ライフサイエンスコーパス: squalene synthase

1 , exhibited lower affinities for recombinant squalene synthase.

2 potencies as inhibitors of recombinant yeast squalene synthase.

3 ctivity against Ras farnesyl transferase and squalene synthase.

4 in isoprenylation that are not inhibitors of squalene synthase.

5 not nSREBP-1a, to activate the promoter for squalene synthase.

6 eductase, farnesyl diphosphate synthase, and squalene synthase.

7 Silencing of N. benthamiana SQUALENE SYNTHASE, a key gene in phytosterol biosynthesi

8 Farnesyl diphosphate, the substrate for squalene synthase, accumulates in the presence of zarago

9 l CoA (HMG CoA) synthase, HMG CoA reductase, squalene synthase, acetyl-CoA carboxylase, fatty acid sy

10 biosynthesis inhibitors with essentially no squalene synthase activity.

11 geranyl-protein transferase-I (GGPTase-I) or squalene synthase activity.

12 Inhibition of FPP or squalene synthase allowed for the further identification

13 These findings were unexpected because squalene synthase, an ancient and likely progenitor to t

14 nes, less robust associations were found for squalene synthase and change in total cholesterol, apoli

15 that a botryococcene synthase would resemble squalene synthase and hence isolated squalene synthase-l

16 olesterol synthesis genes HMG CoA reductase, squalene synthase, and FPP synthase but did not alter le

17 f farnesyl-diphosphate farnesyl transferase (squalene synthase), but not 3-hydroxy-3-methylglutaryl-C

18 Squalene synthase catalyzes the biosynthesis of squalene

19 Squalene synthase catalyzes the conversion of two molecu

20 Squalene synthase catalyzes two consecutive reactions in

21 the crystal structures of recombinant human squalene synthase complexed with several different inhib

22 The strain was blocked at squalene synthase (ERG9 gene) in the isoprenoid pathway

23 anosterol 14alpha-demethylase (CYP51A1), and squalene synthase (farnesyl diphosphate farnesyl transfe

24 yl-CoA carboxylase, stearoyl-CoA desaturase, squalene synthase, farnesyl-pyrophosphate synthase, 3-hy

25 another tightly regulated sterol-responsive squalene synthase gene was unaffected.

26 Transcription of the human squalene synthase (HSS) gene is regulated by variations

27 The expression of human squalene synthase (HSS) gene is transcriptionally regula

28 (K(i) = 0.06 microM, IC(50) = 20 microM) or squalene synthase (IC(50) = 1000 microM).

29 tion of zaragozic acid--a known inhibitor of squalene synthases--impaired biofilm formation and prote

30 aryl-CoA reductase, fatty-acid synthase, and squalene synthase in livers of Zetia/lovastatin-treated

31 farnesyl diphosphate with recombinant yeast squalene synthase in the absence of NADPH gives a mixtur

32 Squalene synthase inhibition with lapaquistat acetate, a

33 f rat hepatocytes as a direct consequence of squalene synthase inhibition, we investigated possible u

34 Lapaquistat acetate is a squalene synthase inhibitor investigated for the treatme

35 In the present study, the squalene synthase inhibitor squalestatin reduced the cho

36 A reductase inhibitor lovastatin and by the squalene synthase inhibitor zaragozic acid A and was pre

37 action for the efficient construction of the squalene synthase inhibitor zaragozic acid C.

38 sterol biosynthetic pathway: squalestatin 1 (squalene synthase inhibitor), (E)N-ethyl-N-(6,6-dimethyl

39 The synthesis of the novel squalene synthase inhibitor, bisabosqual A, was complete

40 tures with SQ-34919, a structurally distinct squalene synthase inhibitor, produced the same selective

41 lates in the presence of zaragozic acid A, a squalene synthase inhibitor.

42 bon diverted from cholesterol synthesis by a squalene synthase inhibitor.

43 ment with multiple statins, bisphosphonates, squalene synthase inhibitors, and small interfering RNA

44 ted a much improved in vitro antioxidant and squalene synthase inhibitory activity (at lower micromol

45 Squalene synthase is inhibited at high concentrations of

46 of PSPP or a prior conformational change in squalene synthase is the rate-limiting step for synthesi

47 nthase, farnesyl pyrophosphate synthase, and squalene synthase, key enzymes for cholesterol synthesis

48 ubation of [(14)C]FDP with recombinant human squalene synthase led to [(14)C]PSDP and [(14)C]squalene

49 l squalene synthase, none of the other three squalene synthase-like (SSL) genes encodes for botryococ

50 esemble squalene synthase and hence isolated squalene synthase-like genes from Botryococcus braunii r

51 4S-hydroxycholesterol, HMG CoA reductase and squalene synthase mRNA levels were significantly decreas

52 B. braunii does harbor at least one typical squalene synthase, none of the other three squalene synt

53 hen co-expressed in yeast with complementary squalene synthase or botryococcene synthase expression c

54 tores are reduced secondary to inhibition of squalene synthase or LDL receptor degradation is disrupt

55 se farnesyl diphosphate synthase rather than squalene synthase or phytoene synthase, which catalyze c

56 conversion to squalene through the action of squalene synthase represents the first committed step in

57 Rat hepatic squalene synthase (RSS, EC 2.5.1.21) contains three cons

58 Squalene synthase (SQase) catalyzes the condensation of

59 Squalene synthase (SQase) catalyzes two consecutive reac

60 heir ability to inhibit rat liver microsomal squalene synthase (SQS) in vitro.

61 ent are a new class of potent, orally active squalene synthase (SQS) inhibitors.

62 in which antioxidant, anti-inflammatory, and squalene synthase (SQS) inhibitory/hypolipidemic activit

63 Squalene synthase (SQS) is a bifunctional enzyme that ca

64 Squalene synthase (SQS) was up-regulated in CL1-5 cells

65 he activity of these compounds against human squalene synthase (SQS), as a counterscreen, finding sev

66 uctase (Red), fatty acid synthase (FAS), and squalene synthase (SQS).

67 es with nanomolar inhibitory activity toward squalene synthase (SQS).

68 One TBF-resistant cosmid encoded squalene synthase (SQS1), which is located upstream of t

69 Squalene synthase (SS) represents a putative branch poin

70 ly enzymes of triterpene aglycone formation: squalene synthase (SS), squalene epoxidase (SE), and bet

71 Two squalene synthase (SS)-like complementary DNAs are ident

72 n to inhibit cholesterol biosynthesis at the squalene synthase step, may afford a novel series of hyp

73 e-specific manner, whereas the expression of squalene synthase, sterol response element-binding prote

74 Conversely, squalene synthase (terminal cholesterol synthesis) block

75 t with squalestatin 1, a potent inhibitor of squalene synthase, the first committed enzyme of sterol