ライフサイエンスコーパス: staphylokinase

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1 ogen activators or by endogenously expressed staphylokinase.

2 facilitate tissue invasion without producing staphylokinase.

3 produce the bacterial plasminogen activator, staphylokinase.

4 ith and match in size the staphylococcal PA, staphylokinase.

5 The majority of S. aureus strains produce staphylokinase, a plasminogen activator capable of inact

6 Unlike staphylokinase, a single domain protein, streptokinase,

7 In vitro, cathelicidin bound directly to staphylokinase and augmented staphylokinase-dependent pl

8 ion was established, the interaction between staphylokinase and plasminogen did not promote systemic

9 "fibrin-dependent mechanisms" (akin to both staphylokinase and tissue Pg activator) that include: 1)

10 ted to the potent serine protease plasmin by staphylokinase and tissue plasminogen activator.

11 erate sequence identity to streptokinase and staphylokinase, bacterial activators of human plasminoge

12 Homology modelling based upon structures of staphylokinase complexed with human microplasminogen sup

13 und directly to staphylokinase and augmented staphylokinase-dependent plasminogen activation and fibr

14 Streptokinase (SK) and staphylokinase form cofactor-enzyme complexes that promo

15 other two phages, phi 13 also introduces the staphylokinase gene (sak) and a second gene related to e

16 Our results point out the dual roles of staphylokinase in S. aureus skin infections as promoting

17 Therefore, we hypothesized that staphylokinase interacts with cathelicidin during the ea

18 te generation and activated plasminogen by a staphylokinase mechanism.

19 At the same time, SKDelta59 is unlike staphylokinase or SK and is more like tissue Pg activato

20 These data suggest that staphylokinase production may be a novel virulence mecha

21 Also, increased staphylokinase production was associated with noninvasiv

22 of activation of human plasminogen (HPg) by staphylokinase (Sak) required formation of an active com

23 investigated the contribution of fibrin and staphylokinase (Sak) to biofilm formation.

24 of the staphylococcal plasminogen activator, staphylokinase (SAK), was analyzed for its ability to me

25 EA, SEG, and SEK and the fibrinolytic enzyme staphylokinase (Sak), was identified in the unannotated

26 The properties of recombinant staphylokinase (SakSTAR) expressed in Pichia pastoris ce

27 nd in vitro and ex vivo assays, we show that staphylokinase, secreted by S. aureus, promoted the esta

28 In this manner, SKDelta59 behaves more like staphylokinase than like SK; it requires plasmin to form

29 ve evolved PAs [e.g., streptokinase (SK) and staphylokinase] that exploit the Pg system to infect ani

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