ライフサイエンスコーパス: stalk

1 hest levels of expression in the nasal optic stalk.

2 P0, to form a structure termed the ribosomal stalk.

3 and Stx2A1 for the ribosome, but not for the stalk.

4 nd unique asparagine-dependent super-helical stalk.

5 hat constitutes the start of the coiled-coil stalk.

6 n extend motile filopodia from their primary stalk.

7 connects the motor domain to its coiled-coil stalk.

8 s typically recognize epitopes within the HA stalk.

9 accumulation and fibre synthesis within the stalk.

10 ranching regulator TEOSINTE BRANCHED1 in the stalk.

11 domain within the attachment protein helical stalk.

12 central rotor stalk and a peripheral stator stalk.

13 linker (NL), which connects the heads to the stalk.

14 f the rhabdomeres, mainly at the rhabdomeral stalk.

15 rely consumed in the rotation of the central stalk.

16 e generation step and rotation of the center stalk.

17 ntain persistent spores on top of a cellular stalk.

18 the rings through bending and hinging of the stalk.

19 he membrane domain by peripheral and central stalks.

20 domains are linked by central and peripheral stalks.

21 robial growth compared to soils amended with stalks.

22 omography and sub-tomogram averaging of cell stalks.

23 es, on the tissue microstructure of mushroom stalks.

24 developing germarium is shaped by the basal stalk, a stack of cells formed by cell intercalation.

25 Whether this rule applies only to anti-stalk Abs or is applicable to any broadly neutralizing A

26 tive positions of the central and peripheral stalks affects c-subunit stepping efficiency.

27 The Dictyostelium stalk always forms at the organizing tip, by a mechanism

28 high concentrations of sucrose in its mature stalk and a considerable portion of carbohydrate metabol

29 and F1 complexes connect via a central rotor stalk and a peripheral stator stalk.

30 the conformational states of the peripheral stalk and assigned flexible regions in the enzyme.

31 osure also changes the interface between the stalk and buttress coiled-coil extensions of the motor d

32 in the F1 domain, and, together, the central stalk and c-ring form the enzyme's rotor.

33 In addition, using IAV without the stalk and catalytic domains of NA as a live attenuated v

34 e Drp1 polymers assemble exclusively through stalk and G-domain dimerizations, which generates an exp

35 extracellular portion of CD23, including the stalk and head domain; 1 variant was identical with the

36 s and non-neutralizing Abs, against both the stalk and head domains.

37 eraction between NiV G and F, where both the stalk and head regions of NiV G interact with F.

38 e part of a structure known as the ribosomal stalk and help orchestrate the elongation phase of trans

39 Mechanical compliances of the stalk and hinge determined based on a 3.3-mus molecular

40 pression upregulated in the Foxg1(-/-) optic stalk and hypothesized that, similar to what is observed

41 elop into a fruiting body that consists of a stalk and spores.

42 s an additional brace between the peripheral stalk and subunit a.

43 und that the morphology of the optic cup and stalk and the closure of the optic fissure were substant

44 ein complexes, such as the flagellum and the stalk and the correct positioning of regulatory proteins

45 molecular dynamics studies suggest that the stalk and the first extracellular loop have critical rol

46 correlated motions among the handle, the L1 stalk and the small subunit in the rotated and non-rotat

47 le is formed by the strongly reflexed cupule stalk and two lateral flaps that partially enclose an er

48 nt ovaries, leading to abnormally wide basal stalks and consequently wide germaria with side-by-side

49 q and metabolite profiling were performed on stalks and leaves.

50 omer consisting of a transmembrane region, a stalk, and a globular head with sialidase activity.

51 es with amino acids (38KQ) deleted in the NA stalk, and changing the amino acid at position 431 from

52 tem cell (FSC) progeny adopt distinct polar, stalk, and main body cell fates.

53 the catalytic alpha3beta3-domain, peripheral stalk, and, in the membrane domain, subunit a and associ

54 extravasated from limbal vessels, angiogenic stalks, and growing tip vessels and migrated toward the

55 Mean stalk angles depend on the separation between their stal

56 lizing antibody titers but not hemagglutinin stalk antibody titers were lower in progestin-treated mi

57 ture agrees quantitatively with experimental stalk architecture.

58 ceptor binding head group stabilizes the 4HB stalk as part of the general mechanism to fine-tune F-ac

59 served in the center of the first epithelial stalk at early-stage embryonic day 12.5 (E12.5) accordin

60 ow the RPE reference plane and the choroidal stalks at 80.4 (24.4) mum below RPE reference plane.

61 kdown of RPL12, a component of the ribosomal stalk, attenuated the translational elongation rate, it

62 eceptors lacking the entire NT including the stalk (B1- and G1-SL, with "SL" indicating "stalkless").

63 ommunity diversity and both habitat area and stalked barnacle (Lepas spp.) abundance.

64 describe the larval adhesive systems in the stalked barnacle, Octolasmis angulata and the findings d

65 Bathymodiolus marisindicus, and Neolepas sp. stalked barnacle.

66 the past few decades, little is known about stalked barnacles.

67 alk, with the micropyle oriented towards the stalk base.

68 sessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets against aerosol-tr

69 axis that bifurcates, with each fork (cupule stalk) bearing a cupule near the tip.

70 and enhanced induction in the presence of HA stalk-binding antibodies in an additive manner.

71 c compounds (WSOCs) were extracted from corn stalk biochar produced at increasing pyrolysis temperatu

72 To compare the defense responses between stalk borer feeding and exogenous MeJA on a transcriptio

73 analysis of growth and morphogenesis in the stalked budding alphaproteobacterium Hyphomonas neptuniu

74 duced antibodies specific to the HA head and stalk, but only HA stalk-specific antibodies mediated AD

75 atter remained in identifiable Fe containing stalks, but carbon was also present in additional pools,

76 The stalk-less dgca- mutant regained its stalk by expression of a light-activated adenylate cycla

77 fied and characterized a region in the NiV-G stalk C-terminal domain that links receptor binding to f

78 In the present study, we identified a NiV-G stalk C-terminal region (amino acids 159 to 163) that is

79 Surprisingly, a formed fusion stalk can be both attracted (i.e., stalkophilic) and rep

80 is the existence in its central region of a stalk capable of connecting capsid and membrane across t

81 ulation of tanycytes within the infundibular stalk/caudal median eminence, termed here gamma tanycyte

82 loss of genes implicated in coordinating tip/stalk cell behaviors, including flt4 and, at later stage

83 cess pFC cell differentiation toward a polar/stalk cell fate through suppressing Hedgehog pathway act

84 PKA and Notch independently regulate tip and stalk cell formation and behavior.

85 g late onset blockage near the terminal cell-stalk cell junction and the ectopic extension of autocel

86 erminal cells being rapidly invaded by their stalk cell neighbor.

87 contribution of tip cell migration rate and stalk cell proliferation rate on the formation of new va

88 ective inactivation of CtrA in the incipient stalked cell compartment.

89 eins are essential for the transition from a stalked cell to a predivisional cell.

90 the preceding stage of the cell cycle (the "stalked" cell), DivL is localized uniformly along the ce

91 the developmental regulator SpmX to the old (stalked) cell pole during the G1-->S transition.

92 inhibition of Alk1 and Alk5, thereby driving stalk-cell behaviour.

93 of neuropilin-1 (Nrp1), which suppresses the stalk-cell phenotype by limiting Smad2/3 activation thro

94 rvation to form a fruiting body made of dead stalk cells and reproductive spores, a process that has

95 ly heterogeneous) fruiting body made of dead stalk cells and spores.

96 thelial cell (EC) specification into tip and stalk cells during angiogenesis.

97 Notch activation in stalk cells leads to proliferation arrest via an unknown

98 ation of new branching vessels; the trailing stalk cells proliferate to develop the vessel.

99 ctivation to render and maintain endothelial stalk cells quiescent.

100 f vascular endothelial growth factor (VEGF), stalk cells, which proliferate and extend the vessels, a

101 nteraction behavior exhibited by the tip and stalk cells.

102 ins (cHA) with intragroup or intergroup head/stalk combinations was generated.

103 The reconstituted pentameric human stalk complex had higher affinity for RTA than the P1-P2

104 The eukaryotic P-stalk contains two P1-P2 protein dimers with a conserved

105 M10 constructs showed that membrane-proximal stalk, cysteine-rich, and disintegrin domains of ADAM10

106 rential TspanC8 binding requirements for the stalk, cysteine-rich, and disintegrin domains.

107 of certain pathways downstream of aGPCRs is stalk-dependent, whereas signaling to other pathways is

108 Here, we show that the stalk domain ((129)KEHPQLGAGTVLLLR(143)) of NKp30 is ver

109 ese findings demonstrate that the HA protein stalk domain can undergo limited drift under immune pres

110 ing antibodies which target the conserved HA stalk domain has become a promising "universal" influenz

111 ntibodies that target the hemagglutinin (HA) stalk domain has renewed hope that the development of "u

112 utational analysis of Vps1 in a helix of the stalk domain identifies a mutant RR457-458EE that binds

113 bodies specific for the influenza HA protein stalk domain is being pursued as a universal strategy ag

114 the importance of specific mutations in the stalk domain is unknown.

115 active antibodies that bind to the conserved stalk domain of influenza B virus hemagglutinin.

116 Therefore, 66Y in the stalk domain of N1 NA was critical for the stability of

117 design of immunogens based on the conserved stalk domain of the influenza virus hemagglutinin.

118 iruses encoding amino acid changes in the HA stalk domain replicated well in vitro, and viruses incor

119 We analyzed human H1 HA head and stalk domain sequences and found substantial variability

120 09 immune subjects and mAbs specific for the stalk domain, viruses were selected in vitro containing

121 also had the unique Y66D substitution in the stalk domain, where 66Y was highly conserved in N1 NAs.

122 s priming effect, we compared H7 HA head and stalk domain-specific B-cell responses in H7N7 LAIV-prim

123 lement in the alpha2(S) helix of the dynamin stalk domain.

124 show autoinhibitory, intermolecular "head-to-stalk" (domain 1 to domain 4-5) interactions, which are

125 ase, with intact F1-catalytic and peripheral stalk domains and the supernumerary subunits e, f, and g

126 domains from exotic influenza A viruses and stalk domains from influenza B viruses.

127 Surprisingly, the stalk domains of NKp30 and NKp46, another NCR employing

128 ent of humoral immunity directed against the stalk domains of the viral hemagglutinin (HA) show promi

129 s in the G receptor binding and F-activating stalk domains, providing insights into the pathway of re

130 s identified unique epitopes on the head and stalk domains.

131 highly bent structural fusion intermediate (stalk) during AP biogenesis and add to the growing body

132 rmed an RNA-seq screen, identifying tip- and stalk-enriched gene sets in the developing collecting du

133 imilarly to wild-type viruses and maintained stalk epitopes, which indicated their potential as vacci

134 ized for growth kinetics and preservation of stalk epitopes.

135 images of hemifusion diaphragms that form as stalks expand and propose a model describing how the fus

136 show that fragment formwation is limited by stalk expansion, a key intermediate of the lipid bilayer

137 al alpha-helical structure to the peripheral stalk, extending from near the top of the enzyme's catal

138 ort neurological remains associated with the stalked eyes and "anterior sclerite" in the (middle Camb

139 ry change as a result of conflict over spore-stalk fate.

140 eased production of Delta, stabilize tip and stalk fates and limit the existence of hybrid tip/stalk

141 vity strongly biases cells towards polar and stalk fates.

142 Stalked fauna are also abundant on the hard substrates o

143 le functional modules (e.g., biosynthesis of stalk, flagellum, or chemotaxis machinery) have consiste

144 These results explain why stalk formation in Dictyostelia always initiates at the

145 ing of a hydrophobic fissure in bilayers for stalk formation, splay within the expanding hemifusion d

146 east energy pathway of membrane fusion, from stalk formation, to pore creation, and through fusion po

147 zed by diguanylate cyclase A (DgcA), induces stalk formation.

148 ors comprising a minor tip adhesin and major stalk-forming subunit.

149 n the enrichment of both, sheath-forming and stalk-forming Zetaproteobacteria.

150 structures of the original spouting vessels (stalks) from the choroid, polypoidal structures, and BVN

151 actually glycosylated (G2 to G7); one in the stalk (G2) and five in the globular head domain (G3 to G

152 rmation of OM-bearing, biogenic ferrihydrite stalks (Gallionella ferruginea-like), which formed follo

153 vation bypassed the c-di-GMP requirement for stalk gene expression.

154 ase (PKA) activity in prestalk cells reduced stalk gene induction by c-di-GMP, whereas PKA activation

155 d cAMP synthesis as well as c-di-GMP-induced stalk gene transcription.

156 ressed ACA, which then acts on PKA to induce stalk genes.

157 B73 is a founder of the Stiff Stalk germplasm pool, while PH207 is a founder of Iodent

158 hairs and five size classes of multicellular stalked glands (or tentacles) with an apical pore.

159 conformation of the HN 4-helix bundle (4HB) stalk have not been studied.

160 we localize flexible hinge points within the stalk helices.

161 as large as approximately 35 degrees at the stalk helix.

162 s including transient fusion, formation of a stalk, hemifusion and the completion of a fusion pore.

163 Hemagglutinin stalk-immunized ferrets had lower viral titers and delay

164 consists of an initial small movement of its stalk in a lateral direction when ADP is released and a

165 The wide basal stalk in Pak mutants enables the formation of extra FSC

166 ing of 12 c-subunits attached to the central stalk in the F1 domain, and, together, the central stalk

167 dent, whereas signaling to other pathways is stalk-independent.

168 They consist on stalks, inflorescences, and leaves, blanched and non-bla

169 toplasmic domains via intermolecular head-to-stalk interactions and supporting dimerization-based Plx

170 omotion of a very short-lived (<50 ms) lipid stalk intermediate is the main factor that favors rapid

171 rable to the energy required to form a lipid stalk intermediate.

172 ly in the storage parenchyma of the maturing stalk internode.

173 he E site of the ribosome and pulling the L1 stalk into a closed position.

174 antibody by first introducing a coiled-coil "stalk" into CDR3H of the antibody herceptin.

175 Pase, the mechanical property of the central stalk is a key determinant of the rate of ATP turnover.

176 n this rotary ATPase subtype, the peripheral stalk is resolved over its entire length of the complex,

177 By translating this unique "stalk-knob" architecture to the humanized antibody trast

178 bovine antibody BLV1H12 folds into a novel "stalk-knob" structural motif and has been exploited to g

179 immunosuppressive antibody based on a novel "stalk-knob" structural motif in the ultralong complement

180 accumulating DNER labeling at the dendritic stalk, labeling that becomes progressively conspicuous b

181 The stalk-less dgca- mutant regained its stalk by expression

182 iffusion due to the additional drag from the stalk-like connection between the two membranes.

183 that, in this species, buds originate from a stalk-like extension of the mother cell whose terminal s

184 PIV5-EGFP viruses with mutations in the head-stalk linker region of HN.

185 Biogenic stalks lost approximately 30% of their initial organic c

186 ly neutralizing anti-hemagglutinin (anti-HA) stalk mAbs require Fc-FcgammaR interactions to mediate i

187 e six chromosomal regions from the Non-Stiff Stalk maize inbred W22 from a single DNA sequence datase

188 atenin target molecules in the optic cup and stalk may underlie the molecular and morphological defec

189 e F-triggering, a notion consistent with the stalk-mediated activation model of paramyxovirus fusion.

190 obtained strong evidence in favor of the HN stalk-mediated activation of paramyxovirus fusion.

191 ifies an unexpected chemodominance of the HA stalk microdomain for small-molecule inhibitors in IAV i

192 ke mechanism, and instead support a flexible stalk model in which interhead strain rotates the rings

193 of DeltaF508-CFTR suggest that the ribosomal stalk modulates the folding efficiency of the mutant and

194 , or CDR3L of Herceptin using an engineered "stalk" motif.

195 tural analysis to localize the origins of L1 stalk movement and to understand its dynamic interaction

196 s stacking interactions with the tRNA elbow, stalk movement is directly linked to intersubunit rotati

197 vitro, and viruses incorporating two of the stalk mutations retained pathogenicity in vivo.

198 a mutation eliminating the membrane-proximal stalk N-glycan with a membrane-distal change in HA1 or H

199 cMed binds Pol II around the Rpb4-Rpb7 stalk near the carboxy-terminal domain (CTD).

200 n such a case, location of the highly curved stalk near the less-ordered and thus (relatively) softer

201 a surprising enhancement in IgA-mediated HA stalk neutralization relative to that achieved by antibo

202 is attached to a membrane-anchored flexible stalk of approximately 80 residues and has three activit

203 confer immunity, namely, that the invariant stalk of cHA antigens is superior to full-length HA anti

204 upregulated expression of Wnt8b in the optic stalk of Foxg1(-/-) mutants before OF closure initiates.

205 ed information on the geometry of the fusion stalk of fully fused membranes is obtained by studying t

206 Abs that bind the highly conserved stem or stalk of HA can be elicited by vaccination in humans and

207 ADCC-mediating antibodies directed to the HA stalk of IBV contribute to cross-protective immunity to

208 of head and neck linker of Cin8 fused to the stalk of kinesin-1.

209 ve, high-affinity IgGs against the conserved stalk of the HA.

210 The L1 stalk of the large ribosomal subunit undergoes large-sca

211 the c-ring of one monomer to the peripheral stalk of the other.

212 head and its junction with the alpha-helical stalk of the prefusion protein.

213 th contrasting nutritional quality (leaf vs. stalk of Zea mays L.).

214 brooding clutches of eggs that were laid on stalks of dead sponges attached to nodules at depths exc

215 Ns in 26 eyes (55.3%, 26 tufts of BVNs), and stalks of origin from the choroid in 26 eyes (55.3%, 26

216 By modifying the beta-strand "stalk" of BLV1H12 with sequences derived from natural or

217 body (hMAb) targeting the hemagglutinin (HA) stalk offers a promising approach to control influenza v

218 rigin from the choroid in 26 eyes (55.3%, 26 stalks) on the en face plane on OCTA.

219 hanical properties of their slender emergent stalks or leaves.

220 across the retina, exit the eye to the optic stalk (OS), and cross the diencephalon midline at the op

221 Ricin toxin A chain (RTA) binds to stalk P-proteins to reach the alpha-sarcin/ricin loop (S

222 ct with the conserved C termini of ribosomal-stalk P-proteins to remove a specific adenine from the s

223 ing to the lipidic junction and a hemifusion-stalk pathway leading to a fusion pore.

224 rodimeric organization of P1-P2 in the human stalk pentamer and functional non-equivalence of the ind

225 fates and limit the existence of hybrid tip/stalk phenotype.

226 n that the short linker between the head and stalk plays a role in "conformational switching" of the

227 All stalks point towards the microtubule minus end.

228 the cell fate-determining kinase DivJ at the stalked pole in Caulobacter, in cousins such as Asticcac

229 ch as Asticcacaulis, SpmX directs organelle (stalk) positioning and possibly other functions.

230 bservation that silencing of other ribosomal stalk proteins partially rescue the loss-of-function phe

231 SCP), a component of the enzyme's peripheral stalk, provides the site at which cyclophilin D interact

232 ence (spike) comprises a multi-noded central stalk (rachis) with tri-partite clusters of uni-florette

233 eceptor-bound conformation prevent premature stalk rearrangements and F activation.

234 tional significance of the membrane-proximal stalk region (MPSR) (HN, residues 37 to 56) of the param

235 he structurally unresolved membrane-proximal stalk region (MPSR) (residues 37 to 58) of HN in the con

236 st, except for an amino acid exchange in the stalk region abolishing the N-linked glycosylation site;

237 Glycosylation of NA in the stalk region affects its structure, activity, and specif

238 ttribute intracellular retention to both the stalk region and parts of the cytoplasmic domain.

239 r microtubule-binding domains located in the stalk region and the C-terminal WD40 domain.

240 This structure shows the stalk region and the essential N-terminal region (NTR) p

241 s targeting the conserved hemagglutinin (HA) stalk region are elicited following sequential infection

242 erally thought that the paramyxoviral G/H/HN stalk region interacts with the F head region.

243 ivity, suggesting that the membrane-proximal stalk region is not necessary for its activation.

244 We show that the stalk region of CD23 is crucially involved in IgE bindin

245 o unknown IgE-binding site was mapped on the stalk region of CD23, and the non-N-glycosylated monomer

246 peptide specifically targeted the conserved stalk region of H1 hemagglutinin and was effective again

247 contrast, antibodies targeting the conserved stalk region of HA exhibit broader reactivity among viru

248 terminants of ectodomain shedding within the stalk region of the IL-23R.

249 al a site of vulnerability located in the GP stalk region proximal to the viral membrane.

250 distal (tips of the gland) and proximal (the stalk region) identities that produce the acini and high

251 lations also elucidate key roles of the NTR, stalk region, and breathing motion of RecU in the format

252 that specifically targets the hemagglutinin stalk region, similar to targeting of antibodies induced

253 ts the antibody responses directed at the HA stalk region.

254 ponses, potentially to the more conserved HA stalk region.

255 bind at least two different epitopes on the stalk region.

256 entate interaction whereby both the head and stalk regions of NiV G interact with NiV F, a new findin

257 f the enzyme were observed, with the central stalk's epsilon subunit in an extended autoinhibitory co

258 vaccination with VSV-cHAs generates greater stalk-specific and cross-reactive serum antibodies than

259 ecific to the HA head and stalk, but only HA stalk-specific antibodies mediated ADCC efficiently and

260 ir potential as vaccine candidates to induce stalk-specific antibodies.

261 cohorts generated a vigorous, high-affinity, stalk-specific antibody response.

262 Additionally, stalk-specific antibody titers were boosted following se

263 Moreover, ferrets possessing HA stalk-specific antibody were protected against novel H1N

264 nation strategies are superior at generating stalk-specific humoral immunity.

265 inine at the active site is critical for non-stalk-specific interactions with the ribosome.

266 Despite a decline in stalk-specific serum antibody titers, sequential sH1N1 i

267 ation strategy is effective at generating HA stalk-specific, broadly cross-reactive serum antibodies

268 Stalked-sponge fauna in the Peru Basin require the prese

269 egions have been described in two Iowa Stiff Stalk (SS) inbreds.

270 The static continuum stalk structure agrees quantitatively with experimental

271 Fe(II) oxidation and, in addition, a twisted stalk structure obtained from an environmental biofilm.

272 d a significant increase in carbonate in the stalk structures, and the appearance of organic globules

273 ance of organic globules not associated with stalk structures.

274 e intact cap containing distinct gills and a stalk, suggests evolutionary stasis of body form for app

275 , we demonstrate that the hemagglutinin (HA) stalk-targeting human monoclonal antibody 81.39a effecti

276 rainfluenza virus (PIV5), a region of the HN stalk that has not had its structure determined by X-ray

277 ggest PGR functions as a resilient, extended stalk that projects the rest of Aap outward from the bac

278 orate morphology characterized by a vertical stalk that spans the retina and branches in each retinal

279 the membrane-distal site of the prefusion HA stalk that was also previously suggested as a target sit

280 a 17-residue H-head segment proximal to the stalk that was unresolved in all five MeV H-head crystal

281 Calculations show that in a stalk, the distal monolayer is stretched and the stored

282 conclude that, together with the top of the stalk, the flexible linker keeps H heads on a leash long

283 rprisingly, in an ATPase devoid of a central stalk, the interfaces of this ring are perfectly designe

284 composition, while direct transition from a stalk to a fusion pore without a hemifusion intermediate

285 from a 'closed' conformation docked near the stalk to an 'open' conformation able to interact with me

286 ically active head and the four-helix bundle stalk to be essential for fusion promotion.

287 with ricin A chain (RTA), which binds to the stalk to depurinate the sarcin/ricin loop (SRL).

288 -hairpin conformation and interacts with the stalk to form a compact beta-sheet structure.

289 nt8b suppression by Foxg1 in the nasal optic stalk to maintain balanced apoptosis and Pax2 expression

290 eceptor binding head serves to stabilize the stalk to regulate fusion.

291 nsformation of Gallionella-like ferrihydrite stalks to Fe (hydroxy)carbonates and Fe sulfides, as wel

292 he dome of the RPE detachment, the choroidal stalks were all in the choroid layer.

293 TF dissociation liberates the 7TM N-terminal stalk, which acts as a tethered-peptide agonist permitti

294 connected by a 12-residue segment termed the stalk, which adopts a beta-strand conformation, instead

295 ports have suggested that the new N-terminal stalk, which is revealed by GAIN domain cleavage, can di

296 The posterior pituitary lobe and stalk, which normally arise from neural ectoderm, were e

297 r interactions of Stx1A1 and Stx2A1 with the stalk, while a conserved arginine at the active site is

298 tx1A1 and Stx2A1 with ribosomes and with the stalk, while mutation of Arg170 at the active site reduc

299 or agonist, was then fused to the engineered stalk with flexible linkers, and a Factor Xa cleavage si

300 or close to, the tip of the reflexed cupule stalk, with the micropyle oriented towards the stalk bas