ライフサイエンスコーパス: ssDNA

1 DHX36 activity depended on a 3' ssDNA extension and was blocked by a polyethylene glycol

2 promotes end resection that generates the 3' ssDNA intermediate for homologous recombination (HR).

3 The 3' ssDNA protrusion formed through resection activates the

4 he 'lead' AdnB motor translocating on the 3' ssDNA strand, but not on the putative 'lagging' AdnA ATP

5 bserved with EcRep and EcUvrD (both 3' to 5' ssDNA translocases).

6 ation Factor C (yRFC) can load yPCNA onto 5'-ssDNA flaps, (CAG)13 triplet repeats, and homoduplex DNA

7 A ssDNA probe specific for HAV (capture probe) was designe

8 Human CST (CTC1-STN1-TEN1) is a ssDNA-binding complex that helps resolve replication pro

9 suggest that Drosophila telomeres possess a ssDNA overhang like the other eukaryotes, and that the t

10 rn, MUS81 cleavage of regressed forks with a ssDNA tail promotes POLD3-dependent fork rescue.

11 reduction in the formation of AID-accessible ssDNA in cells lacking H3.3 is independent of any effect

12 al. (2017) define the nature of accumulated ssDNA present in the neuron and astrocyte cytoplasm of T

13 Accumulated ssDNAs are derived from LINE-1 endogenous retroelements,

14 In addition, ssDNA immobilization and hybridization with its compleme

15 High-affinity ssDNA-binding by RPA depends on two DNA binding domains

16 n translocate rapidly and processively along ssDNA; however, the monomer is a poor helicase.

17 ssDNA tightly, it can be repositioned along ssDNA to follow the advancement of the replication fork.

18 the rate of UvrD monomer translocation along ssDNA is influenced by DNA base composition, with UvrD h

19 kinetic model for Hel308 translocation along ssDNA that sheds light on how superfamily 1 and 2 helica

20 of a complementary ssRNA target activates an ssDNA-specific nuclease activity in the histidine-aspart

21 e catalytic domain of APOBEC3G (A3G-CTD), an ssDNA-specific cytosine deaminase, was expressed in an E

22 we show that replication protein A (RPA), an ssDNA-binding protein, interacts with RNaseH1 and coloca

23 the ERCC1-XPF heterodimer jointly bind to an ssDNA/dsDNA substrate and, thereby, at least partially d

24 -stranded and single-stranded DNA (dsDNA and ssDNA) regions of varying lengths.

25 A to undergo rapid exchange between free and ssDNA-bound states only when free hRPA is present in sol

26 ferent structural features between G4DNA and ssDNA, these binding data indicated that PC4 can interac

27 s study, we used single-molecule imaging and ssDNA curtains to examine the binding interactions of hu

28 NA (dsDNA), single-stranded RNA (ssRNA), and ssDNA/reverse-transcribing viruses could be seen more cl

29 ere, we developed an ultrasensitive antibody-ssDNA aptamer sandwich-type fluorescence immunosensor fo

30 The APOBEC3A-ssDNA complex defines the 5'-3' directionality and subtl

31 NA (ssDNA) probe was hybridized with aptamer ssDNA in solution, followed by co-immobilization with 6-

32 ts the interaction with lambdaexo as well as ssDNA and dsDNA recombination in vivo.

33 ER) steps function on replication-associated ssDNA.

34 bly is next modified by covalently attaching ssDNA strands.

35 t 2-deoxyadenosines in the M13 bacteriophage ssDNA genome.

36 s of the individual collision events between ssDNA aptamer-functionalized AgNPs and a carbon fiber mi

37 SSB homotetramers bind ssDNA in several modes that differ in occluded site size

38 l oligonucleotide binding OB folds that bind ssDNA and four intrinsically disordered C-terminal domai

39 We report here a few Zika NS1-binding ssDNA aptamers selected using the conventional SELEX pro

40 localization at telomeres, Moi neither binds ssDNA nor facilitates Ver binding to ssDNA.

41 Although SSB binds ssDNA tightly, it can be repositioned along ssDNA to fol

42 ing these residues dramatically impairs both ssDNA binding and catalytic activity.

43 replication due to impaired binding to both ssDNA and primase.

44 ne significantly reduced A3G binding to both ssDNA and RNA, whereas Y181A and Y182A mutations only mo

45 peline that integrates sequentially building ssDNA secondary structure from sequence, constructing eq

46 res Chk1 activation known to be catalysed by ssDNA-RPA-ATR signalling at the ends designated for HDR,

47 ng, lipid-containing phage), with a circular ssDNA genome and an internal lipid membrane enclosed in

48 AD52 with replication protein A (RPA)-coated ssDNA, and we monitored the fate of RAD52 during assembl

49 (phospho-)replication protein A (RPA)-coated ssDNA.

50 provides the ability to recognize RPA-coated ssDNA to the tumor suppressor BRCA2, which is complexed

51 and promotes the annealing of complementary ssDNA to generate highly branched duplex DNA structures.

52 ic capture probe and tested on complementary ssDNA and on HAV cDNA.

53 of detection of 0.65pM for the complementary ssDNA and 6.94fg/microL for viral cDNA.

54 DNA before hybridization with complementary ssDNA (20 bases, target) was carried out.

55 ore, we demonstrate the use of a constructed ssDNA knot both to probe the topological conversion cata

56 ort, cyclobutane pyrimidine dimer-containing ssDNA oligos generated during repair of UV-induced damag

57 e that Tyr-315 is essential for coordinating ssDNA interaction with or entry to the deaminase domain

58 that this requirement is due to cytoplasmic ssDNA exonucleases, which inhibit natural transformation

59 th the accumulation of R-loops and cytosolic ssDNA.

60 signal differences enabled us to distinguish ssDNA and dsDNA without using a label or a tag.

61 r this stimulation is an enhancement of DMC1-ssDNA complex formation by the stimulatory BRC repeats.

62 PtNPs are modified with a single-strand DNA (ssDNA) shell that is complementary to the miRNA target.

63 leoprotein filaments on single-stranded DNA (ssDNA) and catalyzes strand invasion with homologous dup

64 high-molecular-weight, single-stranded DNA (ssDNA) and demonstrate that it proceeds by a living chai

65 hat binds complementary single-stranded DNA (ssDNA) and facilitates its annealing to duplex DNA.

66 nce that ComFA binds to single stranded DNA (ssDNA) and has ssDNA-dependent ATPase activity.

67 processes by binding to single-stranded DNA (ssDNA) and interacting with several other DNA binding pr

68 s been shown to mediate single-stranded DNA (ssDNA) and is synthetic lethal with mutations in other k

69 Single-stranded DNA (ssDNA) and RNA regions that include at least four closel

70 ament that assembles on single-stranded DNA (ssDNA) at the sites of DNA damage.

71 The bacterial single-stranded DNA (ssDNA) binding protein SSB is a strictly conserved and e

72 The 2 single-stranded DNA (ssDNA) binding proteins SSB1 and SSB2 are crucial regula

73 The single-stranded DNA (ssDNA) cytidine deaminase APOBEC3F (A3F) deaminates cyto

74 The APOBEC3B (A3B) single-stranded DNA (ssDNA) cytosine deaminase has important roles in innate

75 By rationally designing single-stranded DNA (ssDNA) donors of the optimal length complementary to the

76 e resulting 5'-Flap and single-stranded DNA (ssDNA) gap.

77 oplasm, and deliver the single-stranded DNA (ssDNA) genome to the nucleus, where viral replication oc

78 binding and organizing single-stranded DNA (ssDNA) intermediates.

79 Single-stranded DNA (ssDNA) is notable for its interactions with ssDNA bindin

80 Here we show that single-stranded DNA (ssDNA) knots and links can be created by utilizing the i

81 Ps) self-assembled with single-stranded DNA (ssDNA) of nheA gene immobilized with thiol linker on the

82 ontact with the nascent single-stranded DNA (ssDNA) of the leading strand on active forks than on sta

83 processed to yield long single-stranded DNA (ssDNA) overhangs, which are quickly bound by replication

84 s the immobilization of single stranded DNA (ssDNA) probe sequences on a wide variety of electrode su

85 Thiolated single-stranded DNA (ssDNA) probe was hybridized with aptamer ssDNA in soluti

86 Q5 demonstrated similar single-stranded DNA (ssDNA) reeling activities that were not coupled to GQ un

87 ation is much higher in single-stranded DNA (ssDNA) than in double-stranded DNA, and copying the resu

88 ferential adsorption of single-stranded DNA (ssDNA) to GO over aptamer-target complexes.

89 rected synthesis with a single-stranded DNA (ssDNA) topological structure.

90 titution rates, RNA and single-stranded DNA (ssDNA) viruses may be important constituents of invaded

91 ing protein (SSB) wraps single-stranded DNA (ssDNA) with high affinity to protect it from degradation

92 er preferentially binds single-stranded DNA (ssDNA) with no sequence specificity.

93 A hybrids and displaced single-stranded DNA (ssDNA), has emerged as a major source of genomic instabi

94 signal, accumulation of single-stranded DNA (ssDNA), sensitivity to replication drugs, and chromosome

95 ulate the generation of single-stranded DNA (ssDNA), the enzymatic substrate of AID Here, we report t

96 metal ion, dopamine and single-stranded DNA (ssDNA), with detection limits of 1.2 nM, 1.3 muM and 1 p

97 transcription (PC4), a single-stranded DNA (ssDNA)-binding protein, as a novel G4 interactor.

98 ly, the addition of the single-stranded DNA (ssDNA)-binding replication protein A (RPA) selectively r

99 y digests the 3'-end of single stranded DNA (ssDNA).

100 degrades the 3'-end of single-stranded DNA (ssDNA).

101 ucing long stretches of single-stranded DNA (ssDNA).

102 during translocation on single-stranded DNA (ssDNA).

103 to accumulation of long single-stranded DNA (ssDNA).

104 how that the binding to single-stranded DNA (ssDNA)/dsDNA junctions is dependent on joint binding to

105 Thiol-modified single stranded DNA (ssDNA, 20 bases, capture probe) was chemisorbed to a gol

106 fied with two different single stranded-DNA (ssDNA) chains.

107 hybridization of probe (single stranded DNA-ssDNA) and hybrid (double stranded DNA-dsDNA) both via 3

108 demonstrated that long single-stranded DNAs (ssDNAs) serve as very efficient donors, both for inserti

109 base pairing to direct single-stranded DNAs (ssDNAs) to assemble into desired 3D structures.

110 restart stalled replication from downstream ssDNA.

111 This PCNA sequestration likely exposed ds-ssDNA junctions at replication forks for XPA binding.

112 Each ssDNA is encoded by a gene that is transcribed into non-

113 plasmic deaminase APOBEC3A leads to elevated ssDNA deaminase activity, likely by facilitating opening

114 t Rad53 prevents the generation of excessive ssDNA under replication stress by coordinating DNA unwin

115 Here, we show the ability to express ssDNAs in Escherichia coli (32-205 nt), which can form s

116 Here, we developed a facile ssDNA-seq method, which exploits a novel template-switch

117 ary using a fluorescence-quenching assay for ssDNA annealing activity of RAD52.

118 e unknotting activity for ssRNA, but not for ssDNA.

119 oximately 2 nm, similar to that observed for ssDNA.

120 evealed a multitude of possible pathways for ssDNA to come off SSB punctuated by prolonged arrests at

121 1 and CD2 of A3F plays an important role for ssDNA binding for each individual domain, as well as for

122 er, the conformational distributions of free ssDNA have been difficult to determine.

123 ts by shutting down RAD-51 dissociation from ssDNA.

124 nteract with G4DNA in a manner distinct from ssDNA.

125 monstrate that histones are not evicted from ssDNA after in vitro chromatin resection.

126 First, Srs2 dislodges Rad51 from ssDNA preventing promiscuous strand invasions.

127 may be a hallmark of processes that generate ssDNA, and that posttranslational modification of ssNucs

128 ad us to propose a mechanism whereby genomic ssDNA secondary structure formation during ssDNAp-to-tar

129 structed by coating graphene oxide/ssDNA (GO-ssDNA) on an Au-electrode for VEGF detection, and incorp

130 binds to single stranded DNA (ssDNA) and has ssDNA-dependent ATPase activity.

131 In vitro, RAD52 has ssDNA annealing and DNA strand exchange activities.

132 ose a model in which UvsY promotes a helical ssDNA conformation that disfavors the binding of gp32 an

133 In addition, we reconstitute histone-ssDNA complexes (termed ssNucs) with ssDNA and recombina

134 In ssDNA exonuclease mutants, one arm of homology can be re

135 EC3G (A3G), which may explain differences in ssDNA-binding characteristics between A3F-CD2 and A3G-CD

136 es that brings together residues involved in ssDNA and SSB binding at adjacent sites on the protein s

137 ence the translocation rates, with increased ssDNA base stacking correlated with decreased translocat

138 X-3543, blocks replication forks and induces ssDNA gaps or breaks.

139 5 may be sufficient to competitively inhibit ssDNA deaminase-dependent antiviral activity.

140 odels, transforming the 3D ssRNA models into ssDNA 3D structures, and refining the resulting ssDNA 3D

141 tary to crRNA present in the complex and its ssDNA destruction activity was activated by target RNA.

142 enabled scalable isolation of multi-kilobase ssDNA with high purity and 50-70 % yield.

143 g the complementary strands with the knotted ssDNA templates.

144 bound to surface-immobilized 3'-Cy3-labeled ssDNA, a fluctuating FRET signal is observed, consistent

145 primer-primase complexes left on the lagging ssDNA from primer synthesis in initiating early lagging-

146 tyrosines 181 and 315 directly cross-linked ssDNA.

147 currently are lacking for isolation of long ssDNA, an important material for numerous biotechnologic

148 The human mitochondrial ssDNA-binding protein (mtSSB) is a homotetrameric protei

149 ittle is known about the biophysics of mtSSB-ssDNA interactions.

150 The NeC3PO:ssRNA and NeC3PO:ssDNA complexes fold like closed football with the subst

151 questions about the prevalence of nontailed, ssDNA viruses in soils.

152 The length of the 15-nt ssDNA lattice is sufficient to accommodate up to two coo

153 that yields an internal 1000 nucleotide (nt) ssDNA region when pulled partially into the overstretchi

154 e of A3F-CD2 in complex with a 10-nucleotide ssDNA composed of poly-thymine, which reveals a novel po

155 lation of Mcm2, binding to eighty-nucleotide ssDNA, and recruiting pol alpha to Mcm2-7 in vitro.

156 nd duplex DNA processively in the absence of ssDNA translocation by the canonical motors and that the

157 in diabetes associated with accumulation of ssDNA in immune cells and induction of an interferon res

158 l affinity to DNA; the equilibrium amount of ssDNA bound to SSB was found to depend on the electrolyt

159 To capture the vast array of ssDNA conformations in solution, we pair small angle X-r

160 bes a new procedure for assembling arrays of ssDNA and proteins on paper.

161 replication fork, whereas the association of ssDNA reeling with GQ destabilization is more helicase-s

162 consistent with an initial tight binding of ssDNA to helicase domain 2, followed by transient openin

163 latively simple mechanism for the binding of ssDNA to non-specific SSBs may be at play, which explain

164 odel in the field postulates that binding of ssDNA to the OB core induces the flexible, undefined C-t

165 ure of BIR and propose that tight control of ssDNA accumulated during this process is essential to pr

166 Spontaneous formation of ssDNA bulges and their diffusive motion along SSB surfac

167 thylene blue (MB) with free guanine (3'G) of ssDNA.

168 thylene blue (MB) with free guanine (3'G) of ssDNA.

169 eal a key role for the gradual generation of ssDNA in modulating the binding mode of a multimeric SSB

170 Here, we report measurements of ssDNA and ssRNA elasticity in the intermediate-force reg

171 we characterized the molecular mechanism of ssDNA association with SSB.

172 revealing the architecture and mechanism of ssDNA recognition that is likely conserved among all pol

173 critical role in the assembly mechanisms of ssDNA binding proteins at replication forks and other ss

174 studies, a DNA hairpin adjacent to 33 nt of ssDNA.

175 ein bound nucleic acids with a preference of ssDNA approximately dsDNA > ssRNA, which is distinct fro

176 nformational and electrostatic properties of ssDNA in association with SSBs.

177 during cancer therapy lead to the release of ssDNA fragments from the cell nucleus into the cytosol,

178 Thus, rational removal of ssDNA exonucleases may be broadly applicable for enhanci

179 label the ends of a short (15-nt) segment of ssDNA attached to a model p/t DNA construct and permit u

180 The synthesis of ssDNA oligonucleotides on paper is convenient and effect

181 les the rational, template-free synthesis of ssDNA that can be used for a range of biomedical and nan

182 We describe the use of ssDNA functionalized silver nanoparticle (AgNP) probes f

183 omplexes assembled on preformed ssDNA and on ssDNA generated gradually during 'in situ' DNA synthesis

184 P hydrolysis-fueled translocation of Dna2 on ssDNA facilitates 5' flap cleavage near a single-strand-

185 aptamer applications, focusing explicitly on ssDNA hairpins.

186 rage translocation rate of a UvrD monomer on ssDNA composed solely of deoxythymidylates.

187 gp32 bind much more tightly, can 'slide' on ssDNA sequences, and exhibit binding dynamics that depen

188 idines although decreasing nearly twofold on ssDNA containing equal amounts of the four bases.

189 tSSB tetramer can directly transfer from one ssDNA molecule to another via an intermediate with two D

190 nding activity mediated loading of Exo1 onto ssDNA overhangs.

191 bly of cooperatively bound gp32 protein onto ssDNA sequences located at the replication fork.

192 from ssNucs to either double-stranded DNA or ssDNA.

193 red exchange rates upon complex formation or ssDNA binding.

194 tes strand exchange with homologous ssRNA or ssDNA.

195 n mechanisms similar to those found in other ssDNA replicons.

196 or was constructed by coating graphene oxide/ssDNA (GO-ssDNA) on an Au-electrode for VEGF detection,

197 S have been determined for the pre- and post-ssDNA ejection states.

198 HmtSSB-DNA complexes assembled on preformed ssDNA and on ssDNA generated gradually during 'in situ'

199 We show that HmtSSB binds to preformed ssDNA in two major modes, depending on salt and protein

200 having 22 mers as an amine-terminated probe ssDNA was immobilized on the thin film sensing area thro

201 tly labeled target ssDNA and unlabeled probe ssDNA immobilized on glass surfaces.

202 SNAPCAR-produced ssDNA will expand the scope of applications in nanotechn

203 te a more general role for helicase-promoted ssDNA reeling activity such as removal of proteins at th

204 Purified ssDNA that is produced in vivo is used to assemble large

205 tion forks, and that the inhibition of RAD52-ssDNA binding acts additively with BRCA2 or MUS81 deplet

206 es with our inhibitors showed that the RAD52-ssDNA interaction enables its function at stalled replic

207 to identify compounds that disrupt the RAD52-ssDNA interaction.

208 CC1-XPF complex, XPF specifically recognizes ssDNA.

209 NA 3D structures, and refining the resulting ssDNA 3D structures.

210 ous and relatively stable, and DREEM reveals ssDNA wrapping around histones.

211 e) and with the hybridization between T-rich ssDNA(S1) immobilized on the Fe3O4@SiO2/dendrimers/QDs a

212 RPA-coated single-stranded DNA (RPA-ssDNA), a nucleoprotein structure induced by DNA damage,

213 displaced from the ssDNA, but some RAD52-RPA-ssDNA complexes persisted as interspersed clusters surro

214 We show that RAD52 binds tightly to the RPA-ssDNA complex and imparts an inhibitory effect on RPA tu

215 ion enhances the recruitment of PRP19 to RPA-ssDNA and stimulates RPA ubiquitylation through a proces

216 The second ssDNA chain of the AuNPs provides the possibility to int

217 , with sequences complementary to the second ssDNA linked to the AuNP, have been synthesized and used

218 h-throughput single-stranded DNA sequencing (ssDNA-seq) of cell-free DNA from plasma and other bodily

219 maintaining genome integrity by sequestering ssDNA and mediating DNA processing pathways through inte

220 Zf-GRF fold is typified by a crescent-shaped ssDNA binding claw that is flexibly appended to an APE2

221 ulations of spontaneous association of short ssDNA fragments with SSB detailed a three-dimensional ma

222 Placed in solution, ssDNA-SSB assemblies were observed to change their struc

223 Repeat simulations of the SSB-ssDNA complex under mechanical tension revealed a multit

224 Bulk RNA and substrate ssDNA bind to the same three A3G tryptic peptides (amino

225 g loops is required for binding to substrate ssDNA.

226 ization between fluorescently labeled target ssDNA and unlabeled probe ssDNA immobilized on glass sur

227 We find that dsDNA react differently than ssDNA to the targeted molecules, requiring more energy t

228 Anticipating that ssDNA binding activity underlies the RAD52 cellular func

229 These analyses confirmed that ssDNA can bind UvsY and gp32 independently and also as a

230 We demonstrate that ssDNA-bound hRPA can undergo facilitated exchange, enabl

231 Finally, we show that ssDNA exonucleases inhibit natural transformation in Aci

232 The ssDNA binding protein [gene product 32 (gp32)] of the T4

233 The ssDNA cleavage required mismatches between the 5-tag of

234 The ssDNA products were used to fold various DNA origami.

235 The ssDNA-binding protein RPA promotes both Dna2- and CtIP-M

236 y be displaced from or reorganized along the ssDNA.

237 stent with random diffusion of SSB along the ssDNA.

238 ing their genomes into a host bacterium, the ssDNA bacteriophage PhiX174 is tailless.

239 cated by the well-known Au-thiol binding the ssDNA probe on the surface of an AuNP/graphite cathode.

240 ned to the surface coverage of the NP by the ssDNA aptamers and subsequent conformational changes of

241 ubtle conformational changes that clench the ssDNA within the binding groove, revealing the architect

242 of the RPA and RAD52 was displaced from the ssDNA, but some RAD52-RPA-ssDNA complexes persisted as i

243 2 could bind once RAD51 dissociated from the ssDNA.

244 X foci, like the human telomeres lacking the ssDNA-binding POT1 protein.

245 Next, the ssDNA:miRNA conjugate is formed, which passivates the Pt

246 ation complicates locating the source of the ssDNA cofactor within the transcription complex because

247 he difference between power densities of the ssDNA probe modified cathode in the absence and presence

248 ng of gp32 and initiates the assembly of the ssDNA-UvsX filament.

249 hich forms extended helical filaments on the ssDNA.

250 A2-DSS1 displace RPA and load RAD51 onto the ssDNA.

251 ptic complex, is responsible for pairing the ssDNA with homologous double-stranded DNA (dsDNA), which

252 nd polyethylene glycol spacers show that the ssDNA base also influences translocation processivity.

253 complexes it has been hypothesized that the ssDNA cofactor is obtained from the unpaired non-templat

254 s within this binding site interact with the ssDNA, and mutating these residues dramatically impairs

255 PHF11 interacted with the ssDNA-binding protein RPA and was found in a complex wit

256 dicted that these inhibitors bind within the ssDNA-binding groove of the RAD52 oligomeric ring.

257 w that isolated gp32 molecules bind to their ssDNA targets weakly and dissociate quickly, while coope

258 These ssDNA arrays can be used to detect fluorophore-linked DN

259 It remains unknown how this ssDNA is prevented from unscheduled pairing with the tem

260 pose that uncontrolled Rad51 binding to this ssDNA promotes formation of toxic joint molecules that a

261 e binding of Redbeta(FL) and Redbeta(177) to ssDNA substrate and annealed duplex product may be impor

262 SSB, thereby allowing RecQ to gain access to ssDNA and facilitating DNA unwinding.

263 ng (SSB) proteins bind with high affinity to ssDNA generated during DNA replication, recombination, a

264 We show that the mtSSB tetramer can bind to ssDNA in two distinct binding modes: (SSB)30 and (SSB)60

265 as a DNA helicase or its ability to bind to ssDNA.

266 etics and thermodynamics of mtSSB binding to ssDNA by equilibrium titrations and stopped-flow kinetic

267 mFRET analysis indicates that CST binding to ssDNA is dynamic with CST complexes undergoing concentra

268 enzymatic activity by regulating binding to ssDNA substrates.

269 Upon binding to ssDNA, this fluorescent RPA (RPAf) generates a quantifia

270 in the framework of the model for binding to ssDNA.

271 tions that do not influence RAD51 binding to ssDNA.

272 r binds ssDNA nor facilitates Ver binding to ssDNA.

273 Our studies demonstrated that RPA binds to ssDNA in at least two modes characterized by different d

274 (SSB) is an essential protein that binds to ssDNA intermediates formed during genome maintenance.

275 riphosphate let us deduce that RecQ binds to ssDNA via a near diffusion-limited reaction.

276 We found that the mtSSB tetramer binds to ssDNA with a rate constant near the diffusion limit (2 x

277 ese results suggest that SSB likely binds to ssDNA with high cooperativity in vivo.

278 e reactivated only if miRNA complementary to ssDNA is present.

279 It binds transiently and cooperatively to ssDNA sequences exposed during the DNA replication proce

280 Smc5/6-hinge complex binds preferentially to ssDNA and that this interaction is affected by both 'lat

281 e tightly to annealed duplex product than to ssDNA substrate, while Redbeta(177) binds more tightly t

282 te, while Redbeta(177) binds more tightly to ssDNA.

283 Moreover, we also found that UL8 binds to ssDNAs >50-nucletides long and promotes the annealing of

284 molecular interactions within the POT1-TPP1-ssDNA ternary complex and the conformational changes tha

285 hermodynamic analyses revealed that the UvsY-ssDNA interaction occurs within the assembly via two dis

286 the homodimeric XPF is able to bind various ssDNA sequences but with a clear preference for guanine-

287 ode formed at higher [NaCl] (> 200mM), where ssDNA wraps completely around the tetramer, displays "li

288 We call this method efficient additions with ssDNA inserts-CRISPR (Easi-CRISPR) because it is a highl

289 scribe Easi-CRISPR (Efficient additions with ssDNA inserts-CRISPR), a targeting strategy in which lon

290 LKALELLTNCY189) and has been associated with ssDNA interaction and ribosome biogenesis.

291 -binding domain of Pur-alpha in complex with ssDNA.

292 re of a complex of a cytidine deaminase with ssDNA bound in the active site at 2.2 A.

293 SB), present multiple sites to interact with ssDNA, which has been shown in vitro to enable them to b

294 (ssDNA) is notable for its interactions with ssDNA binding proteins (SSBs) during fundamentally impor

295 le is known about how the CD2 interacts with ssDNA.

296 lymerizing a conducting polymer monomer with ssDNA probe sequence pre-attached.

297 aster and more accurately when provided with ssDNA.

298 histone-ssDNA complexes (termed ssNucs) with ssDNA and recombinant histones and analyze these particl

299 Its co-crystal structure with ssDNA reveals how the conformations of loops and residue

300 ree bypass of deoxyuridines generated within ssDNA and suggest that the APOBEC mutation signature obs

301 by converting cytidines into uridines within ssDNA during replication.