ライフサイエンスコーパス: splicing event

1 e splice form in plants ( 50% of alternative splicing events).

2 f functional protein owing to an alternative splicing event.

3 roximity to either an upstream or downstream splicing event.

4 signed to suppress the oncogenic alternative splicing event.

5 of regulation of this important alternative splicing event.

6 no evidence for a stop codon or alternative splicing event.

7 early acquisition of pluripotency-associated splicing events.

8 tions in RNA repair and nonconventional mRNA splicing events.

9 s maturation requires two cis- and two trans-splicing events.

10 -life but are not required for most pre-mRNA splicing events.

11 as a means to control the temporal order of splicing events.

12 croarrays can be used to detect differential splicing events.

13 erase II over introns and co-transcriptional splicing events.

14 on the type and the frequency of alternative splicing events.

15 ets of human internal exons showing selected splicing events.

16 116 transcriptional termination sites and 80 splicing events.

17 NVs) for several allele-specific alternative splicing events.

18 ntification and visualization of alternative splicing events.

19 ll lack of the prototypical type III latency splicing events.

20 obases, as were intron retention alternative splicing events.

21 ng 84 previously uncharacterized alternative splicing events.

22 periments on eight exon skipping alternative splicing events.

23 of novel exons, and identification of novel splicing events.

24 ging role in gene regulation and alternative splicing events.

25 c expression induces several tissue-specific splicing events.

26 nked to disease and all observed alternative splicing events.

27 ncrease in the probe density for alternative splicing events.

28 ulation and to manipulate disease-associated splicing events.

29 as a high accuracy in detecting differential splicing events.

30 of known and newly identified PTB-regulated splicing events.

31 of cancer versus normal specific alternative splicing events.

32 P binding sites, especially those related to splicing events.

33 ng relative isoform or exon usage in complex splicing events.

34 malian species used for studying alternative splicing events.

35 6.2% of detected mRNAs displayed alternative splicing events.

36 EIDS), for the identification of alternative splicing events.

37 dvance quantification and discovery of novel splicing events.

38 ealing many previously unknown non-canonical splicing events.

39 5 co-regulated a large number of alternative splicing events.

40 rature effects on a large subset of pre-mRNA splicing events.

41 were widespread but rare compared to normal splicing events.

42 nes, and induce H3K36me3-coupled alternative splicing events.

43 reveal hundreds of differential alternative splicing events.

44 ules undergoing multiple distant alternative splicing events.

45 of association between variants and aberrant splicing events.

46 retentions were the most common alternative splicing events, accounting for 33% of all splicing even

47 D1, LSD1n, which results from an alternative splicing event, acquires a new substrate specificity, ta

48 CELF1 by PKC is necessary for regulation of splicing events altered in diabetes.

49 es, but the rules governing and coordinating splicing events among multiple alternate splice sites wi

50 ich is upregulated in gliomas, controls this splicing event and similarly mediates switching to a lig

51 RT-PCR panel that can analyse 96 alternative splicing events and accurately measure the ratio of alte

52 Twelve splicing events and an unexpectedly large number of anti

53 systematically discover aberrant alternative splicing events and characterize potential associated sp

54 h neurodevelopmentally important alternative splicing events and clinically relevant neuronal transcr

55 reference genome or transcriptome, including splicing events and complex variants involving multiple

56 oter, P97, and is modulated by both specific splicing events and conserved cis elements in the upstre

57 and binding activity for six MBNL1-mediated splicing events and found that the splicing activity pro

58 possible to better characterize alternative splicing events and gain insights into splicing mechanis

59 vation of SRSF2 in liver caused dysregulated splicing events and hepatic metabolic disorders, which t

60 plice donor sites was able to abrogate these splicing events and hybrid mRNA formation in Bcl-15 cell

61 isms, for example, detecting alternative RNA splicing events and oncogenic chromosomal rearrangements

62 teins, and strategies to modulate pathologic splicing events and protein-RNA interactions in cancer.

63 Analysis of the splicing events and RNA-Seq based expression profiles re

64 one aberrantly expressed gene, five aberrant splicing events and six mono-allelically expressed rare

65 prioritized lists of results that highlight splicing events and their biological consequences.

66 itate exploration of developmentally altered splicing events and to improve understanding of post-tra

67 tools to discover novel exons, junctions and splicing events and to precisely and sensitively assess

68 ads to define gene structure and alternative splicing events and to quantify transcript abundance alo

69 spliceosome protein can effect both specific splicing events and tumor cell motility.

70 ed the likely causal SNP for the alternative splicing event, and at one, functionally validated the e

71 e splicing events, accounting for 33% of all splicing events, and 43% of the events in coding regions

72 which offers high sensitivity for detecting splicing events, and its application to the unicellular

73 in detection of tissue-specific alternative splicing events, and of cancer versus normal specific al

74 known and novel high-confidence alternative splicing events, and to integrate them with both protein

75 tify variants that correlate with unexpected splicing events, and to measure the splice-modulating po

76 also identified a number of MuLV alternative splicing events, and we uncovered evidence of APOBEC3G (

77 ds of gene models; (iii) propose alternative splicing events; and (iv) predict 5' and 3' untranslated

78 Splicing events antisense to gene models were also detec

79 Moreover, some NF-kappaB alternative splicing events appear to be specific for certain diseas

80 Most alternative splicing events appear to have arisen since the divergen

81 These non-canonical splicing events are a major source of newly emerging tra

82 the rgh3 mutant, a fraction of noncanonical splicing events are altered.

83 ional probability-based models, we show that splicing events are coordinated across these sites.

84 25% of T-cell receptor-mediated alternative splicing events are dependent on JNK signaling.

85 lyses further indicated that the alternative splicing events are important for target gene expression

86 ctions of most species- and lineage-specific splicing events are not known.

87 the same time, a large number of alternative splicing events are observed between different cell type

88 hich most non-mutually exclusive alternative splicing events are randomly combined into individual mR

89 this paper, we propose that most alternative splicing events are the result of noise in the splicing

90 erent genomic rearrangements and alternative splicing events around the junction region lead to multi

91 omputationally expensive, focusing on single splicing events as a proxy for transcriptome characteris

92 dentify novel genome-wide, race-specific RNA splicing events as critical drivers of PCa aggressivenes

93 e-wide characterization of intraerythrocytic splicing events, as captured by RNA-Seq data from four t

94 this study, we sought to analyze alternative splicing events (ASE) that could alter gene function ind

95 pper TopHat, including a novel nonproductive splicing event at the gp350/gp220 locus and several alte

96 ring and quantifying circular and linear RNA splicing events at both annotated and un-annotated exon

97 Combinatorial alternative splicing events at the 5' end of the gene allow for the

98 he gp350/gp220 locus and several alternative splicing events at the LMP2 locus.

99 gnificant frequency, and whether alternative splicing events at these sites are independent of each o

100 e splicing and identifying the difference in splicing events between diseased and healthy tissue is c

101 We identified 593 differential alternative splicing events between HD and control brains.

102 recent discoveries of trans-splicing and cis-splicing events between neighboring genes suggest that t

103 We also identify tens of thousands of novel splicing events beyond those previously annotated by the

104 SSO not only accurately identified canonical splicing events, but also pinpointed novel, but rare, ex

105 merase) is subjected to numerous alternative splicing events, but the regulation and function of thes

106 id (ABA) is shown to mediate the alternative splicing event by reducing the functional Isoform1 and i

107 sically couples transcription elongation and splicing events by interacting with splicing factors thr

108 nds (RACE) experiments and findings of novel splicing events by RNA-seq suggest that the complexity o

109 HnRNP A1 regulates many alternative splicing events by the recognition of splicing silencer

110 ve as an enhancer or repressor of a specific splicing event can change during development.

111 pharmacological manipulation of a single key splicing event can manifest powerful antitumorigenic pro

112 how these splicing factors regulate pre-mRNA splicing events, comparatively little is known about the

113 s of endogenous TDP-43-dependent alternative splicing events conferred by both human wild-type and mu

114 Ldo45 is the product of a splicing event connecting two adjacent genes (YMR147W an

115 and structure in three datasets: alternative splicing events conserved across multiple species, alter

116 in C. elegans is regulated by an alternative splicing event controlled by the SR protein kinase SPK-1

117 Many alternative splicing events create RNAs with premature stop codons,

118 A minimum of 10 splicing events (Delta1Aq, Delta5, Delta5q, Delta8p, Del

119 Indeed, transcriptome-wide analysis of splicing events demonstrated that RBM25 regulates a larg

120 ference genome and a catalog of all possible splicing events developed from the genome, thereby provi

121 gy to identify approximately 700 alternative splicing events directly regulated by the neuron-specifi

122 tigating the molecular mechanisms of complex splicing events, disease associations and the evolution

123 Unfortunately, aberrant splicing events do occur which have been linked to genet

124 that CELF2 controls a similar proportion of splicing events during human thymic T-cell development.

125 d intron to be the most abundant alternative splicing events during lens development.

126 vestigate the transcriptomic alterations and splicing events during mouse lens formation using RNA-se

127 The CAR gene uses multiple alternative splicing events during pre-mRNA processing, thereby enha

128 We propose a working model of the unique splicing event enhanced by the mutation, as well as puta

129 ons and 2301 differentially used alternative splicing events, enriched in genes involved in regulator

130 This splicing event establishes a selectivity filter to restr

131 In the splicing events examined previously, Hu proteins promote

132 ctionally distinct classes of MBNL1-mediated splicing events exist as defined by requirements for ZF-

133 nscripts are most commonly generated by back-splicing events from exons of protein-coding genes.

134 LeafCutter identifies variable splicing events from short-read RNA-seq data and finds e

135 omputational pipeline to detect differential splicing events from the Affymetrix exon junction array

136 promising to uncover many novel alternative splicing events, gene fusions and other variations in RN

137 ed scale at which the expression of specific splicing events has been measured.

138 nd abundance of proteasome-catalyzed peptide splicing events has implications for immunobiology and a

139 Because the most common type of splicing event identified was an alternative start site

140 ional analysis of the introns flanking these splicing events identified enriched and conserved motifs

141 abase, to nearly 90,000 distinct alternative splicing events; (ii) it now provides genome-wide altern

142 actor regulating a wide range of alternative splicing events implicated in neuronal development and m

143 RBFOX1 regulates a wide range of alternative splicing events implicated in neuronal development and m

144 rs of phylogenetically-conserved alternative splicing events important for muscle function.

145 hich is the least understood RNA alternative splicing event in mammalian cells.

146 act of structural changes and an alternative splicing event in MDR49 on DDT-resistance in 91-R, as co

147 A regulated splicing event in protein 4.1R pre-mRNA-the inclusion of

148 An alternative splicing event in the 5' untranslated region allows for

149 le Trachemys scripta elegans, an intraexonic splicing event in the brain-derived neurotrophic factor

150 ariants demonstrated a key role for this RNA splicing event in the resistance of cells to anoikis.

151 Minigene splicing assays revealed a novel splicing event in which insertion of two additional repe

152 s including ERRFI1, ANXA1 and TGFB2, and 182 splicing events in 164 genes, including EP300, PUS3, CLI

153 We reveal 14,353 alternative splicing events in 17,669 novel isoforms at different st

154 We identified 405 splicing events in 323 genes that are significantly affe

155 monitoring expression of 24,426 alternative splicing events in 48 diverse human samples.

156 the strongest predictors of the two aberrant splicing events in a logistic regression model.

157 Several alternative splicing events in both the tumor necrosis factor and To

158 inhibition of some, but not all, endogenous splicing events in cells, as previously reported for the

159 Importantly, we uncover dozens of splicing events in cultured T cells whose changes upon s

160 put data (RNA-seq data) to study alternative splicing events in different types of cells.

161 a sensitive algorithm to detect alternative splicing events in each cell type.

162 l initiation and elongation, and alternative splicing events in ES cells.

163 ELAV, which regulate overlapping networks of splicing events in GABAergic and cholinergic neurons.

164 hment analyses found a substantial number of splicing events in genes related to RNA metabolism.

165 nserved across multiple species, alternative splicing events in genes that are strongly linked to dis

166 nge of antiviral activities, whereas similar splicing events in hapII-RDD resulted in proteins that u

167 By global profiling of the SRSF3-regulated splicing events in human osteosarcoma U2OS cells, we fou

168 fluorescence minigenes to image alternative splicing events in living cells and animals.

169 e used the algorithm to profile differential splicing events in lung adenocarcinoma A549 cells after

170 formed a genome wide analysis of alternative splicing events in lung adenocarcinoma.

171 nvolved in regulation of polyadenylation and splicing events in mammalian transcripts, the G-quadrupl

172 selective pressure to maintain a majority of splicing events in order to retain glial-like characteri

173 nd coupling of specific 5' ends with 3' mRNA splicing events in postmortem human brain and human stem

174 sor for label-free monitoring of alternative splicing events in real-time, without any cDNA synthesis

175 An improved understanding of alternative splicing events in RMS cells will potentially reveal nov

176 ncing to generate a comprehensive profile of splicing events in Schizosaccharomyces pombe, amongst th

177 ng the activity of PSF toward a broad set of splicing events in T cells.

178 and sequencing identified alternate internal splicing events in the 5' end of JSRV env that could sig

179 NA-seq methods to identify known alternative splicing events in the Drosophila sex determination path

180 e investigated the role of SMN-dependent U12 splicing events in the regulation of motor circuit activ

181 latory proteins, and/or specific key altered splicing events in the treatment of cancer.

182 nd sites, as well as hundreds of alternative splicing events in these B1a cells.

183 ic insight into SRSF10-regulated alternative splicing events in vivo and demonstrate that SRSF10 play

184 A proteins regulate at least 700 alternative splicing events in vivo, yet relatively little is known

185 ific subset of target genes, but not general splicing events, in HCET cells to maintain or enhance ep

186 luding insertions, deletions and alternative splicing events, in protein-small molecule affinity, unr

187 haracterized a total of 63 BRCA1 alternative splicing events, including 35 novel findings.

188 erent expressed receptor isoforms because of splicing events, including alternative splice donors and

189 e analysis identified a group of alternative splicing events, including the splicing of small introns

190 he 3' region of NOTCH1, which cause aberrant splicing events, increase NOTCH1 activity and result in

191 a short direct repeat-mediated noncanonical splicing event induced by dexamethasone, which leads to

192 This non-conventional mRNA splicing event initiates the unfolded protein response,

193 decreases the expression of HIV-1 and alters splicing events involved in the production of HIV-1 mRNA

194 to gain mechanistic insight into alternative splicing events involving exons 2 and 16 (E2 and E16) th

195 s of the Arabidopsis JAZ family, alternative splicing events involving retention of this intron gener

196 thought that most canonical or non-canonical splicing events involving U2- and U12 spliceosomes occur

197 A recent study shows that the alternative splicing event is controlled by heterogeneous nuclear ri

198 Each alternative splicing event is controlled by multiple RBPs, the combi

199 Although the splicing event is highly conserved, one splice variant h

200 Previously, we reported that this splicing event is highly dysregulated in aggressive form

201 Moreover, this splicing event is itself dependent on JNK signaling.

202 Although this alternative splicing event is likely regulated by multiple splicing

203 tex1 plants the ratio of certain alternative splicing events is altered.

204 erns, but the developmental control of these splicing events is poorly understood.

205 3 and 4, although the significance of these splicing events is unclear.

206 We suggest RSF, a tool for identifying novel splicing events, is applicable to study a range of disea

207 in the SORT1 mRNA, a pathologically relevant splicing event known to be regulated by TDP-43, is also

208 cis-elements surrounding a given alternative splicing event lead to an integrated splicing decision.

209 These alternative splicing events led to the modulation of potential GAG a

210 factor network interactions and alternative splicing events, little of which can be resolved by long

211 We found that SRSF2 (P95H) misregulates 548 splicing events (<1% of total).

212 For each alternative splicing event, MADS+ evaluates the signals of probes ta

213 otes by alternative splicing, for which such splicing events map to regions of disorder much more oft

214 Other regulated splicing events may determine how an mRNA is utilized in

215 Thus, the alternative splicing event must have emerged before the mouse and hu

216 ion of developmentally regulated alternative splicing events, myotonia, characteristic histological a

217 ha1 and -alpha4, we could validate, in vivo, splicing events observed in in vitro studies.

218 These splicing events occur exclusively in trigeminal ganglia,

219 iversity of protein functions, and alternate splicing events occur in tumors.

220 mical changes in splicing, with differential splicing events occurring more frequently in early devel

221 Moreover, we showed that the alternative splicing event of FGFR2 is associated with virus infecti

222 early in the plant lineage by an alternative-splicing event of the pre-mRNA encoding the chloroplast

223 ls that NOVA2 uniquely regulates alternative splicing events of a series of axon guidance related gen

224 RNAs from multiple species suggests that the splicing events of many strongly included MIR exons have

225 Our data suggest that an alternative splicing event (OPN-c) promotes extracellular cleavage o

226 enes, with significantly increased levels of splicing events, particularly those predicted to have su

227 rates suggest that the number of alternative splicing events per gene has not decreased following dup

228 RNA-Seq evidence, (ii) identify alternative splicing events present in the augmented annotation grap

229 n3 is a regulator of hundreds of alternative splicing events, principally acting as a splicing repres

230 splice sites caused the majority of aberrant splicing events, providing a strategy for recoding lenti

231 ess in vivo can be attributed to alternative splicing events regulated at the level of individual neu

232 sed RNA interference and RNA-seq to identify splicing events regulated by 56 Drosophila proteins, som

233 The inhibitor also reduced misregulation of splicing events regulated by CUGBP1 but not those regula

234 Using mRNA-seq, we identify endogenous splicing events regulated by DAZAP1, many of which are i

235 We also report thousands of alternative splicing events regulated by genetic variants.

236 In the RNA-Seq analysis of alternative splicing events regulated by the epithelial-specific spl

237 ovel analytical tool, we have identified new splicing events regulated by the oncogenic splicing fact

238 k flow for the identification of alternative splicing events relying on the established linear mixed

239 However, the mechanisms regulating this splicing event remain unclear.

240 All of these erythroid stage-specific splicing events represent activated inclusion of authent

241 fine a pathway that regulates an alternative splicing event required for tumour cell proliferation.

242 However, the SRSF3-regulated splicing events responsible for its oncogenic activities

243 TP53 undergoes multiple RNA-splicing events, resulting in at least nine mRNA transcr

244 This alternative splicing event results in the formation of RNA processin

245 Splicing events retain noncatalytic domains while ablati

246 by either fusion genes (DNA level) or trans-splicing events (RNA level).

247 RASL-Seq to identify approximately 40 T cell splicing events sensitive to PSF knockdown, and show tha

248 focused upon modulating the SMN2 alternative splicing event since this would produce more wild-type p

249 st partially, their co-regulated alternative splicing events, suggesting both JMJD6 enzymatic activit

250 e deaminase) showed differential alternative splicing events, suggesting that specific changes in the

251 lignments revealed 1,908 high-confidence new splicing events supported by 10 or more spliced read ali

252 Our analyses also revealed multiple novel splicing events supported by more reads than previously

253 These alternative splicing events target the resulting messenger RNAs for

254 has little or no effect on other inefficient splicing events tested, and ASF/SF2 depletion does not a

255 g from decreased skipping of nPTB exon 10, a splicing event that leads to NMD of nPTB mRNA.

256 etase catalytic nulls created by alternative splicing events that ablate active sites, here a non-spl

257 ploy metabolite-binding RNAs to regulate RNA splicing events that are important for the control of ke

258 We identified many alternative splicing events that are regulated by multiple splicing

259 strategy could be employed to modulate other splicing events that are regulated by RNA secondary stru

260 stigate the complete spectrum of alternative splicing events that are regulated by the epithelium-spe

261 iscovered previously undescribed alternative splicing events that are responsive to CUGBP1 and not MB

262 ad but low frequency alternative or aberrant splicing events that are targeted by nuclear RNA surveil

263 s of controlling the cascade of sex-specific splicing events that controls sexual differentiation in

264 not detect cryptic promoter activity or RNA splicing events that could account for downstream cistro

265 of wild-type plants and identified pre-mRNA splicing events that depend on the maize SMU2 protein.

266 plicing by promoting two intricately coupled splicing events that ensure selection of a weak distal a

267 Here, we review the functions of alternative splicing events that have been experimentally determined

268 ibility to identify differential alternative splicing events that match a given user-defined pattern.

269 ion to control the balance and complexity of splicing events that regulate viral oncoprotein expressi

270 First, we improved the splicing events that remove the gamma-globin intron by o

271 encing we identified a set of 22 alternative splicing events that undergo a developmental switch in s

272 approaches cannot distinguish cis- and trans-splicing events, the extent to which trans-splicing occu

273 is largest assemblage of new and alternative splicing events to date in Plasmodium falciparum provide

274 were mapped to constitutive and alternative splicing events to detect known and new mRNA isoforms ex

275 wn that Mcl-1 pre-mRNA undergoes alternative splicing events to produce two functionally distinct pro

276 molecules designed to alter these and other splicing events typically target continuous linear seque

277 splice site choice at exon 2 (E2) via nested splicing events, ultimately modulating expression of N-t

278 ap can identify major classes of alternative splicing events under a single cellular condition, witho

279 tTG(V1,2) mRNAs were synthesized by a rare splicing event using alternate splice sites within exons

280 hlet mixture model and discovers alternative splicing events using a new graph modular decomposition

281 e expression compendium of human alternative splicing events using custom whole-transcript microarray

282 Using an in vitro minigene system to analyze splicing events, we found reduced wild-type splicing for

283 dentify additional PTB-regulated alternative splicing events, we used quantitative proteomic analysis

284 hat the breast cancer risk and the alternate splicing event were due to the same causal SNP.

285 Four different types of splicing events were affected by dnmt3 gene knockdown, a

286 disease-associated proteins) and 965 altered splicing events were detected (including in sortilin, th

287 In addition, 310 alternative splicing events were detected in 254 (4.5%) genes, most

288 After induction, hundreds of candidate splicing events were detected using the junction mapper

289 Over 11,700 genes and 9,500 splicing events were differentially expressed, providing

290 Novel splicing events were found in members of some gene famil

291 Novel SLE associated splicing events were identified in the T-reg restricted

292 Over 200 previously unannotated splicing events were identified, including examples of r

293 Half of the splicing events were regulated by multiple proteins, dem

294 which apparently formed after an alternative splicing event where the first exon of the MAST2 gene sp

295 equencing junction expression identified 109 splicing events, which were confirmed in a validation se

296 This analysis identified several hundred splicing events whose regulation depended on Mbnl functi

297 ccuracy and could detect up to twice as many splicing events with precision similar to the best refer

298 mosquitoes revealed evidences of alternative splicing events with three transcripts of 2092, 2061 and

299 splicing network of hundreds of alternative splicing events within numerous genes with functions in

300 ic conservation surrounding these regulatory splicing events within splicing factor genes demonstrate