ライフサイエンスコーパス: stall

1 AP-2 assemblies are fleeting and endocytosis stalls.

2 mited time, then autonomously and reversibly stalls.

3 hances its translation by relieving ribosome stalling.

4 ss, and secondary DNA damage related to fork stalling.

5 ent to sites of ICL-induced replication fork stalling.

6 ted a reduction of DNA replication and G0/G1 stalling.

7 utes to R-loop generation and RNA polymerase stalling.

8 sites of DNA-damage-induced replication fork stalling.

9 in the Switch 1 region contribute to pol II stalling.

10 on even in the presence of irreversible fork stalling.

11 NA Damage Tolerance (DDT) response upon fork stalling.

12 s by resolving polyproline-induced ribosomal stalling.

13 RNA degradome data in the study of ribosome stalling.

14 ost, indicated that the uORF causes ribosome stalling.

15 caused G1 cell cycle arrest and S phase fork stalling.

16 osome, and the nascent peptides remaining in stalled 60S exit tunnels are detected by the ribosome-bo

17 esults from a defect in Cdc48 recruitment to stalled 60S particles, a process that requires both Rqc1

18 Whereas the steps from stalled 60S recognition to aberrant peptide polyubiquity

19 s, provides insight to NTD's role in binding stalled 60S subunits.

20 Stalled abducens nerve bundles did not reach the orbit,

21 le embryo imaging of Chn1KI/KI mice revealed stalled abducens nerve growth and selective trochlear an

22 s synthesize a full-length RNA; the majority stall after synthesizing a short RNA.

23 re of a Saccharomyces cerevisiae spliceosome stalled after Prp16-mediated remodelling but before exon

24 s in their 5'- or 3'-untranslated regions to stall and repress XRN1, effectively stabilizing viral RN

25 he Bunyaviridae family, also can effectively stall and repress XRN1.

26 additional families of mammalian RNA viruses stall and repress XRN1.

27 plication stress or DNA damage triggers fork stalling and checkpoint signaling to activate repair pat

28 ve high levels of RNA polymerase II (RNAPII) stalling and DNA accessibility and show specific enrichm

29 to replicative stress due to RNA polymerase stalling and DNA damage.

30 phase progression and induces DNA-polymerase stalling and DNA damage.

31 e of ER-associated mRNAs results in ribosome stalling and mRNA degradation.

32 m of autism in humans, and understanding the stalling and reactivation mechanism could reveal new app

33 Uch37 protein levels with hallmarks of G0/G1 stalling and recovery to their steady-state protein leve

34 biquitous environmental toxin, formaldehyde, stalls and destabilizes DNA replication forks, engenderi

35 However, the event's progression quickly stalled, and the warming remained very weak throughout t

36 HRR, inability to overcome replication fork stalling, and replication stress.

37 rest by polybasic sequences induces ribosome stalling, and the arrest product is degraded by the ribo

38 slation of PCSK9 by inducing the ribosome to stall around codon 34, mediated by the sequence of the n

39 ests that the 2014/15 El Nino (EN) event was stalled as a result of an unusually strong basin-wide ea

40 vercoming cisplatin-induced replication fork stalling, as replication-restart was impaired in both SM

41 Replication forks also appear to stall at an unusually high rate throughout schizogony.

42 l factors, base excision repair in NCPs will stall at the gap-filling step.

43 maintenance methylation state, TE fragments stall at the RdDM phase.

44 e in which neuronal elongation complexes are stalled at AGA codons due to deficiencies in a tRNA(Arg)

45 In the absence of Jmjd2c, differentiation is stalled at an early post-implantation epiblast-like stag

46 Failure to restart replication forks stalled at genomic regions that are difficult to replica

47 howed that RNAP exit kinetics from complexes stalled at later stages of initiation (e.g., from a 7-ba

48 cts of a practical logic technology and have stalled at simple functionality demonstrations.

49 ts application as a widespread technique has stalled at the early stages due to numerous limitations

50 the regulation of mRNA translation complexes stalled at the level of elongation and/or termination.

51 Ribosome profiling reveals that ribosomes stalled at the rotated state with specific pairs of codo

52 rapid dissociation of pol delta from PCNA on stalling at a DNA lesion.

53 e mutagenic consequences of replication fork stalling at a single, site-specific replication barrier

54 Stalling at DNA replication forks generates stretches of

55 on and that their protein knockdown leads to stalling at G0/G1 Moreover, serum-starved cells display

56 l elongation defect, with abundant ribosomes stalling at many sequences, not limited to proline stret

57 lethal options such as herding, fencing, and stalling at night but more details about such successful

58 ), traditionally known to alleviate ribosome stalling at polyproline motifs, can efficiently rescue t

59 the replication machinery showed substantial stalling at sites of damage, and these problems were fur

60 kinetics at stall sites, we induced ribosome stalling at specific codons by starving the bacterium Es

61 oportional to the degree of in vivo ribosome stalling at synonymous codons.

62 ed pool of certain mt-tRNAs and mitoribosome stalling at the corresponding codons.

63 Furthermore, we observed frequent fork stalling at the junction of the common deletion, suggest

64 We demonstrate that transient stalling at this barrier induces a distinct pattern of g

65 vitro oxidation to the mature prFMN cofactor stalls at formation of a radical prFMN species in holoUb

66 The Escherichia coli replisome transiently stalls at leading-strand template lesions and can either

67 at the elongating RNA polymerase II (RNAPII) stalls at this well positioned nucleosome, GnRH-induced

68 ent of such FcgammaR-specific antibodies has stalled because of adverse events, a phenomenon recapitu

69 The cooling trend probably stalled before the beginning of the mid-Pleistocene tran

70 t a single base pair mismatch in the invader stalls branch migration and displacement occurs via dire

71 at recombination induced by replication fork stalling but only a minor role in constraining recombina

72 P can aid in resuming translation elongation stalled by miscoding errors.

73 uate for functional complementation, and the stalled cells arrested prior to cytokinesis.

74 genome instability, causing replication fork stalling, chromosome fragility, and impaired repair.

75 sponse signalling following replication fork stalling/collapse.

76 Characterization of the stalled complexes (designated B(028)) revealed that U4/U

77 ing occurs in the slower phase (>10 s), when stalled complexes release their short RNA and make anoth

78 rogeneous systems have lower energy use near stall conditions and greater energy consumption when unl

79 The use of quality control mechanisms to stall developmental pathways or completely remove defect

80 caused by inordinate sequestration of RPA at stalled DNA replication forks, represents a conserved fe

81 Upon aberrant fork stalling, DNA damage signaling and concomitant H2AX phos

82 INTERPRETATION: Results of trials for stalled drugs are heavily under-reported.

83 nd 46% (94 of 203) of trials of licensed and stalled drugs, respectively.

84 "Stalled" drugs included all experimental agents tested i

85 and a rational design of these materials has stalled due to the lack of an in situ methodology to eas

86 ese observations suggest that a knot-induced stall during degradation of multidomain proteins by AAA

87 Ribosomes can stall during translation due to defects in the mRNA temp

88 F598 is required for ribosomes to terminally stall during translation of poly(A) sequences.

89 -electron microscopy structure of a ribosome stalled during translation of the extremely compacted Ve

90 Ribosome stalling during translation can potentially be harmful,

91 We show that observed stalling during translation correlates with slowed pepti

92 Ribosomes that experience terminal stalls during translation are resolved by ribosome-assoc

93 matic and mechanical cycles of the motor and stalling dynein on the microtubule track.

94 that the DNA polymerase III holoenzyme in a stalled E. coli replisome can directly bypass a single c

95 hree assembly-defective BamA substrates that stall early in the folding process in the periplasm.

96 itination-resistant eS10 ribosomes failed to stall efficiently on poly(A) sequences.

97 iate RNA transcripts during transcription by stalling elongation complexes at catalytically dead EcoR

98 Thus, O. tsutsugamushi temporally stalls ERAD until ERAD-derived amino acids are needed to

99 es from occurring when DNA replication forks stall, even in the absence of ICLs.

100 lood cell transit analysis revealed slow and stalled flow in the regenerated capillaries and extensiv

101 gle rate-limiting barrier and reproduced the stall force and the hand-over-hand dynamics.

102 nesin complex, which reproduces the measured stall force as well as the force required to dislodge th

103 ok tail with a rupture force higher than the stall force of the motor.

104 the cargo is in the vicinity of the mutant's stalling force or a multiple of its stalling force.

105 mutant's stalling force or a multiple of its stalling force.

106 ine residues indicating lowered single motor stalling forces.

107 MRE11 and PTIP, we show that RAD52 promotes stalled fork degradation and chromosomal breakage in BRC

108 repair (HDR), replication fork reversal, and stalled fork protection.

109 ts in the newly replicated region behind the stalled fork, which primarily consist of localized losse

110 ress response proteins stabilize and resolve stalled forks by mechanisms that include fork remodeling

111 that the configuration of DNA polymerases at stalled forks facilitates the resumption of DNA synthesi

112 events the DNA2/WRN-dependent degradation of stalled forks in Abro1-deficient cells.

113 r DNA replication fork repair and restart of stalled forks in human is Metnase (also known as SETMAR)

114 BRCA1-independent RAD51 loading to DSBs and stalled forks in PARPi-resistant BRCA1-deficient cells,

115 nd here we show that recruitment of RAD51 to stalled forks is reduced in the absence of WRN.

116 identify a regulatory pathway that promotes stalled forks recovery from replication stress.

117 Persistence of RTF2 at stalled forks results in fork restart defects, hyperacti

118 fore, Fan1 recruitment enables processing of stalled forks that is essential for genome stability and

119 sights into PrimPol's mode of recruitment to stalled forks to facilitate repriming and restart.

120 e role and regulation of nucleases acting at stalled forks with a focus on the nucleolytic degradatio

121 ts the nascent lagging strands of active and stalled forks, it binds to only the matured (and not elo

122 re11-dependent degradation of nascent DNA at stalled forks, leading to cell lethality.

123 a SNF2-family DNA translocase that remodels stalled forks, restores replication fork stability and r

124 and DDI2 are required for RTF2 removal from stalled forks.

125 '-end resection to mediate DNA processing at stalled forks.

126 it FAN1 to ubiquitylated PCNA accumulated at stalled forks.

127 f the leading strand on active forks than on stalled forks.

128 ed (and not elongating) Okazaki fragments of stalled forks.

129 at extending Okazaki fragments of active and stalled forks.

130 hat tandem duplications form specifically at stalled forks.

131 newly synthesized DNA strands in hydroxyurea-stalled forks.

132 degradation of the newly synthesized DNA at stalled forks.

133 uclease/WRN helicase-mediated degradation of stalled forks.

134 corporate cytosine across from a replication-stalling G-quadruplex.

135 Eviction of the stalled helicase involves K48-linked polyubiquitylation

136 ither causes these magmas to crystallize and stall in reservoirs where they reside under conditions o

137 d presence of sodium ions and aspartate, but stall in sodium alone, providing a direct visualization

138 etects aberrant nascent peptides that remain stalled in 60S ribosomal particles due to a dysfunction

139 We find that canonical autophagy is stalled in DRPLA mice and in human fibroblasts from pati

140 TAX1BP1-deficient T cells exited G0 but stalled in S phase, due to both bioenergetic and biosynt

141 quitylation and degradation of NCs remaining stalled in the 60S subunit.

142 Because fork stalling in FAN1-deficient cells causes chromosomal inst

143 cation foci and counteracts replication fork stalling in RNAPI- and RNAPII-transcribed genes, suggest

144 decay and identified changes in the ribosome stalling index during stress and recovery.

145 ZNF598-mediated stalling initiated the ribosome-associated quality contr

146 discussions that spur progress, rather than stall it.

147 d induction of parasite resistance, however, stalled its further development.

148 once a central area within criminology that stalled just as incarceration rates dramatically climbed

149 Ribosome stalling leads to recruitment of the ribosome quality co

150 d DNA polymerases to bypass replication fork stalling lesions.

151 ed that acute disruption of Vps4 recruitment stalled membrane budding.

152 tress granules (SGs) harbour translationally stalled messenger ribonucleoproteins and play important

153 st of the nascent chains is achieved using a stalling motif, and isotopically labeled RNCs are produc

154 cluding epochs of directed, diffusional, and stalled motion.

155 t include epochs of directed, diffusive, and stalled motion.

156 ivo and in vitro that PrimPol can reinitiate stalled mtDNA replication and can prime mtDNA replicatio

157 Additionally, Rqc2 modifies stalled NCs with a carboxy-terminal, Ala- and Thr-contai

158 s that helps resume DNA replication at forks stalled near bulky adducts on the DNA.

159 ipated in unpublished trials of licensed and stalled neurological drugs, respectively.

160 ers, at least in part via its NTD, to target stalled NSPs for ubiquitylation.

161 Upon translation in vitro, ribosome-stalled NSPs were ubiquitylated in an Ltn1-dependent man

162 SSBs) have been the main focus of efforts to stall obesity.

163 spermidine(3+) did not produce the premature stalling observed in experiments.

164 Ribosome stalls observed at clusters of serine codons in the codo

165 ArfA rescues ribosomes stalled on truncated mRNAs by recruiting release factor

166 codon usage regulates ribosome movement and stalling on mRNA during translation.

167 Ribosome stalling on mRNAs can decrease protein expression.

168 These data suggest that ribosome stalling on Trp codons causes a negative polar effect on

169 counter DNA lesions or other structures that stall or collapse replication forks during the S phase.

170 onserved, and that Eta stimulates release of stalled or arrested TECs.

171 the XPA mislocalization to DSBs occurred at stalled or collapsed replication forks, concurrent with

172 in becomes overwhelmed, and H2O2 degradation stalls or ceases.

173 Here, we demonstrate that UPF1, known to stall peptide release during nonsense-mediated RNA decay

174 Neuronal mRNAs can be packaged in reversibly stalled polysome granules before their transport to dist

175 iated RNA decay, is critical for assembly of stalled polysomes in rat hippocampal neurons derived fro

176 says, we demonstrate restarting autonomously stalled reactions, enabling accurate measurement over fi

177 In the absence of stalling, read-through of poly(A) produces a poly-lysine

178 ation effected a checkpointlike process that stalls recombination by rendering the turnover of a subs

179 G/TfR/Rab11 positive, EEA1/Clathrin negative stalled recycling structures.

180 Wide stalling regions were characterized by high DNAse hypers

181 ealed the mechanism of BLM recruitment after stalled replication and its role during the repair of DN

182 synthesis DNA polymerase that rescues damage-stalled replication by inserting deoxy-ribonucleotides o

183 a new component, Abro1, in the protection of stalled replication fork integrity.

184 Protection of the stalled replication fork is crucial for responding to re

185 RCA2 in homologous recombination, but not in stalled replication fork protection, is primarily associ

186 We show that Abro1 protects stalled replication fork stability by inhibiting DNA2 nu

187 RECQL5 co-operates with WRN on synthetic stalled replication fork-like structures and stimulates

188 Exo1 loading onto a single strand gap at the stalled replication fork.

189 DNA interstrand crosslink repair, repair of stalled replication forks and DNA end joining-it fills a

190 e-strand break repair, rescue, and repair of stalled replication forks and meiosis.

191 s, PhIP treatment increased the frequency of stalled replication forks and reduced fork speed.

192 of ZRANB3 function, which recruits ZRANB3 to stalled replication forks and stimulates its endonucleas

193 In their absence, stalled replication forks are extensively degraded by th

194 /2 cells suggested an aberrant processing of stalled replication forks as the cause of increased muta

195 at RECQ5 removes RAD51 filaments stabilizing stalled replication forks at CFSs and hence facilitates

196 l a mechanism by which cellular responses to stalled replication forks can actively generate genomic

197 Stalled replication forks can be stabilized and restarte

198 y the SCFDia2 complex is critical to restart stalled replication forks during checkpoint recovery.

199 ous recombination (HR) and the protection of stalled replication forks from degradation.

200 ination, the tumor suppressor BRCA2 protects stalled replication forks from nucleolytic degradation.

201 Similarly, after HU induction of stalled replication forks in MCL-1-depleted cells, there

202 51 removal from chromatin and degradation of stalled replication forks in S phase.

203 FANCD2 promotes intramolecular resolution of stalled replication forks in telomeric DNA while BLM fac

204 s been shown to be required for repriming of stalled replication forks in the nucleus, its role in mi

205 ifs is critical for PrimPol's recruitment to stalled replication forks in vivo.

206 The protection and efficient restart of stalled replication forks is critical for the maintenanc

207 ating that RPA-mediated RFWD3 recruitment to stalled replication forks is important for ICL repair.

208 uitment of TopBP1 to sites of DNA damage and stalled replication forks is necessary for downstream ev

209 To generate a free 5' end, stalled replication forks must therefore be cleaved.

210 o1 interact constitutively, and Exo1 repairs stalled replication forks poorly without EEPD1.

211 veal a new aspect of regulated protection of stalled replication forks that involves Abro1.

212 ent, and sensitizes cells to DSBs from IR or stalled replication forks that require HR for repair.

213 onse by mediating the restart of temporarily stalled replication forks thereby suppressing the firing

214 and foci indicating increased conversion of stalled replication forks to double-strand breaks (DSBs)

215 ctivation are required for ETAA1 function at stalled replication forks to maintain genome stability.

216 ucleases have been implicated in cleavage of stalled replication forks to permit end resection, the i

217 genome integrity, DNA repair factors protect stalled replication forks upon replication stress.

218 ing to DNA double-stranded breaks (DSBs) and stalled replication forks, enabling two distinct mechani

219 phase, which leads to impaired resolution of stalled replication forks, insufficient repair of double

220 in, promoting Pol alpha and delta binding to stalled replication forks.

221 l for repair of DNA double-strand breaks and stalled replication forks.

222 sociation of each polymerase with active and stalled replication forks.

223 tinct pattern of association with active and stalled replication forks.

224 ation of checkpoint signaling and restart of stalled replication forks.

225 of the DNA cross-links and stabilization of stalled replication forks.

226 tion-associated DNA damage and protection of stalled replication forks.

227 ese are not commonly present in non-reversed stalled replication forks.

228 no-ubiquitylation and Pol eta recruitment to stalled replication forks.

229 D52 also participates in the recovery of the stalled replication forks.

230 damage arising from nucleolytic cleavage of stalled replication forks.

231 during normal replication and/or to restart stalled replication from downstream ssDNA.

232 is represents a unique mechanism of rescuing stalled replication when dNTP supply is low.

233 as once thought, with DNA damage frequently stalling replication forks.

234 during replication, thereby preventing fork stalling, replication stress, and secondary DNA damage r

235 cause translational infidelity and ribosome stalling, resulting in neurodegeneration.

236 Ribosome stalling results in the production of truncated proteins

237 ovide insights into how HMGA2 interacts with stalled RFs and the function of the process.

238 RQC reactions including dissociation of the stalled ribosome into subunits.Several protein quality c

239 ribosome causes abortive termination of the stalled ribosome.

240 relate with sensitivity to anisomycin, which stalls ribosome at the rotated form.

241 ts showed that chloramphenicol and linezolid stall ribosomes at specific mRNA locations.

242 The proximal factors that sense stalled ribosomes and initiate mammalian ribosome-associ

243 In many bacteria, ArfA recognizes stalled ribosomes and recruits the release factor RF2, w

244 uitylation result in defective resolution of stalled ribosomes and subsequent readthrough of poly(A)-

245 ciated Quality control Complex (RQC) engages stalled ribosomes and targets nascent polypeptides for p

246 Stalled ribosomes are dissociated, aberrant mRNAs are de

247 mbined observations support a model in which stalled ribosomes are reactivated to rapidly generate Ar

248 Stalled ribosomes iteratively served as a ruler to templ

249 ptide release without a stop codon, allowing stalled ribosomes to be recycled.

250 trans-translation leading to accumulation of stalled ribosomes.

251 rotein RACK1 help to resolve poly(A)-induced stalled ribosomes.

252 ion, and abortive (premature) termination of stalled ribosomes.

253 ntrol of protein synthesis and the rescue of stalled ribosomes.

254 tional quality control pathways to recognize stalled ribosomes.

255 tent with two widely-used kinetic models for stalled ribosomes: ribosome traffic jams that block init

256 repair profile suggesting their capacity to stall RNA polymerase (Pol) II and trigger transcription-

257 from Mfd's ability to preferentially act on stalled RNA polymerases (RNAPs).

258 blocks superinfection by coliphage lambda by stalling RNA polymerase (RNAP) translocation specificall

259 ism to efficiently patrol DNA for frequently stalled RNAPs.

260 ized by an endonucleolytic cleavage near the stall sequence, but the mechanistic details are unclear.

261 We also show that reporters harboring stall sequences near the initiation codon, which cannot

262 subsequent readthrough of poly(A)-containing stall sequences.

263 F5A strongly promotes the translation of the stalling sequences identified by profiling and increases

264 eld of thermoelectric materials research has stalled several times, but each time it was rejuvenated

265 f translation initiation rate, the number of stall sites, and the distance between stall sites.

266 To decipher ribosome kinetics at stall sites, we induced ribosome stalling at specific co

267 uning of kinetic rate parameters at ribosome stall sites.

268 ber of stall sites, and the distance between stall sites.

269 scription in the affected region permanently stall, so the failure of R-loop removal in RNase H-defic

270 he swimming speed was lower than that in the stall speed (0.2 m s(-1)) of the device during the feedi

271 s, indicating that, in the absence of H2A.Z, stalled spliceosomes are disassembled, and unspliced RNA

272 that remain in an immature, developmentally stalled state until pupation.

273 well as with TOPBP1 at sites of replication stalls, suggesting a role for Nol12 in the resolution of

274 ated enzyme and unravel a mode of RNA Pol II stalling that is due to alkylation of DNA in the minor g

275 enomic information in unconnected silos will stall the advancement of precision cancer care.

276 eta42 antibodies are a promising strategy to stall the progression of the disease.

277 DNA damage and secondary structures can stall the replication machinery.

278 nce T-cell activation has occurred, however, stalling the rejection process becomes increasingly diff

279 Once bound, viomycin stalls the ribosome in a pretranslocation state for a mi

280 different rates, and a fraction of germlings stall their growth shortly after germination.

281 This stalling time increases linearly with viomycin concentra

282 phodiesterase 2 (TDP2) hydrolase activity on stalled TOP2cc.

283 h accessory protein Ac45, knockdown of which stalled transit of a1 and transferrin-transferrin recept

284 rane-less organelles that are condensates of stalled translation initiation complexes and mRNAs.

285 in translocation into the mammalian ER using stalled translation intermediates.

286 The accumulation of stalled translation preinitiation complexes (PICs) media

287 Mammalian stress granules (SGs) contain stalled translation preinitiation complexes that are ass

288 nd in vivo photoactivatable cross-linking of stalled translocation intermediates, we demonstrate how

289 In eukaryotes, ribosome stalling triggers release of 60S subunits with attached

290 c cross-linkers increase the likelihood of a stalled "tug-of-war" between retrograde and anterograde

291 ughly 1.2 million years ago and cooling then stalled until the present.

292 ication stress is encountered, DNA synthesis stalls until the stress is ameliorated.

293 Diffusion stalls upon encountering a physical barrier in the form

294 rogress along the chromosomes and frequently stall when they encounter DNA lesions, unusual DNA struc

295 k cycle in which translation of COX1 mRNA is stalled when assembly intermediates of Cox1 accumulate t

296 nd this results in accumulation of ribosomes stalled with non-aminoacylated (uncharged) tRNA in the r

297 t couples rG4-mediated reverse transcriptase stalling with next-generation sequencing.

298 spread, or in limited spread that eventually stalled, with both outcomes occurring with approximately

299 In the absence of FANCD2, replication forks stall within the AT-rich fragility core of CFS, leading

300 ed transcripts of multiple arenaviruses also stalled XRN1.