ライフサイエンスコーパス: squint

1 hologue, zDVR-1, and the nodal-related gene, Squint.

2 press bozozok/dharma/nieuwkoid and znr2/ndr1/squint.

3 terns of the nodal-related genes cyclops and squint.

4 , pyramidal signs (33%), headache (23%), and squint (19%) for brainstem tumours; and back pain (67%),

5 eadache (49%), abnormal eye movements (21%), squint (21%), and nausea and vomiting (19%) for central

6 to zebrafish endoderm formation: Cyclops and Squint activate receptors such as TARAM-A; Oep also appe

7 Third, Lefty restricts the range of Squint activity in squint mutant embryos, in which the e

8 ulation but also as long-range inhibitors of Squint activity.

9 These results indicate that Squint acts as a secreted morphogen that does not requir

10 We show that FGFs function downstream of squint and bozozok to turn on chordin expression.

11 tenin activation, FGF signaling and bozozok, squint and chordin expression.

12 te that the zebrafish Nodal-related proteins Squint and Cyclops are required in the YSL for endoderm

13 Whereas different levels of both Squint and Cyclops can induce different downstream genes

14 uthpaw directs left-right asymmetries, while squint and cyclops function earlier to pattern mesendode

15 lateral mesoderm require different levels of squint and cyclops function.

16 activity of a point source of Nodal ligands Squint and Cyclops in a non-cell autonomous manner.

17 al timing of dorsal mesendoderm induction in squint and cyclops mutants suggests that dorsal marginal

18 Mutations in oep eliminate the response to Squint and Cyclops overexpression but are suppressed by

19 In embryos lacking both squint and cyclops, members of the nodal group of TGF-be

20 ations in two zebrafish nodal-related genes, squint and cyclops, to manipulate genetically the levels

21 y double mutants for the nodal-related genes squint and cyclops.

22 are expressed in the early zebrafish embryo, squint and cyclops; antiSOX3c-injection leads to an incr

23 Simultaneous protection of squint and lefty or absence of miR-430 caused an imbalan

24 se mutated in the zebrafish mutants cyclops, squint and one-eyed pinhead (oep), cause HPE.

25 growth factor-beta (TGF-beta) Nodal agonist squint and the TGF-beta Nodal antagonist lefty.

26 that the Nodal-related molecules Cyclops and Squint and the transmembrane protein Oep are essential f

27 ation requires the Nodal signals Cyclops and Squint and their cofactor One-eyed pinhead (Oep) [10-14]

28 Furthermore, we show that maternal Squint and zDVR-1 are not required during the cleavage s

29 of genes encoding the nodal-related factor, Squint, and homeodomain protein, Bozozok, both of which

30 The nodal-related genes cyclops and squint are expressed at the blastoderm margin and are re

31 Although beta-catenin, Bozozok and Squint are known to play major roles in establishing the

32 First, overexpression of cyclops and squint at different doses leads to the induction of floa

33 gnaling by acting not only as antagonists of Squint autoregulation but also as long-range inhibitors

34 ifferent downstream genes, we find that only Squint can function directly at a distance.

35 Loss of the zebrafish Nodal-related protein Squint causes a spectrum of phenotypes including cyclopi

36 sk factor, esotropia, exotropia, strabismus, squint, convergent strabismus, and divergent strabismus.

37 However, in squint;cyclops double mutants, which lack Nodal function

38 ation by the Nodal pathway, behave normal in squint;cyclops mutants but exhibit defective motility in

39 forebrain reduction is suppressed in bozozok;squint;cyclops triple mutants, and is associated with re

40 t embryos (Antivin overexpressing or cyclops;squint double mutants), which show extensive AP brain pa

41 range of Squint signaling before regulating squint expression.

42 onserved Nodal response element (NRE) in the squint first intron, while expression in the extra-embry

43 of embryos lacking both maternal and zygotic squint function revealed that maternal squint is require

44 In zebrafish, Squint functions as a long-range Nodal signal during mes

45 o tissue specific enhancers in the zebrafish squint gene mediate the response to Nodal signals.

46 ansgenic lines with GFP under the control of squint genomic sequences.

47 n and a pathway consisting of beta-catenin-->Squint-->FGF-->Chordin, in which each component is suffi

48 alysis suggests that HST acts in parallel to SQUINT in the regulation of phase change and in parallel

49 We report that the range over which Squint induces mesoderm is reduced by Lefty proteins.

50 expression and FGF signaling is required for Squint induction of chordin.

51 Full rescue of ichabod by Squint is dependent on FGF signaling, and partial rescue

52 Although the Nodal-related protein Squint is expressed in the YSL, its role in this tissue

53 in zebrafish proposes that the TGFss signal Squint is one such factor.

54 gotic squint function revealed that maternal squint is required in some genetic backgrounds for the f

55 SQN (SQUINT) is the Arabidopsis ortholog of the immunophilin

56 ty restricts the range of Squint activity in squint mutant embryos, in which the endogenous gene is n

57 squint mutants lack dorsal mesendodermal gene expression

58 reduced wnt8 expression, as seen in cyclops;squint mutants.

59 eir relation to cyclopia in maternal-zygotic squint (MZsqt) mutants.

60 gned (wearing spectacles) and when they were squinting (not wearing spectacles).

61 Protection of squint or lefty mRNAs from miR-430 resulted in enhanced

62 The squinting response corresponding to PP was assessed by e

63 Second, Lefty regulates the range of Squint signaling before regulating squint expression.

64 ce that Lefty proteins diminish the range of Squint signaling by acting not only as antagonists of Sq

65 ctions exclusively downstream of cyclops and squint signaling.

66 n Arabidopsis, loss-of-function mutations in SQUINT (SQN) reduced the number of juvenile leaves and h

67 Loss-of-function mutations of SQUINT (SQN)-which encodes the Arabidopsis orthologue of

68 Two Nodal-related proteins - Squint (Sqt) and Cyclops (Cyc) - are expressed during ge

69 utants for the zebrafish nodal-related genes squint (sqt) and cyclops (cyc) [3] [4] [5], dorsal margi

70 Here we report that the zebrafish squint (sqt) and cyclops (cyc) genes have essential, alt

71 al signaling pathway, the nodal-related gene squint (sqt) and forkhead box H1 [foxh1; mutant locus sc

72 Gore et al. suggest that the Nodal signal Squint (Sqt) is required as a maternally provided dorsal

73 l transcripts of the zebrafish Nodal factor, Squint (Sqt), are localized to future embryonic dorsal.

74 reas it binds and represses the ligand gene, Squint (Sqt), which drives positive feedback.

75 d the nodal-related (TGF-(beta) family) gene squint (sqt).

76 test the morphogen properties of Cyclops and Squint-two Nodal-related transforming growth factor-beta

77 either Bozozok/Dharma/Nieuwkoid or Znr2/Ndr1/Squint were injected.

78 nal transcripts encoding the zebrafish nodal squint were shown to be localized to the future organize

79 leavage stages ruled out a role for maternal Squint, zDVR-1, or other Activin-like ligands before the