ライフサイエンスコーパス: stage-specific

1 s and TF gene expression is also modular and stage specific.

2 t, stable, disease specific, or even disease stage specific.

3 sis but these metabolic functions may not be stage specific.

4 afficking architectures that are tissue- and stage-specific.

5 c, and cicatricial) identified no pattern as stage-specific.

6 No FAF pattern can be considered stage-specific.

7 infection load were species and life history stage-specific.

8 ortional hazards models were used to compare stage-specific 5-year survival among NHBs, NHWs, and His

9 earum that was recently shown to have sexual stage-specific A-to-I RNA editing.

10 i away from the nuclear periphery determines stage-specific accessibility of Ig loci.

11 irst, local EcR-mediated signaling induces a stage-specific accumulation of lipids in stage-10 oocyte

12 lus subtilis proceeds via the sequential and stage-specific activation of the sporulation-specific si

13 (GFP) reporter transgenic mice that display stage-specific activation of transgenes during odontobla

14 rotein reporter transgenic mice that display stage-specific activation of transgenes during odontobla

15 urther upregulated in pDCs, correlating with stage-specific activity of multiple enhancer elements.

16 , this is controlled by modifications of the stage-specific adhesin lipophosphoglycan (LPG).

17 ESCs, we observed differential developmental stage-specific alterations in lineage specification and

18 We find differential, progression stage-specific alterations in phenotypic heterogeneity a

19 We found several miRNAs with 'stage specific' alterations while others display a clear

20 Stage-specific analyses led to the identification of 3 p

21 monstrates the utility of niche- rather than stage-specific analysis of parasite transcriptomes to id

22 erentiated to hematopoietic precursor cells, stage-specific analysis of T cell maturation confirmed e

23 n of progenitor cells into odontoblasts were stage specific and dependent on the stage of cell maturi

24 ale from ubiquitously expressed to tissue or stage specific and examined their interaction patterns.

25 lncRNA expression patterns that were highly stage specific and were more lineage specific than those

26 We observed a dynamic, stage-specific and density dependent change in Aedes aeg

27 of FGF2 on cells in odontoblast lineage were stage-specific and depended on the stage of cell maturit

28 The stage-specific and differentially expressed unigenes (DE

29 Our results demonstrated differentiation stage-specific and dose-dependent roles of EED in normal

30 asites during TMP-SMX administration induces stage-specific and long-lived pre-erythrocytic protectiv

31 ates, identifying thousands of developmental-stage-specific and shared QTL.

32 The datasets on stage-specific and SHB1-induced gene expression and gene

33 stages, and that ALBA4 associates with both stage-specific and stage-independent partners to produce

34 that microbiota ecology appears to be cancer stage-specific and strongly associated with histological

35 istry and a validated antibody selection for stage-specific and type-specific markers in autopsy tiss

36 ivity is known to depend on factors that are stage specific, and we describe a novel approximately 70

37 mmunocytochemistry employing anti-Toxoplasma stage-specific antibodies to confirm diagnosis and also

38 y morphological criteria and the analysis of stage-specific antigens (i.e., IGFBP1, PRL).

39 The cells displayed enhanced expression of stage-specific antigens that extravillous CTBs normally

40 Appropriate differentiation-stage-specific application of Gsk3 inhibitor, Wnt inhibi

41 tem that takes into account the demonstrated stage-specific architecture of the pair-rule gene networ

42 Also, we found that differentiation-stage-specific ARIH2 transcription was regulated by the

43 tissues, giving insight into cell-type- and stage-specific AS mechanisms in plants.

44 These QTLs were developmental stage specific, as different QTLs were detected before a

45 (MMB) additionally triggered strong sex- and stage-specific attraction in several Caenorhabditis spec

46 orm papillae and taste buds, most likely via stage-specific autocrine and/or paracrine mechanisms, an

47 ed activity windows and were associated with stage-specific biological functions and regulatory pathw

48 (2)(+) from intracellular stores to activate stage-specific Ca(2)(+)-dependent protein kinases.

49 Recent findings highlighted that upstream of stage-specific Ca(2+) effectors is a conserved interplay

50 Stage-specific cardiac structures were dissected from 8

51 onitoring human cardiac disease according to stage-specific cardiogenesis, this study demonstrates RB

52 o model human cardiac disease according to a stage-specific cardiogenic roadmap, we established a new

53 iagnosis), and subsequent (ie, metachronous) stage-specific CBC occurrences in women who were diagnos

54 cal malaria and parasitemia, and fewer blood-stage specific CD4(+) T cells coproducing interleukin-10

55 o receive DP had higher frequencies of blood-stage specific CD4(+) T cells coproducing interleukin-2

56 es using quantitative real-time PCR revealed stage-specific changes in Cas-PMCA abundance during the

57 reservation, and exhibit ductal- and disease-stage-specific characteristics.

58 The L3-stage-specific chitinase OvCHT1 has been implicated in t

59 MOF is therefore a developmental-stage-specific chromatin regulator found to be essential

60 that may be relevant in the establishment of stage-specific clinical management.

61 Together, we identify stage-specific co-regulators Kaiso and Sox10 that sequen

62 indings greatly enhance our understanding of stage-specific community assembly patterns in the fish g

63 enerated different tissue- and developmental stage-specific conditional knockout mice carrying Smarcb

64 Specifically, new fetal stage-specific contacts were uncovered between a region

65 s of additional regulators in a lineage- and stage-specific context.

66 f primary human cells, we defined cell cycle stage-specific contributions of Rad18 to genome maintena

67 ally, we uncovered cell-type- and cell-cycle-stage-specific control of the mechanosensation of myosin

68 Using stage-specific Cre alleles, we uncovered distinct roles

69 uish CFLD from CFnoLD and determine fibrosis stage-specific cut-off values.

70 ould provide a powerful means of identifying stage-specific defects in diseases associated with patho

71 zyme that breaks down L-2HG, is required for stage-specific degradation of the L-2HG pool.

72 Stage-specific, "delayed time to" FAP-related events are

73 Using developmental stage-specific deletion of Arl13b in mouse cortical prog

74 Using stage-specific deletion of monocytic leukemia zinc finge

75 DP stage-specific deletion of the E3 ligase Cul3, or of Bcl

76 Stage-specific depletion experiments further demonstrate

77 erythrocyte attachment and invasion in vivo, stage-specific depletion uncovered roles in gamete devel

78 erns changed through the night highlighted a stage-specific difference, whereby the repertoire of suc

79 ing the cell cycle were detected, there were stage-specific differences between cell types.

80 These observations demonstrate stage-specific differences in the effect of Hh signaling

81 coneogenesis pathway in Leishmania, although stage-specific differences in their contribution to this

82 Here we show a developmental stage-specific differential expression pattern of Nfatc1

83 t regulatory mechanisms that orchestrate the stage-specific differentiation process, we developed a c

84 maps, we identify thousands of developmental stage-specific DMRs (dsDMRs) across zebrafish developmen

85 Therefore, bypassing stage-specific DNA demethylation has significant consequ

86 to quantitatively and simultaneously measure stage-specific drug effects on parasites at different de

87 Our findings classify developmental stage-specific early, middle and late meiotic transcript

88 major life stage and incorporate these into stage-specific ecological models to reveal the life stag

89 marked, dose-responsive disruptions in sleep stage-specific EEG spectral profiles compared with vehic

90 In addition, we showed a stage-specific effect of Activin in promoting keratinocy

91 FR) ligand amphiregulin acts as an important stage-specific effector of estrogen signaling.

92 mechanisms that underlie these developmental stage-specific effects are incompletely understood.

93 se motion parameters was able to distinguish stage-specific effects of environmental stressors in mos

94 hat these differing observations accrue from stage-specific effects of Hh signaling in the developing

95 aureus sepsis, we demonstrate marked disease stage-specific effects of the anticoagulant and cell sig

96 -1, and the TGF-beta peptide DAF-7 each have stage-specific effects on behavioral trajectories, imply

97 can interact with TR4 to elicit differential stage-specific effects on globin gene transcription.

98 nipostin A indicates that it exhibits growth stage-specific effects that differ from compounds that i

99 In contrast to these stage-specific effects, loss of the histone methyltransf

100 ivity, as well as the cell and developmental stage-specific effects, will need to be carefully consid

101 atal prostate and confirmed the operation of stage-specific effects.

102 ion through infection, which may explain the stage-specific efficacy of different anthelmintic drugs.

103 ze Globo H (GH) and the GH-related epitopes, stage-specific embryonic antigen 3 (SSEA3) (also called

104 elective for GH and the GH-related epitopes, stage-specific embryonic antigen 3 (SSEA3) and SSEA4, al

105 onic antigen 3 (SSEA3) (also called Gb5) and stage-specific embryonic antigen 4 (SSEA4).

106 LewisX (LeX), also known as stage-specific embryonic antigen-1 or CD15, is a defined

107 The effects of SSEA-1(+) (stage-specific embryonic antigen-1) PSCs was studied in

108 eight of 11 GBM cell lines are positive for stage-specific embryonic antigen-4 (SSEA-4), and immunoh

109 How stage-specific enhancer dynamics modulate gene expressio

110 neurons is controlled by a dynamic relay of stage-specific enhancers.

111 , at DGET a researcher can analyze tissue or stage-specific enrichment for an inputted list of genes

112 re could be employed to identify how similar stage-specific environmental sensitivity determines dist

113 These results demonstrate widespread, stage-specific epigenetic changes during myelomagenesis

114 ic transcription factors occupancy underlies stage-specific events in development, homeostasis and di

115 thologs and other pseudogenes also displayed stage-specific expression and editing in Neurospora cras

116 lgorithm that leverages both differentiation stage-specific expression data and large-scale heterogen

117 cs, CNS cell type-specific and developmental stage-specific expression libraries are rapidly enhancin

118 Our data reveal that tissue and stage-specific expression of ankyrin isoforms relies on

119 Furthermore, promyelocyte stage-specific expression of genes coding for paucimanno

120 r function by enforcing proper developmental stage-specific expression of multiple genes through chro

121 Developmental stage-specific expression of the beta-type globin genes

122 l, providing a molecular explanation for the stage-specific expression of the Lmo2-induced gene expre

123 Stage-specific expression patterns of chemotaxis-associa

124 To identify novel surface markers with stage-specific expression patterns, we explored the reac

125 me miRNAs exhibited tissue- or developmental stage-specific expression patterns.

126 onstrained linear regression to characterize stage-specific expression profiles within mixed-stage po

127 Markers with stage-specific expression were identified using a transg

128 parasite-derived cAMP in host-cell invasion, stage-specific expression, and asexual differentiation.

129 AMP in T. gondii affects host-cell invasion, stage-specific expression, and parasite differentiation.

130 role for the ENO1 3'-untranslated region in stage-specific expression.

131 reas, the remaining Rr-ctl genes showed life stage-specific expression.

132 hting how identification and manipulation of stage-specific factors that specify HSC developmental st

133 hey are mediated by combinations of core and stage-specific factors.

134 79860CC also have greater stage-constant and stage-specific fibrosis progression rates (P<0.0001 for

135 conclude that Xist spreading takes distinct stage-specific forms.

136 n Pet-1 targets uncovers a distinct neonatal stage-specific function for Pet-1, during which it promo

137 echanism of type I IFN signaling in pDCs and stage-specific function of immune cells in generating po

138 ccurs during mammary gland development and a stage-specific function of mCripto-1 signaling during ma

139 A stage-specific functional analysis revealed overrepresen

140 This stage-specific functionality arises from profound shifts

141 These results establish cell-autonomous and stage-specific functions for the small Rho GTPases Cdc42

142 genic homeostasis is ensured by differential stage-specific functions of SRF target gene products in

143 ated genes represent current and consecutive stage-specific functions, and downregulated genes repres

144 proteins are essential and to identify their stage-specific functions.

145 Stage-specific gene deletion in trophoblasts reveals tha

146 ation of the molecular players that regulate stage-specific gene expression and Pol II pausing will c

147 Stage-specific gene expression of some of these expanded

148 cteristic development cycle correlating with stage-specific gene expression profiles.

149 domain-containing protein, thereby mediating stage-specific gene expression programs and post-meiotic

150 ibute to this tightly controlled tissue- and stage-specific gene expression.

151 Here we used inducible and stage-specific gene targeting approaches to elucidate th

152 We observed acquisition of H3K27me3 on stage-specific genes during meiotic progression, indicat

153 loying two new statistical tools to identify stage-specific genes over time (SCPattern) and to recons

154 MLL4 exhibits cell-type- and differentiation-stage-specific genomic binding and is predominantly loca

155 s probably contribute to the DC maturational stage-specific glucocorticoid sensitivity.

156 The model also describes the stage specific growth of maturing oocytes within the ova

157 s AGSC biology and gametogenesis, we derived stage-specific high-resolution profiles of DNA methylati

158 ork to RUNX1-ETO expression is developmental stage specific, highlighting the molecular mechanisms de

159 We used our stage-specific hPSC differentiation method to obtain and

160 Existing data indicate that a stage-specific increase in intracellular free Ca(2+) sti

161 A stage-specific increase in the synthesis of AMG+4 was fu

162 Mov10l1(-/-) germ-cell fractions indicated a stage-specific increase of retrotransposition in the ear

163 triple-gene knockout hPSC lines, as well as stage-specific inducible gene knockout during hPSC diffe

164 bly directed into cardiomyocytes (CMs) using stage-specific induction protocols.

165 We propose that stage-specific interactions between ApiAP2 proteins on p

166 cens as a model organism, we identify here a stage-specific iron-regulatory machinery comprising a tw

167 short in vivo half-life of the drug and the stage-specific lag time and provides the framework for u

168 The secondary end point was stage-specific likelihood of receiving postoperative sys

169 Stage-specific lineage-tracing of Fgf10(+) tanycytes usi

170 equences function in vivo as a developmental stage-specific, lineage-restricted enhancer.

171 types are typically tissue and developmental stage specific, making relevant phenotypes difficult to

172 y genes that are expressed in a sex- or life stage-specific manner and characterize the transcription

173 differentiation is regulated in a cell- and stage-specific manner by complex networks of intergenic

174 sensory functional organization emerge in a stage-specific manner during sleep.

175 The LTRs function in a stage-specific manner during the oocyte-to-embryo transi

176 nitor cell (HSPC) numbers are also seen in a stage-specific manner in human MDS samples as well as in

177 ts beta-type globin genes in a developmental stage-specific manner to stimulate transcription.

178 ng the mGluR5-Erk pathway in a developmental stage-specific manner to treat TSC.

179 Only TP53 and SMAD4 mutations occurred in a stage-specific manner, confined to HGD and EAC, respecti

180 for Bcl11b expression, these inputs act in a stage-specific manner, providing a multitiered mechanism

181 to selected transcripts in a differentiation stage-specific manner, supporting the hypothesis that al

182 larval crawling behavior in a developmental stage-specific manner.

183 lase (ENO1 and ENO2) that are expressed in a stage-specific manner.

184 specify PRC1 function in both a context- and stage-specific manner.

185 murine embryonic kidneys in a developmental stage-specific manner.

186 genes that are expressed in a developmental stage-specific manner.

187 quires hypoxia-inducible factors (HIFs) in a stage-specific manner.

188 controlled in a temporal and differentiation stage-specific manner.

189 helial cells, in a tissue- and developmental stage-specific manner.

190 g structure is persistent in Plasmodium in a stage-specific manner.

191 in situ and real-time expression analyses of stage-specific markers highlighted defects of primitive

192 This approach correctly identified known stage-specific markers of cardiomyocyte differentiation,

193 Among the stage-specific markers were the cell adhesion proteins C

194 This approach affirmed the utility of known stage-specific markers, as well as identifying additiona

195 mined by expression of microRNA clusters and stage-specific markers.

196 pports B lineage cells through developmental stage-specific mechanisms.

197 The identity of stage-specific metabolic programs and their impact on ad

198 Our findings suggest that stage-specific methylation and demethylation events in C

199 n-affinity miRNA pull-down approaches reveal stage-specific miR-219 targets in oligodendrocytes and f

200 Furthermore, we found that 24 PCD stage-specific miRNAs are aberrantly overexpressed in mu

201 temporally altered, revealing estrous cycle stage-specific modifications to the hypothalamic-pituita

202 short period of time is regulated by precise stage-specific molecular mechanisms.

203 By using highly sensitive stage-specific molecular methods to detect P. falciparum

204 dult NAFLD cohort studies reporting fibrosis stage-specific mortality (0-4).

205 stage 0 as a reference population, fibrosis stage-specific mortality rate ratios (MRRs) with 95% con

206 conserved RBPs, some of which are potential stage-specific mRNA interactors that likely reflect the

207 This organization implies that tissue or stage specific networks can be best identified from inte

208 ndrocyte development and uncover a cohort of stage-specific oligodendrocyte-restricted lncRNAs, inclu

209 IFN-gamma has a disease stage-specific opposing function in EAE.

210 ion of adequately adapted parasite forms and stage-specific organelles.

211 iants that specify tissue- and developmental stage-specific organization of TFIID or SAGA complexes,

212 Stage, and stage-specific outcome (7th edition), on the test set re

213 logy, permitting the pair-rule genes to play stage-specific patterning roles.

214 ponse elements (PREs) to maintain tissue and stage-specific patterns of gene expression.

215 mus under the control of the parasite sexual stage-specific pfs16 gene promoter.

216 -BAC16, which facilitated the delineation of stage-specific phenotypes.

217 vestigation of possible correlations between stage-specific preferential trans-splicing or polyadenyl

218 ic signatures that could be used to identify stage-specific prognostic subgroups of AML.

219 These results reveal distinct developmental stage-specific programs involved in cardiac mitochondria

220 -CAP and profilin, in combination with three stage-specific promoters and mapped the phenotypes affor

221 Using developmental stage-specific promoters to express FCU-GFP enables the

222 early and late odontoblast marker genes and stage-specific proteases involved in dentin maturation.

223 e depleted for interactions among tissue- or stage- specific proteins, which instead interact primari

224 ins to which are attached various tissue- or stage-specific proteins.

225 tion for codons that are most accurate given stage-specific queuosine modification levels.

226 two distinct developmental phases, each with stage-specific rate and morphologic parameters.

227 umber of genes, with a strong preference for stage-specific rather than lineage-specific genes.

228 and in vivo approaches, we report here that stage-specific reciprocal dorso-ventral inductive intera

229 specialized mechanisms enforce lineage- and stage-specific recombination.

230 These findings reveal that stage-specific redox responses distinguish human GC B ce

231 iding possible explanations for the observed stage-specific reduction in cellular expansion.

232 a given gene and provide tissue-specific and stage-specific regulation of gene expression.

233 Thus, the lineage- and developmental stage-specific regulation of PRC2 subunit composition le

234 cus is a paradigm of cell- and developmental stage-specific regulation.

235 e subjected to region and neurodevelopmental stage-specific regulation.

236 anisms of Ca(2+) homeostasis in a network of stage-specific regulator and effector pathways now repre

237 Using Ontogenet, we found differentiation stage-specific regulators of mouse hematopoiesis and ide

238 The primary end point was stage-specific relative survival, an objective measure o

239 istinct prognostic subgroups, especially for stage-specific reporting of survival in prospective clin

240 togenesis, function to direct cell type- and stage-specific repression of translation of the core G2/

241 differentiating stimuli and were detected in stage-specific repressive protein complexes containing t

242 together, our findings define developmental-stage-specific requirements for canonical PRC2 complexes

243 e of early lethality of CXCR4(-/-) mice, and stage-specific requirements for CXCR4 in thymus colonisa

244 These data reveal stage-specific requirements for LUBAC in coordinating th

245 key downstream physiological output enabling stage-specific responses to 20E that are required to adv

246 ased approach can be used to uncover disease-stage-specific responses to drugs.

247 Stage-specific responses to pCO2 (385-6000 muatm) were s

248 at interactive scaling alters population and stage-specific responses to rising temperatures, such th

249 We aimed to quantify the fibrosis stage-specific risk of all-cause and liver-related morta

250 otivated by our genome-wide data uncovered a stage-specific role for TEAD/YAP factors in mammalian he

251 ontext of several transcription factors, the stage-specific role of GATA3 in NK cell development has

252 nogenesis and into the adult uncovered novel stage-specific roles for Mnx1 in endocrine lineage alloc

253 e-protecting DNA repair, RNR has complex and stage-specific roles in carcinogenesis.

254 stem cells but has critical and contrasting stage-specific roles in discrete hematopoietic lineages.

255 Here, we report the stage-specific roles of PRC2 epigenetic regulators in em

256 ow that, in each species, 26G siRNAs trigger stage-specific secondary siRNA formation.

257 Therefore, miR160 dictates developmental stage-specific sensitivities to auxin and cytokinin to d

258 al regulatory model in tissue and life cycle stage-specific silencing by NuRD complexes.

259 ndergo significant tissue- and developmental stage-specific size changes.

260 ages with microbiota signatures that include stage-specific species.

261 Most developmental stage-specific splicing changes affected by drought were

262 Stage-specific sub1 invalidation during prehepatocytic d

263 Congruently, stage-specific subcellular relocalization of Tfe3 sugges

264 inadequacy and excess in each sex- and life stage-specific subgroup by both the UIC cutoff method an

265 odine inadequacy and excess in sex- and life stage-specific subgroups of the US population: one that

266 f iodine inadequacy across all sex- and life stage-specific subgroups with the iodine intake cutoff m

267 We identified developmental-stage-specific super-enhancers and showed that most epig

268 This work identifies a set of novel stage-specific surface markers that can be used as a com

269 itated by the identification of lineage- and stage-specific surface markers, the continued identifica

270 ese data indicate that, during thymopoiesis, stage-specific surface translocation of TMEM131L may reg

271 sought association between plasma 25-OHD and stage-specific survival and tested for interaction betwe

272 dance probability estimate (CPE) of 0.57 for stage-specific survival.

273 lectively, these studies demonstrate a novel stage-specific susceptibility of A. fumigatus to zinc an

274 oping NK cells undergo unique, developmental stage-specific sustained and transient interactions with

275 Collectively, our findings suggest a stage-specific switch in CSC regulation during disease p

276 , conditional targeting revealed a postnatal stage-specific switch in Pet-1 targets from 5-HT synthes

277 We developed a stage-specific T cell differentiation protocol to valida

278 owever, Cdx genes and multiple Hox genes are stage-specific targets of Sp1 and are downregulated at a

279 Here we define a stage-specific Tcf7l2-regulated transcriptional circuitr

280 ollaborative interactions among OSK and with stage-specific TFs direct both somatic-enhancer inactiva

281 asite metabolism to the activation of sexual-stage-specific transcription and gametocyte formation.

282 g of their function, we mapped OSKM-binding, stage-specific transcription factors (TFs), and chromati

283 interleukin-7 and pre-BCR signaling) and the stage-specific transcription factors SpiB and Aiolos (cr

284 are governed by cell type- and developmental stage-specific transcription factors.

285 mature B cells is stringently controlled by stage-specific transcription factors.

286 and preimplantation development, we defined stage-specific transcription, which highlighted the clea

287 odulated pervasively and direct lineage- and stage-specific transcription.

288 Gene expression profiling reveals dynamic stage-specific transcriptional patterns that may link de

289 ation poise C/EBPbeta to execute diverse and stage-specific transcriptional programs by exploiting an

290 , operate repeatedly to regulate tissue- and stage-specific transcriptional responses during developm

291 Stage-specific transcriptome profiling identified differ

292 Here we sequence the genome and stage-specific transcriptomes of the dampwood termite Zo

293 bridization, real-time quantitative PCR, and stage-specific transcriptomic analyses show that brachio

294 iparum clones depends on both high levels of stage-specific transcripts and high genetic diversity of

295 Stage-specific transcripts are associated with immune de

296 Identification of photoperiod and stage-specific transcripts gives insights into the regul

297 tantial association between histone PTMs and stage-specific transition provides insights into the int

298 the genetic regulatory mechanisms underlying stage-specific transitions between self-renewing and pro

299 proposed method can be used to estimate the stage-specific transmission rates and prevalence of HIV.

300 s substrate pool in a cyclin- and cell cycle stage-specific way.