ライフサイエンスコーパス: stalling

1 of transcripts that cause transient ribosome stalling.

2 e SUMOylated in response to replication fork stalling.

3 caused G1 cell cycle arrest and S phase fork stalling.

4 cultured cells is stimulated by translation stalling.

5 human replisome dynamics in response to fork stalling.

6 multiply ubiquitinated upon replication fork stalling.

7 e suhB mutant, indicating increased ribosome stalling.

8 the nascent chain can weaken or even abolish stalling.

9 hich positions spanned by the ribosome cause stalling.

10 tion coupling inhibits RNA polymerase (RNAP) stalling.

11 hereas amino acids like Arg and His promoted stalling.

12 e ribosomes promote rather than inhibit RNAP stalling.

13 l play a central role in triggering ribosome stalling.

14 ) after hydroxyurea-induced replication fork stalling.

15 d lagging-strand templates and relieved fork stalling.

16 tion in filopodial dynamics, leading to axon stalling.

17 agents that lead to translational errors or stalling.

18 rized by ribosomes, leading to translational stalling.

19 e-wide restart of replication following fork stalling.

20 plication restart following fork replication stalling.

21 ment in the ribosome tunnel is important for stalling.

22 hances its translation by relieving ribosome stalling.

23 hk1 release prompts TLS to avoid replication stalling.

24 presence of SecM in the exit tunnel induces stalling.

25 er hydroxyurea (HU)-induced replication fork stalling.

26 ss, and secondary DNA damage related to fork stalling.

27 ent to sites of ICL-induced replication fork stalling.

28 ted a reduction of DNA replication and G0/G1 stalling.

29 utes to R-loop generation and RNA polymerase stalling.

30 sites of DNA-damage-induced replication fork stalling.

31 in the Switch 1 region contribute to pol II stalling.

32 on even in the presence of irreversible fork stalling.

33 NA Damage Tolerance (DDT) response upon fork stalling.

34 s by resolving polyproline-induced ribosomal stalling.

35 RNA degradome data in the study of ribosome stalling.

36 synthesis (TLS) that alleviates replication stalling.

37 ents of ribosome initiation, elongation, and stalling.

38 ost, indicated that the uORF causes ribosome stalling.

39 ociated with a reduction in replication fork stalling, a known trigger for HR and loss of MRN from te

40 , G-quadruplexes) cause DNA replication fork stalling, activate DNA damage responses, and represent h

41 PTC function, but a mutated AAP that lacked stalling activity did not.

42 lasticity, reducing fitness, and potentially stalling adaptation and migration.

43 uated its ubiquitination in response to fork-stalling agents UV and hydroxyurea in cultured cells.

44 These include axon stalling along the midline, running within the midline,

45 ean +/- standard deviation) of torque before stalling, an amount sufficient to melt DNA of arbitrary

46 mutant of Pol eta increased replication fork stalling and activated the replication checkpoint.

47 rance (DDT) pathways to avoid prolonged fork stalling and allow for completion of DNA replication.

48 nt in zelda mutants both reduces replication stalling and bypasses the requirement for a functional c

49 plication stress or DNA damage triggers fork stalling and checkpoint signaling to activate repair pat

50 red to induce site-specific replication fork stalling and chromosomal HR/SCR in mouse cells.

51 The S phase delay appears to be due to the stalling and collapse of replication forks.

52 nct HR-mediated repair upon replication fork stalling and collapse.

53 implying that they are poised to respond to stalling and collapse.

54 or TCR using a system in which transcription stalling and damage location can be uncoupled.

55 acids as the major determinant of ribosomal stalling and demonstrate that it produces false signals

56 ve high levels of RNA polymerase II (RNAPII) stalling and DNA accessibility and show specific enrichm

57 phase progression and induces DNA-polymerase stalling and DNA damage.

58 to replicative stress due to RNA polymerase stalling and DNA damage.

59 ms for replication, resulting in replication stalling and double-strand breaks, which are suspected t

60 ns as an HR regulator after replication fork stalling and during double-strand break repair.

61 e-site occupancy concentrations, whereas the stalling and free rotation experiments have multiple-sit

62 e of ER-associated mRNAs results in ribosome stalling and mRNA degradation.

63 m of autism in humans, and understanding the stalling and reactivation mechanism could reveal new app

64 onsisting of binding, activation, unwinding, stalling and reactivation stages.

65 Uch37 protein levels with hallmarks of G0/G1 stalling and recovery to their steady-state protein leve

66 mal tunnel can act in cis to induce ribosome stalling and regulate expression of downstream genes.

67 associated with unscheduled replication fork stalling and restart, and suppresses tumorigenesis, at l

68 HR), non-homologous end joining (NHEJ), fork stalling and template switching (FoSTeS), and microhomol

69 nsidering the DNA replication model of 'fork stalling and template switching' for CNV formation, we h

70 n the central nervous system causes ribosome stalling and widespread neurodegeneration.

71 HRR, inability to overcome replication fork stalling, and replication stress.

72 rest by polybasic sequences induces ribosome stalling, and the arrest product is degraded by the ribo

73 ting rate constants and free energies to the stalling angle.

74 vercoming cisplatin-induced replication fork stalling, as replication-restart was impaired in both SM

75 rapid dissociation of pol delta from PCNA on stalling at a DNA lesion.

76 e mutagenic consequences of replication fork stalling at a single, site-specific replication barrier

77 This stalling at C:8-oxo-G can be overcome by a switch from p

78 bmillisecond interrogation with preferential stalling at cognate sites may be common to various DNA-b

79 licing repression occurs through spliceosome stalling at complex A.

80 amily DNA polymerases alleviates replication stalling at DNA damage.

81 herefore suggest that whereas DNA polymerase stalling at DNA lesions activates ATR to protect cell vi

82 telomeres, consistent with replication fork stalling at DNA lesions.

83 Stalling at DNA replication forks generates stretches of

84 BRIP1 helicase causes persistent replication stalling at G-quadruplex structures, demonstrating a vit

85 eficient C. elegans is caused by replication stalling at G-quadruplexes.

86 on and that their protein knockdown leads to stalling at G0/G1 Moreover, serum-starved cells display

87 Ethanol-stressed cells exhibited ribosomal stalling at internal AUG codons, which may be ameliorate

88 l elongation defect, with abundant ribosomes stalling at many sequences, not limited to proline stret

89 lethal options such as herding, fencing, and stalling at night but more details about such successful

90 ally, loss of CSA or CSB leads to polymerase stalling at non-B DNA in a neuroblastoma cell line, in p

91 Stalling at poly-Pro motifs is alleviated by the elongat

92 ), traditionally known to alleviate ribosome stalling at polyproline motifs, can efficiently rescue t

93 ro and in vivo reporter assays revealed that stalling at PPP motifs is influenced by the sequence con

94 In bacteria, stalling at PPP motifs is rescued by the elongation fact

95 and Thr preceding the stall site suppressed stalling at PPP motifs, whereas amino acids like Arg and

96 dent mutations occur at sites of replication stalling at short repeated sequences capable of forming

97 the replication machinery showed substantial stalling at sites of damage, and these problems were fur

98 kinetics at stall sites, we induced ribosome stalling at specific codons by starving the bacterium Es

99 of primer utilization, preventing polymerase stalling at specific sequence contexts, and overcoming p

100 oportional to the degree of in vivo ribosome stalling at synonymous codons.

101 on to stable G4s, contributes to replication stalling at telomeres.

102 ed pool of certain mt-tRNAs and mitoribosome stalling at the corresponding codons.

103 ontralateral floorplate border, resulting in stalling at the exit site or even caudal turns.

104 p formation on the ligand-coated hemisphere, stalling at the Janus interface, and rapid membrane prot

105 Furthermore, we observed frequent fork stalling at the junction of the common deletion, suggest

106 de antibiotics, which do not induce ribosome stalling at the uORF of the ermC resistance gene, trigge

107 We demonstrate that transient stalling at this barrier induces a distinct pattern of g

108 reduction of Pol II progression (pausing or stalling) at the Igh-V, additional steps such as prematu

109 discovered biphasic force that overcomes the stalling barrier.

110 ently occurs in response to replication fork stalling before any measurable DNA double-strand breaks

111 ucleosomes are low barriers and cause RNAPII stalling both at the entry site and near the dyad axis.

112 Rad18 mediates tolerance of replication fork-stalling bulky DNA lesions, but whether Rad18 mediates t

113 rylation (RPA2-P) following replication fork stalling but has no obvious effect on RPA2-P following r

114 at recombination induced by replication fork stalling but only a minor role in constraining recombina

115 Here we demonstrate that stalling by yeast replicative Pols delta and epsilon inc

116 e alone and that the force needed to release stalling can be generated in vivo by a nascent chain fol

117 Pol II stalling can be overcome by irradiation involving the ep

118 Our data suggest that ribosome stalling can occur at a surprisingly large number of low

119 Replication fork stalling can promote genomic instability, predisposing t

120 sequence contexts, and overcoming polymerase stalling caused by topological constraint allowing the t

121 genome instability, causing replication fork stalling, chromosome fragility, and impaired repair.

122 with replication and repair, provoking fork stalling, chromosome fragility, and recombination.

123 this activity is stimulated by the RNA polII stalling cofactor Spt5 and the 11-subunit cellular nonco

124 DNA replication, leading to replication fork stalling, collapse, HR and subsequent recombination-medi

125 sponse signalling following replication fork stalling/collapse.

126 -coupled repair or, in response to prolonged stalling, degradation of the polymerase.

127 Stalling depended on interaction between a GAr and a sui

128 These findings uncover a translational stalling-dependent protein aggregation mechanism, and pr

129 imulate the frameshifting, without involving stalling detectable by toe-printing.

130 ates but are heavily constrained by the mean stalling distance of replication forks, and that, for ge

131 NCI, contribute to the repair of replication-stalling DNA lesions.

132 Upon aberrant fork stalling, DNA damage signaling and concomitant H2AX phos

133 tructures are implicated in replication fork stalling, DNA double strand breaks (DSBs) and human dise

134 5) . (CAG)(45) causes local replication fork stalling, DNA hairpin formation, and TNR instability.

135 stress correlates with DNA polymerase (Pol) stalling during bypass of ribonucleotides in DNA templat

136 epeat also causes orientation-dependent fork stalling during replication in vitro and in vivo.

137 ed for ciliary metachronal synchrony, random stalling during the power/recovery stroke transition, an

138 Ribosome stalling during translation can be caused by a number of

139 Ribosome stalling during translation can potentially be harmful,

140 We show that observed stalling during translation correlates with slowed pepti

141 Ribosome stalling during translation has recently been shown to c

142 In bacteria, ribosome stalling during translation of ErmBL leader peptide occu

143 Addition of eIF5A relieves ribosomal stalling during translation of three consecutive Pro res

144 matic and mechanical cycles of the motor and stalling dynein on the microtubule track.

145 pulling force and ranking them according to stalling efficiency.

146 olides had dramatically different effects on stalling efficiency.

147 identify mutations that further increase the stalling efficiency.

148 iate RNA transcripts during transcription by stalling elongation complexes at catalytically dead EcoR

149 tification of enhancers, lncRNAs, and RNAPII stalling/elongation dynamics.

150 nzyme progress is interrupted by pausing and stalling events that can slow degradation in a sequence-

151 Stalling experiments are considered in which rates of in

152 Reasonable agreement is found with stalling experiments for ATP and GTP binding.

153 sults of controlled rotation experiments and stalling experiments, for the range of angles where the

154 Hence, the stalling force measured by single-molecule force spectro

155 use the large step size and relatively small stalling force of myoVa leads to a high sensitivity of m

156 the cargo is in the vicinity of the mutant's stalling force or a multiple of its stalling force.

157 consistent with the experimentally observed stalling force required to stop the motor completely on

158 mutant's stalling force or a multiple of its stalling force.

159 ine residues indicating lowered single motor stalling forces.

160 corporate cytosine across from a replication-stalling G-quadruplex.

161 After transient stalling, G-quadruplexes are efficiently unwound and rep

162 Stalling growth through nutrient depletion, or the speci

163 M-FANCD2 complex following APH-mediated fork stalling in a manner dependent on MRE11 and FANCD2, foll

164 ty to restart DNA replication following fork stalling in comparison with control cells.

165 t TRF2 overexpression results in replication stalling in duplex telomeric repeat tracts and the subse

166 Unproductive ribosome stalling in eubacteria is resolved by the actions of Smp

167 ing is coordinated with replicative helicase stalling in eukaryotes, but the mechanism underlying thi

168 Because fork stalling in FAN1-deficient cells causes chromosomal inst

169 sence of functional DHX33, consistent with a stalling in initiation, and DHX33 more preferentially pr

170 emonstrate that it produces false signals of stalling in low-coverage data.

171 8 and TREX2 also suppressed replication fork stalling in response to nucleotide depletion.

172 cation foci and counteracts replication fork stalling in RNAPI- and RNAPII-transcribed genes, suggest

173 lococcus aureus ErmCL leader peptide induces stalling in the presence of clinically important macroli

174 lism, the primary causes of replication fork stalling include secondary DNA structures, highly transc

175 fs that otherwise would induce translational stalling, including polyproline.

176 ruitment and SCE induced by replication fork stalling independent of ATR.

177 decay and identified changes in the ribosome stalling index during stress and recovery.

178 Interestingly, replication fork stalling induced fusion for identical and mismatched rep

179 genomic stability following replication fork stalling, induced by either ICL damage or replicative st

180 ZNF598-mediated stalling initiated the ribosome-associated quality contr

181 ribonucleotide bypass reveal that increased stalling is associated with displacement of Tyr391 and a

182 Replicative polymerase stalling is coordinated with replicative helicase stalli

183 Whether this modification responds to RNAPII stalling is not yet known.

184 NC stalling is recognized by the Rqc2/Tae2 RQC subunit, whi

185 that viral latency products may repress via stalling key mediators that in turn modulate glycolysis.

186 Ribosome stalling leads to cleavage of the mRNA and induction of

187 Ribosome stalling leads to recruitment of the ribosome quality co

188 d DNA polymerases to bypass replication fork stalling lesions.

189 Stalling may also occur at a third stage of translocatio

190 e find that residues upstream of the minimal stalling motif can either enhance or suppress this effec

191 st of the nascent chains is achieved using a stalling motif, and isotopically labeled RNCs are produc

192 In other stalling motifs, peptidyl transfer to certain aminoacyl-

193 similar to other ligand-independent ribosome stalling motifs.

194 lide does not preferentially induce ribosome stalling near the 5' end of mRNAs, but rather acts at sp

195 spermidine(3+) did not produce the premature stalling observed in experiments.

196 Increased polymerase stalling occurred on the G-rich template, compared with

197 tide-bond formation, such that translational stalling occurs when three or more consecutive prolines

198 uch as starvation and antibiotics, can cause stalling of bacterial ribosomes, which may alter gene ex

199 he loss of FMRP does not result in a general stalling of cerebral cortex maturation.

200 This recruitment drives slowing or stalling of DNA replication at transcriptionally engaged

201 w, we will discuss the stresses that lead to stalling of each of the polymerases and how the cell rec

202 nctional investigations demonstrate that the stalling of mRNA precursors on spliceosomes is required

203 elease from the hsp70 promoter, and causes a stalling of mRNA production during phases of transcripti

204 ued the oxidative damage induced replication stalling of mtDNA, reduced mtDNA point mutation load, an

205 This leads to stalling of pol delta at 8-oxo-G after incorporation of

206 cription termination after prolonged pausing/stalling of Pol II.

207 Furthermore, we show that the stalling of PolB1 at the lesion site can be relieved by

208 t negative form of Chd1 results in increased stalling of PolII past the entry site of the promoter pr

209 of DNA replication after hydroxyurea-induced stalling of replication forks, reduced repair of spontan

210 iency and reduce DNA strand breaks caused by stalling of replication forks.

211 replication failing due to the irreversible stalling of replication forks.

212 Stalling of ribosome at the PA5471 leader peptide (PA547

213 Arrhythmic translation caused by temporal stalling of ribosome during translation elongation is es

214 nonstop mRNA, which we hypothesize involves stalling of ribosomes on the polyA tail.

215 anisms have evolved mechanisms to manage the stalling of ribosomes upon translation of aberrant mRNA.

216 Transcriptional stress leading to stalling of RNA polymerase can also be caused by DNA dam

217 o-2'-deoxyadenosine (CydA) induces prolonged stalling of RNA polymerase II (Pol II) followed by trans

218 repression of several Hox genes in part via stalling of RNA polymerase II (RNA Pol II).

219 Stalling of RNA Polymerase II (RNAPII) on chromatin duri

220 Exposure to chronic morphine increased stalling of RNA polymerase II at these Bdnf promoters in

221 Convergent transcription causes stalling of RNA polymerase II during transcription, whic

222 ct cell viability and prevent apoptosis, the stalling of RNA polymerases instead activates ATR to ind

223 Efficient stalling of RNAP II is essential for efficient TCR.

224 bility and can eventually lead to a dramatic stalling of several unrelated signaling and cellular pro

225 The stalling of the circadian rhythm suggests temporary cyst

226 understanding the underlying mechanisms and stalling of the dedifferentiation process would be highl

227 The nature of the coupling between the stalling of the elongated nascent peptide chain in the r

228 sfRNA results from stalling of the host 5'-3' exoribonuclease XRN1/Pacman o

229 It is thought that stalling of the mitochondrial replication machinery duri

230 eir accumulation in the genome that leads to stalling of the replication DNA polymerases and poor les

231 l stress within the DNA template may lead to stalling of the replication fork.

232 NA polymerases at replication forks to avoid stalling of the replication machinery and consequent gen

233 the virus-induced DNA damage response (DDR), stalling of the replication of MVM genomes with hydroxyu

234 s including misfolding of a nascent chain or stalling of the ribosome during translation of mRNA.

235 emplate or the ribosome itself also leads to stalling of the ribosome, and the cell responds by degra

236 insights into drug-induced, peptide-mediated stalling of the ribosome.

237 cription, and translation stress all lead to stalling of their respective polymerases (DNA polymerase

238 Single-molecule methods revealed stalling of translation at the entrance of the peptide e

239 in bacterial proteomes and show evidence of stalling on endogenous E. coli proteins.

240 Ribosome stalling on eukaryotic mRNAs triggers cotranslational RN

241 codon usage regulates ribosome movement and stalling on mRNA during translation.

242 Ribosome stalling on mRNAs can decrease protein expression.

243 A replication in trans by counteracting fork stalling on replication barriers, such as G4 quadruplex

244 G4 formation is not required for polymerase stalling on telomeric lagging strands and suggest that a

245 isfolding or mutation may disrupt the 40S IC stalling on the start codon, thereby altering the string

246 These data suggest that ribosome stalling on Trp codons causes a negative polar effect on

247 on may occur primarily upon ribosome slowing/stalling or at promoter-proximal locations that limit th

248 nflict, as well as inappropriate replication stalling or blockage at Ter sites outside of the terminu

249 nating nucleoside analogs (CTNAs) that cause stalling or premature termination of DNA replication for

250 o evidence for decreased rates of transport, stalling, or increased retrograde transport.

251 tially with protein density when approaching stalling osmotic compression.

252 f new agents for rare cancers are at risk of stalling owing to the ever-increasing complexity and cos

253 the average rate, concurrent with increased stalling, pausing, arrest, and/or backtracking (transcri

254 sequences, has little or no effect on other stalling peptides.

255 romoter in NAc only, suggesting that Pol II "stalling" primes Fosb for induction in this region upon

256 replication origin usage combined with fork stalling promotes repeat instability during early embryo

257 In the absence of stalling, read-through of poly(A) produces a poly-lysine

258 ion stress, as shown by the presence of fork stalling, reduction of fork speed, and premature senesce

259 Wide stalling regions were characterized by high DNAse hypers

260 as once thought, with DNA damage frequently stalling replication forks.

261 that promotes template-switching and acts by stalling replication rather than by direct nucleotide ba

262 during replication, thereby preventing fork stalling, replication stress, and secondary DNA damage r

263 e results show directly that TNR replication stalling, replication stress, hairpin formation, and ins

264 cause translational infidelity and ribosome stalling, resulting in neurodegeneration.

265 Pol II stalling results from impaired loading of the template b

266 Ribosome stalling results in the production of truncated proteins

267 is of a set of plasticity-reated proteins by stalling ribosomal translocation on target mRNAs.

268 blocks superinfection by coliphage lambda by stalling RNA polymerase (RNAP) translocation specificall

269 onitor RNA G4-mediated reverse transcriptase stalling (RTS) events.

270 F5A strongly promotes the translation of the stalling sequences identified by profiling and increases

271 nome-wide replication restart following fork stalling similar to that observed after STN1 depletion.

272 5' end of mRNAs, but rather acts at specific stalling sites that are scattered throughout the entire

273 ation risk is causally unrelated to promoter stalling (Spt5), transcriptional activity, or off-target

274 TM and Rad3 related) during replication fork stalling stabilizes the replisome, but how these modific

275 bosomes on coding sequences known to trigger stalling, such as polyproline.

276 ated enzyme and unravel a mode of RNA Pol II stalling that is due to alkylation of DNA in the minor g

277 ons in A/T-rich DNA such as replication fork stalling that is implicated in early stage carcinogenesi

278 the lesion at a reduced rate after replisome stalling, that one replisome is capable of skipping mult

279 it is possible to manipulate phagocytosis by stalling the centripetal movement of the phagosome using

280 ing strand template arrests the replisome by stalling the CMG helicase.

281 During stalling the free energy profile of the enzymatic steps

282 hat Cdc45-ssDNA interaction is important for stalling the helicase during replication stress.

283 However, the results suggest that stalling the processive movement and low off-rates resul

284 nce T-cell activation has occurred, however, stalling the rejection process becomes increasingly diff

285 we could show that (i) at the time point of stalling, the beta-barrel appears folded; (ii) the stall

286 mporarily stalled ribosome and length of the stalling, the ribosomes must be synchronized during tran

287 sient attrition mediated by replication fork stalling, this is balanced not only by temporal expansio

288 This stalling time increases linearly with viomycin concentra

289 h FoSTeS and/or MMBIR and serial replication stalling to be the predominant mechanisms leading to NF1

290 In eukaryotes, ribosome stalling triggers release of 60S subunits with attached

291 analysis, we provide a distinct hierarchy of stalling triplets, ranging from strong stallers, such as

292 se translocase to slip on its protein track, stalling unfolding and interrupting degradation.

293 t Ytel repeats cause strong replication fork stalling, we suggest that formation of double-stranded D

294 es, namely convergent transcription and Pol2 stalling, were detected at breakpoints.

295 ribosome is slow, resulting in translational stalling when several Pro have to be incorporated into t

296 es of polypeptides that induce translational stalling when synthesized on a ribosome.

297 te the existence of a force regime far below stalling where the mechanical power transduced by the ra

298 rant or problematic mRNAs can cause ribosome stalling which leads to the production of truncated or d

299 t couples rG4-mediated reverse transcriptase stalling with next-generation sequencing.

300 o a cascade of subsequent errors and kinetic stalling, with the typical mutational event consisting o