ライフサイエンスコーパス: sporulation

1 a lytic transglycosylase (LT) essential for sporulation.

2 ating that CD1492 is a negative regulator of sporulation.

3 ertions that trigger premature initiation of sporulation.

4 y regulatory protein controlling clostridial sporulation.

5 ipate in cell-cell signaling pathways during sporulation.

6 multicellular fruiting body development, and sporulation.

7 AbrB repression in regulating C. perfringens sporulation.

8 switch from fermentation to respiration and sporulation.

9 pression to developmental transitions during sporulation.

10 uring mitosis, and if Boi1 is present during sporulation.

11 nd membrane fission during Bacillus subtilis sporulation.

12 ses are involved in their degradation during sporulation.

13 Mutations in the devTRS genes impair sporulation.

14 during the critical period of commitment to sporulation.

15 A cooperatively regulate genes important for sporulation.

16 on of the dev operon, which is important for sporulation.

17 iological functions ranging from motility to sporulation.

18 ch as energy regulation, transportation, and sporulation.

19 lus subtilis 168 and plays a key role in its sporulation.

20 teins in that neither is required for sexual sporulation.

21 lloprotease that cleaves Pro-sigma(K) during sporulation.

22 enes are employed for GABA generation during sporulation.

23 om DeltabsrA cultures also resulted in early sporulation.

24 aturation, but CcdA2 could still function in sporulation.

25 ted accumulation of Spo0A approximately P on sporulation.

26 n, YlbF was shown to regulate competence and sporulation.

27 environment in a manner that promotes early sporulation.

28 cific lipid to drive membrane fission during sporulation.

29 echanism for altering the timing of onset of sporulation.

30 ting that sigma(K) is also necessary in late sporulation.

31 e KinA threshold, resulting in completion of sporulation.

32 s disruption of virulence, pigmentation, and sporulation.

33 rence may be through an inhibitory effect on sporulation.

34 aximin (at similar sub-MICs) did not inhibit sporulation.

35 lon are translated at different times during sporulation.

36 ain under selective conditions that required sporulation.

37 evel of epsilon toxin production and repress sporulation.

38 enriched in genes involved with dormancy and sporulation.

39 the TCA cycle and lipid biosynthesis during sporulation.

40 ess, which controls many genes essential for sporulation.

41 ain vegetative growth and prevent entry into sporulation.

42 s an inhibitor that blocks the initiation of sporulation.

43 pores, a process collectively referred to as sporulation.

44 n factor sigma(F), a hallmark for entry into sporulation.

45 the enzyme is tetrameric during B. subtilis sporulation.

46 ce KinA can bypass the salt-imposed block in sporulation.

47 wall biogenesis during growth, division and sporulation.

48 rocesses: protein sorting to the vacuole and sporulation.

49 l division relative to the chromosome during sporulation.

50 tional, and other signals that normally make sporulation a post-exponential-phase response.

51 During the early stages of sporulation, a subpopulation of Bacillus subtilis cells

52 positive and negative signals, ensuring that sporulation, a time- and energy-consuming process that m

53 xplained by continuous selection to increase sporulation ability in young colonies.

54 influence or trigger chromosome segregation, sporulation, aerotaxis, and social behaviors, including

55 Bacterial sporulation allows starving cells to differentiate into

56 ed DPA(2,6) uptake into developing spores in sporulation, although the variant proteins were still lo

57 exists in a low-activity (pT) form early in sporulation and a high-activity (pT/pY) form later in th

58 wth or cell division, but delayed entry into sporulation and abrogated cortex assembly.

59 onsistently underexpressed pathways included sporulation and amino acid biosynthesis, whereas up-regu

60 localizes in weak polar foci at the onset of sporulation and as a brighter midcell focus at the time

61 Disruption of rsbN causes precocious sporulation and biochemical experiments demonstrate that

62 mental changes leading to biofilm formation, sporulation and competence.

63 lsed response allows cells to decide between sporulation and continued vegetative growth during each

64 rent study asked whether CodY also regulates sporulation and CPE production in SM101, a derivative of

65 ed strain recovered wild-type levels of both sporulation and CPE production.

66 wth, pigment and aerial mycelium production, sporulation and dimorphic transition to blastospore prod

67 ling between synthesis and hydrolysis during sporulation and elongation, respectively.

68 the abrB gene in SM101 reduced the levels of sporulation and enterotoxin production, supporting the i

69 film formation, we found that RapP regulates sporulation and genetic competence as a result of its ab

70 oligopeptide permease that is essential for sporulation and genetic competence development, proved t

71 In this review, the regulation of the sporulation and germination pathways and the morphogenes

72 hese polyketides act as chemical triggers of sporulation and granulose accumulation in this strain.

73 w that disruption of the gene CD3668 reduces sporulation and increases toxin production and motility.

74 olved in the regulatory cascade of bacterial sporulation and inhibits the open complex formation due

75 ikingly, extra copies of septin CDC10 rescue sporulation and LEP localization in cells lacking Sma1,

76 DnfA is involved in asexual sporulation and polarized growth.

77 data indicate that CD1492 negatively affects sporulation and positively influences motility and virul

78 significantly stimulates biofilm-associated sporulation and production of an undefined brown pigment

79 chanisms of PHB contribution to B. anthracis sporulation and provide valuable insight into the metabo

80 protease to degrade SpoIVA, thereby halting sporulation and resulting in lysis of defective sporulat

81 ignificant since CPE is produced only during sporulation and since C. perfringens can sporulate in th

82 Complementation of sigK restored sporulation and solventogenesis to wild-type levels.

83 bromii strains possess a full complement of sporulation and spore germination genes and we demonstra

84 of differentiation such as those that allow sporulation and spore germination, (iii) contribution to

85 n of environmental conditions prompting cell sporulation and spores germination.

86 eRS is required in B. subtilis for efficient sporulation and suggests that editing by aminoacyl-tRNA

87 ve renamed this locus rstA, for regulator of sporulation and toxins.

88 rs serve a different function in controlling sporulation and virulence in C. difficile than in Bacill

89 discovery of new genes and novel pathways in sporulation and, combined with the recently completed nu

90 ng (S)-malate and ornithine, quorum sensing, sporulation, and cell wall remodeling, suggesting a glob

91 nteractions known to mediate quorum sensing, sporulation, and other adaptive phenotypes.

92 signal transduction, adhesion, conjugation, sporulation, and outer membrane protein folding.

93 aspects of the fungus, such as germination, sporulation, appressorial formation as well as its patho

94 ID nevertheless plays auxiliary roles during sporulation, as it enhances levels of the exosporium mor

95 Through targeted gene knock-outs, sporulation assays and microscopic investigations we fou

96 The same QTLs determined delayed sporulation at the seedling stage in laboratory experime

97 During sporulation, Bacillus subtilis divides around the nucleo

98 ation kinases, without which the deferral of sporulation became ultrasensitive to kinase expression.

99 ictyostelium, did not affect Polysphondylium sporulation, but prevented encystation.

100 related with within-host growth and onset of sporulation, but total spore production is decoupled fro

101 We have reported that this complex acts in sporulation by accelerating the phosphorylation of the r

102 Sporulation by Bacillus subtilis is a cell density-depen

103 inase and was originally proposed to promote sporulation by directly phosphorylating Spo0A.

104 processes with population density including sporulation, cannibalism, biofilm formation and genetic

105 During Bacillus subtilis sporulation, chromosome copy number is reduced to two, a

106 R analysis clearly demonstrated that, during sporulation, codY transcript levels remained high in SM1

107 s that govern the developmental processes of sporulation, competence and biofilm formation.

108 uding the bacterial developmental pathway to sporulation, competence, and protease secretion.

109 enes involved in cellular processes, such as sporulation, competence, virulence, biofilm formation, c

110 nant exposure time, germinant concentration, sporulation conditions, and spore heat activation, as pr

111 om weak vegetative growth to induced asexual sporulation (conidiation) along a decreasing phenazine g

112 ication of the system-level mechanism of the sporulation decision is hindered by a lack of direct con

113 The sporulation defect ranged from 3-fold to 30-fold and was

114 anisms have been disabled have a synergistic sporulation defect suggesting that both localization fac

115 utants that are delayed in the initiation of sporulation, defective in membrane remodeling, and impai

116 ng PSM, but previous studies noted only mild sporulation defects upon septin mutation.

117 nt with exogenous fatty acids overcame these sporulation defects, highlighting the importance of the

118 entified 133 out of the 148 genes with known sporulation defects.

119 ys a critical role in growth, asexual/sexual sporulation, deoxynivalenol production and virulence in

120 Bacillus subtilis sporulation depends on the forespore membrane protein Sp

121 f 79 amino acids within the meiosis-specific sporulation domain SPO22.

122 gest that the phosphorelay is tuned to favor sporulation during growth in gastrointestinal B. subtili

123 Sporulation during growth occurs because Spo0A is more a

124 Suppressors that modestly increase sporulation efficiency at high salinity map to the codin

125 However, sporulation efficiency drastically decreases concomitant

126 However, the sporulation efficiency in this artificial two-component

127 lative to that in the parental strain, while sporulation efficiency is unaffected in the mutants.

128 0A regulon expression, and that reduction in sporulation efficiency results from the reversal of that

129 ulence factor expression, and a reduction in sporulation efficiency.

130 inducible promoters can efficiently trigger sporulation even under nutrient rich conditions.

131 tant oligopeptide autoinducer competence and sporulation factor (CSF, also termed PhrC), a member of

132 wider SEDS (shape, elongation, division and sporulation) family have now emerged as a previously unk

133 of the SEDS (shape, elongation, division and sporulation) family of proteins, which have essential bu

134 nd subsequent development of mycelium and/or sporulation; fifthly, assessments were carried out over

135 During sporulation, GadA alone is required for generating GABA

136 that a recently identified, highly conserved sporulation gene ylyA encodes a novel RNA polymerase-bin

137 ic (spoIIID) and forespore-specific (spoIIR) sporulation genes also was inhibited by FDX and OP-1118

138 resulted in the earlier expression of early sporulation genes and increased sporulation in vitro.

139 BldD represses expression of sporulation genes during vegetative growth in a manner t

140 ation through an analysis of the presence of sporulation genes in various firmicutes, including those

141 ng (Tn-seq) to assess whether there were any sporulation genes left to be discovered.

142 ral gene for the S-layer protein Sap and the sporulation genes spo0A, spo0B, and spo0F in B. anthraci

143 bacteria (Firmicutes) and requires signature sporulation genes that are highly conserved across membe

144 t target of BldD, which functions to repress sporulation genes, including whiG, ftsZ and ssgB, during

145 nd was due to a delay in activation of early sporulation genes.

146 cutes revealed typically clostridial sets of sporulation genes.

147 ich controls transcription of a multitude of sporulation genes.

148 nt signal transduction system is to regulate sporulation genes.

149 ficile and Bacillus subtilis at the level of sporulation, germination, and spore coat and exosporium

150 he mechanisms underlying PHB contribution to sporulation have not been defined.

151 Thus, Hho1 may play a dual role during sporulation: Hho1 and Ume6 depletion facilitates the ons

152 tarvation persists and halting commitment to sporulation if nutrients reappear.

153 found to be highly induced during submerged sporulation in a bldN-dependent manner.

154 se of checkpoints that govern the entry into sporulation in B. subtilis and discuss how the use of re

155 ese permeases are known to positively affect sporulation in Bacillus species through the import of sp

156 for signal transduction in the initiation of sporulation in Bacillus subtilis and in bacterial two-co

157 on septum near a randomly chosen pole during sporulation in Bacillus subtilis creates unequal sized d

158 bsrA) is important for appropriate timing of sporulation in Bacillus subtilis in that cells lacking 6

159 Sporulation in Bacillus subtilis is governed by a cascad

160 Entry into sporulation in Bacillus subtilis is governed by a phosph

161 During sporulation in Bacillus subtilis, germinant receptors as

162 During sporulation in Bacillus subtilis, the only convex (posit

163 cking in vivo basement layer assembly during sporulation in Bacillus subtilis.

164 e initiates and controls the early stages of sporulation in C. difficile are not highly conserved in

165 permeases, Opp and App, in the regulation of sporulation in C. difficile.

166 Loss of AcrA and AcgA, both essential for sporulation in Dictyostelium, did not affect Polysphondy

167 (6)A methyltransferase, Ime4, in meiosis and sporulation in diploid strains is very well studied, but

168 robial redox metabolites are key signals for sporulation in filamentous fungi, which are communicated

169 e device in studying growth, germination and sporulation in Fusarium virguliforme that causes sudden

170 indicate that B. subtilis blocks entry into sporulation in high-salinity environments preventing com

171 ely, expression of the two lncRNAs abolishes sporulation in MATa/alpha diploids.

172 udied were expressed in the forespore during sporulation in parallel with the associated GR operon, a

173 elae, which is capable of fairly synchronous sporulation in submerged growth conditions.

174 factor SigF controls late development during sporulation in the filamentous bacterium Streptomyces co

175 Sporulation in the model endospore-forming organism Baci

176 ion of early sporulation genes and increased sporulation in vitro.

177 plays a significant role in pathogenesis and sporulation in vivo.

178 ex biochemical diversification of LDs during sporulation in which Sfh3 and select other LD proteins r

179 hout engulfment suggests new roles for PG in sporulation, including a new model for how PG synthesis

180 t upon Septoria infection but reduced fungal sporulation indicating that TaR1 is key for prolonging t

181 hat deletion of CD1492 resulted in increased sporulation, indicating that CD1492 is a negative regula

182 y, both activities of Sae2 are important for sporulation, indicating that the processing of meiotic b

183 anscriptional profiling uncovered additional sporulation-induced genes required for successful spore

184 ur analysis also revealed that as many as 36 sporulation-induced genes with no previously reported mu

185 Here, we describe a sporulation-induced protein, RefZ, that facilitates the

186 strongly reduced when cells are grown under sporulation-inducing conditions.

187 (F) in individual cells held under constant, sporulation-inducing conditions.

188 chanism, presumably in order to overcome the sporulation inhibition it imposed.

189 DNA is a potential target for development of sporulation inhibitors.

190 Sporulation initiates with an asymmetric cell division,

191 Sporulation initiation in Bacillus subtilis is controlle

192 he nutritional status of the environment and sporulation initiation in C. difficile.

193 gh the phosphorelay is the limiting step for sporulation initiation in the gut strain.

194 During sporulation, initiation of cortex assembly depends on th

195 st-studied model organism Bacillus subtilis, sporulation involves over 500 genes, many of which are c

196 Central to the decision of entering sporulation is a phosphorelay, through which sensor kina

197 The initial step of sporulation is asymmetric cell division, leading to a la

198 Sporulation is critical for C. perfringens type A food p

199 resistance in the harsh food environment and sporulation is essential for CPE production.

200 The initiation of sporulation is known to be regulated through activation

201 ng multiple rounds of vegetative growth when sporulation is not required.

202 s provide further evidence that C. difficile sporulation is regulated differently from that of other

203 One of the major challenges of sporulation is the assembly of a protective, multilayere

204 Endospore formation (sporulation) is a well conserved microbial developmental

205 During sporulation, it takes an average of 10.5 h for a conidio

206 The sporulation killing factor (SKF) is a 26-residue ribosom

207 d a key positive feedback loop involving the sporulation kinases, without which the deferral of sporu

208 suggest that Opp and App indirectly inhibit sporulation, likely through the activities of the transc

209 produce cell-cycle coordinated pulses of the sporulation master regulator Spo0A approximately P.

210 Sporulation master regulator, Spo0A, is activated by a p

211 ate supernatants from modified Duncan-Strong sporulation (MDS) medium cultures of three CPE-positive

212 ately 6.3 to 7.8, or at 4 degrees C in spent sporulation medium caused no significant changes in ribo

213 up to 30 days at 37 or 50 degrees C in spent sporulation medium degraded significant amounts of 3PGA

214 as some metabolism in spores stored in spent sporulation medium.

215 or partially suppress the phenotypes of > 25 sporulation mutants.

216 ole for the arrangement of Bacillus subtilis sporulation network genes on opposite sides of the chrom

217 We show that the arrangement of two sporulation network genes, one located close to the orig

218 unction of the conserved architecture of the sporulation network is controlling Spo0A activation dyna

219 This imbalance is detected by the sporulation network to produce cell-cycle coordinated pu

220 GRN differs strikingly from those governing sporulation of Bacillus and Streptomyces, suggesting tha

221 it activates or represses many genes during sporulation of Bacillus subtilis.

222 ial formation of complex fruiting bodies and sporulation of M. xanthus.

223 ey reduce mortality and also decrease fungal sporulation on dead aphids which may help protect nearby

224 jection assays, with eruption and subsequent sporulation on host cadavers greatly reduced in the muta

225 onSIX6 gene in Fon race 1 did not affect the sporulation or growth rate of the fungus but significant

226 ype, yet the mutants exhibited no changes in sporulation or spore resistance to heat.

227 For successful sporulation, oriC must be captured in the forespore.

228 ution of OM damage, increasing developmental sporulation outcomes of the combined population by allow

229 led that high salinity blocks entry into the sporulation pathway at a very early stage.

230 During CDI, C. difficile induces a sporulation pathway that produces more spores; these spo

231 , it has completely lost its activity in the sporulation pathway.

232 leads to all cell types exhibiting an early-sporulation phenotype.

233 Several mutants had novel sporulation phenotypes.

234 ng the penetrance of the ylbF, ymcA and yaaT sporulation phenotypes.

235 po0F approximately P, an intermediate of the sporulation phosphorelay system.

236 ese data show that sigma(K) is necessary for sporulation prior to spo0A expression.

237 investigated in planta and fungal growth and sporulation production was measured in vitro.

238 mutant, and Cdc11 and Cdc12 fail to restore sporulation proficiency to spr3Delta/spr3Delta spr28Delt

239 opment may help maintain the fidelity of the sporulation program in the species.

240 ary deterioration and ultimately loss of the sporulation program.

241 Stage II sporulation protein D (SpoIID) is a lytic transglycosyla

242 Spo0J (stage 0 sporulation protein J, a member of the ParB superfamily)

243 o factors with limited similarity to the Rap sporulation proteins of other spore-forming bacteria.

244 ein SpoIIIAH at the septum to localize other sporulation proteins.

245 gene expression is independent of additional sporulation proteins; vegetative cells engineered to div

246 Bacillus subtilis sporulation provides a dramatic example of intercompartm

247 n, 6S-2 RNA does not influence the timing of sporulation, providing further evidence of the independe

248 Similar to other Rap proteins that control sporulation, Rap60 modulates phosphorylation of the tran

249 ically degraded soon after expression during sporulation, rather than escaping the developing spore.

250 nitrogen regulation protein NT-NtrC, and the sporulation response regulator Spo0F.

251 iately trigger the activation of GerA during sporulation resulting in premature germination.

252 merase systems, shape, elongation, division, sporulation (SEDS)-family proteins working within the cy

253 During Bacillus subtilis sporulation, segregating sister chromosomes are anchored

254 n event in which the synthesis of ladders of sporulation septa convert multigenomic hyphae into chain

255 reptomyces dynamins specifically localize to sporulation septa in an FtsZ-dependent manner.

256 The sspA deletion mutant exhibits irregular sporulation septation and altered spore shape, suggestin

257 rowth, co-ordinating their expression during sporulation septation.

258 poIIQ is required to recruit SpoIIIAH to the sporulation septum on the mother cell side; however, the

259 solutely required to recruit SpoIIIAH to the sporulation septum on the mother-cell side, however the

260 alization microscopy in strains with a thick sporulation septum to investigate the architecture and f

261 in that is produced under the control of the sporulation sigma factor sigma(F) to create a negative f

262 genes under the control of the late-acting, sporulation sigma factor sigma(G) in Bacillus subtilis.

263 l analyses indicate that pzX co-forms during sporulation, so that upon the release of the spore to th

264 e have analyzed the regulation of the unique sporulation-specific diadenylate cyclase CdaS.

265 in regulating the autophosphorylation of the sporulation-specific kinase KinA, a novel activity for R

266 he absence of structural information for the sporulation-specific LT enzymes has hindered mechanistic

267 Fluorescence microscopy of sporulation-specific promoter fusions to gfp revealed th

268 t target for SigF, the gene sspA, encoding a sporulation-specific protein.

269 on in Bacillus species through the import of sporulation-specific quorum-sensing peptides.

270 acts in parallel with but distinct from the sporulation-specific RacA pathway of oriC placement, and

271 This is the first sporulation-specific sigma factor shown to have two deve

272 uential and stage-specific activation of the sporulation-specific sigma factors, sigma(H) (early), si

273 ion defect due to the decreased stability of sporulation-specific Z-rings, as demonstrated by kymogra

274 olventogensis (buk, ctf, aldh, adh, bcd) and sporulation (spo0A, sigE, sigma-70, bofA), cell motility

275 veral pathways known to impact the timing of sporulation, such as the skf- and sdp-dependent cannibal

276 from thick to thin and back to thick during sporulation suggest that both forms of PG have the same

277 logical problems (alternative sigma factors, sporulation, swarming, biofilm formation, stochastic cel

278 we propose that it is the timing of onset of sporulation that is altered.

279 n of the dormant cell type called the spore (sporulation), the direct link between PHB accumulation a

280 During sporulation, the filamentous bacteria Streptomyces under

281 e programs include the initiation of meiotic sporulation, the formation of filamentous growth structu

282 aimed to define the genomic requirements for sporulation through an analysis of the presence of sporu

283 A is a bifunctional protein that upregulates sporulation through an unidentified pathway and represse

284 at PHB deficiency impairs Bacillus anthracis sporulation through diminishing the energy status of the

285 gulated cell death maintains the fidelity of sporulation through selective removal of cells that misa

286 2) A sporulation timer whose clock rate is regulated by cell

287 n function-from an ancestral role regulating sporulation to a derived role regulating biofilm formati

288 Despite the importance of sporulation to C. difficile pathogenesis, the molecular

289 dynamics of spore germination, colonization, sporulation, toxin activity, and disease progression thr

290 in the M. xanthus chromosome did not impair sporulation under laboratory conditions.

291 , it became apparent that CodY regulation of sporulation varies among different C. perfringens strain

292 Sporulation vs. competence provides a prototypic example

293 k between PHB accumulation and efficiency of sporulation was observed in multiple studies.

294 tracellular carbon and energy source fueling sporulation was proposed several decades ago, the mechan

295 for SpoIIID and sigma(K) during C. difficile sporulation, we analyzed spoIIID and sigK mutants using

296 To assess the role of CdaS in sporulation, we assayed the germination of wild type and

297 mutants that were defective in motility and sporulation were rescued by OME with healthy donors.

298 Both FDX and OP-1118 (1/4x MIC) inhibited sporulation when added to early-stationary-phase cells i

299 fungal mycelium growth, cell densities, and sporulation, which enhanced the disease symptoms of suga

300 A, sigma(F), sigma(E), and sigma(G), but not sporulation, which was blocked past the sigma(G) stage o