ライフサイエンスコーパス: squamous carcinoma

1 cancers (NSCLCs) (19 adenocarcinomas and 19 squamous carcinoma).

2 nsgenic mice elicits a multistage pathway to squamous carcinoma.

3 omplete response rate noted in patients with squamous carcinoma.

4 gitis before developing verrucous esophageal squamous carcinoma.

5 etically-defined, incurable subtype of human squamous carcinoma.

6 ncreased in mouse skin papillomas but not in squamous carcinomas.

7 ysplasias, and further increased in invasive squamous carcinomas.

8 r of progression from papillomas to invasive squamous carcinomas.

9 ls of 10/10 surgical specimens of human lung squamous carcinomas.

10 ally significant role in the pathogenesis of squamous carcinomas.

11 14E6(WT)) develop epithelial hyperplasia and squamous carcinomas.

12 lective retinoids inhibited DNA synthesis in squamous carcinoma 1483 cells transfected with RXRalpha

13 response rate was observed in patients with squamous carcinoma (20%) compared with those with adenoc

14 The PIK3CA was amplified in 70% of squamous carcinomas, 38% of large cell carcinomas, 19% o

15 erestingly expression was almost confined to squamous carcinomas (41%), being rare in pulmonary adeno

16 nts with adenocarcinoma (46%) and those with squamous carcinoma (50%), and for patients with metastat

17 pillomas, but 1 of 96 grafts progressed to a squamous carcinoma after 1 year.

18 skin grafts, and seven grafts progressed to squamous carcinoma after 6-12 months.

19 ble stage T2N+, or T3-T4N0-3M0 biopsy-proven squamous carcinoma, age at least 18 years, PS 0 to 2, go

20 tumoral patterns in and between conventional squamous carcinoma and squamous carcinoma variants.

21 /progenitor cells are the cells of origin of squamous carcinoma and that cooperation between Sox2 and

22 ected patients presenting with head and neck squamous carcinoma and whose tumor cytospins had been pr

23 Sixty-one percent of squamous carcinomas and 40% of adenocarcinomas of the ce

24 ar can host metastatic deposits, and primary squamous carcinomas and adenocarcinomas.

25 ternal ear can be the site of development of squamous carcinomas and basal-cell carcinomas; the middl

26 rupted in cell lines and primary tumors from squamous carcinomas and glioblastomas.

27 Among the controls, squamous carcinomas and melanomas showed negative result

28 sebaceous tumors immunohistochemically from squamous carcinomas and melanomas, which showed negative

29 gnostic and therapeutic target in esophageal squamous carcinomas and possibly more generally in other

30 ctival intraepithelial neoplasias, 7 in situ squamous carcinomas) and 5 as nonsquamous (1 pingueculum

31 One hundred ninety-nine patients had squamous carcinoma, and 38 had adenocarcinoma/adenosquam

32 ssed in human hepatocellular carcinoma, lung squamous carcinoma, and lung adenocarcinoma in smokers.

33 frequent cancer of the uterine cervix after squamous carcinoma, and the most frequent histotype is t

34 ssment of all tumors revealed fibrosarcomas, squamous carcinomas, and mixed tumors.

35 e mice, UMSCC-22B formed well-differentiated squamous carcinomas, and oral administration (daily, 5 d

36 ct the epidermis from tumorigenesis and that squamous carcinomas are sensitive to inhibition of PPAR-

37 upon combined deletion of Dnmt3a and Dnmt3b, squamous carcinomas become more aggressive and metastati

38 aNp63alpha expression in normal bronchus and squamous carcinomas but not in normal lung or in adenoca

39 proto-oncogene MYC is frequently altered in squamous carcinomas, but this is insufficient to drive c

40 ary lung adenocarcinomas and 19 primary lung squamous carcinomas by immunohistochemistry.

41 ous studies have reported inhibition of A431 squamous carcinoma cell growth by nanomolar concentratio

42 human cancer xenografts derived from a human squamous carcinoma cell line (SQ-20B).

43 y in EGF- or SF-stimulated invasion, a human squamous carcinoma cell line (UM-SCC-1) was triggered at

44 an ovarian cancer cell line A2780, the human squamous carcinoma cell line Cal27, and their cisplatin

45 The SQ20B head and neck squamous carcinoma cell line demonstrated loss of EGF-de

46 of nude mice transplanted with a human oral squamous carcinoma cell line revealed that serum alpha-N

47 ation assays against the human head and neck squamous carcinoma cell line SCC25 after 72 h of treatme

48 he expression of the TbetaR-II receptor in a squamous carcinoma cell line that expressed reduced leve

49 nt path for lactate uptake by a human cervix squamous carcinoma cell line that preferentially utilize

50 1 (RAIG1), which was induced by ATRA in the squamous carcinoma cell line UMSCC-22B.

51 Using a squamous carcinoma cell line we show that endogenous acc

52 he full-length human GKLF from an esophageal squamous carcinoma cell line.

53 d two Fz (Fz-2, 5) genes in 10 head and neck squamous carcinoma cell lines (HNSCC).

54 Three human head and neck squamous carcinoma cell lines (UMSCC1, UMSCC14A, and UMS

55 cing TGFalpha or COX-2 expression in several squamous carcinoma cell lines, indicating alterations in

56 taR-II) serine-threonine kinase in two human squamous carcinoma cell lines.

57 ated by p38alpha/beta and required for human squamous carcinoma cell quiescence in vivo.

58 Head and neck squamous carcinoma cell xenografts treated with concurre

59 and induced apoptosis of human head and neck squamous carcinoma cells (HNSCC).

60 ciated RhoGEF (LARG)) in human head and neck squamous carcinoma cells (HNSCC-HSC-3 cell line).

61 cer stem-like cells (CSC), including in oral squamous carcinoma cells (OSCC).

62 eceptor (EGFR) in the malignant phenotype of squamous carcinoma cells (SCC).

63 ndent kinase inhibitor p21WAF1 in both human squamous carcinoma cells and normal keratinocytes overex

64 ivation is a general mechanism by which oral squamous carcinoma cells are resistant to TNF killing an

65 ocks cell cycle progression of head and neck squamous carcinoma cells at G(1)-S and G(2)-M by inducin

66 porter level simultaneously in head and neck squamous carcinoma cells by quantitative live microscopy

67 We used KLN 205 squamous carcinoma cells embedded in an agarose gel and

68 esponse in monolayer and 3D cultures of A431 squamous carcinoma cells following photosensitization by

69 re unable to lead the collective invasion of squamous carcinoma cells in an organotypic skin model.

70 cancer cells, and LU-HNSCC-25 head and neck squamous carcinoma cells in phosphate buffered saline.

71 es loaded with EGFR-directed siRNA to murine squamous carcinoma cells in vitro reduced EGFR expressio

72 transcutaneous injection of 5 X 10(5) murine squamous carcinoma cells into the floor of the mouth of

73 the beta4-dependent signaling in A431 human squamous carcinoma cells is dependent on the syndecan fa

74 Ectopic expression of p12(DOC-1) in squamous carcinoma cells led to the reversion of in vitr

75 The addition of EGF to either A431 squamous carcinoma cells or DiFi colon cancer cells resu

76 Ectopic expression of p12 in squamous carcinoma cells reversed the malignant phenotyp

77 We found that HSC-3 human squamous carcinoma cells survived and grew readily as mo

78 minant negative Fyn decreases the ability of squamous carcinoma cells to invade through Matrigel in v

79 , we report that the migration of breast and squamous carcinoma cells toward either lysophosphatidic

80 athymic mice and radiosensitization of human squamous carcinoma cells transfected with a vector expre

81 nalogue 13 against SCC25 human head and neck squamous carcinoma cells was 18 nM, suggesting lack of t

82 RNA levels and zinc-induced apoptosis in rat squamous carcinoma cells were reduced by specific small

83 ation (IR) we have studied human mammary and squamous carcinoma cells which are autocrine growth regu

84 s a key cytoprotective pathway in A431 human squamous carcinoma cells which is activated in response

85 In contrast, transfection of H226 human lung squamous carcinoma cells with sense-VEGF121 or sense-VEG

86 m primary keratinocytes, transformed Pam 212 squamous carcinoma cells, and metastases of Pam 212.

87 In A431 squamous carcinoma cells, decorin proteoglycan or protei

88 s overexpressing DeltaNp63alpha and in human squamous carcinoma cells, DeltaNp63alpha physically asso

89 When delivered into squamous carcinoma cells, phosphopeptides spanning Y1068

90 and differentiation of SqCC/Y1 head and neck squamous carcinoma cells, they were transfected with RAR

91 Here, we extend this observation to squamous carcinoma cells, which express high levels of M

92 enhance radiation-induced apoptosis in A431 squamous carcinoma cells.

93 ed on the activation SAPK/JNKs in SiHa human squamous carcinoma cells.

94 d sustained phosphorylation of MAP kinase in squamous carcinoma cells.

95 GF-mediated induction of Cox-2 in human oral squamous carcinoma cells.

96 cts of ALRT1550 on cellular proliferation in squamous carcinoma cells.

97 1, was identified and characterized in human squamous carcinoma cells.

98 lation of the IGF-IR in bladder, breast, and squamous carcinoma cells.

99 initiate GJ assembly de novo in A431D human squamous carcinoma cells.

100 for curcumin-mediated radiosensitization of squamous carcinoma cells.

101 trate of IP6K2) induced cell death in SCC22A squamous carcinoma cells.

102 l factor for quiescent but not proliferative squamous carcinoma cells.

103 hown that p38 activation induces dormancy of squamous carcinoma cells.

104 ith erlotinib in SQ20B and gefitinib in HSC3 squamous carcinoma cells.

105 ratinocytes (HaCaT) as well as head and neck squamous carcinoma cells.

106 Squamous carcinoma-derived A431 cells were used because

107 Squamous carcinomas developed in a multistage pathway ex

108 ps receiving UV treatment; unequivocal human squamous carcinomas developed in two of these.

109 chemically induced Hras mutations to promote squamous carcinoma development.

110 adenocarcinoma (12 of 23 patients; 52%) and squamous carcinoma (eight of 12 patients; 66%).

111 In this patient, verrucous squamous carcinoma evolved from chronic esophagitis, squ

112 analysed 64 primary untreated head and neck squamous carcinoma for the loss of imprinting in the IGF

113 In addition, we analyzed 37 oral squamous carcinomas for EGFR expression and found 24.3%

114 though cytokeratin expression was typical of squamous carcinoma, gene expression profiling was done t

115 Four patients with squamous carcinoma had nodal metastases and 5 had MFN.

116 SiHa cells are derived from a human cervical squamous carcinoma, harbor a fully integrated copy of th

117 development and progression of head and neck squamous carcinoma (HNSC) are largely unknown.

118 We studied 11 head and neck squamous carcinoma (HNSC) cell lines and 46 primary tumo

119 we studied several karyotyped head and neck squamous carcinoma (HNSCC) cell lines (UMSCC-17A, -17B,

120 ciated with the development of head and neck squamous carcinoma (HNSCC)-in particular, oropharyngeal

121 Head and neck squamous carcinomas (HNSCC) present as dense epithelioid

122 ote invasion and metastasis in head and neck squamous carcinomas (HNSCCs), a finding that unveils new

123 Only a subset of squamous carcinomas, however, express the gene at levels

124 In breast cancer specimens and head-neck squamous carcinomas, however, uridine cleavage was only

125 ell carcinoma (SCC) cells, we cultured human squamous carcinoma (HSC-3) cells in suspension on plates

126 two popular chemotherapy drugs on human oral squamous carcinoma (HSC-3) cells.

127 so plays oncogenic roles in the formation of squamous carcinoma in several organs, including the esop

128 d that 29% (12/42) of human Bowen's disease (squamous carcinoma in situ) or SCC cases had absent or r

129 of the chromosome 11q13 in breast cancer and squamous carcinomas in the head and neck results in freq

130 p63 genomic sequence was amplified in 88% of squamous carcinomas, in 42% of large cell carcinomas, an

131 markedly sensitized transgenic epidermis to squamous carcinoma induction following a single dose of

132 during normal epithelial cell migration and squamous carcinoma invasion.

133 uisite for normal keratinocyte migration and squamous carcinoma invasion.

134 in human differentiated myeloid (THP-1) and squamous carcinoma (KB-31) cell lines.

135 n cancer condition characterized by multiple squamous-carcinoma-like locally invasive skin tumors tha

136 ls with p53 functional status in a series of squamous carcinoma lines has revealed an association bet

137 on in multiple primary and established human squamous carcinoma lines resulted in enhanced expression

138 is suggests that deltaNp63 overexpression in squamous carcinomas may serve to maintain the basal cell

139 vestigated differential gene expression in a squamous carcinoma model established in syngeneic mice.

140 relate with histological classification with squamous carcinomas more frequently MAGE-A positive than

141 ary carcinomas, we found that development of squamous carcinomas occurs independently of CtsB.

142 e have been the most active single agents in squamous carcinoma of the cervix identified so far by th

143 rove response rates and possible survival in squamous carcinoma of the cervix.

144 oducible multi-stage progression to invasive squamous carcinoma of the epidermis has been achieved in

145 treatment of locally advanced, nonmetastatic squamous carcinoma of the head and neck (HNC).

146 Squamous carcinoma of the head and neck and esophageal c

147 on of new active agents for the treatment of squamous carcinoma of the head and neck remains a high p

148 c amplification of p63 in the development of squamous carcinoma of the lung and that patients with NS

149 Patients with stage III or IV squamous carcinoma of the oral cavity, oropharynx, or hy

150 A renal transplant recipient with recurrent squamous carcinoma of the scalp underwent an excision th

151 identified the lymphatics in dysplasias and squamous carcinomas of the cervix and skin.

152 Squamous carcinomas of the cervix, skin, esophagus, and

153 papillomavirus-infected lesions and advanced squamous carcinomas of the cervix.

154 nges have been defined for centrally arising squamous carcinomas of the lung, they have been poorly d

155 The most noticeable lesions were invasive squamous carcinomas of the skin and oral mucosa.

156 ntiated neuroendocrine carcinoma, three; and squamous carcinoma, one.

157 n important component of the early stages in squamous carcinoma progression may be a modest decrease

158 1 years); 44% and 35% had adenocarcinoma and squamous carcinoma, respectively; and more patients enro

159 -SDT) could induce apoptosis in human tongue squamous carcinoma SAS cells through mitochondrial pathw

160 lysed 30 primary invasive oral and laryngeal squamous carcinomas (SC), with concurrent dysplastic les

161 ineteen patients had adenocarcinoma (AD), 14 squamous carcinoma (SCC), and seven poorly differentiate

162 The radiation responses of two squamous carcinomas, SCC-9 (oropharynx) and HEP-2 (laryn

163 ain are resistant to the development of skin squamous carcinomas (SCCs) induced by an activated Ras o

164 rray comparative genomic hybridization in 21 squamous carcinomas (SqCas) and 16 adenocarcinomas (AdCa

165 Our results show that in squamous carcinoma T-HEp3 cells, which display low PERK-

166 ng SqCCs were more similar to those of other squamous carcinomas than to alterations in lung ADCs.

167 In squamous carcinomas, TP63 is commonly amplified, and Del

168 a significant growth inhibition of colon and squamous carcinoma tumor xenografts.

169 between conventional squamous carcinoma and squamous carcinoma variants.

170 in clinical specimens of human head and neck squamous carcinoma, we found evidence that TGF-beta/Notc

171 deltaNp63 is overexpressed in squamous carcinomas where it is associated with prolifer

172 ly, c-Myc plus Bcl-XL transformants mimicked squamous carcinomas, whereas H-Ras-, EGFR-, and Akt-driv

173 tinocytes or cells derived from HPV-negative squamous carcinomas, which exhibited only slight decreas

174 h esophageal cancer (700 adenocarcinoma, 353 squamous carcinoma) who underwent R0 esophagectomy with

175 re would affect the biology of an orthotopic squamous carcinoma xenograft.