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1 ss-catenin activation level was assessed in tumors by qu
2 ss-HBCD was biotransformed to two mercapturic acid pathw
3 ss-siRNAs combine the simplicity and favorable biodistri
4 ABAA-R PAMs can increase significantly INS-1 ss-cell replication, which is enhanced by exogenous GABA
6 ancer drug and modified into a dimer (CPT)2 -ss-Mal, in which two CPT molecules are connected by a re
10 Introduction of test sequences containing 3' ss into monocistronic luciferase reporter vectors widely
13 3-angstrom resolution, revealing that the 3' ss is mainly recognized through non-Watson-Crick base pa
14 arching spliced sequences against 5'ss and 3'ss sequences from the well-known orthologous U12-type sp
15 last intron processing, alternative 5 and 3'ss usage and exon skipping are marked by distinct patter
16 ese results reveal important links between 3'ss control and ATM-dependent responses to double-strand
20 ine at rs609621 in the NSE 3' splice-site (3'ss), which is predominant in high cancer risk population
25 19% in eyes with PDR (0.020 +/- 0.005 mm(3), ss = -0.01, P = .01) compared to controls (0.025 +/- 0.0
27 s/U1 base-pairing, we estimate that 10,248 5'ss ( approximately 5% of human 5'ss) in 6577 genes use b
28 med by searching spliced sequences against 5'ss and 3'ss sequences from the well-known orthologous U1
32 ODE samples indicated that the presence of 5'ss with U12-type signature is more frequent than U2-type
33 scriptome-wide free-energy calculations of 5'ss/U1 base-pairing, we estimate that 10,248 5'ss ( appro
34 cells, we now demonstrate that many other 5'ss are recognized via noncanonical base-pairing register
37 tion, despite its distal position from the 5'ss (85 bp downstream), induces cis alterations in pre-mR
38 involving bulged nucleotides on either the 5'ss or U1 RNA strand, which we term "bulge registers." By
42 to generate three constructs ((ss)DFO-5B1, (ss)FL-5B1, and (ss)dual-5B1) in which the immunoreactivi
46 ovo lipogenesis (DNL), 45% slower fatty acid ss-oxidation, and 40% decreased VLDL-triglyceride export
51 PARs and NMDARs, as well as alpha7 and alpha*ss* nAChRs, but no evidence was found for mEPSCs associa
52 c alpha7 receptors and the heteromeric alpha*ss* receptors) as well as the two types of glutamate rec
54 tidase that degrades insulin and the amyloid ss-protein and is strongly implicated in the pathogenesi
56 onmelanoma cancers may involve some ss-1 and ss-2 HPV types, but the biology of most ss-HPV types and
58 rrestin 1 and 2 binding, internalization and ss-arrestin-mediated proliferation and adipogenesis.
59 ee constructs ((ss)DFO-5B1, (ss)FL-5B1, and (ss)dual-5B1) in which the immunoreactivity was not affec
60 otransporters, functionalized with antibody, ss-DNA, aptamer or lectin receptors, are particularly us
61 arkers p21(CIP1/WAF1), senescence-associated ss-galactosidase (SA-ss-gal), and p16(INK4a) were increa
62 poptotic but displayed senescence associated-ss-galactosidase activity and upregulated p16, indicatin
65 response behaviour of the DNA bioelectrode (ss th-DNA/ZNF/Pt/Si) has been studied by both differenti
67 or not (hen egg lysozyme; HEL) expressed by ss-cells have proven useful in dissecting the developmen
68 inhibition of human huntingtin expression by ss-siRNAs that target the expanded CAG repeats within th
69 .g., occludin-ZO-1, CAR-ZO-1, and N-cadherin-ss-catenin), through a down-regulation of p-Akt1-S473 an
72 ulin (Ig) molecules that efficiently capture ss-cell antigens allows autoreactive B-lymphocytes bypas
73 of change were associated with baseline CCT (ss = -0.1 to -0.09 and -0.011, respectively, all P < .00
74 I restriction enzymes, single-stranded cDNA (ss-cDNA) ligation using T4 polynucleotide kinase and Cir
75 rences in the biologic properties of certain ss-type HPV that affect their impact on carcinogenesis i
77 igase, Escherichia coli FadD, in the E. coli ss-oxidation pathway and deletion of RpfB from the Xcc g
80 g methodology to generate three constructs ((ss)DFO-5B1, (ss)FL-5B1, and (ss)dual-5B1) in which the i
81 volved in GC differentiation including CREB, ss-catenin, AKT, p42/44 MAPK, GAB2, GSK-3ss, FOXO1, and
82 D presented a statistically thinner mean CT (ss = -21.9, P = .006) and CT in all the individual ETDRS
83 lved in L-cysteine metabolism: cystathionine-ss-synthase (CBS) and cystathionine-gamma-lyase (CSE).
84 ncreasing the number of helix-destabilizing, ss-branched valine or isoleucine residues within the TMD
86 CK5, vimentin) and lineage differentiation (ss-tubulin IV+ ciliated cells, MUC5AC+ goblet cells, p63
87 lly immobilization of the single strand DNA (ss-DNA) probe and hybridization with the target miRNA se
88 n response of a secondary single-strand DNA (ss-DNA) to the unhybridized part of the target much like
89 de aerogel labeled with a single strand DNA (ss-HSDNA/rGOae) modified on a rotating disk electrode (R
90 using responsiveness of single-stranded DNA (ss-DNA), far less work has been done for the manipulatio
91 y immobilized single stranded thiolated DNA (ss th-DNA) probe of N. meningitides onto the nanostructu
92 the FTIR analysis of extracted RNA, ds-DNA, ss-cDNA and isolated nuclei, we verified that the spectr
94 oportion of duplex nucleic acids in mixed ds/ss nucleic acid solutions, demonstrating significant adv
100 th Daun02 in the dlBST previously expressing ss-galactosidase under control of the FosB/DeltaFosB pro
102 w that variation in the abundance of the FLM-ss splice form strictly correlate (R(2) = 0.94) with flo
103 sure per 1-week increment and change in FLZ (ss = .00; P = .51) or change in HLZ (ss = .00; P = .40).
106 ce to develop surrogate phosphate analog for ss-siRNA and demonstrates that ss-siRNA provides an alte
108 Thr(350) and Ser(349) are not necessary for ss-arrestin recruitment, but are involved in the stabili
109 terminal tail were primarily responsible for ss-arrestin 1 and 2 binding, internalization and ss-arre
110 o enhance the ability of GABA, secreted from ss-cells, or exogenously administered, to promote ss-cel
112 involved in the stabilization of the GHSR1a-ss-arrestin complex in a manner that determines the ulti
113 1, respectively, all P < .001) and glaucoma (ss = -6.8 to -5.6, P </= .009, and -0.75 to -0.69, P </=
114 as significantly associated with the global (ss = 0.026, P < .01) and temporal sector coefficient of
121 physically stable upon reconstitution in HP-ss-CD solutions, and are able to retain anethole after 6
124 ntiviral vector (LV) that incorporates human ss-interferon scaffold/matrix-associated region sequence
127 se results have four broad implications: (i) ss-siRNAs will not always behave similarly to analogous
128 ers (H3N2 swine IAV-alpha and H3N2 swine IAV-ss) with a sensitivity of 84.9% and a specificity of 100
130 ectivity of anti-CAG oligonucleotides; (iii) ss-siRNAs can function through multiple mechanisms and;
131 ging ) and single-shot echo-planar imaging ( ss-EPI single-shot echo-planar imaging ) with or without
132 e, there is no evidence for discrepancies in ss-sl calcifying depth habitat or seasonality in the Gul
133 ing insertion in a regulatory DNA element in ss that lowers the ratio of Ss(ON) to Ss(OFF) cells.
135 s = -0.533; P = 0.001), portal inflammation (ss = 0.291; P = 0.030), and absence of an ileocecal valv
136 roup was also found to have a higher initial ss value than the male control group (P = .040), and the
137 sic residues energetically steer an inverted ss 5'-flap through a gateway over FEN1's active site and
138 ntiate the actions of GABA secreted by islet ss-cells on GABAA-Rs and provide a new class of drugs fo
139 nctional numeracy more than six years later (ss = 0.195, p = .0014) controlling for intelligence, wor
140 e analysis, age-adjusted small bowel length (ss = -0.533; P = 0.001), portal inflammation (ss = 0.291
144 ated two new leptin-P85 conjugates: one, Lep(ss)-P85(L), containing one P85 chain and another, Lep(ss
145 stabilized composite phase change materials (ss-CPCMs) through a facile self-assembly process using C
146 ze, but formed two hydroxylated metabolites; ss- and gamma-HBCD were both extensively metabolized via
148 and ss-2 HPV types, but the biology of most ss-HPV types and their possible connections to human dis
149 inant role of neurons in driving the myocyte ss-adrenergic phenotype, where SHR cultures elicited hei
154 nanorod for nanorods with a high density of ss-DNA molecules was quantified through a combination of
157 In this study, we studied the effects of ss-3 type HPV49 in a novel transgenic (Tg) mouse model,
159 -casting method for better immobilization of ss DNA while MWCNTs are incorporated into the zeolite-as
161 mpound heterodimers exhibit higher levels of ss- and dsDNA degradation activities than the homodimers
162 In benign tumors, we defined three levels of ss-catenin activation related to specific mutations: (1)
164 ing, or otherwise optimizing, the loading of ss-DNA in monolayers on gold nanorods could be a useful
167 kinase and CircLigase, and polymerization of ss-cDNA to double-stranded cDNA (ds-cDNA) by Phi29 polym
168 this chip-based platform enabled tracking of ss-lap-induced DNA damage repair when biological criteri
170 mma-aminobutyric acid receptors (GABA-Rs) on ss-cells can promote their survival and replication.
174 ble to use chemical modification to optimize ss-siRNA properties and improve their potential for drug
176 f HBCD diastereomers followed the rank order ss > gamma > alpha, and was >65% of that administered.
178 major factor for predicting K(max) outcome (ss coefficient = 0.709, P = .02), whereas age, sex, and
181 ile the autoimmune destruction of pancreatic ss-cells underlying type 1 diabetes (1D) development is
182 The beta genus of human papillomaviruses (ss-HPV) includes approximately 50 different viral types
184 -induced cremaster arteriole injury, and PDI(ss-oo) mice had attenuated platelet accumulation in FeCl
185 In vitro aggregation of platelets from PDI(ss-oo) mice and PDI-null platelets was reduced; however,
188 d enzyme, enzyme type (cellulase, pectinase, ss-glucosidase), and hydrolysis time (1, 4, 8, 24 h) on
192 ith markers of epithelial junction proteins (ss-catenin and connexin 43), of stromal keratocytes (CD3
193 ariant associations in the Estrogen Receptor-ss (ESR2) gene, as well as a set of rare and common vari
196 The DSC results indicated that the PEG/RMS ss-CPCM was a promising candidate for building thermal e
197 indicated that the properties of the PEG/RMS ss-CPCMs are influenced by the adsorption limitation of
199 , senescence-associated ss-galactosidase (SA-ss-gal), and p16(INK4a) were increased 2-, 8-, and 20-fo
202 lexes revealed mechanisms of 5'-splice site (ss) recognition, branching, and intron release, but lack
206 correlation of this change with the specific ss-lap-induced redox cycle using rational controls.
207 ing a robust and reproducible site-specific (ss) labeling methodology to generate three constructs ((
209 nally, ARGs, including the extended-spectrum ss-lactam- and aminoglycoside-resistance genes, were ide
215 roteins specifically degraded single-strand (ss) RNAs in vitro; but neither miRNAs nor miRNA*s in viv
216 e-dimensional structures of single stranded (ss) DNA required for aptamer applications, focusing expl
221 ase translocation over long single-stranded (ss) DNA (>200 nt) with no apparent secondary structure.
224 activity of NPH I requires single-stranded (ss) DNA as a cofactor; however, the source of this cofac
228 in controlling infection of single-stranded (ss) DNA geminiviruses and ssRNA viroids, respectively, b
230 on of lesions in persistent single-stranded (ss) DNA has been recently found in several types of canc
231 orks generates stretches of single-stranded (ss) DNA on both strands that are exposed to nucleolytic
232 Such studies often embed a single-stranded (ss) DNA region within a longer double-stranded (ds) DNA
236 annealing of complementary single-stranded (ss) DNA, a crucial step in DNA synthesis, repair and rec
238 s a presynaptic filament on single-stranded (ss) DNA, which catalyses pairing with homologous double-
239 onserved C-terminal tail of single-stranded (ss) DNA-binding protein (SSB), which is known to bind Es
245 me, the interaction of long single-stranded (ss) RNAs with cognate homologous double-stranded (ds) DN
246 ent studies have shown that single-stranded (ss) viral RNAs fold into more compact structures than ra
251 -assisted immobilization of single-stranded (ss)DNA on gold surfaces is achieved by applying a pulse-
253 ng domain (CTD) which binds single-stranded (ss)DNA, and the BRC repeats, which bind RAD51 and modula
254 tive and tunable loading of single-stranded (ss-DNA) molecules onto gold nanorods was achieved throug
255 ite G. ruber (W) morphotypes, sensu stricto (ss) and sensu lato (sl), has hypothesized differences in
259 ybridization between ss DNA probe and target ss DNA was detected by reduction in current, generated b
260 ntify wide range of the complementary target ss th-DNA in the range 5-240 ng mul(-1) with good linear
263 as been difficult to examine the role of TGF-ss in post-natal tooth development due to perinatal leth
265 te analog for ss-siRNA and demonstrates that ss-siRNA provides an alternative strategy for therapeuti
269 types, including immune cells, EPOR and the ss-common receptor (CD131) form heteromers (the innate r
270 rved in an analogous Tg model expressing the ss-2 HPV38 E6 and E7 oncogenes at the same anatomic site
271 onfirmed in transgenic plants expressing the ss-glucuronidase reporter gene fused to the NtPDR1 promo
272 ving a cyclic voltammetric response from the ss-HSDNA/rGOae electrode in three different charges of t
273 th about 19% of enzymes dissociated from the ss/dsDNA junction after translocating across the ssDNA r
278 The effect of hydrodynamic diffusion of the ss-HSDNA/rGOae rotating disk electrode (RDE) toward AFB1
281 required to unwind the fork compared to the ss/ds junction, suggesting that binding to the fork lead
283 ng pattern similar to that observed with the ss/ds junction, consistent with disruption of the intera
287 voltammetry from these chips at therapeutic ss-lap concentrations of high statistical significance o
288 particles was easily displaced by thiolated ss-DNA, forming a tunable density of single-stranded DNA
290 We show that CST binds preferentially to ss-dsDNA junctions, an activity that can explain the inc
291 only able measure total carotenoids as total ss-carotene, HPLC enables the determination of individua
292 wing ventricular injection of Cholera toxin, ss subunit (CTss), a tracer frequently used in brain cir
294 = 0.030), and absence of an ileocecal valve (ss = 0.267; P = 0.048) were predictive for fibrosis stag
296 ared with DW diffusion-weighted imaging with ss-EPI single-shot echo-planar imaging , and it improved
297 aun02 in the LHb previously transfected with ss-galactosidase under control of the FosB promoter.
300 s show that lithium, an activator of the Wnt/ss-catenin signaling pathway, slows melanoma progression
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