle mass.

243 Human PHLPP1 encodes two splice variants - PHLPP1alpha (~140-150 kDa) and PHLPP1b

244 th of details in terms of genes, expression, splice variants, polymorphisms, and other features.

245 We previously reported that SmgGDS splice variants promote prenylation and trafficking of G

246 n did not change, whereas the minor-to-major splice variant ratios increased with age.

247 Although both splice variants regulate death receptor (DR)-induced apo

248 eriments reveal that these intron-containing splice variants remain within the nucleus, which allows

249 proportion of splicing errors to functional splice variants remains highly debated.

250 These splice variants represent a short (CT-short without poly

251 Expression of GIRK2a, an SNX27-insensitive splice variant, restored GABABR-activated GIRK currents

252 Furthermore, an alternative splice variant resulting in a truncated protein was pres

253 sing a miR refractory acetylcholinesterase-R splice variant showed a parallel propensity for convulsi

254 In addition, DAB2IP can inhibit several AR splice variants showing constitutive activity in PCa cel

255 monstrate that this evolutionarily conserved splice variant shows higher antiviral activity than full

256 pocampal, and motor neuron development, with splice variants similar to the variants seen in our pati

257 of hormones and neurotransmitters, and both splice variants, SNAP-25a and SNAP-25b, can participate

258 Using splice variant-specific antibodies, we detected K-Ras4A

259 phic response is dependent on the TrpC4alpha splice variant-specific sequence that binds to PIP2.

260 e harbors a previously uncharacterized XIRP2 splice variant, suggesting XIRP2's role in the hair cell

261 Seven haplotypes (hap I-VII) and four mRNA splicing variants (SV) of A3H have been identified.

262 GHRH-R and its splice variant, SV1, were present in 22Rv1, LNCaP, and V

263 These functions are associated with over 200 splice variants (SVs), most of which are catalytic nulls

264 expression analyses identify TaAGL33 and its splice variant TaAGL22 as the FLC orthologs in wheat (Tr

265 Co-expression with distinct ClC-3 splice variants targets ClC-4 to late endosome/lysosomes

266 The SAP102 splice variant that possesses a C-terminal insert (I2) b

267 axis has a key role in regulating the CD44E splice variant that promotes gastric tumorigenesis.

268 ytes from AML patients and with a novel CD33 splice variant that retains CD33 intron 1.

269 anscripts led us to identify NT5E-2, a novel splice variant that was expressed at low abundance in no

270 contributes to pre-mRNA metabolism, and the splice variants that accumulate in sic mutants likely af

271 rganizer of NBs, is expressed as a number of splice variants that all efficiently recruit p53 partner

272 , identified multiple novel intron-retaining splice variants that are developmentally regulated and m

273 event in plants, often leads to PTC-carrying splice variants that are insensitive to NMD; this led us

274 n of constitutively active androgen receptor splice variants that drive disease progression.

275 redicted deleterious nonsynonymous, stop, or splice variants that segregated with severe COPD in at l

276 Of the splice variants, the most common results in a stop codon

277 ion in CDI was observed in two major channel splice variants, though to different extents.

278 lectrophysiological characterization of this splice variant through whole-cell patch clamping on tran

279 absence of the CTM, allowing short Cav1.342A splice variants to activate at lower voltages without af

280 ng at a depth that allows even low-frequency splice variants to be monitored.

281 These results highlight the potential of RNA splice variants to serve as novel biomarkers and molecul

282 of TRPM2 and its interaction with the short splice variant TRPM2 short variant (TRPM2-S) in mediatin

283 ethod identified 32 potential exonic cryptic splice variants, two of which were experimentally evalua

284 he production of a low-level rodless plectin splice variant unaffected.

285 rally mediated expression of the versican V3 splice variant (V3) by ASMCs retards cell proliferation

286 VLDLR has two major alternative splice variants, VLDLRI and VLDLRII, but their biologica

287 Interestingly, this splice variant was expressed in human regulatory T cells

288 ably, this increased burden of NMD, INIT and splice variants was more pronounced in a set of 1397 inn

289 NA levels for the various mu opioid receptor splice variants were assessed to determine whether stabi

290 We observed that the analysed IGF-1 mRNA splice variants were characterized by multimodal distrib

291 Two VAL1 splice variants were identified through RNA sequencing a

292 Three KCC2 splice variants were identified: the formerly described

293 cating pervasive splicing; yet most of these splicing variants were cryptic and increased in nuclear

294 by pharmaceutical companies possess certain splice variants, which evade inactivation.

295 One of these splice variants, which is also expressed by mouse macrop

296 y unappreciated evolutionarily conserved Md1 splice variant with important functions in the regulatio

297 and proteome repertoires, creating different splice variants with distinct cellular functions.

298 The receptor CXCR3 can have two splice variants with opposite functions.

299 ual cells predominantly express single hTERT splice variants, with the alpha+/beta- variant exhibitin

300 rexpress specifically the extra long Galphas splice variant (XLalphas).