ライフサイエンスコーパス: staphylococci

1 vity against an array of multidrug-resistant staphylococci.

2 aB inhibitors to combat biofilm formation by staphylococci.

3 Ps) are highly conserved in streptococci and staphylococci.

4 hibit the growth and virulence of pathogenic staphylococci.

5 erial adhesins conserved in streptococci and staphylococci.

6 card for Enterococcus and the API system for staphylococci.

7 esins that are conserved in streptococci and staphylococci.

8 Hla might prevent invasive skin infection by staphylococci.

9 ment of 25 cases of CIED endocarditis due to staphylococci.

10 Cmec) by horizontal gene transfer from other staphylococci.

11 Gap3 are conserved in many streptococci and staphylococci.

12 y of biofilm growth with special emphasis on staphylococci.

13 nd complements the tagO mutant phenotypes of staphylococci.

14 patients infected with methicillin-sensitive staphylococci.

15 without inappropriate amplification of other staphylococci.

16 C test could predict the presence of mecA in staphylococci.

17 tively distinguish S. lugdunensis from other staphylococci.

18 f S. aureus when one of two cultures yielded staphylococci.

19 wo cultures is positive by Gram staining for staphylococci.

20 and antimicrobial resistance determinants of staphylococci.

21 s that have not been previously described in staphylococci.

22 nterpretations of nonsusceptible results for staphylococci.

23 Linezolid coverage was >98% against staphylococci.

24 LTA synthesis and the growth of ltaS mutant staphylococci.

25 n and the risk of resistance to mupirocin in staphylococci.

26 ss bridges of peptidoglycan, thereby killing staphylococci.

27 ococci (all E. faecium) but none (0/22) with staphylococci.

28 mecA-mediated oxacillin resistance in canine staphylococci.

29 id (ypfP) bound GFP-CWT similar to wild-type staphylococci.

30 suggesting a common regulatory mechanism in staphylococci.

31 ts in a manner similar to that for wild-type staphylococci.

32 moglobin and transport of this compound into staphylococci.

33 es-specific association of the reporter with staphylococci.

34 ate resistance to beta-lactam antibiotics in staphylococci.

35 disease caused by S. epidermidis and related staphylococci.

36 itis, compared with other coagulase-negative staphylococci.

37 ating persisting intracellular reservoirs of staphylococci.

38 a-sheet peptide) against multidrug resistant staphylococci.

39 ing-protein 2a of methicillin resistant (MR) staphylococci.

40 e predominant isolate was coagulase negative Staphylococci.

41 terotoxins excreted into foods by strains of staphylococci.

42 cal bacteria in addition to streptococci and staphylococci.

43 identified and readily transferred to other staphylococci.

44 gowns was performed with coagulase-negative staphylococci.

45 lococci, 15 strains of methicillin-sensitive staphylococci, 10 strains of heterologous genera (all at

46 ous fungi (25, 39.1%) and coagulase-negative staphylococci (14, 21.9%) comprised a majority.

47 the sensor was tested with 36 strains of MR staphylococci, 15 strains of methicillin-sensitive staph

48 s aureus (28%), and other coagulase-negative staphylococci (16%).

49 n oncology locations were coagulase-negative staphylococci (16.9%), Escherichia coli (11.8%), and Ent

50 ermidis (MSSE) (9), other coagulase-negative staphylococci (19), Streptococcus salivarius (5), Strept

51 Common pathogens were coagulase-negative staphylococci (21%, 10/48) and methicillin-sensitive Sta

52 ausal microorganisms were coagulase-negative staphylococci (24%), followed by Staphylococcus aureus (

53 The most frequent microorganisms were staphylococci (28.7%), followed by streptococci (20.4%)

54 Erythromycin resistance was high for staphylococci (30.6 to 94.1%) with inducible clindamycin

55 nerated data showed that oxacillin-resistant staphylococci (57.0% overall) had slightly higher dalbav

56 Bacteria cultured included staphylococci (59/126, 46.8%), Gram-negative rods (34/12

57 terquartile range, 59.8-77.6]); causation by staphylococci (62 [35.0% {95% CI, 28.0%-42.5%}] Staphylo

58 ne were active against oxacillin-susceptible staphylococci (82 to 99% susceptible), with lower suscep

59 hylococcus aureus, 26.6%; coagulase-negative staphylococci, 9.7%).

60 nts [23.0%]), followed by coagulase-negative staphylococci (94 patients [16.9%]).

61 Staphylococci, above all Staphylococcus aureus and S. ep

62 dards Institute were compared by testing 567 staphylococci against trimethoprim-sulfamethoxazole.

63 Biofilm formation by AD-associated staphylococci almost certainly plays a major role in the

64 The proportion of coagulase negative Staphylococci among the Gram positive bacterial isolates

65 This resulted in 13.6% VM errors (3/22) with staphylococci and 14.3% VM errors (2/14) with enterococc

66 lower than the reference MICs for 69% of the staphylococci and 25% of the enterococci.

67 o)ethyl ketones inhibit sortase enzymes from staphylococci and bacilli.

68 siella pneumoniae whereas Coagulase negative Staphylococci and Bacillus spp. are common causes of pos

69 This study generated susceptibility data for staphylococci and beta-hemolytic streptococci from 52 U.

70 t of wall teichoic acid (WTA) in bacilli and staphylococci and capsular polysaccharides (CPS) in stre

71 ctic acid bacteria were always present while staphylococci and coliform bacteria disappeared after 30

72 household transmission of S aureus and other staphylococci and describes contamination of household e

73 32-fold underestimation of activity against staphylococci and enterococci because of oritavancin's s

74 d 99% essential agreement for the testing of staphylococci and enterococci by the Vitek 2.

75 lightly declined, whereas coagulase-negative staphylococci and enterococci consistently increased ove

76 pparent increase in linezolid-nonsusceptible staphylococci and enterococci following a laboratory cha

77 recent emergence of linezolid-nonsusceptible staphylococci and enterococci is providing a challenge f

78 lity testing (AST) of challenge and clinical staphylococci and enterococci recovered from patients in

79 in the range of 0.5-4 mug/mL against the MDR Staphylococci and Enterococci species.

80 Staphylococci and enterococci were the most common agent

81 m-positive pathogens: vancomycin-susceptible staphylococci and enterococci, glycopeptide-intermediate

82 ethod for detecting linezolid-nonsusceptible staphylococci and enterococci, MicroScan results showed

83 g all those available on Vitek 2 for testing staphylococci and enterococci.

84 to traditional methods for the ID and AST of staphylococci and enterococci.

85 acterial pathogens, including drug-resistant staphylococci and enterococci.

86 for antimicrobial susceptibility testing of staphylococci and enterococci.

87 ymes to their close relatives throughout the staphylococci and explore the substrate specificities of

88 teins are conserved in many streptococci and staphylococci and have been implicated in bacterial viru

89 ibody showed improved clearance of pulmonary staphylococci and improved survival.

90 m was an early event in the evolution of the staphylococci and long preceded the development of the n

91 Collectively, these results suggest that staphylococci and other bacterial pathogens exploit the

92 ry out carbon catabolite repression (CCR) in staphylococci and other Gram-positive bacteria.

93 adhesion in biofilms may be conserved among staphylococci and other Gram-positive bacteria.

94 Coagulase-negative staphylococci and other gram-positive organisms were the

95 also studied; fsrB is a homologue of agrB of staphylococci and participates in regulation of gelE-spr

96 ibodies, which trigger phagocytic killing of staphylococci and protect mice against lethal bloodstrea

97 aureus colonies distinguishes it from other staphylococci and related Gram-positive cocci.

98 icting mecA-mediated oxacillin resistance in staphylococci and revised Table 2C in CLSI document M100

99 ibacterial compound active against resistant staphylococci and some clinically relevant Gram negative

100 Coagulase-negative staphylococci and Staphylococcus aureus, in 42% and 29%

101 Staphylococci and streptococci are considered predominan

102 cies; this may have clinical relevance since staphylococci and streptococci are the most common cause

103 ads among bacteria, with multidrug-resistant staphylococci and streptococci infections posing major t

104 gorization of potentially indicated species (staphylococci and streptococci).

105 than that of vancomycin when tested against staphylococci and streptococci.

106 comparative population genetics results for staphylococci and the first statistical evidence for a c

107 characterization, correlation, and impact of staphylococci and their biofilms in AD.

108 lieve the environmental hit in AD relates to staphylococci and their biofilms, which occlude sweat du

109 bility testing of other beta-lactams against staphylococci and to indicate that susceptibility to the

110 of TarM revealed an ancient origin in other staphylococci and vertical inheritance during S. aureus

111 s cultured were typically coagulase-negative staphylococci and were associated with increased levels

112 ne residues and reduced biofilm formation by staphylococci and Y. pestis in vitro.

113 6% {95% CI, 24.9%-39.0%}] coagulase-negative staphylococci); and a high prevalence of health care-ass

114 ia, including enterococci, streptococci, and staphylococci, and antibodies against LTA have been show

115 ropionibacterium species, coagulase-negative staphylococci, and Corynebacterium species were the micr

116 coccus epidermidis, other coagulase-negative Staphylococci, and Corynebacterium species.

117 om three gram-positive species (pneumococci, staphylococci, and group B streptococci) during the expo

118 The gene orfX is conserved among all staphylococci, and its complete sequence is maintained u

119 glycoproteins are conserved in streptococci, staphylococci, and lactobacilli, and are required for ba

120 porting recommendations for beta-lactams and staphylococci, and microbiologic data and clinical data

121 ded gram-positive cocci (45%), predominantly staphylococci, and nosocomial gram-negative bacilli (27%

122 cally relevant pathogens (e.g., enterococci, staphylococci, and streptococci) are Gram-positive (G+),

123 micin, possess activity against Enterococci, Staphylococci, and Streptococci, and other Gram-positive

124 rynebacterium, Acinetobacter, Brevundimonas, Staphylococci, Aquabacterium, Sphingomonas, Streptococcu

125 Staphylococci are a frequent cause of bloodstream infect

126 Staphylococci are a major health threat because of incre

127 Staphylococci are able to use nitrate as an alternative

128 sions requires that these coagulase-positive staphylococci are accurately identified and specifically

129 Staphylococci are commensal bacteria that colonize the e

130 y Sec (SecA2/Y2) systems of streptococci and staphylococci are dedicated to the transport of large se

131 Further, EsaC production is repressed when staphylococci are grown in broth and increased when stap

132 ycoproteins identified from streptococci and staphylococci are important for bacterial adhesion and b

133 oteins (SRRPs) conserved in streptococci and staphylococci are important for bacterial colonization a

134 Staphylococci are important opportunistic pathogens.

135 medical devices by common pathogens such as staphylococci are not only associated with increased mor

136 The SecA2 proteins of streptococci and staphylococci are paralogues of SecA and are presumed to

137 Staphylococci are the leading causes of endovascular inf

138 Coagulase-negative staphylococci are the most frequently recovered pathogen

139 gram-positive (G(+)) bacteria, most commonly staphylococci, are thought to be the main pathogens.

140 contributes to the extraordinary success of staphylococci as colonizers and infective agents on huma

141 cultural findings showing coagulase-negative staphylococci as the most common isolates (68%) in prost

142 p with cellular GTPases is not unique to the staphylococci, as homologs from Bacillus subtilis and En

143 s also presented, with the highest MIC among staphylococci at only 0.25 mug/mL.

144 ploits the specificity and physiology of the Staphylococci bacteriophage K to identify Staphylococcus

145 In post-meconium samples, the abundance of staphylococci became negatively associated with NEC deve

146 Staphylococci become resident in households, either as c

147 agr is conserved throughout the staphylococci but has diverged along lines that appear t

148 ction of inducible clindamycin resistance in staphylococci, but only a disk approximation test for th

149 e not yet known, opsonophagocytic killing of staphylococci by phagocytic cells offers opportunities t

150 Taken together, MyD88-dependent sensing of staphylococci by resident dermal Mvarphis is key for a r

151 t, we characterize a genetic locus unique to staphylococci called rsr that has a role in repressing t

152 Our study indicates that staphylococci can react to human AMPs by specific mechan

153 We demonstrate that staphylococci capture hemoglobin on the bacterial surfac

154 ve poor final acuity than coagulase-negative staphylococci cases (adjusted OR, 11.28; 95% CI, 3.63-35

155 Staphylococcus aureus and other staphylococci cause severe human disease, and there are

156 Staphylococcus aureus and coagulase-negative staphylococci clinical isolates cultured at our institut

157 sistance of S. aureus and coagulase negative staphylococci clinical isolates to tetracycline or rifam

158 occus spp. (P = 0.85) and coagulase-negative staphylococci (CNS) (P = 0.88).

159 he dominant isolates were Coagulase negative Staphylococci (CNS) 9(29.0%), Staphylococcus aureus (S.

160 Coagulase-negative staphylococci (CNS) are important causes of infective en

161 Coagulase-negative staphylococci (CNS) were the most commonly isolated orga

162 s, Staphylococcus aureus, coagulase-negative staphylococci (CNS), Peptostreptococcus spp., Bacteroide

163 demonstrated the presence of thick clumps of staphylococci colonizing the wound bed.

164 ted pathogen, followed by Coagulase negative staphylococci (CoNS) (33.5%) and Klebsiella species (4.7

165 organisms identified were Coagulase-negative Staphylococci (CoNS) [65.9% (91/138)] and Staphylococcus

166 ferentiate S. aureus from coagulase-negative staphylococci (CoNS) and other Gram-positive cocci (GPC)

167 Coagulase-negative staphylococci (CoNS) and Staphylococcus aureus are part

168 transfer originating from coagulase-negative staphylococci (CoNS) and through clonal transmission.

169 Coagulase-negative staphylococci (CoNS) are the main cause of catheter-rela

170 Coagulase-negative staphylococci (CoNS) form a thick, multilayered biofilm

171 ing methicillin-resistant coagulase-negative staphylococci (CoNS) is not known.

172 e, virulent member of the coagulase-negative staphylococci (CoNS) that is responsible for severe, rap

173 s-level identification of coagulase-negative staphylococci (CoNS) using matrix-assisted laser desorpt

174 Staphylococcus aureus and coagulase-negative staphylococci (CoNS) were 99.5% (217/218) and 98.8% (487

175 Coagulase negative Staphylococci (CoNS) were the most common bacteria (54.6

176 s, a 1.4-fold increase in coagulase-negative staphylococci (CoNS), and a 3.9-fold increase in other b

177 ant S. aureus (MRSA), and coagulase-negative staphylococci (CoNS), including methicillin-resistant Co

178 of Staphylococcus aureus, coagulase-negative staphylococci (CoNS), Streptococcus pneumoniae, Haemophi

179 e rapid identification of coagulase-negative staphylococci (CoNS).

180 caused by enterococci and coagulase-negative staphylococci (CoNS; adjusted SHR, 0.91; 95% CI, .50-1.6

181 reviews beta-lactam resistance mechanisms in staphylococci, current antimicrobial susceptibility test

182 ed tissues using a specific antibody against staphylococci demonstrated the presence of thick clumps

183 reaction for species-level identification of staphylococci, detection of genes encoding Panton-Valent

184 Methicillin resistance among staphylococci did not increase during the 5-year study p

185 redundant, and so the evasion strategies of staphylococci display redundant functions as well.

186 ss lesions into purulent exudate, with which staphylococci disseminate to produce new infectious lesi

187 Thus, staphylococci employ envelope proteins at discrete stage

188 Under anaerobic conditions, staphylococci employ the nitrate regulatory element (Nre

189 The microflora comprised staphylococci, enterococci (2.2 log(10)CFU/g) and lactic

190 ng Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus faecalis, E. faecium, E. avi

191 Staphylococci, Escherichia coli, and Candida spp. were i

192 Thus, staphylococci exploit the ubiquitous and multifunctional

193 Pathogenic staphylococci express several different SD proteins that

194 portions were highest for coagulase-negative staphylococci followed by gram-negative rods and Staphyl

195 cycle activity can be induced by preventing staphylococci from exogenously acquiring a TCA cycle-der

196 y isolated species of the coagulase negative staphylococci from human stool.

197 inds the Fcgamma domains of IgG and protects staphylococci from opsonophagocytic clearance.

198 Staphylococci grow as communities at the center of absce

199 such as vancomycin-resistant Enterococci and Staphylococci has become a major global health hazard.

200 y indicate that quorum-sensing regulation in staphylococci has important, previously unknown function

201 CR), which confers methicillin resistance in staphylococci, has the added potential to reduce antibio

202 s in 5.8% (26/443), other coagulase-negative staphylococci in 6.0% (27/448), Propionibacterium acnes

203 le modulins, surfactant peptides secreted by staphylococci in a quorum-sensing controlled fashion, st

204 Animals that succumbed to challenge harbored staphylococci in abscess lesions and in blood.

205 e associated with reduced survival of mutant staphylococci in blood and diminished virulence in mice.

206 Differentiating staphylococci in blood cultures is a critical issue, par

207 T-PCR, and TCT4 for direct identification of staphylococci in blood cultures.

208 sor described has the potential to detect MR staphylococci in clinical samples with a high degree of

209 eptococcus pneumoniae and Coagulase negative Staphylococci in endophthalmitis diagnoses.

210 -lactam susceptibility in coagulase-negative staphylococci in our laboratory.

211 rated activity against methicillin-resistant staphylococci including investigational cephalosporins,

212 ctive in vitro bactericidal activity against staphylococci, including methicillin- and multi-drug-res

213 showed strong antibacterial activity against staphylococci, including MRSA strain, but did not affect

214 Although coagulase-negative staphylococci, including Staphylococcus epidermidis, are

215 infection vs. 14 days for coagulase-negative staphylococci infection [p < 0.001]).

216 usly unknown mechanism by which a product of staphylococci inhibits skin inflammation.

217 ne responsible for methicillin resistance in staphylococci, inserts into the chromosome at a specific

218 y to recruit PML within hours in response to staphylococci, irrespective of bacterial viability.

219 The shape of Staphylococci is principally maintained by peptidoglycan

220 though the agr system is conserved among the staphylococci, it has undergone significant evolutionary

221 occi were less bactericidal and cocolonizing staphylococci less susceptible to this effect; however,

222 icillin and other beta-lactam antibiotics in staphylococci, mecA, is carried on a genomic island, SCC

223 he accessory Sec systems of streptococci and staphylococci mediate the transport of a family of large

224 rug has demonstrated potent activity against staphylococci (minimum inhibitory concentration [MIC] fo

225 confirm whether colonization with commensal staphylococci modulates skin immunity and attenuates dev

226 on, which in turn renders the lukAB-negative staphylococci more susceptible to killing by neutrophils

227 biology of the disease has also changed, and staphylococci, most often associated with health-care co

228 owered the bacterial burden in a neutropenic Staphylococci murine infection model.

229 challenge panel of enterococci (n = 50) and staphylococci (n = 50), including 17 and 15 isolates tha

230 robacteriaceae (n=22) and coagulase-negative staphylococci (n=6).

231 Further, Deltalcp mutant staphylococci no longer restricted the deposition of Lys

232 nd other superantigens by coagulase-negative staphylococci, no associated pathogenicity islands have

233 streptococci (2 of 5), or coagulase-negative staphylococci (none of 8) (P = 0.02).

234 Division in Staphylococci occurs equatorially and on specific sequen

235 ne sensitivity testing in coagulase-negative staphylococci often lead to the use of potentially less-

236 Agr is a global regulatory system in the staphylococci, operating by a classical two-component si

237 e samples (730) contained coagulase-negative staphylococci or nonstaphylococci as assessed by the Qui

238 to cause serious diseases from the vaginal (staphylococci) or oral mucosa (streptococci) of the body

239 cin-intermediate S. aureus isolates; and 102 staphylococci other than S. aureus (non-S. aureus).

240 However, a minority of the Staphylococci overcome the KC's antimicrobial defenses.

241 niae and Escherichia coli in Conjunctivitis; Staphylococci, P. aeruginosa and E. coli in dacryocystit

242 In staphylococci, partial de-N-acetylation of the exopolysa

243 Staphylococci produce autoinducing peptides (AIPs) as qu

244 . coli in dacryocystitis; Coagulase negative Staphylococci, Pseudomonas aeruginosa and Staphylococcus

245 bacter, Enterobacter, and coagulase-negative staphylococci recovered from the hands and immediate env

246 ococci are grown in broth and increased when staphylococci replicate in serum or infected hosts.

247 l as collagen deposits and immune cells with staphylococci replicating at the center of these lesions

248 Contrary to other coagulase-negative staphylococci, S. lugdunensis bound to VWF under flow, t

249 Through the agr quorum-sensing system, staphylococci secrete unique autoinducing peptides (AIPs

250 Notably, Staphylococci spp. from CNA exhibit low identification r

251 taphylococcus aureus, and coagulase-negative staphylococci strains.

252 er dividing the isolates into two subgroups, staphylococci, streptococci, and enterococci (n = 217) a

253 tection of 12 different organisms, including staphylococci, streptococci, and enterococci, as well as

254 the greatest burden of disease being due to staphylococci, streptococci, and enterococci.

255 e identification of 305 clinical isolates of staphylococci, streptococci, and related genera by compa

256 eral, regional differences in activity among staphylococci, streptococci, Haemophilus spp., and Morax

257 S rRNA gene PCR/pyrosequencing as containing staphylococci, streptococci, or enteric Gram-negative ro

258 w, Staphylococcus aureus, Coagulase negative Staphylococci, Streptococcus pneumoniae and Pseudomonas

259 of the respective clinical diagnose include Staphylococci, Streptococcus pyogenes and Pseudomonas ae

260 s and Pseudomonas aeruginosa in blepharitis; Staphylococci, Streptococus pneumoniae, Pseudomonas aeru

261 in 2009, the CLSI altered the guidelines for staphylococci such that disk diffusion was no longer an

262 soluble hTSP-1 to proteolytically pretreated staphylococci suggested a proteinaceous nature of potent

263 Of 118 strains of coagulase-negative staphylococci tested, 81 were oxacillin resistant and 37

264 14- to 17-kb mobile pathogenicity islands in staphylococci that carry genes for superantigen toxins a

265 esins found in a variety of streptococci and staphylococci that have been implicated in bacterial pat

266 In staphylococci the SaPI strategy seems to have prevailed

267 In staphylococci, the adhesins extracellular adherence prot

268 For non-S. aureus staphylococci, the CA, EA, VME, major errors, and minor

269 Despite being secreted by virulent staphylococci, the contribution of PI-PLC to the capacit

270 ic gram-positive cocci (GPC), and especially staphylococci, the most common causative organisms.

271 On Staphylococci, the MSCRAMMs often have multiple ligands.

272 Although early colonization is dominated by Staphylococci, their significant decline contributes to

273 For the non-S. aureus staphylococci, there was 98.0% agreement for the ID of 1

274 For the staphylococci, there was 98.9% categorical agreement (CA

275 dispensable for the early immune response to staphylococci, they contributed to Mvarphi renewal after

276 rial adhesins found in many streptococci and staphylococci; they play important roles in bacterial bi

277 In staphylococci, this exopolysaccharide matrix is composed

278 hich are often complicated by the ability of staphylococci to grow as biofilms.

279 , leading to increased binding of CS-treated staphylococci to immobilized fibronectin and increased a

280 ted binding efficiency for late growth phase staphylococci to immobilized platelets, compared with th

281 lammatory cell death, which was required for staphylococci to penetrate across a keratinocyte barrier

282 tic resistance genes and immunizes avirulent staphylococci to prevent the spread of plasmid-borne res

283 vidual transcript responses to Hla-secreting staphylococci was notable for upregulation of host cytok

284 consecutive patients with coagulase-negative staphylococci were analyzed for comparison.

285 Colonies resembling staphylococci were confirmed as S. aureus by standard me

286 Coagulase-negative staphylococci were identified in 7 eyes.

287 of 73% contamination when coagulase-negative staphylococci were identified, 67.6% prevalence of risk

288 In this study, staphylococci were isolated from retail pork and retail

289 Staphylococci were isolated using selective enrichment m

290 rast, in post-meconium, increased numbers of staphylococci were negatively associated with NEC.

291 Staphylococci were quantified from tampons/diaphragms in

292 In particular, commensal staphylococci were significantly less abundant in infant

293 The very major error rates for staphylococci were the highest for VITEK (35.7%), Etest

294 Staphylococci were the most common causal agents, accoun

295 Staphylococci were the most common pathogen (47%), but p

296 Coagulase-negative staphylococci were the only pathogens associated with sh

297 Phi function is supported by the response to staphylococci, where TLR13 and UNC-93B limit the cytokin

298 ed wall peptides, blocked GFP-CWT binding to staphylococci, whereas murein monomers or lysostaphin-so

299 cross-walls and in the relative abundance of staphylococci with cross-walls, suggesting that spd muta

300 fected samples contained multidrug-resistant staphylococci, with S aureus (42.0%) and Staphylococcus