ライフサイエンスコーパス: staggered

1 end-to-end) rather than transverse (or half-staggered).

2 ayer insertion transitions are different but staggered.

3 Both eclipsed (1a) and staggered (1b) conformations are found in solution; the

4 asimir force phase transitions between these staggered 2D materials induced by the complex interplay

5 In staggered 3-month intervals, ASP teams at 3 hospitals re

6 ure demonstrates that both eclipsed (3a) and staggered (3b) allyl conformation are present.

7 RAD at 2.5 mg/kg + Neoral at 7.5 mg/kg (n=6) staggered 6 hr apart.

8 -438 are weakly correlated along c to form a staggered ABAB stacking that reduces the Coulomb repulsi

9 tive PNA-like conditions, culminating in the staggered abandonment of many major Native American rive

10 asitoid introduction, despite releases being staggered across locations in different years.

11 The second is the staggered addition of short-duration plugs of analyte to

12 efined as RV1 and OPV given on the same day; staggered administration as RV1 and OPV given >/=1 day a

13 3) Staggered administration of RAD+Neoral avoided the pharm

14 For staggered administration, we found no evidence that the

15 Myosin heads are not staggered along the length of tapered thick filaments as

16 probiotic kefir given in combination with a staggered and tapered antibiotic withdrawal regimen may

17 ic data establish that the allyl ligands are staggered and that the trimethylsilyl substituents are i

18 from tetrameric complexes of extended, half-staggered, and antiparallel oriented coiled-coils.

19 its cognate site 5'-ACGCGT-3' as a stacked, staggered, and noncovalent cooperative dimer.

20 A lattice quench is designed to convert the staggered angular momentum, previously thought by expert

21 tronger hyperconjugative interactions in the staggered anti and gauche conformers than the eclipsed s

22 gnetic resonance spectroscopy, to show how a staggered antiparallel coiled-coil 'BASS' (bipolar assem

23 whose shape and volume are consistent with a staggered antiparallel dimer.

24 (f) group bind to the minor groove of DNA as staggered, antiparallel dimers in a sequence-specific ma

25 ve at their cognate DNA sequence as stacked, staggered, antiparallel dimers.

26 The staggered appearance of primary response cytokines direc

27 ion often occurs abruptly, but a slower more staggered approach may also be used.

28 cleotide binding to two subunits, generate a staggered arrangement of ClpX subunits and pore loops ar

29 to play a major role in the formation of the staggered arrangement of collagen molecules within the m

30 Crosslinking experiments suggest a staggered arrangement of pore loops in the hexamer and n

31 ide-chains in the primary sequence and the D-staggered arrangement of the triple-helices.

32 he Col108 mini-fibrils are consistent with a staggered arrangement of triple helices having a stagger

33 lignment to a stable approximately one-third staggered arrangement.

34 ar fibres comprised of micelle subunits in a staggered arrangement.

35 tions between the triple helices in a 1-unit staggered arrangement.

36 (or platelets), and (ii) the imbricated, or staggered, arrangement of these lamellea, bound by biopo

37 nts in which the three strands are held in a staggered array by disulfide bonds.

38 BD bind to the response element in a regular staggered array having pseudodyad symmetry.

39 t consists of collagen fibrils composed of a staggered array of ultra-long tropocollagen (TC) molecul

40 four p53 moieties are placed laterally in a staggered array on the external side of the DNA loop and

41 ovalent assembly of fibrin units into a half-staggered array.

42 ntribution from microfibrils not involved in staggered arrays became more dominant.

43 Staggered arrays of collagen molecules form fibrils, whi

44 structure, the microtubules were arranged in staggered arrays, cross-linked by tau proteins.

45 The magnifications and staggered arrivals of the supernova images probe the cos

46 In addition, to direct staggered assembly of peptides and to foster fibrillogen

47 xtures) from those where odourant onsets are staggered (asynchronous mixtures) down to an onset delay

48 r the lowest-energy triplet excited state of staggered [Au(CN)(2)(-)](2) show the formation of a Au-A

49 plain the diastereoselectivity that involves staggered axial attack on the sp(2) carbon opposite to t

50 and Nb:STO heterojunction, and it exhibited staggered band alignment.

51 istinct semiconductor materials with type II staggered band offset are both in contact with one small

52 y photoemission experiments, that a type-II, staggered, band alignment of ~ 0.4 eV exists between ana

53 ructure shows open protein conformations and staggered base pair conformations, indicating that N7-me

54 omplexes adopt an open protein conformation, staggered base pair, and one active-site metal ion.

55 ilaments, consisting of tightly paired, half-staggered beta strands related by a screw axis, can be f

56 wings of Microraptor could have resembled a staggered biplane configuration during flight, where the

57 ning Pro-Hyp-Gly repeating sequences and two staggered bipyridine ligands within the peptide was synt

58 e, and then catalyse a concerted four-strand staggered break in the DNA substrates whilst forming tra

59 ike what was previously thought, most of the staggered breaks are not generated by random nicking.

60 D attacks cytosines on both DNA strands, and staggered breaks are processed to blunt DSBs at the init

61 molecules, called retroposons, integrate at staggered breaks in mammalian chromosomes.

62 g is supposed to form circular plasmids with staggered breaks, which can be repaired in Escherichia c

63 o different vectors were infused together or staggered by 1, 3, or 5 weeks, and two-color fluorescent

64 Breaks in the individual strands are staggered by 4 bp, producing a four nucleotide 5' extens

65 agen molecules, types II and III in register staggered by 4D from another type III molecule.

66 monomer adopt out-of-plane positions and are staggered by about three peptide layers ( approximately

67 ntiparallel coiled coil, with the two chains staggered by only 4 amino acids and displaying hydrophob

68 A crystal lattice comprising uniformly staggered C5H5 rings was found to be lower in energy by

69 chain and the mutation site in a neighboring staggered chain influences the disruption of the standar

70 y in PBDT[2F]T leads to more pronounced, yet staggered, chain stacking, which generally leads to high

71 Transposase made a staggered cleavage at the P-element termini that is nove

72 he 20 bp centred on the midpoint of the 4 bp staggered cleavage made by gyrase to be the 'core' and t

73 calation of the hydrocarbon at either of the staggered cleavage sites or immediately adjacent to the

74 Staggered cleavages occur at both ends of the transposon

75 We identified a pair of transient staggered cleavages six base-pairs apart centered around

76 R repertoire is progressively diversified by staggered clonotypic expansion, according to functional

77 nded porous graphitic layers that are either staggered (COF-1, P6(3)/mmc) or eclipsed (COF-5, P6/mmm)

78 In the crystal, 1 forms staggered cofacial dimers (centroid distance of 3.38 A).

79 sites are closely aligned within the quarter-staggered collagen fibril, suggesting a multivalent inte

80 evels did not differ between monotherapy and staggered combination therapy for RAD but were lower for

81 Simultaneous or staggered combined treatment dramatically reduced histol

82 We observe that staggered commutation enables time-reversal symmetry bre

83 sive non-reciprocity based on the concept of staggered commutation.

84 have a high-spin (S = 2) ground state in the staggered configuration (180 degrees rotation angle).

85 TP analogs not pairing with but instead in a staggered configuration relative to 1,N(6)-dA in the ant

86 e six Au(2)(SR)(3) staples are arranged in a staggered configuration, and the Au(38)S(24) framework h

87 nal porous layers that are likely stacked in staggered conformation (hxl topology).

88 emonstrate that the two p53 dimers favored a staggered conformation in which they make favorable inte

89 P-driven proton pumping, indicating that the staggered conformation is compatible with normal enzymat

90 fferent interactions indicates that ethane's staggered conformation is the result of preferential sta

91 rotator at a geometry that destabilizes the staggered conformation of the rotator through van der Wa

92 onverts to the thermodynamically more stable staggered conformation when heated above 85 degrees C.

93 The epsilon C.dA alignment adopts a staggered conformation with each residue displaced towar

94 The molecules adopt the staggered conformation with the tertiary fluorine in the

95 s of cyclic alcohols intrinsically prefers a staggered conformation, although the eclipsed conformati

96 eral, methyl groups pack well in the default staggered conformation, except for the terminal methyl g

97 ate that [1-(t-Bu)C(9)H(6)](2)Cr exists in a staggered conformation, with Cr-C (av) = 2.32(4) A.

98 t, have no influence on the preference for a staggered conformation.

99 able eclipsed conformation and the preferred staggered conformation.

100 e-chains of residues adopt several specific, staggered conformations, known as rotamers within protei

101 provides the products in their lower energy staggered conformations.

102 on leads to the formation of polymers with a staggered contoured spiral structure.

103 Staggered coupling of the two opposing hexamers position

104 nd in light of the apparently well-conserved staggered cross-heme wire structural motif in functional

105 However, the orientation of the staggered cross-link can have a significant effect on th

106 ar models suggest that formation of the -GC- staggered cross-link disrupts hydrogen bonding and may a

107 stability of the duplex that contains a -GC- staggered cross-link is 10 degrees C lower than the melt

108 Unlike the -CG- staggered cross-link, in which the cross-linked base pai

109 is seen with the duplex that contains a -CG- staggered cross-link.

110 Mismatched C-C or -CG- staggered cross-linked duplexes that have complementary

111 t just one of the two sites and results in a staggered cut 25-26 nt downstream of the top strand sequ

112 hromosome fragmentation that involves a 6 bp staggered cut in the chromosome.

113 Finally, we discuss how the staggered-cut palindromic target site model can be used

114 lanogaster genome to test predictions of the staggered-cut palindromic target site model for DNA tran

115 tes indicates that DNA transposons recognize staggered-cut palindromic target site motifs (TSMs).

116 We show that IntN1 makes 7 bp staggered cuts on the top and bottom strands.

117 Excision of CTnDOT involves staggered cuts that produce 5 bp chromosomal sequences a

118 Previously we showed that IntN1 makes 7-bp staggered cuts within the NBU1 att sites, and certain mi

119 mes, and this resulted in small, overlapping staggered deletions in this region among the different c

120 In anti-T coimmunoprecipitation experiments, staggered deletions spanning the amino-terminal 250 amin

121 A staggered delivery scheme of the two agents (TMRE inject

122 The staggered delivery strategy was evaluated under both nor

123 From the average EH values for staggered dimers and trimers, the excited-state Au-Au an

124 he hydride and a -CH2CH2O(t)Bu ligand with a staggered disposition.

125 ed and provide evidence supporting a role in staggered DNA double-strand break repair.

126 ds, respectively, and for jointly generating staggered DNA double-strand breaks.

127 Moreover, Cpf1 cleaves DNA via a staggered DNA double-stranded break.

128 it ('/' denotes the cleavage site) producing staggered DNA ends.

129 ed annealing and extension steps to generate staggered DNA fragments and promote crossover events alo

130 n metallic strip with periodic subwavelength staggered double groove arrays supported by a flexible d

131 The break appears to be a staggered double-strand break consistent with an error i

132 (single-strand nicks at Mu ends, joined to a staggered double-strand break in the target), the flanki

133 repeats, suggesting an origin via repair of staggered double-strand breaks.

134 ner than those predicted by the classic half-staggered, double-stranded mechanism, must quickly form.

135 Electrokinetic effects drive the assembly of staggered doublets and triplets of nanorods that are mov

136 es and indicates that most repair events for staggered DSBs, at least in barley, involve the sister c

137 e tetrahydrofuran residues in the (AP)(2)-5'-staggered duplex contrasts with their smooth alignment a

138 e sugar-phosphate backbone in the (AP)(2)-3'-staggered duplex.

139 Waals repulsive interactions and reduces the staggered/eclipsed relative energy difference.

140 A-damaging chemotherapy, we report that time-staggered EGFR inhibition, but not simultaneous coadmini

141 ible dielectric substrate, leading to unique staggered EM coupling and waveguiding phenomenon.

142 ersial whether Cas9 generates blunt-ended or staggered-ended breaks with overhangs in the DNA.

143 , suggesting that exoribonucleases generated staggered ends in the absence of specific Mini-III-catal

144 at Cas9-catalyzed DNA cleavage produces 1-bp staggered ends rather than generally assumed blunt ends.

145 ear nuclease-hypersensitive duplex and leave staggered ends with 5-nucleotide-long 3'-extensions.

146 '-R on each strand to produce four-base (5') staggered ends.

147 the date of seroconversion and incorporating staggered entries into each period were used.

148 Survival analysis with staggered entry was used to evaluate the effect of HAART

149 2011-2012 was the result of >/=6 temporally staggered events, spanning from 1 reactivation case to a

150 The staggered extension process (StEP) consists of priming t

151 The staggered extension process (StEP) is essentially a modi

152 rounds of evolution using DNA shuffling and staggered extension process (StEP) resulted in modest im

153 R reaction and further diversified through a staggered extension process.

154 s the result of sampling error or temporally staggered extinctions is unclear.

155 metry: Multiple Hox genes are expressed in a staggered fashion along its primary body axis, and the t

156 g Critical Care implementation occurred in a staggered fashion between October 2011 and November 2012

157 perpendicular to the flow direction and in a staggered fashion in the 450-pL mixing chamber to enhanc

158 and it promotes the molecules to stack in a staggered fashion thereby pairing itself with either a p

159 on strategies implemented prospectively in a staggered fashion.

160 mass spectrometry (LC/MS/MS), and eight-way staggered flow injection MS/MS following 384-well plate

161 joining, a substrate containing a model of a staggered free radical-mediated double-strand break, wit

162 e-series microbial RNA-Seq analyses revealed staggered functional responses to diet shifts throughout

163 leghemoglobin is established by a favorable staggered geometry of the proximal histidine.

164 ectrometry (MUX-LC/MS/MS), four-way parallel staggered gradient liquid chromatography tandem mass spe

165 it utilizes a finite-difference method on a staggered grid to solve for the acoustic eigenmodes (fie

166 /-5 and 638+/-106 ng/ml; P<0.04) than in the staggered group (28+/-3 and 318+/-25 ng/ml) in which all

167 RAD and CsA day-14 trough levels in the staggered group were the same or lower than trough level

168 %-54%) than those who received both vaccines staggered >/=1 day (63%; 57%-70%; P < .001).

169 Here, we report our observations of multiple staggered helical structures of two canonical coiled coi

170 changes in the helical registry that lead to staggered helices have only been proposed for a few spec

171 usual heptad register shift between adjacent staggered helices.

172 f this 'desensitization ring' is mediated by staggered helix contacts between adjacent subunits, whic

173 study we examine the experimental use of the staggered herringbone mixer (SHM) for the signal enhance

174 In this study we examine the use of the staggered herringbone mixer (SHM) to increase the effici

175 annels (called reactor I) and the other with staggered herringbone mixers (called reactor II), were s

176 onfigurations, including the slanted groove, staggered herringbone, and herringbone mixers.

177 e and flanking ion-pairs were used to direct staggered heterodimers.

178 The crystal structure reveals a staggered hula-hoop geometry.

179 dule combining 2 distinct vaccine types in a staggered immunization regimen: one inducing high-titer

180 witch from proliferation to meiotic entry is staggered in late-larval and adult germlines.

181 proposed in which fibrillin-1 molecules are staggered in microfibrils.

182 The ends of the two protofilaments are staggered in relation to each other, suggesting that cap

183 reo-(tBu3SiO)3HTaCHDCHDOEt (2-CHDCHDOEt) are staggered in solution, according to (1)H NMR spectroscop

184 tioned on opposite strands of the duplex and staggered in the 3' (-1 duplex, (AP) 2-1 duplex) or 5' (

185 In the first duplex, the AP residues are staggered in the 3' orientation [-3 duplex, (AP)(2)-3 du

186 le in the second duplex, the AP residues are staggered in the 5' orientation [+3 duplex, (AP)(2)+3 du

187 est that SL RNA transcription termination is staggered in the T tract and is followed by nucleolytic

188 ly detectable in the brain of mice given two staggered injections of LPS.

189 on the non-complementary strand, leading to staggered instead of blunt DNA breaks.

190 Staggered interruption, whereby nucleos(t)ide reverse tr

191 All mustards selectively formed two base-staggered interstrand crosslinks between the 5'G and the

192 s of a -CG- or -GC- step are linked to give "staggered" interstrand cross-links were prepared using a

193 The two ring-shaped hexamers are staggered, leading to a kinked axial channel.

194 A superior fit is obtained with D-staggered left-handed microfibril structures.

195 hat it is associated with bypasses involving staggered lengths of untranslated information.

196 The conjugate forms a staggered linear oligomer that differs substantially fro

197 In the solid state, 1 and 2 exist in the staggered, linear conformation, stacked head-to-tail, wi

198 magnetic monopole crystal is stabilized by a staggered magnetic field in the pyrochlore iridate Ho2Ir

199 poles in a spin ice at equilibrium through a staggered magnetic field.

200 hase, the interaction dominates and produces staggered magnetic ordering.

201 The staggered magnetization of the 5 nm thick CuMnAs layer i

202 of a peak in the spin structure factor and a staggered magnetization that is close to the ground-stat

203 hiopods), and Dfd (in both brachiopods) show staggered mesodermal expression.

204 es and analyses of isolated Ca2+-containing, staggered microfibrillar arrays were used to interpret t

205 The ligands bind in a staggered mode with respect to one another creating a si

206 us providing further support for the quarter-staggered model of collagen fibril axial structure.

207 ddle of the sequence appears to mediate this staggered molecular packing through its indirect water-m

208 he distances between the C3 centroids of the staggered monomers are at the short end of those normall

209 es to bind in the minor groove of DNA in the staggered motif, and it also increases the binding affin

210 inding of polyamides to DNA in a stacked and staggered motif.

211 These staggered multispecies waves of diel gene transcription

212 s spillover excitation generates patterns of staggered neurotransmitter release from different MNTB a

213 Staggered nicks are introduced at cosN to generate the c

214 mediator of the breakage, processing of the staggered nicks induced by DNA topoisomerase II, includi

215 The cleavage reaction introduces staggered nicks into the downstream cosN to generate the

216 packaging enzyme of phage lambda, introduces staggered nicks into viral concatemeric DNA to initiate

217 tion mechanism by making a pair of transient staggered nicks invariably at 6-bp spacing as the reacti

218 virus chromosome where terminase introduces staggered nicks to cut the concatemer to generate unit-l

219 u polymerase generating a plasmid containing staggered nicks.

220 th each strand being interrupted by inherent staggered nicks.

221 tinct conformations, either eclipsed (1a) or staggered-off (1b).

222 (C-H) bonds determines the preference of the staggered or eclipsed structure as the energy minimum st

223 nteractions that constrain the subunits to a staggered or out-of-phase mode of operation.

224 e of a spectacular ultracold superfluid with staggered orbital currents in optical lattices.

225 dimers are arranged in an anti-parallel and staggered orientation at this site.

226 In contrast, the staggered orientation of the proximal histidine found in

227 C2 can populate two distinct orientations: a staggered (out-of-register) fibril and an aligned (in-re

228 owed up until death or the end of the study (staggered over 2001-06) by use of direct or proxy interv

229 tial colonization of different haplotypes is staggered over time and when a barrier to colonization i

230 ent of the photosynthetic protein complexes, staggered over two tightly stacked planes.

231 odels and left- and right-handed models with staggered packing in the coiled-coil domains.

232 anded dimeric coiled-coil and whether or not staggered pairing between nonhomologous residues in the

233 e RstR footprints exhibited a characteristic staggered pattern of DNase I-accessible regions that sug

234 Staggered patterns of withdrawal of life-support therapy

235 lanced state via heterozygote advantage (the staggered phase), and (iii) finally, if recombination un

236 pological band structure originates from the staggered phases of sp orbital tunnelling, requiring nei

237 endent joining of the recessed viral ends to staggered phosphates in a target DNA.

238 Staggered plantings indicated that interactions likely o

239 broadband coplanar waveguide (CPW) to planar staggered plasmonic waveguide (PSPW) transitions are des

240 des at subwavelength scale enabled by planar staggered plasmonic waveguides (PSPWs).

241 ) pyrimidinone photoadduct in each strand at staggered positions 28 base pairs apart.

242 ctrostatic and hydrogen bond interactions at staggered positions along the linear assembly.

243 ed plasmids in which each strand carried, at staggered positions, a single thymine-thymine pyrimidine

244 etries using molds with rectangular internal staggered posts (mesh, ME), without posts (plain sheet,

245 For peristaltic motor patterns, the staggered premotor temporal pattern determines the phase

246 Regeneration was found to be a staggered process, with only 25% of axons crossing the r

247 erogeneous populations of non-productive and staggered productive intermediates arise at different re

248 anscriptionally active nuclear extracts show staggered products in the T tract, directed by eight or

249 the growing season resulted in a gap in the staggered progression of flowering and fruiting in the c

250 tituted vertices of 9 strongly interact in a staggered propellane-like fashion.

251 miner-blind study comparing the effects of a staggered prophylaxis on gingivitis was then conducted,

252 However, this "staggered regeneration" can be temporally compressed by

253 C and Tb'A90C, indicating the existence of a staggered relationship between helices of the two chimer

254 r, the M3 segments from the two subunits are staggered relative to each other in the vertical axis of

255 Individual neurons had transient activation staggered relative to one another in time, forming a seq

256 The formation of collagen fibrils from staggered repeats of individual molecules has become "ac

257 oser than in canonical coiled coils, and are staggered, resulting in a bend.

258 Intriguingly, in this process, the staggered riboflavin dimers do not interact in ground an

259 of rotational substeps, and that stalks form staggered, right-handed coiled coils, are investigated h

260 ization exhibited a spatially and temporally staggered sequence leading to the adult pattern.

261 oreover, C2c1-mediated cleavage results in a staggered seven-nucleotide break of target DNA.

262 e molecular packing is speculated to be by a staggered sheet or microfibril arrangement.

263 nvolve the two FPH-1 molecules in a slightly staggered, side-by-side, and antiparallel arrangement su

264 o an A/T rich sequence of 6 bp in a slightly staggered, side-by-side, and antiparallel arrangement.

265 recently proposed mechanism of inversion via staggered single-strand breaks as well as ectopic recomb

266 the attachment of each element 3' DNA end to staggered sites in the host DNA by element-encoded integ

267 es which were assumed to define the putative staggered sites of cleavage.

268 f a hexagonal lattice, such a state supports staggered spin loop currents in real space.

269 The staggered spin-orbit order spontaneously breaks rotation

270 wo heterocycles at the C-terminal and (ii) a staggered stacking mode in which the N-terminal heterocy

271 mamido polyamides bind preferentially in the staggered stacking mode, while the unsubstituted analogu

272 positional isomer of the recently reported "staggered" stannyl-ligated counterpart [Ge18Pd3{Sn(i)Pr3

273 was for 3 months (13 weeks) per center, with staggered start dates to account for seasonal variation.

274 g with MMS for 35 weeks at each center, with staggered start times.

275 The staggered states occur less than 2% of the time and abou

276 a coupled fashion as against the traditional staggered stick-slip motion.

277 We found that the preference of the staggered structure over the eclipsed structure of BH(3)

278 Stabilization of the staggered structure through rotation-induced weakening o

279 e favorable, because it will experience only staggered substituents.

280 ltered and results in what we have termed a "staggered sweep." It is named for its three-phased traje

281 explains and predicts the annually repeated, staggered, synchronous and bimodal flowering of many tre

282 orm to probe Dirac-like physics in honeycomb staggered systems in such a ubiquitous interaction.

283 ame time organize into laminar patterns with staggered terminations that stack along the septo-tempor

284 s by providing subjects a prophylaxis at two staggered time points.

285 ates, which are believed to be linked to the staggered titration of key acidic residues.

286 The change from a staggered to a gauche indenyl orientation lowers the sym

287 ed by Ras via a conformational change from a staggered to an eclipsed position of the nonbridging oxy

288 ii) intercalation immediately outside of the staggered Top2 cleavage site, and to a lesser extent in

289 ic positions in a duplex sequence containing staggered Top2 cleavage sites on both strands.

290 ed by subtle energetic differences between a staggered transition state with less torsional strain an

291 hin the bilayer because they assemble into a staggered transmembrane beta-sheet.

292 cyclosporin was 143+/-13 and for RAD 38+/-3.Staggered treatment completely prevented rejection in fo

293 The strategy depends on the formation of a staggered triple helical species facilitated by intercha

294 ental change resulted in a major, temporally staggered turnover event that profoundly reorganized mar

295 an extended conformation most likely with a staggered versus stacked alignment.

296 ive immune responses, respectively, arise in staggered waves of development from distinct progenitors

297 intensity, are illusory when sarcomeres are staggered with respect to one another.

298 es of the two hexagonal layers are partially staggered, with one hexagonal layer rotated by about 16

299 teau with rA8; another proposed a so-called 'staggered zipper' model in which oligo(rA) strands overl