ライフサイエンスコーパス: spontaneously hypertensive

1 the individual CYP4A genes in the kidneys of spontaneously hypertensive and Wistar-Kyoto rats.

2 ion had minimal effects on the baroreflex in spontaneously hypertensive BPH-2 control mice, which exh

3 prevents ischemic and hemorrhagic stroke in spontaneously hypertensive, genetically stroke-prone (SH

4 S development in obese diabetic Zucker fatty/Spontaneously hypertensive heart failure F1 hybrid (ZSF1

5 Spontaneously hypertensive heart failure myocytes were c

6 measured in 5 groups of rats: (1) obese male spontaneously hypertensive heart failure rats (SHHF) at

7 alazine (a vasodilator) were administered to spontaneously hypertensive heart failure rats between 6

8 action coupling and nitroso-redox balance in spontaneously hypertensive heart failure rats with dilat

9 l NO synthase-deficient (NOS1(-/-)) mice and spontaneously hypertensive heart failure rats, to test t

10 remodeling in a model of established HF, the spontaneously hypertensive/HF (SHHF) rat.

11 min and rosiglitazone) in a genetic model of spontaneously hypertensive, insulin-resistant rats (SHHF

12 4A8 mRNA was also found in 3- and 4-week-old spontaneously hypertensive kidneys.

13 Elevated Chga occurs in spontaneously hypertensive rat (SHR) adrenal glands and

14 oad LVH using 2 standard rat models: (1) the spontaneously hypertensive rat (SHR) and (2) aortic band

15 The spontaneously hypertensive rat (SHR) and its normotensiv

16 xygen consumption have been described in the spontaneously hypertensive rat (SHR) and may contribute

17 binant inbred (RI) strains, derived from the spontaneously hypertensive rat (SHR) and normotensive Br

18 organism, mated it with the stroke-resistant spontaneously hypertensive rat (SHR) and performed a gen

19 quantify metabolic substrate shifts with the spontaneously hypertensive rat (SHR) as a model of left

20 for this heightened action of Ang II in the spontaneously hypertensive rat (SHR) brain neurons.

21 regulatory brain areas, was increased in the spontaneously hypertensive rat (SHR) compared to the Wis

22 in was significantly enhanced in the RVLM of spontaneously hypertensive rat (SHR) compared with normo

23 rent at physiological membrane potentials in spontaneously hypertensive rat (SHR) compared with Wista

24 The adult spontaneously hypertensive rat (SHR) has been shown to e

25 The spontaneously hypertensive rat (SHR) has been suggested

26 The spontaneously hypertensive rat (SHR) has been widely use

27 IL-17 family in genetic hypertension in the spontaneously hypertensive rat (SHR) has not been invest

28 factor that stimulates myocytes growth, from spontaneously hypertensive rat (SHR) heart and patients

29 The spontaneously hypertensive rat (SHR) is a model of these

30 In contrast, the spontaneously hypertensive rat (SHR) is highly resistant

31 The spontaneously hypertensive rat (SHR) is insulin resistan

32 The spontaneously hypertensive rat (SHR) is often used as a

33 P-catalyzed EET formation was altered in the spontaneously hypertensive rat (SHR) kidney.

34 Using the spontaneously hypertensive rat (SHR) model of ADHD, we r

35 In the spontaneously hypertensive rat (SHR) model of genetic hy

36 tatively the cTnI phosphorylation changes in spontaneously hypertensive rat (SHR) model of hypertensi

37 chronic cardiac injury was evaluated in the spontaneously hypertensive rat (SHR) model.

38 robust in vivo blood pressure lowering in a spontaneously hypertensive rat (SHR) model.

39 We tested the hypothesis that in spontaneously hypertensive rat (SHR) NO produced central

40 fold in renal cortical S9 fractions from the spontaneously hypertensive rat (SHR) relative to the nor

41 middle cerebral artery occlusion (tMCAO) in spontaneously hypertensive rat (SHR) resulted in signifi

42 ng clinically relevant cyclic stretch and in spontaneously hypertensive rat (SHR) retina.

43 The spontaneously hypertensive rat (SHR) strain exists in li

44 Previous studies in the spontaneously hypertensive rat (SHR) support a role for

45 Previous studies in the spontaneously hypertensive rat (SHR) support a role for

46 P expression is significantly reduced in the spontaneously hypertensive rat (SHR) which could contrib

47 and SHR.WKY-Sa) derived from a cross of the spontaneously hypertensive rat (SHR) with the Wistar-Kyo

48 aintenance of elevated blood pressure in the spontaneously hypertensive rat (SHR), a genetic model fo

49 nd maintenance of high blood pressure in the spontaneously hypertensive rat (SHR), a model of primary

50 The spontaneously hypertensive rat (SHR), a putative animal

51 The spontaneously hypertensive rat (SHR), a widely used anim

52 vents the development of hypertension in the spontaneously hypertensive rat (SHR), an animal model fo

53 In the spontaneously hypertensive rat (SHR), in spite of normal

54 rtriglyceridemia and hyperinsulinemia of the spontaneously hypertensive rat (SHR).

55 d to be increased in proximal tubules of the spontaneously hypertensive rat (SHR).

56 when administered orally at 10 mg/kg to the spontaneously hypertensive rat (SHR).

57 ADHD as well as an animal model of ADHD, the spontaneously hypertensive rat (SHR).

58 olic heart failure (HF) were examined in the spontaneously hypertensive rat (SHR).

59 ain-specific translational regulation in the spontaneously hypertensive rat (SHR/Ola).

60 eart rate (HR), observed in the stroke-prone spontaneously hypertensive rat (SHRSP(HD)), is a primary

61 We used the stroke-prone spontaneously hypertensive rat (SHRSP) as a model organi

62 The stroke-prone spontaneously hypertensive rat (SHRSP) is a genetically

63 ntegrity and wall pathology were examined in spontaneously hypertensive rat and chronic angiotensin I

64 ntegrity and wall pathology were examined in spontaneously hypertensive rat and chronic angiotensin I

65 lodalton protein isolated from hypertrophied spontaneously hypertensive rat and dilated cardiomyopath

66 1a(+) immune cells are dominant in the (SHR) spontaneously hypertensive rat and expand in response to

67 This study explored the spontaneously hypertensive rat as an animal model of pul

68 himeric Wistar-Kyoto rats reconstituted with spontaneously hypertensive rat BM.

69 The spontaneously hypertensive rat can be a model of pulmona

70 in, a hypertrophic activator identified from spontaneously hypertensive rat heart and cardiomyopathic

71 the cortex and outer medulla of 1-4-week-old spontaneously hypertensive rat kidneys relative to the c

72 We have used a spontaneously hypertensive rat model to investigate the

73 either the overload of heart failure (or the spontaneously hypertensive rat model) or the profound un

74 nder Dox-induced cardiotoxic conditions in a spontaneously hypertensive rat model.

75 e rats and transplanted into recipient adult spontaneously hypertensive rat spleens.

76 The increase in blood pressure in spontaneously hypertensive rat was associated with gut p

77 od pressure in the aorta-ligated rat and the spontaneously hypertensive rat when administered orally.

78 reflex-function curves is exaggerated in the spontaneously hypertensive rat where the cardiac compone

79 rom normal (Wistar Kyoto) and hypertrophied (spontaneously hypertensive rat) rats was investigated by

80 ion-induced damage than is the kidney of the spontaneously hypertensive rat, and (b) establish the fe

81 an animal model of stroke, the stroke-prone spontaneously hypertensive rat, implicated the gene enco

82 s chronic hypertension develops in the young spontaneously hypertensive rat, medullary Na,K-ATPase ac

83 izes the authors' recent experience with the spontaneously hypertensive rat, the best experimental mo

84 In the MCAO model, conducted in the spontaneously hypertensive rat, the more polar 3-hydroxy

85 y approximately 15 mm Hg, exclusively in the spontaneously hypertensive rat.

86 term reduction in high blood pressure in the spontaneously hypertensive rat.

87 id formation and renal function in the young spontaneously hypertensive rat.

88 Furthermore, antihypertensive effects in spontaneously hypertensive rats (SHR) also revealed that

89 the susceptibility of 5- to 6-month-old male spontaneously hypertensive rats (SHR) and age/sex-matche

90 The development of hypertension in spontaneously hypertensive rats (SHR) and hyperactive vo

91 edback (TGF) activity in 7-wk-old, euvolemic spontaneously hypertensive rats (SHR) and in Wistar-Kyot

92 ne rats (SHR-SP) have more brain injury than spontaneously hypertensive rats (SHR) and normotensive c

93 Spontaneously hypertensive rats (SHR) and normotensive W

94 smutase (ECSOD) reduces arterial pressure in spontaneously hypertensive rats (SHR) and whether its he

95 Cell counts were also made in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (

96 Spontaneously hypertensive rats (SHR) are the most widel

97 myosin light chain kinase (smMLCK) by using spontaneously hypertensive rats (SHR) as an experimental

98 solated carotid body glomus cells from young spontaneously hypertensive rats (SHR) before the onset o

99 mined in DHI, Losartan, and placebo- treated Spontaneously Hypertensive Rats (SHR) by both noninvasiv

100 Ischemic tolerance was induced in spontaneously hypertensive rats (SHR) by injection of a

101 d renal sympathetic nerve activity (RSNA) in spontaneously hypertensive rats (SHR) compared to normot

102 red in distal mesenteric arteries from adult spontaneously hypertensive rats (SHR) compared with norm

103 ion showed greater levels of PRR mRNA in the spontaneously hypertensive rats (SHR) compared with norm

104 gher in the paraventricular nucleus (PVN) of spontaneously hypertensive rats (SHR) compared with thei

105 uscle cells (ASMCs) obtained from adult male spontaneously hypertensive rats (SHR) compared with thos

106 After a period of stable hypertrophy, male spontaneously hypertensive rats (SHR) develop heart fail

107 wever, AMPAR-EPSCs of labeled PVN neurons in spontaneously hypertensive rats (SHR) displayed inward r

108 Experiments used spontaneously hypertensive rats (SHR) during the early d

109 Recent evidence in vivo indicates that spontaneously hypertensive rats (SHR) exhibit an increas

110 Spontaneously hypertensive rats (SHR) had a 90 min middl

111 Spontaneously hypertensive rats (SHR) have an activated

112 nsive strain rats having the highest and the spontaneously hypertensive rats (SHR) having the lowest

113 Spontaneously hypertensive rats (SHR) respond with exagg

114 ied the metabolic effects of pioglitazone in spontaneously hypertensive rats (SHR) that harbor a dele

115 d Ang II-induced inhibition of baroreflex in spontaneously hypertensive rats (SHR) versus WKY rats.

116 Male 20-week-old spontaneously hypertensive rats (SHR) were divided into

117 Groups of spontaneously hypertensive rats (SHR) were given 1 mg/kg

118 al behavior were examined in male and female spontaneously hypertensive rats (SHR), a commonly used a

119 evation of peripheral vascular resistance in spontaneously hypertensive rats (SHR), a glucocorticoid-

120 rted that subjects with ADHD as well as male spontaneously hypertensive rats (SHR), a strain that is

121 KY) rats with borderline hypertension and in spontaneously hypertensive rats (SHR), a widely used gen

122 responses are impaired in arterioles of male spontaneously hypertensive rats (SHR), but they are stil

123 In spontaneously hypertensive rats (SHR), cannabinoid-1 rec

124 In spontaneously hypertensive rats (SHR), high NaCl diets i

125 us injection of AdECSOD(R213G) or AdECSOD in spontaneously hypertensive rats (SHR), immunostaining de

126 t regressing left ventricular hypertrophy in spontaneously hypertensive rats (SHR), possibly because

127 II (Ang II) and associated tissue injury in spontaneously hypertensive rats (SHR).

128 tail artery from normotensive rats (NTR) or spontaneously hypertensive rats (SHR).

129 lar smooth muscle cells (VSMC) isolated from spontaneously hypertensive rats (SHR).

130 Sprague-Dawley (SD), Wistar-Kyoto (WKY), and spontaneously hypertensive rats (SHR).

131 in normotensive (Wistar Kyoto rat, WKY) and spontaneously hypertensive rats (SHR).

132 s been shown to induce ischemic tolerance in spontaneously hypertensive rats (SHR).

133 of normotensive Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR).

134 follow the development of chronic changes in spontaneously hypertensive rats (SHR).

135 st the ability to suppress blood pressure in spontaneously hypertensive rats (SHR).

136 inea pigs; and (3) vasoregulatory effects in spontaneously hypertensive rats (SHR).

137 in a rat model of chronic hypertension, the spontaneously hypertensive rats (SHR).

138 y on BP, cardiac function, and remodeling in spontaneously hypertensive rats (SHR).

139 intain resting sympathetic vasomotor tone in spontaneously hypertensive rats (SHR).

140 sartan on the progression of renal injury in spontaneously hypertensive rats (SHR).

141 ts and increases smMLCK promoter activity in spontaneously hypertensive rats (SHR).

142 ransplanted into unilaterally nephrectomized spontaneously hypertensive rats (SHR-RT1.N strain) that

143 in response to increased flow, stroke-prone spontaneously hypertensive rats (SHR-SP) exhibited a sma

144 Female spontaneously hypertensive rats (SHR; age, 4 months) wer

145 onducted on 4- to 5-week-old prehypertensive spontaneously hypertensive rats (SHRs) and age-matched n

146 N-mediated actions of Ang II are enhanced in spontaneously hypertensive rats (SHRs) and contribute to

147 aimed to observe effects of BSJYD on LVH in spontaneously hypertensive rats (SHRs) and explore its p

148 sparks in ventricular cells from 6-month-old spontaneously hypertensive rats (SHRs) and from age- and

149 eurons isolated from the stellate ganglia of spontaneously hypertensive rats (SHRs) and their normote

150 corded in spinally projecting PVN neurons in spontaneously hypertensive rats (SHRs) and Wistar-Kyoto

151 bers from normotensive Wistar-Kyoto rats and spontaneously hypertensive rats (SHRs) by cytofluorimetr

152 In pre-hypertensive (PH) and adult spontaneously hypertensive rats (SHRs) carotid body type

153 ker, candesartan, was orally administered to spontaneously hypertensive rats (SHRs) for 40 days, foll

154 a larger amplitude and shorter decay time in spontaneously hypertensive rats (SHRs) than in Wistar-Ky

155 Immune-competent spontaneously hypertensive rats (SHRs) were implanted wi

156 vior and social interaction were examined in spontaneously hypertensive rats (SHRs), a commonly used

157 tivity of spinally projecting PVN neurons in spontaneously hypertensive rats (SHRs), but not in normo

158 In spontaneously hypertensive rats (SHRs), high ABP is asso

159 These effects are exaggerated in spontaneously hypertensive rats (SHRs), resulting in an

160 study, we examined conditioned inhibition in spontaneously hypertensive rats (SHRs), the most well-va

161 ex function in Wistar-Kyoto (WKY) but not in spontaneously hypertensive rats (SHRs).

162 ta(1)-ARs as well as lower blood pressure in spontaneously hypertensive rats (SHRs).

163 ist improves the baroreceptor reflex gain in spontaneously hypertensive rats (SHRs).

164 kDa (LFH <3 kDa) were orally administered to spontaneously hypertensive rats (SHRs).

165 ing shift that diminishes GABA inhibition in spontaneously hypertensive rats (SHRs).

166 VN neurons and sympathetic vasomotor tone in spontaneously hypertensive rats (SHRs).

167 on NTS baroreceptor second-order neurons in spontaneously hypertensive rats (SHRs).

168 tivity of PVN presympathetic neurons in male spontaneously hypertensive rats (SHRs).

169 dritic spine density are increased in NTS of spontaneously hypertensive rats (SHRs).

170 icroangiopathy in salt-loaded, stroke-prone, spontaneously hypertensive rats (SHRSP) without controll

171 duced a long-term antihypertensive effect in spontaneously hypertensive rats and antifibrotic effects

172 , purified, and sequenced from the hearts of spontaneously hypertensive rats and dilated cardiomyopat

173 ivation, attenuated hypertension in both the spontaneously hypertensive rats and the chronic angioten

174 Fetal hepatocytes were harvested from spontaneously hypertensive rats and transplanted into re

175 manner, with similar levels of inhibition in spontaneously hypertensive rats and Wistar-Kyoto rats; m

176 antly larger increases in MAP and HR in male spontaneously hypertensive rats as compared to normotens

177 ide hydrolase (sEH) reduce blood pressure in spontaneously hypertensive rats as well as the findings

178 mmunohistochemical staining of the aortae of spontaneously hypertensive rats demonstrated strong corr

179 Wistar Kyoto rat BM, the resultant chimeric spontaneously hypertensive rats displayed significant re

180 l ester was given by daily s.c. injection to spontaneously hypertensive rats exposed to filtered air

181 The right MCA was occluded in spontaneously hypertensive rats for 0, 60 and 120 min.

182 (AT(1)R-AS) in a retroviral vector prevents spontaneously hypertensive rats from developing hyperten

183 (ii) Spontaneously hypertensive rats have more orexin neurons

184 Spontaneously hypertensive rats received either bilatera

185 f the cationic peptides (200mg/kgbodywt.) to spontaneously hypertensive rats resulted in a more rapid

186 m channel blocker, SNX-111, was evaluated in spontaneously hypertensive rats subjected to 60 min of f

187 greater renal vasoconstriction in 7-wk-old, spontaneously hypertensive rats than in Wistar-Kyoto rat

188 Here, in ventricular myocytes from spontaneously hypertensive rats that develop heart failu

189 e used an animal model of ischemic stroke in spontaneously hypertensive rats to determine whether or

190 Male spontaneously hypertensive rats underwent occlusion of t

191 blood pressure reduction in both normal and spontaneously hypertensive rats via interactions with th

192 ithelial cells derived from Wistar-Kyoto and spontaneously hypertensive rats were grown to confluency

193 RF-RDN (n=14) or sham-RDN (n=14) treatment, spontaneously hypertensive rats were subjected to 30 min

194 Halothane-anesthetized spontaneously hypertensive rats were subjected to middle

195 Spontaneously hypertensive rats were treated with 2, 3-d

196 lly, AM404 reduced hyperactivity in juvenile spontaneously hypertensive rats, a putative model of att

197 n distal middle cerebral artery occlusion in spontaneously hypertensive rats, a strain representative

198 nd we have described disordered breathing in spontaneously hypertensive rats, an animal model of gene

199 enase and the development of hypertension in spontaneously hypertensive rats, and 2) a relationship b

200 n myotrophin-induced cardiac hypertrophy, in spontaneously hypertensive rats, and in dilated cardiomy

201 After BM ablation in spontaneously hypertensive rats, and reconstitution with

202 tolic blood pressure (Delta=48+/-5 mm Hg) in spontaneously hypertensive rats, indicating that SNX5 de

203 d 20-HETE formation in renal microsomes from spontaneously hypertensive rats, it has been proposed th

204 In older spontaneously hypertensive rats, it reduced left ventric

205 In anesthetized spontaneously hypertensive rats, the middle cerebral art

206 After oral administration to spontaneously hypertensive rats, the S1P1 selective comp

207 al cerebral ischemia and 24 h reperfusion in spontaneously hypertensive rats.

208 ificantly upregulated compared with sham-RDN spontaneously hypertensive rats.

209 e similar in the kidneys of Wistar-Kyoto and spontaneously hypertensive rats.

210 pressure in response to vasoconstrictors in spontaneously hypertensive rats.

211 antagonist SC51322 reduced blood pressure in spontaneously hypertensive rats.

212 ratory reflex conditions and elevated in the spontaneously hypertensive (SH) rat - and yet the exact

213 attenuates the development of high BP in the spontaneously hypertensive (SH) rat model of human essen

214 tablishment of the hypertensive state in the spontaneously hypertensive (SH) rat.

215 Wistar-Kyoto normotensive (WKY) and spontaneously hypertensive (SH) rats implanted with radi

216 a indices were also noted in prehypertensive spontaneously hypertensive (SH) rats, which are known to

217 amus and brainstem of Wistar Kyoto (WKY) and spontaneously hypertensive (SH) rats.

218 Male healthy Wistar Kyoto (WKY), spontaneously hypertensive (SH), and SH heart failure (S

219 flex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertens

220 re isolated from 18- to 24-month-old failing spontaneously hypertensive (SHR) or age-matched Wistar-K

221 ECS refractoriness in Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats which vary in aden

222 in Wistar-Kyoto (WKY), Sprague-Dawley (SD), spontaneously hypertensive (SHR), and deoxycorticosteron

223 of the cerebellar fastigial nucleus (FN) in spontaneously hypertensive (SHR), Wistar-Kyoto (WKY) and

224 development was assessed in male and female spontaneously hypertensive (SHR), Wistar-Kyoto (WKY), an

225 The stroke-prone spontaneously hypertensive (SHRSP) rat is a model of hum

226 antan-1-yl-ureido) dodecanoic acid (AUDA) in spontaneously hypertensive stroke-prone (SHRSP) rats pro

227 In spontaneously hypertensive stroke-prone (SP) rats receiv

228 The spontaneously hypertensive stroke-prone rat (SHRSP) is a

229 We tested the following hypotheses: a) spontaneously hypertensive stroke-prone rats (SHR-SP) ha

230 9/9) and 36/14 (+/- 4/3), respectively, for spontaneously hypertensive Wistar Kyoto rats (SHR), and

231 red among 4 strains of rats: Sprague-Dawley, Spontaneously Hypertensive, Wistar Kyoto (WKY), and Brow