ライフサイエンスコーパス: spliceosomal

1 nuclear RNAs (snRNAs) incompletely processed spliceosomal.

2 rminal RNA Recognition Motif (RRM) domain of spliceosomal A protein of the U1 small nuclear ribonucle

3 the Tetrahymena group I intron or the yeast spliceosomal ACT1 intron at the same location is not sub

4 as a protein that is intimately involved in spliceosomal activation and the catalytic reaction.

5 al proteins, revealing a new role of Brr2 in spliceosomal activation in addition to U4/U6 unwinding.

6 for retaining U5 and U6 snRNPs during/after spliceosomal activation through its interaction with snR

7 owever, the truncation significantly impairs spliceosomal activation, leading to a dramatic reduction

8 /U6 RNA duplex, which is a critical step for spliceosomal activation.

9 ible for U4/U6 unwinding, a critical step in spliceosomal activation.

10 s, transposons, and other introns, including spliceosomal and group II self-splicing introns.

11 omplex in OIS and demonstrate a link between spliceosomal and ribosomal components, functioning indep

12 ctivate essential RNAs, including ribosomal, spliceosomal and telomeric RNAs, cisplatin binding sites

13 on, SMN-C1 treatment increases the levels of spliceosomal and U7 small-nuclear RNAs and corrects RNA

14 thase to modify newly synthesized ribosomal, spliceosomal, and possibly other RNAs.

15 e U1 snRNP to specific pre-mRNAs, permitting spliceosomal assembly and splicing.

16 licing in rnp-4f, which encodes a Drosophila spliceosomal assembly factor.

17 These results identify the A complex as the spliceosomal assembly step dedicated to splice site pair

18 zation/calcium signaling controls a critical spliceosomal assembly step to regulate the variant subun

19 gesting a previously unknown role of Prp8 in spliceosomal assembly through its interaction with U1 sn

20 plice site pairing are separate steps during spliceosomal assembly, and ATP hydrolysis drives the irr

21 These results demonstrate the early spliceosomal association of Bud31 and provide plausible

22 Sde2 facilitates spliceosomal association of Cactin/Cay1, with a function

23 s, yet no three-dimensional structure of any spliceosomal ATPases/helicases is known.

24 tibodies binding multiple epitopes of Ro and spliceosomal autoantigens.

25 t at a lower level than the WT Brr2) and the spliceosomal B complex.

26 ate stage during conversion of pre-catalytic spliceosomal B complexes into activated B(act) complexes

27 ide insights into substrate selection during spliceosomal branching catalysis; additionally, this sys

28 Recently reported structures of the spliceosomal C complex with the cleaved 5' exon and lari

29 hat snoRNP proteins bind specifically at the spliceosomal C1 complex stage.

30 trons, and the property that links them with spliceosomal catalysis, is their ability to undergo spli

31 ring binds to the TER1 precursor, stimulates spliceosomal cleavage and promotes the hypermethylation

32 that the widespread and basal N. crassa-type spliceosomal cleavage mechanism is more ancestral than t

33 The discovery of a prevalent, yet distinct, spliceosomal cleavage mechanism throughout diverse funga

34 The first spliceosomal cleavage reaction generates the mature 3' e

35 tly upstream and partly overlapping with the spliceosomal cleavage site is a putative binding site fo

36 ombe telomerase RNA (SpTER1) is generated by spliceosomal cleavage, a reaction that corresponds to th

37 nts the second step of splicing and promotes spliceosomal cleavage.

38 Spliceosome assembly was blocked at the pre-spliceosomal complex A stage.

39 SON is a key component of the spliceosomal complex and a critical mediator of constitu

40 n of prespliceosomal complex A and the early spliceosomal complex B but, interestingly, not the very

41 Formation of the first ATP-independent spliceosomal complex commits the pre-mRNA to the general

42 tri-snRNP is a 1.5-megadalton pre-assembled spliceosomal complex comprising U5 small nuclear RNA (sn

43 o produce a 29-A density map of a stable 37S spliceosomal complex from the genetically tractable fiss

44 The U5 spliceosomal complex of eight highly conserved proteins

45 rabbits received a peptide from the Sm B/B' spliceosomal complex previously shown to be immunogenic

46 protein that associates with the activated B spliceosomal complex SKIP.

47 become committed at the first ATP-dependent spliceosomal complex when rearrangements lock U2 snRNP o

48 cle and the pre-mRNA results in a productive spliceosomal complex, leading to intermediates and produ

49 Gemin5, a component of the spliceosomal complex, was chosen for further study.

50 ed in intermolecular interactions within the spliceosomal complex.

51 n by regulating the function of the U2 snRNA spliceosomal complex.

52 e the NTR, Prp43_Ntr1GP disassembles earlier spliceosomal complexes (A, B, B(act)), indicating that N

53 ctors in nuclear speckles and assembles into spliceosomal complexes in association with low-abundance

54 We propose that spliceosomal complexes provide a platform for siRNA gene

55 Early spliceosomal complexes were also immunoprecipitated by t

56 ecurring theme regards the dynamic nature of spliceosomal complexes, which may be even more intricate

57 by promoting the formation of ATP-dependent spliceosomal complexes.

58 pered progress in analyzing the structure of spliceosomal complexes.

59 we demonstrate to have multiple partners in spliceosomal complexes.

60 ght on the dynamic assembly of this critical spliceosomal component and elucidate the molecular inter

61 Pre-mRNA processing factor 3 (PRPF3) is a spliceosomal component essential for pre-mRNA processing

62 Ott1 (Rbm15), a spliceosomal component originally identified as a fusion

63 F65) with the splicing factor 1 (SF1) or the spliceosomal component SF3b155 are exchanged during a cr

64 , the recognition of the intron substrate by spliceosomal components and the assembly of these compon

65 Growing evidence suggests that core spliceosomal components differentially affect RNA proces

66 events further assembly of the U1 snRNP with spliceosomal components downstream.

67 TDP-43 also recruits key spliceosomal components from Cajal bodies.

68 ing competition for specific binding between spliceosomal components involved in recognition of 5' an

69 t exonic splicing enhancers recruit multiple spliceosomal components required for the initial recogni

70 actors is consistent with the elimination of spliceosomal components that play a peripheral or modula

71 pre-mRNA maturation through the bridging of spliceosomal components to H3K4me3 via CHD1.

72 n the absence of the approximately 200 other spliceosomal components, performs a two-step reaction wi

73 t GFP-CDKC2 fusion proteins co-localize with spliceosomal components, that the expression of CDKC2 mo

74 or basic metabolites and retains a subset of spliceosomal components, with a transcriptome broadly fo

75 vival of Motor Neuron, a master assembler of spliceosomal components.

76 the mRNA export complex TREX-2 and multiple spliceosomal components.

77 3p-associated material includes the expected spliceosomal components; however, we also identify sever

78 y1p acts together with U6 snRNA to promote a spliceosomal conformation favorable for first-step chemi

79 mplex recovered with a mutant version of the spliceosomal core protein Prp8p.

80 SCNM1 is also co-immunoprecipitated with the spliceosomal core Smith (Sm) proteins and demonstrates f

81 act modus operandi of Prp43 and of all other spliceosomal DEAH-box RNA helicases is still elusive.

82 c maturases in bacteria into their versatile spliceosomal descendants in the nucleus.

83 lso will be useful for the analysis of other spliceosomal DExD-box ATPases/helicases.

84 M interaction also inhibits the formation of spliceosomal E complex and splicing.

85 ate pre-mRNAs, have been an early feature of spliceosomal evolution?

86 steps, identified Prp8, the highly conserved spliceosomal factor.

87 ions related to RNA processing such as SF3B1 spliceosomal factor.

88 Core spliceosomal factors (such as SF3B1 and U2AF1) associate

89 Defective or imbalanced expression of spliceosomal factors has been linked to human disease; h

90 uncharacterized protein found in some human spliceosomal fractions.

91 els of snoRNA that target spliceosomal RNAs, spliceosomal function, and heart development.

92 efore are likely indirect effects of altered spliceosomal function, consistent with prior data showin

93 Many fundamental aspects of spliceosomal function, including the identity of catalyt

94 Spliceosomal gene mutations are always heterozygous and

95 d pharmacologic evidence that leukemias with spliceosomal gene mutations are preferentially susceptib

96 of the mechanistic and biological effects of spliceosomal gene mutations in MDSs as well as the regul

97 tiology and highlights the complexity of the spliceosomal gene network.

98 f expressing the most common mutation in the spliceosomal gene SF3B1 on hematopoiesis.

99 Engineered variable expression of the spliceosomal gene SNRNP40 promotes metastasis, attributa

100 Spliceosomal genes are probably tumor suppressors, and t

101 Mutations affecting spliceosomal genes that result in defective splicing are

102 Recently, recurrent mutations of spliceosomal genes were frequently identified in myeloid

103 asms was performed, and somatic mutations in spliceosomal genes were identified.

104 oding splicing factors (which we refer to as spliceosomal genes) are commonly found in patients with

105 e identified additional somatic mutations in spliceosomal genes, including SF3B1, U2AF1, and SRSF2.

106 One of these spliceosomal genes, U2AF1, was affected by canonical som

107 ying the ordered addition of Brr2, a pivotal spliceosomal helicase, to the U5 snRNP.

108 standing of the functions of Brr2p and other spliceosomal helicases has been limited by lack of knowl

109 d carboxyl-terminal domain also found in the spliceosomal helicases Prp16, Prp22, and Prp43.

110 intron-specific splicing function and early spliceosomal interactions and suggests links with cell c

111 lex formed between the branch site (BS) of a spliceosomal intron and its cognate sequence in U2 snRNA

112 sent a method in which we use the pattern of spliceosomal intron conservation to develop a series of

113 ces from the well-known orthologous U12-type spliceosomal intron database U12DB.

114 The most obvious spliceosomal intron duplication pathways involve an RNA

115 Therefore, for a spliceosomal intron to be originated by duplication, eit

116 speculation on a possible interplay between spliceosomal introns and ectopic expression at the origi

117 nd more abrupt increases in the abundance of spliceosomal introns and mobile genetic elements.

118 between group II introns and both eukaryotic spliceosomal introns and non-LTR-retrotransposons.

119 r the emergence of eukaryotic retroelements, spliceosomal introns and other key components of the spl

120 sons thought to be evolutionary ancestors of spliceosomal introns and retroelements in eukaryotes.

121 that are widely held to be the ancestors of spliceosomal introns and retrotransposons that insert in

122 d to share common ancestry with both nuclear spliceosomal introns and retrotransposons, which collect

123 The proposed sources of spliceosomal introns are exons, transposons, and other i

124 Spliceosomal introns are thought to be the most likely s

125 evolutionary perspective because the nuclear spliceosomal introns are thought to derive from group II

126 ypothesized to be the progenitor not only of spliceosomal introns but also of non-LTR retrotransposon

127 Spliceosomal introns can occupy nearby rather than ident

128 A new study reports creation of spliceosomal introns in multiple related fungal species

129 II introns, tRNA and/or archaeal introns and spliceosomal introns in nuclear pre-mRNA.

130 that today living organisms can acquire new spliceosomal introns in their genes.

131 A new genome-wide analysis of spliceosomal introns indicates massive loss and gain of

132 ring between U2 snRNA and the branch site of spliceosomal introns is essential for spliceosome assemb

133 ionary forces responsible for the origins of spliceosomal introns remain mysterious.

134 The evolutionary origin of spliceosomal introns remains elusive.

135 the Stentor genome, we discover the smallest spliceosomal introns reported for any species.

136 Group II and spliceosomal introns share a common splicing pathway and

137 Thus, the primordial spliceosomal introns were, most likely, U2-type.

138 een proposed for the origin and evolution of spliceosomal introns, a hallmark of eukaryotic genes.

139 e commonly believed to be the progenitors of spliceosomal introns, but they are notably absent from n

140 ron loss or evolution into protein-dependent spliceosomal introns, consistent with the bacterial grou

141 evolution, as they are likely progenitors of spliceosomal introns, retroelements, and other machinery

142 The two types of eukaryotic spliceosomal introns, U2 and U12, possess different spli

143 fer, reside in a genome of 19.7 Mbp with 235 spliceosomal introns.

144 bed; some of the latter contained functional spliceosomal introns.

145 to promote the splicing of both group II and spliceosomal introns.

146 associated with mobile elements, group I and spliceosomal introns.

147 he evolution of mobile group II introns into spliceosomal introns.

148 e in D. melanogaster and to have eight short spliceosomal introns.

149 RNAs that are ancestrally related to nuclear spliceosomal introns.

150 of splicing reactions for both group II and spliceosomal introns.

151 m nuclear genomes and drove the evolution of spliceosomal introns.

152 hanistically similar to the metazoan nuclear spliceosomal introns; therefore, group II introns have b

153 These included the U1 spliceosomal lncRNA and RP11-462G22.1, each entailing se

154 number of introns and a concomitant loss of spliceosomal machinery components.

155 hermore, we identify high variability in the spliceosomal machinery gene set.

156 Somatic mutations of the spliceosomal machinery occur frequently in adult patient

157 scape in PDAC with underlying changes in the spliceosomal machinery.

158 kely has other introns and fully functional, spliceosomal machinery.

159 These spliceosomal mutations often occur in a mutually exclusi

160 To determine the functional effect of spliceosomal mutations, we evaluated pre-mRNA splicing p

161 and patient-derived xenograft AMLs carrying spliceosomal mutations.

162 The solution structure of the spliceosomal pre-mRNA branch site showed that a phylogen

163 ntron in a transcription factor-like gene, a spliceosomal processed intron in its DNA polymerase gene

164 Our data expose a spliceosomal progression cycle of U2 stem IIa formation,

165 We show that human eIF4G-like spliceosomal protein (h)CWC22 directly interacts with th

166 esults also demonstrate an analogy between a spliceosomal protein and ribosomal proteins that insert

167 They have both been shown to be part of sub- spliceosomal protein complexes that are essential for pr

168 iate with splicing factor 3B1 (SF3B1), a key spliceosomal protein of the U2 small nuclear ribonucleop

169 human orthologue of Saccharomyces cerevisiae spliceosomal protein Prp2, an RNA-dependent ATPase that

170 elomerase, and retroviral RTs as well as the spliceosomal protein Prp8 in eukaryotes.

171 The auxiliary spliceosomal protein SCNM1 contributes to recognition of

172 Beag encodes a spliceosomal protein similar to splicing factors in huma

173 n, a fragment of human fibrillarin (GAR) and spliceosomal protein SmB.

174 isrupted one allele of the gene encoding the spliceosomal protein SmD3, creating a model of haploinsu

175 amers of I-E(k)-containing peptides from the spliceosomal protein U1-70 that specifically stain disti

176 rminal RNA recognition motif (RRM) domain of spliceosomal protein U1A, interacting with its RNA targe

177 and interacts with RNA polymerase II and the spliceosomal protein U5-15kD.

178 provide a mechanistic link between a mutant spliceosomal protein, alterations in the splicing of key

179 Recently, mutations in a gene encoding a spliceosomal protein, SF3B1, were discovered in a distin

180 tified that mutations in genes encoding core spliceosomal proteins and accessory regulatory splicing

181 xpression by promoting methylation of the Sm spliceosomal proteins and significantly altering the spl

182 However, the functions of many auxiliary spliceosomal proteins are still unknown.

183 Mutations affecting spliceosomal proteins are the most common mutations in p

184 Recently, recurrent mutations in numerous spliceosomal proteins have been associated with a number

185 STIPL1 is a homolog of the spliceosomal proteins TFP11 (Homo sapiens) and Ntr1p (Sa

186 mutations in predicted splicing factors and spliceosomal proteins that affect cell fate, the circadi

187 CDC5L and PLRG1 are both spliceosomal proteins that are highly conserved across s

188 3 subsets: 1) 60 kd Ro, 52-kd Ro, and La, 2) spliceosomal proteins, and 3) double-stranded DNA (dsDNA

189 cancer and that mutations in genes encoding spliceosomal proteins, as well as mutations affecting th

190 etry, we identify approximately 145 distinct spliceosomal proteins, making the spliceosome the most c

191 control deubiquitination of histone H2B and spliceosomal proteins, respectively.

192 s interaction with snRNAs and possibly other spliceosomal proteins, revealing a new role of Brr2 in s

193 ropose that the reversible ubiquitination of spliceosomal proteins, such as Prp3, guides rearrangemen

194 s screening resulted in the isolation of two spliceosomal proteins, U1-70K and U2AF(35) b that are kn

195 Here, we report that the spliceosomal Prp19 complex modifies Prp3, a component of

196 he similarity between maturases and the core spliceosomal Prp8 protein further supports this intrigui

197 Consistently, H2A.Z promotes efficient spliceosomal rearrangements involving the U2 snRNP, as H

198 ion, cytokine activity, protein kinases, RNA spliceosomal ribonucleoproteins, intracellular signaling

199 II gene-external promoters, including the U6 spliceosomal RNA and selenocysteine tRNA genes.

200 peting stem IIa and stem IIc helices are key spliceosomal RNA elements that optimize juxtaposition of

201 signal recognition particle and the yeast U2 spliceosomal RNA homolog.

202 esidues in several non-coding RNAs: tRNA, U2 spliceosomal RNA, and steroid receptor activator RNA.

203 (Met) were vastly underrepresented, while U6 spliceosomal RNA, which functions in the nucleus, was en

204 e-specific 2'-O-methylation of ribosomal and spliceosomal RNAs and are critical for gene expression.

205 ant noncoding RNAs such as tRNAs, rRNAs, and spliceosomal RNAs are also heavily modified and depend o

206 n Prp24 that suppress mutations in U4 and U6 spliceosomal RNAs cluster primarily in the beta-sheet of

207 g specific nucleotides of ribosomal RNAs and spliceosomal RNAs for biochemical modification.

208 ial for ribosome biogenesis, modification of spliceosomal RNAs, and telomerase stability.

209 otected regions within small nucleolar RNAs, spliceosomal RNAs, microRNAs, tRNAs, long noncoding (lnc

210 a link between levels of snoRNA that target spliceosomal RNAs, spliceosomal function, and heart deve

211 ated in the 28S and 18S ribosomal RNAs and 2 spliceosomal RNAs, U2 and U6.

212 -nucleotide subdomain derived from the U2:U6 spliceosomal RNAs.

213 The C-terminal tails of spliceosomal Sm proteins contain symmetrical dimethylarg

214 ith ribonucleoprotein Gemin proteins but not spliceosomal Sm proteins needed for snRNP assembly.

215 lts in the complete loss of sDMA residues on spliceosomal Sm proteins.

216 he SL for mRNA and an intron that contains a spliceosomal (Sm) binding site.

217 t the SMN protein plays an important role in spliceosomal small nuclear ribonucleoprotein (snRNP) bio

218 The initial steps of spliceosomal small nuclear ribonucleoprotein (snRNP) mat

219 Here we show that GEMIN2, a spliceosomal small nuclear ribonucleoprotein assembly fa

220 , which has a well characterized function in spliceosomal small nuclear ribonucleoprotein assembly.

221 e in its function as an assembly machine for spliceosomal small nuclear ribonucleoprotein particles (

222 SMN is important for the biogenesis of spliceosomal small nuclear ribonucleoprotein particles,

223 mponents of the CB, such as the SMN complex, spliceosomal small nuclear ribonucleoproteins (RNPs), sm

224 plays an essential role in the production of spliceosomal small nuclear ribonucleoproteins (snRNPs) a

225 ) complex is essential for the biogenesis of spliceosomal small nuclear ribonucleoproteins (snRNPs) a

226 erized function of SMN is as an assembler of spliceosomal small nuclear ribonucleoproteins (snRNPs).

227 s in pre-mRNA splicing, forming the cores of spliceosomal small nuclear ribonucleoproteins (snRNPs).

228 N complex) that functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs).

229 The SMN complex functions in the assembly of spliceosomal small nuclear ribonucleoproteins and probab

230 plays an essential role in the biogenesis of spliceosomal small nuclear ribonucleoproteins in all tis

231 NF family of proteins found in the U1 and U2 spliceosomal small nuclear ribonucleoproteins is highly

232 Gemin7 interacts with several Sm proteins of spliceosomal small nuclear ribonucleoproteins, in partic

233 protein complex required for the assembly of spliceosomal small nuclear ribonucleoproteins.

234 er RNA (pre-mRNA) splicing requires multiple spliceosomal small nuclear RNA (snRNA) and pre-mRNA rear

235 nesis of eukaryotic ribosomal RNA (rRNA) and spliceosomal small nuclear RNA (snRNA), uridines at spec

236 he long-unknown methyltransferase for the U6 spliceosomal small nuclear RNA (snRNA).

237 Most of the major spliceosomal small nuclear RNAs (snRNAs) (i.e. U1, U2, U

238 Because spliceosomal small nuclear RNAs (snRNAs) bind the substr

239 toplasmic injection of fluorescently labeled spliceosomal small nuclear RNAs (snRNAs), target the nas

240 modification of nucleotides in ribosomal and spliceosomal small nuclear RNAs, respectively.

241 r, binds to trimethylguanosine (TMG) caps on spliceosomal small nuclear RNAs.

242 emble Sm cores similar to those found on the spliceosomal small nuclear RNPs (snRNPs).

243 s important for the biogenesis of ribosomes, spliceosomal small nuclear RNPs, microRNAs and the telom

244 interactions with the C-terminal tail of the spliceosomal SmN/B/B' proteins in FAS/CD95 alternative s

245 8, promotes transcription of RNAPII-specific spliceosomal snRNA and small nucleolar RNA (snoRNA) gene

246 the first time that 5FU incorporates into a spliceosomal snRNA at natural pseudouridylation sites in

247 s have now shown that mutations in one minor spliceosomal snRNA, U4atac, are linked to a rare autosom

248 Spliceosomal snRNAs and ribosomal RNAs in metazoans cont

249 supports both the catalytic potential of the spliceosomal snRNAs and their resemblance to elements of

250 to that typical for eukaryotes, T. vaginalis spliceosomal snRNAs lack a cap and may contain 5' monoph

251 resulted in the coprecipitation of the five spliceosomal snRNAs, core Sm polypeptides, and the U1-sp

252 methylguanosine (TMG) caps characteristic of spliceosomal snRNAs.

253 erogeneous mixture of pre-mRNAs and the five spliceosomal snRNAs.

254 of Cajal bodies (CBs), major NBs involved in spliceosomal snRNP assembly and their role in genome org

255 nuclear RNAs (snRNAs)-and promotes efficient spliceosomal snRNP assembly.

256 SMN protein in orchestrating the assembly of spliceosomal snRNP particles and subsequently regulating

257 This loss of spliceosomal snRNP production results in increased splic

258 Here we present the detailed structure of a spliceosomal snRNP, revealing a hierarchical network of

259 k) physically associates with both dSNUP and spliceosomal snRNPs and localizes to nuclear Cajal bodie

260 In particular, the minor spliceosomal snRNPs are affected, and some U12-dependent

261 All spliceosomal snRNPs have a common core of seven Sm prote

262 ago, the structure, assembly and function of spliceosomal snRNPs have been extensively studied.

263 on exon 7 splicing, demonstrating that core spliceosomal snRNPs influence SMN2 alternative splicing.

264 The five major spliceosomal snRNPs were observed in both complexes by a

265 unique Sm core that differs from that of the spliceosomal snRNPs, and an essential heat labile proces

266 ins effect nuclear localization of the other spliceosomal snRNPs, the Lsm proteins mediate U6 snRNP l

267 he protein is required for the biogenesis of spliceosomal snRNPs, which are essential components of t

268 tate proper cotranscriptional association of spliceosomal snRNPs.

269 c proteins that are crucial to biogenesis of spliceosomal snRNPs.

270 rucial role in the biogenesis of four of the spliceosomal snRNPs.

271 the subcellular localization of both SMN and spliceosomal snRNPs.

272 ly and metabolism of several RNPs, including spliceosomal snRNPs.

273 their excision process resembles the nuclear spliceosomal splicing pathway.

274 ingly, the mechanistic basis for restricting spliceosomal splicing to the first transesterification r

275 vators promote the formation of PPIs between spliceosomal sub-complexes, whereas repressors mostly op

276 ositive regulators include components of the spliceosomal subcomplex U1 small nuclear ribonucleoprote

277 We find that individual spliceosomal subcomplexes associate with pre-mRNA sequen

278 en the C/D guide RNA and large ribosomal and spliceosomal substrate RNAs.

279 cifically SAP155 and U5-116 kDa, are the key spliceosomal substrates for these phosphatases.

280 ation within a putative RNA binding protein (spliceosomal timekeeper locus1 [STIPL1]) that induces a

281 lla, Salmonella, and Listeria interfere with spliceosomal U snRNA maturation in the cytosol.

282 Here, we show that each of the major spliceosomal U snRNAs (U2, U4, and U5), as well as the m

283 n mammals, small multigene families generate spliceosomal U snRNAs that are nearly as abundant as rRN

284 The assembly of spliceosomal U snRNPs depends on the coordinated action

285 The formation of Sm core structures of spliceosomal U-rich small nuclear ribonucleoprotein part

286 sans-fille (snf), a protein component of the spliceosomal U1 and U2 snRNPs.

287 Human spliceosomal U1 small nuclear ribonucleoprotein particle

288 exons by promoting productive docking of the spliceosomal U1 snRNP to a suboptimal 5' splice site.

289 The conserved spliceosomal U1-70K protein is thought to play a key rol

290 cterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases

291 The spliceosomal U1C protein is critical to the initiation a

292 embryonic stem (ES) cells, Ro binds variant spliceosomal U2 snRNAs.

293 The spliceosomal U4/U6 di-snRNP contains extensively base pa

294 ) genes, which encode core components of the spliceosomal U6 small nuclear ribonucleoprotein complex,

295 and adenosine nucleosides from the 3' end of spliceosomal U6 small nuclear RNA (snRNA), directly cata

296 tions for up to ~160-nt-long RNAs, including spliceosomal U6 small nuclear RNA and a cyclic-di-AMP bi

297 The spliceosomal U6 snRNA is an exception, being stably asso

298 e Lsm2-Lsm8 complex binds and stabilizes the spliceosomal U6 snRNA, whereas the Lsm1-Lsm7 complex fun

299 hodiesterase that regulates the stability of spliceosomal U6-RNA.

300 een proposed that defects in the assembly of spliceosomal uridine-rich small nuclear ribonucleoprotei