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1 ncreased signaling and characterizes a GPR56 splice variant.
2 Factor H levels, especially carriers of the splice variant.
3 e production of PKC betaII and the VEGF 165b splice variant.
4 died, because it has been considered a minor splice variant.
5 use brain, with ClC-3c being the predominant splice variant.
6 ulin and of its muscle-specific metavinculin splice variant.
7 nt systems via expression of different ClC-3 splice variants.
8 WERING LOCUS M-beta (FLM-beta) and FLM-delta splice variants.
9 might be exploited to target specific CXCR3 splice variants.
10 eptor gene OPRM1 creates multiple C-terminal splice variants.
11 nduced changes in the levels of SRSF2 3' UTR splice variants.
12 own to repress translation of specific SRSF2 splice variants.
13 ng a set of 6TM truncated mu-opioid receptor splice variants.
14 distinct modes of targeting of the two K-Ras splice variants.
15 has four isoforms (PDE4A-D) with at least 25 splice variants.
16 is known about miRNA regulation of the OPRM1 splice variants.
17 tially due to the increased expression of AR splice variants.
18 macological targeting of individual receptor splice variants.
19 a context-dependent algorithm for selecting splice variants.
20 different genes, alternative promoters, and splice variants.
21 vel expression of the transporters and their splice variants.
22 of mRNA encoding different IGF-1 alternative splicing variants.
23 ncluding expression of AR gene mutations and splicing variants.
24 ull-length AR (twofold, P < 0.05) and the AR splice variants 1 (threefold, P < 0.05) and 7 (threefold
25 rcise-induced expression of total BDNF, BDNF splice variants 1, 2, 4, 6 and fibronectin type III doma
26 exonic mutation c.3538G>A causes 3 in-frame splicing variants (23del, 26del, and 23/26del) which can
29 pression of the splice variant of RAGE (RAGE splice variant 4), which is resistant to ectodomain shed
30 y showed that detection of androgen receptor splice variant 7 (AR-V7) in circulating tumor cells (CTC
31 mine if pretherapy nuclear androgen-receptor splice variant 7 (AR-V7) protein expression and localiza
33 transcripts including the androgen-receptor splice variant 7 in a cohort of prostate cancer patients
35 thesized that detection of androgen-receptor splice variant 7 messenger RNA (AR-V7) in circulating tu
36 usly that the detection of androgen receptor splice variant-7 (AR-V7) mRNA in circulating tumor cells
37 otype and coexistence of more than one TNNT2 splicing variant (90.5% GG v 41.7% GA/AA; P = .005).
39 eceptor-deficient mouse that lacks all Oprm1 splice variants, ablating mu-opioid activity in these an
41 gene expression analysis for RBM20-dependent splice variants affected sarcomeric (TTN and LDB3) and c
42 full-length transcript and the most frequent splice variants (AID-DeltaE4a, AID-DeltaE) were detected
43 (LHY) and CIRCADIAN CLOCK ASSOCIATED1 (CCA1) splice variants, among other alternatively spliced trans
44 greater amounts of a non-coding Neurog3 mRNA splice variant and had fewer Neurog3/Insm1 co-expressing
46 y transcript has three potential alternative splice variants and cell-type specific expression result
47 we describe examples of these CKD-associated splice variants and ideas on how to manipulate them for
48 be gathered from this database for different splice variants and ncRNAs, such as microRNAs and lincRN
50 e results in reduced bimodality of all hTERT splice variants and significant upregulation of alpha sp
51 ology of ligand binding to CXCR3 alternative splice variants and their downstream signaling pathways
53 s with novel transcription initiation sites, spliced variants and alternative polyadenylation sites.
55 sequencing-based RNA-seq is able to identify splicing variants and single nucleotide variants in one
56 Quiescent LNEPs activate a DeltaNp63 (a p63 splice variant) and cytokeratin 5 remodelling program af
57 urrent depends on the species of origin, the splice variant, and the concentration of the purinergic
58 identified including indels, stop-gain/loss, splice variants, and recurrent gene variants indicative
60 both full-length androgen receptor (fAR) and splice variant AR (AR-V7) to inhibit AR transcriptional
61 ealed that miR-124 directly downregulated AR splice variants AR-V4 and V7 along with EZH2 and Src, on
63 course of development, including in abnormal splice variants (AR-SV)-driven advanced stage castration
66 ing to upregulation of the androgen receptor splice variant AR3 which has been shown to play a role i
67 use cerebellum revealed that thousands of RE splice variants are associated with translating ribosome
68 static to sic-3, indicating the LHY and CCA1 splice variants are needed for sic-3 circadian clock phe
69 ctivated states, and the differences between splice variants are occluded by antiepileptic drugs that
72 In contrast, the microtubule-interacting splice variant ARv567 was sensitive to taxane-induced mi
73 at two clinically relevant androgen receptor splice variants, ARv567 and ARv7, differentially associa
75 findings highlight the importance of an MDM2 splice variant as a critical modifier of both p53-depend
76 same pattern of 5' untranslated region (UTR) splice variants as the transgenic mice and the human can
77 Ps may control expression of AR-V7 and other splice variants as well as their downstream functions in
78 rotein fragments from two different human CT splice variants, as predicted from SCA6 patients, in PCs
79 n transcript isoforms, including length- and splice variants, as well as between overlapping polycist
82 e differential expression of two alternative splice variants (ASV), which differ in length and in the
83 microheterogeneity with numerous alternative splice variants (ASVs) and post-translational modificati
88 ternate 5'-splice donor sites, to yield five splice variants (canine mda-7sv1, canine mda-7sv2, canin
89 te RNA processing of caspase-9 generates the splice variants caspase 9a (C9a) and caspase 9b (C9b).
91 rom the aberrant expression of the embryonic splice variant CaV1.1e in the skeletal muscles of myoton
92 ength CaV1.3L and two C-terminally truncated splice variants (CaV1.342A and CaV1.343S) and their modu
93 derived from mice expressing different CD44 splice variants (Cd44(+/+), Cd44(-/-), Cd44(s/s), or Cd4
94 ified compound heterozygosity for a maternal splicing variant (chr5:60195556, NM_000082:c.618-2A > G)
95 genome, assemble transcripts including novel splice variants, compute the abundance of these transcri
96 CRs), Oprm1 also produces a set of truncated splice variants containing only six transmembrane domain
98 pended on glycolysis, which controlled Foxp3 splicing variants containing exon 2 (Foxp3-E2) through t
100 sults demonstrate that the production of DCC splice variants controlled by NOVA has a crucial functio
101 nt splicing products and loss of canonically spliced variants correlate with stage and progression in
106 d that expression of alpha6 integrin and its splice variants differs between epithelial and mesenchym
108 splasin A (EDA) is produced as 2 full-length splice variants, EDA1 and EDA2, that bind to EDA recepto
109 racting partners represent contribution from splicing variants, emphasizing the importance of isoform
113 hout exon 2 revealed that both groups of FIR splice variants facilitate tumor-supporting effects.
115 xpression of the constitutively-active AR-V7 splice variant generated by AR cryptic exon 3b inclusion
117 or drug target, has a highly conserved minor splice variant, GRgamma, which differs by a single argin
118 the splicing event is highly conserved, one splice variant has been selectively removed from Nav1.1
120 ile mutations in MST1R are rare, alternative splice variants have been previously reported in epithel
121 eptor agonists at the two most abundant hH3R splice variants (hH3R445 and hH3R365) across seven signa
122 e, we provide mechanistic insight that FGFR3 splice variants IIIb and IIIc impact considerably on the
123 ), and replicated previous associations of a splice variant in APOC3 (rs138326449) with triglycerides
125 isoform of CaMKII is the predominant nuclear splice variant in the adult heart and regulates cardiomy
128 es is cancer, many reports detail pathogenic splice variants in diseases ranging from neuromuscular d
129 Using PCR approaches we have identified two splice variants in human tissues, which we have named MT
131 modifications act on the p53 protein and its splice variants in stem and progenitor cells to silence
132 concentrations for the different IGF-1 mRNA splice variants in the cohort of tissues by employing su
137 5[C] are associated with expression of CASP8 splice variants in which sequences from intron 8 are ret
138 of SCN5A cardiac sodium (Na(+)) channel mRNA splice variants in white blood cells (WBCs) with risk of
139 , 37 base pairs upstream from an alternative splicing variant in NDUFAF6 chr8:96046951 A > G; rs74395
144 We previously identified TRAILshort, a TRAIL splice variant, in HIV-infected patients and characteriz
145 c glycine receptor channels, including their splice variants, in the same cellular expression system
146 sed expression of an exon 10-skipped CYP24A1 splice variant; in a minigene model the latter was atten
147 relin, receptors and the recently discovered splicing variant In1-ghrelin, in human normal pituitarie
151 rovide converging evidence indicating that a splice variant isoform of the Acbd7 mRNA is expressed an
152 arkedly reduce the activity of wild-type and splice variant isoforms of AR at submicromolar doses.
153 Transcript levels for pan-ErbB4, four ErbB4 splicing variants (JM-a, JM-b, CYT-1, CYT-2), parvalbumi
157 though SRPK1 readily phosphorylates RS2 in a splice variant lacking the N-terminal RS domain (Tra2bet
159 Recent reports highlight the emergence of AR splice variants lacking the LBD that can arise during di
161 neffective or where constitutively active AR splice variants, lacking the LBD, become overexpressed.
162 we identify biallelic mutations in PIEZO1 (a splicing variant leading to early truncation and a non-s
163 ed lens epithelium-derived growth factor p75 splicing variant (LEDGF), which is a reader protein of H
164 e found that FKBP65 forms complexes with LH2 splice variants LH2A and LH2B but not with LH1 and LH3.
166 e kinase (PK) over its constitutively active splice variant M1 isoform is considered critical for aer
167 estigated the relationship between macroH2A1 splice variants, macroH2A1.1 and macroH2A1.2, and liver
169 es the generation of the proapoptotic, short splicing variant (MCL1-S) and diminishes the antiapoptot
171 erns, we hypothesized that these WBC-derived splice variants might further stratify patients with HF
173 Here we demonstrated that a truncated 6TM splice variant, mMOR-1G, can rescue IBNtxA analgesia in
174 ially deleterious (nonsynonymous, stop-gain, splice) variants (n = 2,398 for EA; n = 1,693 for AA) an
175 competes with both HGF/SF and its truncated splice variant NK1 for MET binding, despite the location
176 s to quantify any human protein and numerous spliced variants, non-synonymous mutations, and post-tra
179 Vertebrates have evolved a neuron-specific splice variant of C-Src, N1-Src, which differs from C-Sr
182 w that the resurgence of a specific neonatal splice variant of CaV1.2 channels in adult heart under s
183 ing to increased expression of a mesenchymal splice variant of CD44 and a more invasive phenotype.
184 echanism featuring translation of a specific splice variant of CDKN1A that facilitates G1 arrest and
186 g the production of the extra domain-B (EDB) splice variant of fibronectin (FN), a hallmark of tumor
190 the formation of MDM2-ALT1, a stress-induced splice variant of MDM2, even under normal conditions.
193 d haplotype likely reintroduced an ancestral splice variant of OAS1 encoding a more active protein, s
194 Here we describe rPGRP-LC, an alternative splice variant of PGRP-LC that selectively dampens immun
195 -/-) mice, which lack the NH2-amino terminal splice variant of PTEN, were unable to eradicate Pseudom
197 The presence of the neuronal-specific N1-Src splice variant of the C-Src tyrosine kinase is conserved
198 pe of splicing usually gives rise to a minor splice variant of the endogenous gene and in silico anal
199 e investigated the signaling regulation of a splice variant of the estrogen receptor, namely estrogen
205 three transcription start sites and several splice variants of ChemR23 in both monocytes and macroph
206 RT-PCR in mouse brain, we detected two novel splice variants of Htt that lacked the 111-bp exon 29 (H
210 k, we report the identification of two novel splice variants of Md1, which are expressed at similar l
211 resistance in C. finmarchicus, we identified splice variants of NaVs that were predicted to be toxin
212 ula densa expresses alpha-, beta-, and gamma-splice variants of neuronal nitric oxide synthase 1 (NOS
215 and temporal distribution of three selected splice variants of the breast cancer susceptibility gene
216 unknown stoichiometry of the three different splice variants of the capsid protein in adeno-associate
222 for the H3R; further, it is unknown whether splice variants of the same receptor engender the same o
224 nique on the localization of NMD-insensitive splice variants of two Arabidopsis thaliana genes, RS2Z3
225 this study we analyzed whether NGT and both splice variants of UGT (UGT1 and UGT2) are able to inter
226 taining the stress-regulated exon (STREX), a splice-variant of the alpha-subunit that displays altere
227 l cells and promoted cell death, a truncated spliced variant of Bnip3 mRNA deleted for exon 3 (Bnip3D
230 of fusion proteins in plants, we show that a splicing variant of AtGLR3.5 targets the inner mitochond
231 ernative splicing of SCN5A mRNA and that the splicing variant of SCN5A produced in DM presents a redu
232 d downregulation of a short alternative mRNA splicing variant of the methyl-CpG binding domain 2 gene
236 ing, the method found three cryptic intronic splice variants (one known and two experimentally verifi
240 ween the large number of active and inactive splice variants, or gain-of-function and loss-of-functio
242 tor co-activator 1 alpha (PGC1alpha) and its splice variant PGC1alpha4 increase skeletal muscle mass.
244 th of details in terms of genes, expression, splice variants, polymorphisms, and other features.
248 eriments reveal that these intron-containing splice variants remain within the nucleus, which allows
251 Expression of GIRK2a, an SNX27-insensitive splice variant, restored GABABR-activated GIRK currents
253 sing a miR refractory acetylcholinesterase-R splice variant showed a parallel propensity for convulsi
254 In addition, DAB2IP can inhibit several AR splice variants showing constitutive activity in PCa cel
255 monstrate that this evolutionarily conserved splice variant shows higher antiviral activity than full
256 pocampal, and motor neuron development, with splice variants similar to the variants seen in our pati
257 of hormones and neurotransmitters, and both splice variants, SNAP-25a and SNAP-25b, can participate
259 phic response is dependent on the TrpC4alpha splice variant-specific sequence that binds to PIP2.
260 e harbors a previously uncharacterized XIRP2 splice variant, suggesting XIRP2's role in the hair cell
263 These functions are associated with over 200 splice variants (SVs), most of which are catalytic nulls
264 expression analyses identify TaAGL33 and its splice variant TaAGL22 as the FLC orthologs in wheat (Tr
269 anscripts led us to identify NT5E-2, a novel splice variant that was expressed at low abundance in no
270 contributes to pre-mRNA metabolism, and the splice variants that accumulate in sic mutants likely af
271 rganizer of NBs, is expressed as a number of splice variants that all efficiently recruit p53 partner
272 , identified multiple novel intron-retaining splice variants that are developmentally regulated and m
273 event in plants, often leads to PTC-carrying splice variants that are insensitive to NMD; this led us
275 redicted deleterious nonsynonymous, stop, or splice variants that segregated with severe COPD in at l
278 lectrophysiological characterization of this splice variant through whole-cell patch clamping on tran
279 absence of the CTM, allowing short Cav1.342A splice variants to activate at lower voltages without af
281 These results highlight the potential of RNA splice variants to serve as novel biomarkers and molecul
282 of TRPM2 and its interaction with the short splice variant TRPM2 short variant (TRPM2-S) in mediatin
283 ethod identified 32 potential exonic cryptic splice variants, two of which were experimentally evalua
285 rally mediated expression of the versican V3 splice variant (V3) by ASMCs retards cell proliferation
288 ably, this increased burden of NMD, INIT and splice variants was more pronounced in a set of 1397 inn
289 NA levels for the various mu opioid receptor splice variants were assessed to determine whether stabi
290 We observed that the analysed IGF-1 mRNA splice variants were characterized by multimodal distrib
293 cating pervasive splicing; yet most of these splicing variants were cryptic and increased in nuclear
296 y unappreciated evolutionarily conserved Md1 splice variant with important functions in the regulatio
299 ual cells predominantly express single hTERT splice variants, with the alpha+/beta- variant exhibitin
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