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1 lutamine and asparagine metabolism in vessel sprouting.
2 in the induction of angiogenic genes during sprouting.
3 sis regulates EC rearrangement during vessel sprouting.
4 w growth with little contribution from local sprouting.
5 -8-mediated lymphatic endothelial cell (LEC) sprouting.
6 ecessary for EC proliferation and angiogenic sprouting.
7 i1 and Klf2 also markedly impaired lymphatic sprouting.
8 ils both galectin-8- and VEGF-C-mediated LEC sprouting.
9 trunk endothelial cells can limit their over-sprouting.
10 th factor-beta, indicating less atrial nerve sprouting.
11 jected into the PNG, indicative of augmented sprouting.
12 sm may even override signals inducing vessel sprouting.
13 lly suppressed erythrocytosis and angiogenic sprouting.
14 ratory and proliferative state during vessel sprouting.
15 net creates a barrier to axonal regrowth and sprouting.
16 uced shear stress to activation of lymphatic sprouting.
17 unction after SCI via inhibition of neuronal sprouting.
18 , but did not affect the shear threshold for sprouting.
19 beta1 integrin at sites of failed angiogenic sprouting.
20 nRH neurons counteract Sema3A-induced axonal sprouting.
21 -35%, while the same was increased by 67% by sprouting.
22 in turn controls axon growth and growth cone sprouting.
23 ar stress threshold that triggers angiogenic sprouting.
24 e deficient in migration, cord formation and sprouting.
25 nctional excitatory synapses, despite robust sprouting.
26 , and aortic ring endothelial cell outgrowth/sprouting.
27 ciated with abnormal hippocampal mossy fiber sprouting.
28 l cell proliferation and ex vivo aortic ring sprouting.
29 tro endothelial tube formation, and spheroid sprouting.
30 unctional blockade of p75(NTR) decreased rMF sprouting.
31 s are maintained, likely due to preferential sprouting.
32 ytoskeletal machinery necessary for neuronal sprouting.
33 sm underlying laminar flow-induced lymphatic sprouting.
34 gulate NOTCH1 activity and enhance lymphatic sprouting.
35 lock repolarization and reduce migration and sprouting.
36 were dispensable for IL-31-induced neuronal sprouting.
37 , whereas siRNA-mediated knockdown increased sprouting.
38 oteins that promote ex vivo choroidal vessel sprouting.
40 ewly formed vessels) and characterization of sprouting activity (e.g., endothelial tip cell density,
42 mycin blocks granule cell axon (mossy fiber) sprouting after epileptogenic injuries, including piloca
43 e basal parts of the skull and spinal canal, sprouting along the blood vessels and cranial and spinal
44 us, which raises questions about the role of sprouting and adult neurogenesis in sustaining seizure-l
45 rfering RNAs or GapmeRs inhibited angiogenic sprouting and alignment of endothelial cells in response
47 tion, the potential role of both cholinergic sprouting and dentate hyperactivity in AD symptomatogene
50 aam1 cooperatively regulate initiation of EC sprouting and directional migration via MT reorganizatio
51 studies, we found that GDF10 produced axonal sprouting and enhanced functional recovery after stroke;
53 o study chemokine gradient-driven angiogenic sprouting and find that matrix degradability modulates t
57 mber A (CLEC14A) display enhanced angiogenic sprouting and hemorrhage as well as enlarged jugular lym
59 nerally, antioxidant activity decreased with sprouting and increased in the presence of light, whose
60 , and that infection results in lymph vessel sprouting and increased lymphatic area in granulomatous
61 In contrast, moderate spontaneous axonal sprouting and induced-sprouting seen under different con
62 athway is a critical regulator of angiogenic sprouting and is involved in vascular development in the
63 , the compensatory nature of the cholinergic sprouting and its putative mechanisms remain elusive.
66 le of shear stress in controlling angiogenic sprouting and offer a potential homeostatic mechanism fo
67 sion of GAP43 (P < 0.01), a marker of axonal sprouting and plasticity, in the peri-infarct cortex.
68 ) post-SE infusion of bumetanide reduced rMF sprouting and recurrent seizures in the chronic epilepti
72 xonal dieback of DRG axons, and promotes CST sprouting and regenerative axon growth in both acute and
74 inating NGF signaling to regulate collateral sprouting and structural plasticity of intact adult axon
75 work reveals that FOS stimulates endothelial sprouting and that perturbation of normal FOS degradatio
76 ed, but the factors that suppress angiogenic sprouting and their impact on the BBB are poorly underst
78 required for VEGFA-induced HRMVEC migration, sprouting and tube formation in vitro and hypoxia-induce
82 The role of factors that promote endothelial sprouting and vascular leak, such as vascular endothelia
84 ne expression, cancer cell migration, vessel sprouting, and cancer cell killing effect compared to na
85 inosine on motor and cognitive deficits, CST sprouting, and expression of synaptic proteins in an exp
86 effects of hapto- and mechanotaxis on vessel sprouting, and mechano-sensitive dynamic vascular remode
87 migration, tracheal branching, blood vessel sprouting, and the migration of the lateral line primord
88 ociated with adult sensory axonal collateral sprouting, and this association may offer new insights f
90 be required to discriminate between distinct sprouting angiogenesis and EndMT responses of different
92 ls, and to identify novel genes that control sprouting angiogenesis and lineage specification of bloo
93 in tumor endothelial cells, and it promotes sprouting angiogenesis and modulates endothelial functio
94 how that the ectodomain of CLEC14A regulates sprouting angiogenesis and suggests a role for RHBDL2 in
95 anscription factors as crucial regulators of sprouting angiogenesis directly downstream from VEGFA.
97 CLEC14A-MMRN2 binding has a role in inducing sprouting angiogenesis during tumour growth, which has t
98 and many other key genes up-regulated during sprouting angiogenesis in both physiological and tumor v
99 +) and clec14a(-/-) mice revealed defects in sprouting angiogenesis in CLEC14A-deficient animals.
105 ue Notch target gene expression and the KLF4 sprouting angiogenesis phenotype by supplementation of D
107 encodes a transcription factor implicated in sprouting angiogenesis) is required for its VEGF-mediate
108 es decreased Dll4/Notch signaling, excessive sprouting angiogenesis, and defects in developmental vas
109 Tie1 regulates tumor angiogenesis, postnatal sprouting angiogenesis, and endothelial cell survival, w
110 find that ECs dynamically repolarize during sprouting angiogenesis, and excess centrosomes block rep
111 beds hypoxia induces tip cell formation and sprouting angiogenesis, here we demonstrate that hypoxia
113 While this occurs predominately through sprouting angiogenesis, tumor cells have also been shown
118 ic cancer cells (CCs) stimulate blood vessel sprouting (angiogenesis), aimed at restoring O2 delivery
120 a molecular hierarchy that induces vascular sprouting, APC vessel niche affinity and APC vessel occu
121 disease, associated with distal motor axonal sprouting as part of the reinnervation response that dev
122 t of the MDM2/p53-IGF1R axis enhances axonal sprouting as well as functional recovery after spinal co
123 CC2, and ectopic recurrent mossy fiber (rMF) sprouting as well as telemetric electroencephalographic
125 ls leads to aberrant vascular remodeling and sprouting, as well as markedly reduced filopodia formati
126 tly suppressed angiogenesis in the choroidal sprouting assay ex vivo and inhibited ocular development
128 man umbilical vein endothelial cell spheroid-sprouting assay, we found CLEC14A to be a regulator of s
129 rings from VimKO mice and in endothelial 3D sprouting assays can be rescued by reactivating Notch si
131 opic granule cells, mossy cells, mossy fiber sprouting, astrogliosis, and GABAergic interneurons.
132 Ablation of the corticospinal neurons with sprouting axons abolishes the improved behavioural perfo
133 e an initial signal orchestrating pulp nerve sprouting beneath carious injury, a critical step in den
134 were increased in neurons during collateral sprouting but decreased following injury, suggesting tha
136 mous inhibition of ERK prevented endothelial sprouting, but did not prevent initial artery differenti
140 mechanistic insight in the control of vessel sprouting by glycolysis, and suggesting anti-glycolytic
141 ectopic expression of miR-200 inhibited this sprouting by indirectly reducing the protein levels of P
142 or the glycolytic activator PFKFB3 in vessel sprouting by regulating cytoskeleton remodelling, migrat
146 ity to respond to growth factors with axonal sprouting, cell hypertrophy, and activation of functiona
148 st distinctive feature of sprouts, being the sprouting conditions determinant for the free amino acid
149 al composition changes promoted by different sprouting conditions of four varieties of Brassica olera
150 noninjured neurons, often termed collateral sprouting, contributes to both adaptive and pathological
151 tion, we show a direct limb motor control by sprouting CST axons, providing direct evidence for the r
153 nhibiting glutaminase 1 (GLS1) caused vessel sprouting defects due to impaired proliferation and migr
154 fatty acid oxidation (FAO), causes vascular sprouting defects due to impaired proliferation, not mig
155 also be applied to prevention of pre-harvest sprouting during crop production, and therefore contribu
157 R2 signalling pathway as well as ablation of sprouting ECs diminished tumour vascularization and grow
158 for dynamic repolarization and migration of sprouting ECs that contribute to blood vessel formation.
159 stinguished by PI3K/AKT activation, enhanced sprouting efficiency, elevated VEGF-C expression and COX
163 gen and aspartate to asparagine) impaired EC sprouting even in the presence of glutamine and asparagi
164 d the data collected in-situ from angiogenic sprouting experiments and identified the differentiated
166 itive performance through a fast cholinergic sprouting followed by a slower glutamatergic reinnervati
169 asculature is thought to form exclusively by sprouting from embryonic veins (lymphangiogenesis).
173 rly, SAD suppressed VEGF-induced microvessel sprouting from rat aortic ring and blood vessel formatio
176 ls of cervical and thoracic skin develop via sprouting from venous-derived lymph sacs, vessels of lum
178 in vivo spared dermatome model of collateral sprouting identified the adaptor protein CD2-associated
180 ese mice as a tool to manipulate cholinergic sprouting in a disease-relevant way, we showed that this
182 sistent with an increase in lymphatic vessel sprouting in a three-dimensional lymphatic ring assay.
184 tubule formation in HMEC-1 cells, angiogenic sprouting in aortic ring explants, and retinal revascula
186 during the ovarian cycle and promotes axonal sprouting in hypothalamic neurons secreting gonadotropin
192 we show that IL6 can directly induce vessel sprouting in the ex vivo aortic ring model, as well as e
193 making it unlikely that blocking sympathetic sprouting in the local DRGs or hindpaw was the sole mech
195 t that kindlin-2 is necessary for angiogenic sprouting in vitro and for developmental and tumor angio
196 ody perturbed tube formation and endothelial sprouting in vitro and in vivo, with a similar phenotype
197 nd had enhanced capacity to induce lymphatic sprouting in vivo This mutant may be useful for developi
201 em in experimental epilepsy, involving fiber sprouting into the dentate molecular layer and a paralle
206 ing the circuit-level determinants of axonal sprouting is important for repairing motor circuits afte
207 g viable motor neurons; however, this axonal sprouting is insufficient to compensate for motor neuron
211 is a key regulator of angiogenesis, in which sprouting is regulated by an equilibrium between inhibit
212 born granule cells to functional mossy fiber sprouting is unknown, primarily due to technical barrier
213 the initial stage of vascular remodeling and sprouting lymphangiogenesis were examined by comparing t
214 trol of dentate hyperactivity by cholinergic sprouting may be involved in functional compensation aft
215 Assembly of these vascular networks involves sprouting, migration and proliferation of endothelial ce
218 The molecular systems that underlie axonal sprouting, neurogenesis, and gliogenesis after stroke ha
220 ant neurite outgrowth and hippocampal axonal sprouting observed in knock-in mice expressing FAD-linke
221 sFlt1: sflt1 mutants exhibit the venous over-sprouting observed in radial glia-ablated larvae, and sF
224 nary vessels form in zebrafish by angiogenic sprouting of arterial cells derived from the endocardium
226 ds in the adult brain, we imaged post-lesion sprouting of cerebellar climbing fibres (CFs) in mice us
228 stered 28 d after stroke induced significant sprouting of corticospinal axons originating in the peri
230 ecruit activated stromal cells and guide the sprouting of endothelial cells in a spatially resolved m
232 contrast to the corticospinal system, where sprouting of fibers and rearrangements of circuits in re
234 of recombinant cleaved CLEC14A inhibited the sprouting of human and murine endothelial cells 3-fold i
235 aneous recovery was accompanied by extensive sprouting of intact rubrofugal and rubrospinal projectio
237 ells contribute to the pathologic retrograde sprouting of mossy fiber axons, both hallmarks of tempor
238 undergo major reorganization, including the sprouting of mossy fibers in the dentate gyrus; they est
239 ion in assays of endothelial tube formation, sprouting of neovessels from murine aorta, and angiogene
243 c islet grafts was devoid of lesions because sprouting of recipient capillaries reestablished blood f
245 with ligand-specific Notch1 decoys increased sprouting of sinusoidal endothelial cells into micrometa
246 ine the role of mTOR in promoting collateral sprouting of spared axons, a key axonal remodeling mecha
248 mesencephalic neurons and axon outgrowth and sprouting of striatal terminals in developing rat brain.
249 in the pulp and to the healing mechanism by sprouting of the nerve fiber's terminal branches beneath
250 spinal cord promote axonal regeneration and sprouting of the optic nerve after crush and of supraspi
251 tion in zebrafish embryos leads to excessive sprouting of the trunk vessels around the spinal cord, a
252 eta signaling, promoted significant vascular sprouting of TNBC cells, in part, by direct repression o
255 ator of cytokine-activated pathway, promotes sprouting of uninjured CST axons to the denervated spina
256 endothelial progenitors (vasculogenesis) and sprouting of vessels from pre-existing ones (angiogenesi
258 yos bearing this deletion failed to initiate sprouting or differentiation of trunk lymphatic vessels
259 he results showed that turned green and also sprouting or rotting potato flesh contain high amounts o
260 q in axon growth and guidance to include the sprouting patterns of descending corticospinal tract axo
261 es in local narrowings of vessels to trigger sprouting, perhaps ultimately to normalize shear stress
262 as signaling counteracts VEGF-induced vessel sprouting, permeability, and invasive activities of endo
264 rter GCaMP3 unexpectedly inhibited lymphatic sprouting, presumably by disturbing calcium signaling.
267 ery of VEGF-C into the adult eye resulted in sprouting, proliferation, and growth of SC endothelial c
269 r determine the potency of mTOR in promoting sprouting responses, we coinactivate PTEN and CSPGs, and
270 ate spontaneous axonal sprouting and induced-sprouting seen under different conditions in young adult
274 stimulation produced proprioceptive afferent sprouting that was accompanied by significant corticospi
275 er of mossy cells, the extent of mossy fiber sprouting, the extent of astrogliosis, or the number of
276 oliferation that interferes with coordinated sprouting, thereby causing hyperplasia and vessel enlarg
278 ocess, linking pulp fibroblasts to the nerve sprouting through the complement system activation.
279 al vessels by being either positioned at the sprouting tip cells or tethered along the vessel walls.
281 e, we demonstrated that corticospinal fibers sprouting to the denervated side of the cord following p
282 ted that transmural flow guided preferential sprouting toward paths of draining interstitial fluid fl
284 luster formation followed by rapid extensive sprouting, ultimately resulting in a stable interconnect
285 ively, we show that Apln-CreER distinguishes sprouting vessels from stabilized vessels in multiple pa
286 uates in individual endothelial cells within sprouting vessels in the mouse retina in vivo and in cor
290 a disease-relevant way, we showed that this sprouting was necessary and sufficient for the acute com
291 y model was used to confirm that this robust sprouting was not species or injury model specific.
294 by inhibiting proliferation, migration, and sprouting, whereas siRNA-mediated knockdown increased sp
295 establish that pericytes promote endothelial sprouting, which results in the loss of side branches an
296 ed myoblast cell cycle arrest, migration and sprouting, which were inhibited by higher doses (40-60 m
297 loss of function led to defective lymphatic sprouting, while Dtx3l gain of function rescued impaired
300 ary study integrates EC metabolism in vessel sprouting, yielding mechanistic insight in the control o
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