ライフサイエンスコーパス: spontaneously hypertensive rat

1 y approximately 15 mm Hg, exclusively in the spontaneously hypertensive rat.

2 term reduction in high blood pressure in the spontaneously hypertensive rat.

3 id formation and renal function in the young spontaneously hypertensive rat.

4 ificantly upregulated compared with sham-RDN spontaneously hypertensive rats.

5 e similar in the kidneys of Wistar-Kyoto and spontaneously hypertensive rats.

6 pressure in response to vasoconstrictors in spontaneously hypertensive rats.

7 antagonist SC51322 reduced blood pressure in spontaneously hypertensive rats.

8 al cerebral ischemia and 24 h reperfusion in spontaneously hypertensive rats.

9 lly, AM404 reduced hyperactivity in juvenile spontaneously hypertensive rats, a putative model of att

10 n distal middle cerebral artery occlusion in spontaneously hypertensive rats, a strain representative

11 nd we have described disordered breathing in spontaneously hypertensive rats, an animal model of gene

12 ntegrity and wall pathology were examined in spontaneously hypertensive rat and chronic angiotensin I

13 ntegrity and wall pathology were examined in spontaneously hypertensive rat and chronic angiotensin I

14 lodalton protein isolated from hypertrophied spontaneously hypertensive rat and dilated cardiomyopath

15 1a(+) immune cells are dominant in the (SHR) spontaneously hypertensive rat and expand in response to

16 duced a long-term antihypertensive effect in spontaneously hypertensive rats and antifibrotic effects

17 , purified, and sequenced from the hearts of spontaneously hypertensive rats and dilated cardiomyopat

18 ivation, attenuated hypertension in both the spontaneously hypertensive rats and the chronic angioten

19 Fetal hepatocytes were harvested from spontaneously hypertensive rats and transplanted into re

20 manner, with similar levels of inhibition in spontaneously hypertensive rats and Wistar-Kyoto rats; m

21 ion-induced damage than is the kidney of the spontaneously hypertensive rat, and (b) establish the fe

22 enase and the development of hypertension in spontaneously hypertensive rats, and 2) a relationship b

23 n myotrophin-induced cardiac hypertrophy, in spontaneously hypertensive rats, and in dilated cardiomy

24 After BM ablation in spontaneously hypertensive rats, and reconstitution with

25 This study explored the spontaneously hypertensive rat as an animal model of pul

26 antly larger increases in MAP and HR in male spontaneously hypertensive rats as compared to normotens

27 ide hydrolase (sEH) reduce blood pressure in spontaneously hypertensive rats as well as the findings

28 himeric Wistar-Kyoto rats reconstituted with spontaneously hypertensive rat BM.

29 The spontaneously hypertensive rat can be a model of pulmona

30 mmunohistochemical staining of the aortae of spontaneously hypertensive rats demonstrated strong corr

31 Wistar Kyoto rat BM, the resultant chimeric spontaneously hypertensive rats displayed significant re

32 l ester was given by daily s.c. injection to spontaneously hypertensive rats exposed to filtered air

33 The right MCA was occluded in spontaneously hypertensive rats for 0, 60 and 120 min.

34 (AT(1)R-AS) in a retroviral vector prevents spontaneously hypertensive rats from developing hyperten

35 (ii) Spontaneously hypertensive rats have more orexin neurons

36 in, a hypertrophic activator identified from spontaneously hypertensive rat heart and cardiomyopathic

37 an animal model of stroke, the stroke-prone spontaneously hypertensive rat, implicated the gene enco

38 tolic blood pressure (Delta=48+/-5 mm Hg) in spontaneously hypertensive rats, indicating that SNX5 de

39 d 20-HETE formation in renal microsomes from spontaneously hypertensive rats, it has been proposed th

40 In older spontaneously hypertensive rats, it reduced left ventric

41 the cortex and outer medulla of 1-4-week-old spontaneously hypertensive rat kidneys relative to the c

42 s chronic hypertension develops in the young spontaneously hypertensive rat, medullary Na,K-ATPase ac

43 We have used a spontaneously hypertensive rat model to investigate the

44 either the overload of heart failure (or the spontaneously hypertensive rat model) or the profound un

45 nder Dox-induced cardiotoxic conditions in a spontaneously hypertensive rat model.

46 rom normal (Wistar Kyoto) and hypertrophied (spontaneously hypertensive rat) rats was investigated by

47 Spontaneously hypertensive rats received either bilatera

48 f the cationic peptides (200mg/kgbodywt.) to spontaneously hypertensive rats resulted in a more rapid

49 Elevated Chga occurs in spontaneously hypertensive rat (SHR) adrenal glands and

50 oad LVH using 2 standard rat models: (1) the spontaneously hypertensive rat (SHR) and (2) aortic band

51 The spontaneously hypertensive rat (SHR) and its normotensiv

52 xygen consumption have been described in the spontaneously hypertensive rat (SHR) and may contribute

53 binant inbred (RI) strains, derived from the spontaneously hypertensive rat (SHR) and normotensive Br

54 organism, mated it with the stroke-resistant spontaneously hypertensive rat (SHR) and performed a gen

55 quantify metabolic substrate shifts with the spontaneously hypertensive rat (SHR) as a model of left

56 for this heightened action of Ang II in the spontaneously hypertensive rat (SHR) brain neurons.

57 regulatory brain areas, was increased in the spontaneously hypertensive rat (SHR) compared to the Wis

58 in was significantly enhanced in the RVLM of spontaneously hypertensive rat (SHR) compared with normo

59 rent at physiological membrane potentials in spontaneously hypertensive rat (SHR) compared with Wista

60 The adult spontaneously hypertensive rat (SHR) has been shown to e

61 The spontaneously hypertensive rat (SHR) has been suggested

62 The spontaneously hypertensive rat (SHR) has been widely use

63 IL-17 family in genetic hypertension in the spontaneously hypertensive rat (SHR) has not been invest

64 factor that stimulates myocytes growth, from spontaneously hypertensive rat (SHR) heart and patients

65 The spontaneously hypertensive rat (SHR) is a model of these

66 In contrast, the spontaneously hypertensive rat (SHR) is highly resistant

67 The spontaneously hypertensive rat (SHR) is insulin resistan

68 The spontaneously hypertensive rat (SHR) is often used as a

69 P-catalyzed EET formation was altered in the spontaneously hypertensive rat (SHR) kidney.

70 Using the spontaneously hypertensive rat (SHR) model of ADHD, we r

71 In the spontaneously hypertensive rat (SHR) model of genetic hy

72 tatively the cTnI phosphorylation changes in spontaneously hypertensive rat (SHR) model of hypertensi

73 chronic cardiac injury was evaluated in the spontaneously hypertensive rat (SHR) model.

74 robust in vivo blood pressure lowering in a spontaneously hypertensive rat (SHR) model.

75 We tested the hypothesis that in spontaneously hypertensive rat (SHR) NO produced central

76 fold in renal cortical S9 fractions from the spontaneously hypertensive rat (SHR) relative to the nor

77 middle cerebral artery occlusion (tMCAO) in spontaneously hypertensive rat (SHR) resulted in signifi

78 ng clinically relevant cyclic stretch and in spontaneously hypertensive rat (SHR) retina.

79 The spontaneously hypertensive rat (SHR) strain exists in li

80 Previous studies in the spontaneously hypertensive rat (SHR) support a role for

81 Previous studies in the spontaneously hypertensive rat (SHR) support a role for

82 P expression is significantly reduced in the spontaneously hypertensive rat (SHR) which could contrib

83 and SHR.WKY-Sa) derived from a cross of the spontaneously hypertensive rat (SHR) with the Wistar-Kyo

84 aintenance of elevated blood pressure in the spontaneously hypertensive rat (SHR), a genetic model fo

85 nd maintenance of high blood pressure in the spontaneously hypertensive rat (SHR), a model of primary

86 The spontaneously hypertensive rat (SHR), a putative animal

87 The spontaneously hypertensive rat (SHR), a widely used anim

88 vents the development of hypertension in the spontaneously hypertensive rat (SHR), an animal model fo

89 In the spontaneously hypertensive rat (SHR), in spite of normal

90 rtriglyceridemia and hyperinsulinemia of the spontaneously hypertensive rat (SHR).

91 d to be increased in proximal tubules of the spontaneously hypertensive rat (SHR).

92 when administered orally at 10 mg/kg to the spontaneously hypertensive rat (SHR).

93 ADHD as well as an animal model of ADHD, the spontaneously hypertensive rat (SHR).

94 olic heart failure (HF) were examined in the spontaneously hypertensive rat (SHR).

95 ain-specific translational regulation in the spontaneously hypertensive rat (SHR/Ola).

96 Furthermore, antihypertensive effects in spontaneously hypertensive rats (SHR) also revealed that

97 the susceptibility of 5- to 6-month-old male spontaneously hypertensive rats (SHR) and age/sex-matche

98 The development of hypertension in spontaneously hypertensive rats (SHR) and hyperactive vo

99 edback (TGF) activity in 7-wk-old, euvolemic spontaneously hypertensive rats (SHR) and in Wistar-Kyot

100 ne rats (SHR-SP) have more brain injury than spontaneously hypertensive rats (SHR) and normotensive c

101 Spontaneously hypertensive rats (SHR) and normotensive W

102 smutase (ECSOD) reduces arterial pressure in spontaneously hypertensive rats (SHR) and whether its he

103 Cell counts were also made in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (

104 Spontaneously hypertensive rats (SHR) are the most widel

105 myosin light chain kinase (smMLCK) by using spontaneously hypertensive rats (SHR) as an experimental

106 solated carotid body glomus cells from young spontaneously hypertensive rats (SHR) before the onset o

107 mined in DHI, Losartan, and placebo- treated Spontaneously Hypertensive Rats (SHR) by both noninvasiv

108 Ischemic tolerance was induced in spontaneously hypertensive rats (SHR) by injection of a

109 d renal sympathetic nerve activity (RSNA) in spontaneously hypertensive rats (SHR) compared to normot

110 red in distal mesenteric arteries from adult spontaneously hypertensive rats (SHR) compared with norm

111 ion showed greater levels of PRR mRNA in the spontaneously hypertensive rats (SHR) compared with norm

112 gher in the paraventricular nucleus (PVN) of spontaneously hypertensive rats (SHR) compared with thei

113 uscle cells (ASMCs) obtained from adult male spontaneously hypertensive rats (SHR) compared with thos

114 After a period of stable hypertrophy, male spontaneously hypertensive rats (SHR) develop heart fail

115 wever, AMPAR-EPSCs of labeled PVN neurons in spontaneously hypertensive rats (SHR) displayed inward r

116 Experiments used spontaneously hypertensive rats (SHR) during the early d

117 Recent evidence in vivo indicates that spontaneously hypertensive rats (SHR) exhibit an increas

118 Spontaneously hypertensive rats (SHR) had a 90 min middl

119 Spontaneously hypertensive rats (SHR) have an activated

120 nsive strain rats having the highest and the spontaneously hypertensive rats (SHR) having the lowest

121 Spontaneously hypertensive rats (SHR) respond with exagg

122 ied the metabolic effects of pioglitazone in spontaneously hypertensive rats (SHR) that harbor a dele

123 d Ang II-induced inhibition of baroreflex in spontaneously hypertensive rats (SHR) versus WKY rats.

124 Male 20-week-old spontaneously hypertensive rats (SHR) were divided into

125 Groups of spontaneously hypertensive rats (SHR) were given 1 mg/kg

126 al behavior were examined in male and female spontaneously hypertensive rats (SHR), a commonly used a

127 evation of peripheral vascular resistance in spontaneously hypertensive rats (SHR), a glucocorticoid-

128 rted that subjects with ADHD as well as male spontaneously hypertensive rats (SHR), a strain that is

129 KY) rats with borderline hypertension and in spontaneously hypertensive rats (SHR), a widely used gen

130 responses are impaired in arterioles of male spontaneously hypertensive rats (SHR), but they are stil

131 In spontaneously hypertensive rats (SHR), cannabinoid-1 rec

132 In spontaneously hypertensive rats (SHR), high NaCl diets i

133 us injection of AdECSOD(R213G) or AdECSOD in spontaneously hypertensive rats (SHR), immunostaining de

134 t regressing left ventricular hypertrophy in spontaneously hypertensive rats (SHR), possibly because

135 tail artery from normotensive rats (NTR) or spontaneously hypertensive rats (SHR).

136 lar smooth muscle cells (VSMC) isolated from spontaneously hypertensive rats (SHR).

137 Sprague-Dawley (SD), Wistar-Kyoto (WKY), and spontaneously hypertensive rats (SHR).

138 in normotensive (Wistar Kyoto rat, WKY) and spontaneously hypertensive rats (SHR).

139 s been shown to induce ischemic tolerance in spontaneously hypertensive rats (SHR).

140 of normotensive Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR).

141 follow the development of chronic changes in spontaneously hypertensive rats (SHR).

142 st the ability to suppress blood pressure in spontaneously hypertensive rats (SHR).

143 inea pigs; and (3) vasoregulatory effects in spontaneously hypertensive rats (SHR).

144 in a rat model of chronic hypertension, the spontaneously hypertensive rats (SHR).

145 y on BP, cardiac function, and remodeling in spontaneously hypertensive rats (SHR).

146 intain resting sympathetic vasomotor tone in spontaneously hypertensive rats (SHR).

147 sartan on the progression of renal injury in spontaneously hypertensive rats (SHR).

148 ts and increases smMLCK promoter activity in spontaneously hypertensive rats (SHR).

149 II (Ang II) and associated tissue injury in spontaneously hypertensive rats (SHR).

150 ransplanted into unilaterally nephrectomized spontaneously hypertensive rats (SHR-RT1.N strain) that

151 in response to increased flow, stroke-prone spontaneously hypertensive rats (SHR-SP) exhibited a sma

152 Female spontaneously hypertensive rats (SHR; age, 4 months) wer

153 onducted on 4- to 5-week-old prehypertensive spontaneously hypertensive rats (SHRs) and age-matched n

154 N-mediated actions of Ang II are enhanced in spontaneously hypertensive rats (SHRs) and contribute to

155 aimed to observe effects of BSJYD on LVH in spontaneously hypertensive rats (SHRs) and explore its p

156 sparks in ventricular cells from 6-month-old spontaneously hypertensive rats (SHRs) and from age- and

157 eurons isolated from the stellate ganglia of spontaneously hypertensive rats (SHRs) and their normote

158 corded in spinally projecting PVN neurons in spontaneously hypertensive rats (SHRs) and Wistar-Kyoto

159 bers from normotensive Wistar-Kyoto rats and spontaneously hypertensive rats (SHRs) by cytofluorimetr

160 In pre-hypertensive (PH) and adult spontaneously hypertensive rats (SHRs) carotid body type

161 ker, candesartan, was orally administered to spontaneously hypertensive rats (SHRs) for 40 days, foll

162 a larger amplitude and shorter decay time in spontaneously hypertensive rats (SHRs) than in Wistar-Ky

163 Immune-competent spontaneously hypertensive rats (SHRs) were implanted wi

164 vior and social interaction were examined in spontaneously hypertensive rats (SHRs), a commonly used

165 tivity of spinally projecting PVN neurons in spontaneously hypertensive rats (SHRs), but not in normo

166 In spontaneously hypertensive rats (SHRs), high ABP is asso

167 These effects are exaggerated in spontaneously hypertensive rats (SHRs), resulting in an

168 study, we examined conditioned inhibition in spontaneously hypertensive rats (SHRs), the most well-va

169 ex function in Wistar-Kyoto (WKY) but not in spontaneously hypertensive rats (SHRs).

170 ta(1)-ARs as well as lower blood pressure in spontaneously hypertensive rats (SHRs).

171 ist improves the baroreceptor reflex gain in spontaneously hypertensive rats (SHRs).

172 kDa (LFH <3 kDa) were orally administered to spontaneously hypertensive rats (SHRs).

173 ing shift that diminishes GABA inhibition in spontaneously hypertensive rats (SHRs).

174 VN neurons and sympathetic vasomotor tone in spontaneously hypertensive rats (SHRs).

175 on NTS baroreceptor second-order neurons in spontaneously hypertensive rats (SHRs).

176 tivity of PVN presympathetic neurons in male spontaneously hypertensive rats (SHRs).

177 dritic spine density are increased in NTS of spontaneously hypertensive rats (SHRs).

178 eart rate (HR), observed in the stroke-prone spontaneously hypertensive rat (SHRSP(HD)), is a primary

179 We used the stroke-prone spontaneously hypertensive rat (SHRSP) as a model organi

180 The stroke-prone spontaneously hypertensive rat (SHRSP) is a genetically

181 icroangiopathy in salt-loaded, stroke-prone, spontaneously hypertensive rats (SHRSP) without controll

182 e rats and transplanted into recipient adult spontaneously hypertensive rat spleens.

183 m channel blocker, SNX-111, was evaluated in spontaneously hypertensive rats subjected to 60 min of f

184 greater renal vasoconstriction in 7-wk-old, spontaneously hypertensive rats than in Wistar-Kyoto rat

185 Here, in ventricular myocytes from spontaneously hypertensive rats that develop heart failu

186 izes the authors' recent experience with the spontaneously hypertensive rat, the best experimental mo

187 In the MCAO model, conducted in the spontaneously hypertensive rat, the more polar 3-hydroxy

188 In anesthetized spontaneously hypertensive rats, the middle cerebral art

189 After oral administration to spontaneously hypertensive rats, the S1P1 selective comp

190 e used an animal model of ischemic stroke in spontaneously hypertensive rats to determine whether or

191 Male spontaneously hypertensive rats underwent occlusion of t

192 blood pressure reduction in both normal and spontaneously hypertensive rats via interactions with th

193 The increase in blood pressure in spontaneously hypertensive rat was associated with gut p

194 ithelial cells derived from Wistar-Kyoto and spontaneously hypertensive rats were grown to confluency

195 RF-RDN (n=14) or sham-RDN (n=14) treatment, spontaneously hypertensive rats were subjected to 30 min

196 Halothane-anesthetized spontaneously hypertensive rats were subjected to middle

197 Spontaneously hypertensive rats were treated with 2, 3-d

198 od pressure in the aorta-ligated rat and the spontaneously hypertensive rat when administered orally.

199 reflex-function curves is exaggerated in the spontaneously hypertensive rat where the cardiac compone