ライフサイエンスコーパス: spontaneous mutation

1 ia inter- and intragenomic recombination and spontaneous mutation.

2 reby limiting illegitimate recombination and spontaneous mutation.

3 integrity and do so, in part, by suppressing spontaneous mutation.

4 imply a role for yafN, yafO, and/or yafP in spontaneous mutation.

5 f Min 2 (Mom2) locus that is the result of a spontaneous mutation.

6 coli pol IV, which enhances the frequency of spontaneous mutation.

7 uivalent to approximately 100 generations of spontaneous mutation.

8 geting the pcaHG genes of A. tumefaciens for spontaneous mutation.

9 alleles appear in populations through random spontaneous mutation.

10 ern, though the condition has a high rate of spontaneous mutation.

11 that cells usually use and a major source of spontaneous mutation.

12 gnificantly different initial frequencies of spontaneous mutations.

13 arental origin trends for different types of spontaneous mutations.

14 mismatch repair (MMR) increases the risk of spontaneous mutations.

15 y involving pharmaceutical manipulations and spontaneous mutations.

16 out an accompanied increased accumulation of spontaneous mutations.

17 tuitous repair may be an important source of spontaneous mutations.

18 rotective mechanisms have elevated levels of spontaneous mutations.

19 t significantly increase the accumulation of spontaneous mutations.

20 Two sites showed selective enrichment of spontaneous mutations.

21 tiology composed of dominant-acting de novo (spontaneous) mutations.

22 auses severe polyarthritis in bone phenotype spontaneous mutation 1 (BPSM1) mice.

23 s of PilC-mediated pilus phase variation and spontaneous mutation, a finding consistent with a role f

24 In this report, we analyze spontaneous mutations accumulated over thousands of gene

25 The polyploid state reduces spontaneous mutation accumulation by gene conversion, th

26 phenotype in such mice is due to accelerated spontaneous mutation accumulation, we crossed these muta

27 l responses degrade over time as a result of spontaneous mutation accumulation.

28 experienced an average of 370 generations of spontaneous mutation accumulation.

29 These spontaneous mutations affected two regions of the TolC p

30 The per-genome, per-generation rate of spontaneous mutation affecting fitness (U) and the mean

31 entation to deficiencies to map QTL at which spontaneous mutations affecting Drosophila abdominal and

32 ts are widely used to estimate parameters of spontaneous mutations affecting fitness.

33 Moreover, we found that mice carrying a spontaneous mutation allelic to the most common mutation

34 ia coli results in an increased frequency of spontaneous mutation and an imbalance in dNTP pool level

35 freading act in parallel pathways to prevent spontaneous mutation and cancer.

36 2 protein functions in a process that avoids spontaneous mutation and insures faithful meiotic chromo

37 yp-resistant Mom2R phenotype resulted from a spontaneous mutation and linkage analysis localized Mom2

38 tandard approach for inferring properties of spontaneous mutation and necessitates further developmen

39 data provide a better understanding of EBOV spontaneous mutation and suggest that ribavirin may have

40 ation of nuclease activities led to frequent spontaneous mutations and accumulation of incompletely d

41 potential for epistatic interactions between spontaneous mutations and QTL affecting bristle number o

42 nhance, rather than diminish, the effects of spontaneous mutations and recombinations.

43 uency ( approximately 10(-2) to 10(-4)) than spontaneous mutations, and all phenotypes were reversibl

44 The chemical events responsible for spontaneous mutation are also highly sensitive to temper

45 The rates and patterns of spontaneous mutation are fundamental parameters of molec

46 ble, error-prone DNA polymerase IV (DinB) in spontaneous mutation are resolved by the finding that mu

47 Our results suggest that rare spontaneous mutations are an important contributor to ri

48 Because a considerable fraction of spontaneous mutations are caused by TE insertions, where

49 mmonium are in AMT4 and a high proportion of spontaneous mutations are caused by transposon-related e

50 Using data on older donors, we show that spontaneous mutations are not uniformly distributed thro

51 Spontaneous mutations are stochastic events.

52 Spontaneous mutations are the source of genetic variatio

53 Estimates suggest that spontaneous mutations arise in about a third of those ce

54 Spontaneous mutations arising during ES cell culture may

55 E. coli nfi(-)alkA(-) strain protected from spontaneous mutations arising in saturated cultures and

56 In this study, we present evidence for two spontaneous mutations as the molecular basis for this SC

57 We have isolated a number of spontaneous mutations as well as constructed directed mu

58 Spontaneous mutations associated with cancer also lie do

59 The hyperlipidemia results from spontaneous mutation at a locus, Hyplip1, on distal mous

60 lectively neutral makes it possible to study spontaneous mutation at a new level of resolution.

61 ng cells, like other cells, probably undergo spontaneous mutation at a rate of 10(-9) per nucleotide.

62 , mutS60, results in almost normal levels of spontaneous mutations at 37 degrees C but above this tem

63 Spontaneous mutations at numerous sites distant from the

64 These results eliminate spontaneous mutation, between-strain complementation, an

65 ty to select directly strains that contain a spontaneous mutation blocking the beta-ketoadipate pathw

66 select for Acinetobacter strains containing spontaneous mutations blocking expression of pcaH or -G,

67 Additional spontaneous mutations blocking vanA and vanB expression

68 We promoted the accumulation of spontaneous mutations by subjecting independent lineages

69 Rates of random, spontaneous mutation can vary plastically, dependent upo

70 The rough coat (rc) spontaneous mutation causes sebaceous gland (SG) hypertr

71 A spontaneous mutation causing deafness and circling behav

72 This is the first report of a spontaneous mutation causing HCM in a non-human species.

73 y, as demonstrated by increased frequency of spontaneous mutations, chromosome nondisjunction, and te

74 to demonstrate that the measured effects of spontaneous mutations, combined with stabilizing selecti

75 oximately a 100-fold increase in the rate of spontaneous mutation compared with prophage-free strains

76 Spontaneous mutations conferring drug resistance were co

77 The other three spontaneous mutations created the same frameshift near t

78 Mice carrying a spontaneous mutation, Dancer (Dc), exhibit CL/P in homoz

79 Both glycosylases increased spontaneous mutation, decreased cell viability, and sens

80 e-genome sequencing to identify nearly 1,000 spontaneous mutation events accumulated over approximate

81 were conducted to examine recombination and spontaneous mutation events within clusters of resistanc

82 NA represents a potential source of frequent spontaneous mutation for hyperthermophiles.

83 inbred lines that were allowed to accumulate spontaneous mutations for 10, 19, and 47 generations.

84 tions in a set of lines that had accumulated spontaneous mutations for 33 generations.

85 ls deficient in MMR are grown anaerobically, spontaneous mutation frequencies are reduced compared wi

86 Spontaneous mutation frequencies of JP26 mutY mutants, a

87 lementation of the JP26 mutY mutant restored spontaneous mutation frequencies to wild-type levels.

88 Spontaneous mutation frequencies were scored in cohorts

89 Strains lacking MutS exhibited increased spontaneous mutation frequencies, and reversion assays d

90 treated with DEA/NO had significantly higher spontaneous mutation frequencies, increased numbers of A

91 functional Fpg, MutY or Smn showed elevated spontaneous mutation frequencies; and, these mutator phe

92 em, termed mutators, which exhibit increased spontaneous-mutation frequencies.

93 howed that MmuNeil3 greatly reduced both the spontaneous mutation frequency and the level of FapyG in

94 ency, additional loss of Mbd4 does not alter spontaneous mutation frequency at the endogenous Dlb-1b

95 iability and no growth defects or changes in spontaneous mutation frequency but had increased sensiti

96 Spontaneous mutation frequency in somatic cells is appro

97 if the lack of poleta significantly elevates spontaneous mutation frequency in various organs and tis

98 We determined the spontaneous mutation frequency of EBOV, which is relevan

99 uorescent protein were used to determine the spontaneous mutation frequency of EBOV.

100 2 cells results in an 8-fold increase in the spontaneous mutation frequency of lambdacII mutants comp

101 c) The deletion of e.1 does not increase the spontaneous mutation frequency of T4 phage.

102 oxidized [Fe-S] clusters, and decreased the spontaneous mutation frequency of the cells.

103 e are viable and do not show the increase in spontaneous mutation frequency or cancer incidence that

104 The high spontaneous mutation frequency previously observed in fp

105 These results demonstrate that EBOV has a spontaneous mutation frequency similar to those of other

106 Spermatogenic cells exhibit a lower spontaneous mutation frequency than somatic tissues in a

107 urther, and the mutant had a slightly higher spontaneous mutation frequency than the wild type in the

108 sensitivity to stress-related chemicals and spontaneous mutation frequency).

109 king both of these activities exhibit a high spontaneous mutation frequency, and here we show that al

110 osatellite instability (MSI) and an elevated spontaneous mutation frequency, characteristic of MMR-de

111 used to infect bacterial cells to obtain the spontaneous mutation frequency.

112 by organic peroxides and it had the highest spontaneous mutation frequency.

113 o oxidized [Fe-S] clusters, and decrease the spontaneous mutation frequency.

114 d not only strain-dependent increases in the spontaneous-mutation frequency but also shifts in mutati

115 estimates of the rate and fitness effect of spontaneous mutations generated by mutation accumulation

116 Spontaneous mutations generated in the ORF14, ORF16, and

117 Recently, genes responsible for these spontaneous mutations have been identified.

118 Although spontaneous mutations have the potential to generate abu

119 evealed that the underlying genes of natural spontaneous mutations high pigment 1 (hp1), high pigment

120 Spontaneous mutations identified in vanK include a hot s

121 osegrass was previously shown to stem from a spontaneous mutation in an alpha-tubulin gene.

122 A study of spontaneous mutation in Arabidopsis thaliana was initiat

123 A spontaneous mutation in Bruton's tyrosine kinase (Btk) i

124 ecombination could be an important source of spontaneous mutation in cells that are not proliferating

125 y reported that in the Nuc1 rat, which has a spontaneous mutation in Cryba1 (the gene encoding betaA3

126 letions appear to play a much larger role in spontaneous mutation in D. melanogaster than in H. sapie

127 s of retinal amacrine cells from mice with a spontaneous mutation in Down syndrome cell adhesion mole

128 investigate the molecular nature and rate of spontaneous mutation in Drosophila melanogaster, we scre

129 Analysis of mice that carry a spontaneous mutation in DSCAM (DSCAM(del17)) revealed gr

130 Moreover, mechanisms of spontaneous mutation in E. coli remain obscure.

131 Here, we identify a spontaneous mutation in GALC, GALCtwi-5J, that precisely

132 esults reveal that ZIKV evolved to acquire a spontaneous mutation in its NS1 protein, resulting in in

133 Mice with a spontaneous mutation in Ncf1, which encodes the NCF1 (p4

134 This trait was due to a spontaneous mutation in the gene encoding the transcript

135 Recently, a spontaneous mutation in the gene encoding trafficking pr

136 Here we characterize a new spontaneous mutation in the mouse, cappuccino (cno), tha

137 r these conditions, the bacterium acquires a spontaneous mutation in the putative promoter region of

138 Here we describe a spontaneous mutation in the Zdhhc13 (zinc finger, DHHC d

139 8- to 15-fold increases in the frequency of spontaneous mutation in their germlines.

140 rophages, macrophages from mice that carry a spontaneous mutation in TLR4 (P712H) were hyporesponsive

141 (sw/sw)) mice previously reported to carry a spontaneous mutation in Wnt1 share major features of OI

142 p a high-resolution picture of the effect of spontaneous mutations in a hypermutator (DeltamutS) stra

143 y serotype M1 GAS strains have high rates of spontaneous mutations in covS during invasive GAS infect

144 To detect spontaneous mutations in csrRS, mucoid and large colony

145 Three populations were screened for spontaneous mutations in downy mildew resistance.

146 In mice carrying spontaneous mutations in Dscam (Dscam(del17) ; Dscam(2J)

147 y and mismatch repair, we accumulated 40,000 spontaneous mutations in eight diploid yeast strains in

148 Tumorigenesis was assisted by either spontaneous mutations in Kras or experimental introducti

149 ecame invasive; invasion was associated with spontaneous mutations in Kras.

150 Spontaneous mutations in mice have already provided impo

151 ontribute significantly to the appearance of spontaneous mutations in microorganisms and in human dis

152 ts, more than half the leukemic mice develop spontaneous mutations in Notch1.

153 nthesis, our work identified the spectrum of spontaneous mutations in plastids and reveals that this

154 -lamp biomicroscopy, and ERG to discover new spontaneous mutations in strains from the Genetic Resour

155 However, both the rate and spectrum of spontaneous mutations in T. thermophilus resembled those

156 The authors propose these two spontaneous mutations in the canine VMD2 gene, which cau

157 Routine characterization of spontaneous mutations in the gal operon guided the disco

158 far been described for these proteoglycans, spontaneous mutations in the human and induced deletions

159 Inherited or spontaneous mutations in the human homologue of the Dros

160 Spontaneous mutations in the murine Eda (Tabby) phenocop

161 Mice with spontaneous mutations in the PC-1 gene have hypermineral

162 We have found that most spontaneous mutations in the thyA gene of Escherichia co

163 e and a description of the properties of new spontaneous mutations in the unicellular green alga Chla

164 Further, spontaneous mutations in these subunits that impair axon

165 A number of spontaneous mutations in this antenna region cause the h

166 responsible for a significant proportion of spontaneous mutations in this cancer cell line.

167 )Ink4a/Arf(-/-) mNSC-derived tumors revealed spontaneous mutations in Tp53 in vivo with subsequent do

168 opportunity to investigate the formation of spontaneous mutations in vaccinia virus, which encodes i

169 e (pol) IV, a protein involved in increasing spontaneous mutations in vivo.

170 ion of PKR activity reduced the frequency of spontaneous mutations in vivo.

171 stigation had shown that a large fraction of spontaneous mutations inactivating Acinetobacter protoca

172 The nature of spontaneous mutations, including their rate, distributio

173 Loss of GpsB can be suppressed by spontaneous mutations, including within the gene encodin

174 If so, our data imply that one generation of spontaneous mutation increases the developmental time by

175 major forces are postulated to contribute to spontaneous mutations: intrinsic DNA polymerase errors,

176 The rate of spontaneous mutation is a key parameter in modeling the

177 Knowledge of the rate and nature of spontaneous mutation is fundamental to understanding evo

178 ave a mutator phenotype in which the rate of spontaneous mutation is greatly elevated, and they frequ

179 These results suggest that the site(s) of spontaneous mutation is in a gene(s) which lies upstream

180 Because spontaneous mutation is the source of all genetic divers

181 Understanding patterns of spontaneous mutations is of fundamental interest in stud

182 most direct and unbiased method of studying spontaneous mutations is via mutation accumulation (MA)

183 ce of a resistant subclone that has acquired spontaneous mutations largely independent of initial the

184 n serum transferrin (Trf) as the result of a spontaneous mutation linked to the murine Trf locus.

185 uble helix, Watson and Crick suggested that "spontaneous mutation may be due to a base occasionally o

186 With information on spontaneous mutations now available in a variety of orga

187 ur results show that much of the increase in spontaneous mutation observed in an exo1Delta strain is

188 A molecular analysis of spontaneous mutations observed for the nonirradiated tis

189 Transversions dominate the spectrum of spontaneous mutations observed here, whereas transitions

190 P) degradation of RNA is responsible for the spontaneous mutations observed in an MMR-deficient backg

191 urable effect, suggesting that a fraction of spontaneous mutations occur as a result of dinB polymera

192 lly very low, and it is widely accepted that spontaneous mutations occur at defined, but different, r

193 urs while phage DNA is outside the host, and spontaneous mutations occur during phage DNA replication

194 n NH(4)(+)-limited chemostat, two sequential spontaneous mutations occurred.

195 --> T transitions, which are the most common spontaneous mutations occurring in living organisms and

196 rial cells varies widely depending on when a spontaneous mutation occurs during growth of the culture

197 udies, a synergistic increase in the rate of spontaneous mutations occurs in the absence of POLeta in

198 Spontaneous mutation of Fas (lpr) or FasL (gld) complete

199 Spontaneous mutation of the NPC-1 gene in mice generates

200 Here we report that spontaneous mutation of the transcription factor FOXP3 r

201 Our data show that spontaneous mutation of the transcriptional regulator ha

202 ombinant inbred congenic strain HcB-19 has a spontaneous mutation of the Txnip gene, and we now show

203 emains stable under cultural drift, i.e. the spontaneous mutation of traits in the population, still

204 Spontaneous mutations of a dominant allele (I or i(i)) t

205 Eleven spontaneous mutations of acetyl-CoA carboxylase have bee

206 e a higher proportion of frameshifts than do spontaneous mutations of the same substrate.

207 arge experiment that examined the effects of spontaneous mutations on age-specific mortality rates in

208 Age-specific effects of spontaneous mutations on mortality rates in Drosophila a

209 ations in two sets of lines with accumulated spontaneous mutations on the second chromosome.

210 ns in pcaH or -G were suppressed either by a spontaneous mutation or by a PCR-generated random mutati

211 , E2f2-, and E2f3-deficient cells, either by spontaneous mutation or by conditional gene ablation, pr

212 Another spontaneous mutation (P228H) in Gabrb1 also causes high

213 Spontaneous mutations play a fundamental role in the mai

214 inase mutants have an increased frequency of spontaneous mutation, possibly due to uracil misincorpor

215 These spontaneous mutations potentially result from disruption

216 s were at substantial densities, to minimize spontaneous mutation prior to irradiation.

217 We analyzed spontaneous mutation processes across multiple genomic r

218 stood about the genome-wide impact of MMR on spontaneous mutation processes and the extent to which M

219 or MMR exhibit a 10- to 100-fold increase in spontaneous mutation rate (mutator phenotype), and inact

220 rains exhibited comparable increases in both spontaneous mutation rate and chromosome aberrations.

221 However, present estimates of the spontaneous mutation rate and spectrum are derived from

222 on of recD2 confers a modest increase in the spontaneous mutation rate and that the mutational signat

223 Here, we directly estimated the spontaneous mutation rate by sequencing new Drosophila m

224 We recently found that an elevated spontaneous mutation rate can also result from increased

225 Recently, the genome-wide spontaneous mutation rate in inbred lines of Caenorhabdi

226 The maize spontaneous mutation rate is estimated to be 2.17 x 10(-

227 During cell division, the spontaneous mutation rate is expressed as the probabilit

228 We estimated a spontaneous mutation rate of at least 4 x 10(-9) substit

229 an explain why cancers arise even though the spontaneous mutation rate of differentiated mammalian ce

230 The spontaneous mutation rate of plasmid-borne lacS was 175-

231 balance probably contributes toward the high spontaneous mutation rate of the mitochondrial genome.

232 3-L612M S. cerevisiae strain has an elevated spontaneous mutation rate that is likely due to reduced

233 An argument is presented that the spontaneous mutation rate, the core of evolution theory,

234 -patch repair synthesis might lead to a high spontaneous mutation rate, unless subsequent steps in th

235 ll division exhibit substantial increases in spontaneous mutation rate.

236 ation of ETH1 in apn1 strains also increased spontaneous mutation rates 9- or 31-fold compared to the

237 e, reduces DNA binding in vitro and elevates spontaneous mutation rates and resistance to MNNG treatm

238 processes requires that factors determining spontaneous mutation rates and spectra be identified and

239 NA backbone or mismatched base have elevated spontaneous mutation rates consistent with defective mis

240 A polymerases can also give rise to elevated spontaneous mutation rates if they are allowed to replic

241 Spontaneous mutation rates in the homozygous and heteroz

242 Dm mutants were identified corresponding to spontaneous mutation rates of 10(-3) to 10(-4) per gener

243 siae was identified on the basis of elevated spontaneous mutation rates of haploid cells deleted for

244 Over 70 years ago, increased spontaneous mutation rates were observed in Drosophila s

245 decreasing SAM levels significantly affected spontaneous mutation rates, leading us to conclude that

246 Typically, RNA viruses have high spontaneous mutation rates, which permit rapid adaptatio

247 narily conserved inhibitor of p53, caused by spontaneous mutation recently has been associated with a

248 was found to suppress the increased rates of spontaneous mutation, recombination, and chromosome loss

249 Two other spontaneous mutations result from insertion of novel DNA

250 The spontaneous mutation resulting in this phenotype was not

251 We report here that spontaneous mutations resulting from replication errors,

252 For instance, spontaneous mutations resulting in non- functional alpha

253 We also identify the spontaneous mutation rib-vertebrae as a hypomorphic muta

254 time appears critical to the suppression of spontaneous mutation; second, 3 weeks following exposure

255 these organisms exhibit rates and spectra of spontaneous mutations similar to MMR-bearing species, su

256 ains deficient in RNH35 displayed a distinct spontaneous mutation spectrum of deletions characterized

257 seudogene divergence accurately reflects the spontaneous mutation spectrum.

258 port provides experimental evidence that the spontaneous mutation T544I is a tissue culture adaptatio

259 evidence showing that it is the result of a spontaneous mutation (T544I) specific to tissue culture

260 icate two-to threefold higher frequencies of spontaneous mutations than in the mouse, with most of th

261 The positional cloning of a spontaneous mutation that caused lipopolysaccharide resi

262 the molecular basis for high growth (hg), a spontaneous mutation that causes a 30-50% increase in po

263 Here we have studied a new spontaneous mutation that causes severe polyarthritis in

264 in a region containing blind-sterile (bs), a spontaneous mutation that causes spermatogenic defects a

265 Hemoglobin deficit (hbd) mice carry a spontaneous mutation that impairs erythroid iron assimil

266 6(lu/lu)mouse model, which harbors a natural spontaneous mutation that inactivates plzf.

267 enA mtrR penB gonococcal strain (PR100) as a spontaneous mutation that increased resistance to penici

268 (Wa-1) mice inherit an autosomal recessive, spontaneous mutation that results in a postnatal reducti

269 pinal tract defects in mice homozygous for a spontaneous mutation that truncates the Dcc transcript.

270 r-naked hairless (Hr(N)) is a semi-dominant, spontaneous mutation that was suggested by allelism test

271 In addition, several spontaneous mutations that abolish detectable UL41 activ

272 used a frameshift reversion assay to examine spontaneous mutations that accumulate in yeast strains d

273 g resistance (MDR) transporters, we isolated spontaneous mutations that altered the substrate specifi

274 ents were identified in a genetic screen for spontaneous mutations that caused colonies of strain D39

275 Two spontaneous mutations that confer rapamycin resistance a

276 Pif1-deficient cells, which was relieved by spontaneous mutations that eliminated their ability to f

277 on was initiated with the following premise: spontaneous mutations that increase virus release will b

278 n Oxytricha and a template that can transmit spontaneous mutations that may arise during somatic grow

279 Spontaneous mutations that restore spreading have been p

280 Spontaneous mutations that suppress arrest occur with a

281 Normal cells minimize spontaneous mutations through the combined actions of po

282 l mutability, as they possessed low rates of spontaneous mutation to drug resistance.

283 with each other and mismatch repair to limit spontaneous mutation to less than 1 per genome per cell

284 for a frequency as high as 2.8 x 10(-6) for spontaneous mutation to resistance to optochin and was 1

285 n frequency was accompanied by high rates of spontaneous mutation to rifampicin and nalidixic acid re

286 hpC mutants differed in their frequencies of spontaneous mutation to rifampin resistance and in their

287 correlated with DNA damage, the frequency of spontaneous mutation to rifampin resistance was studied.

288 To estimate these quantities, we allowed spontaneous mutations to accumulate for 10 generations i

289 These clones were prone to spontaneous mutation upon further propagation, however,

290 to measure the genome-wide mutation rate for spontaneous mutations, using measurements of traits in i

291 t the DNA lesions responsible for changes in spontaneous mutation, viability, and alkylation sensitiv

292 We discovered a new spontaneous mutation (vortex, symbol vtx) of Atp6v1b1 in

293 The nature of the spontaneous mutation was a single base-pair deletion in

294 n, we found that the rate of accumulation of spontaneous mutations was similar in fetuses produced by

295 Spontaneous mutations were accumulated for approximately

296 Spontaneous mutations were accumulated in 100 replicate

297 We obtained proof that the observed spontaneous mutations were responsible for improved fitn

298 odes DNA polymerase IV and greatly increases spontaneous mutations when overexpressed.

299 in the low-risk families is mainly caused by spontaneous mutation with high penetrance in males and r

300 nce exchange between strains as well as from spontaneous mutation, with interstrain recombination bei