ライフサイエンスコーパス: staple

1 people who rely on sorghum as their dietary staple.

2 ently links the ribosome subunits via an RNA staple.

3 idity unmatched by peptides bearing a single staple.

4 cting residues with a constraining, olefinic staple.

5 ns form electron-dense plaques which we term staples.

6 variants containing rigid perfluoroaromatic staples.

7 linkage, it is referred to as 'double-click' stapling.

8 trated increased alpha helicity upon peptide stapling.

9 erwent haemorrhoidectomy (open 11; closed 3; stapled 1), and two rubber band ligation.

10 e permeable, by performing a case study on a stapled 12-mer peptide named NYAD-1.

11 the wound are brought together with sutures, staples, adhesive glue or clips.

12 mportantly, chemical stability of the formed staples allowed us to use this motif in the native chemi

13 rcement of fissure openings as compared with stapling alone, with or without tissue sealant or glue,

14 rcement of fissure openings as compared with stapling alone, with or without tissue sealant or glue,

15 thesis to introduce a single all-hydrocarbon staple along one face of an alpha-helical peptide greatl

16 eable, hydrocarbon-stapled synthetic peptide stapled alpha-helical peptide derived from mastermind-li

17 Stapled alpha-helical peptides have emerged as a promisi

18 ructurally and functionally mimic the parent stapled alpha-peptide in its ability to enter certain ty

19 resistant to proteolysis than is the parent stapled alpha-peptide.

20 We show that a stapled alpha/beta-peptide can structurally and function

21 places isoleucine 689 with an S-gamma-methyl stapled amino acid, and has significantly higher affinit

22 a methyl group in the gamma-position of the stapling amino acid S5.

23 The overall results confirm that the stapled analog of TM4(88-100) retains the structural com

24 ein binding motif onto a covalent side-chain staple and applied to the peptide to enhance its helicit

25 The sham diet restricted a similar number of staple and non-staple foods as the low FODMAP diet; the

26 However, in contrast to stapled and compression colorectal anastomoses, the tech

27 errupted vs continuous sutures, hand-sewn vs stapled and compression colorectal anastomosis, and anas

28 Staples and soluble aggregates placed in cis-Golgi ciste

29 We report the discovery of a peptide stapling and macrocyclization method using thiol-ene rea

30 ture, initial origami concentration, missing staples, and origami geometry.

31 s major organic forms from commonly consumed staples, and the effect of heat processing on the same.

32 Radiation therapy is a staple approach for cancer treatment, whereas radioresis

33 e, we report the use of a diversity-oriented stapling approach to produce autophagy-inducing peptides

34 Staples are fraught with limitations including high-loca

35 Whereas the membrane staples are located in the flattened, stacked central re

36 the rotating arrangement of the four dimeric staples as well as the arrangement of the bridging thiol

37 This work introduces in situ stapling as a versatile biocompatible technique with man

38 e that D-loop interactions act as "molecular staples" at the icosahedral 2-fold symmetry axis and sig

39 We synthesized stapled Axin mimetic analogues and demonstrated increase

40 Here we report the crystal structure of a stapled bicyclic peptide inhibitor G7-B1 in complex with

41 ve generated alpha/beta-peptides based on a "stapled" Bim BH3 alpha-peptide, which contains a hydroca

42 Double-click stapling can enhance the binding affinity, proteolytic s

43 r basis of zinc (Zn) uptake and transport in staple cereal crops is critical for improving both Zn co

44 omized trial confirmed that reinforcement of stapled closure during distal pancreatectomy reduces the

45 sion was performed in 172 (90%), followed by stapled colorectal anastomosis (n=26; 15%), manual coloa

46 ted peptide-MHC (pMHC) class I multimers are staple components of the immunologist's toolbox, enablin

47 ding to peptides bearing multiple contiguous staples connected by a central spiro ring junction.

48 r cell penetrating ability compared to their stapled counterparts, suggesting that this technology ma

49 Rice (Oryza sativa), the staple crop for the largest number of people on earth, i

50 lives in countries sourcing nearly all their staple crop imports from partners who deplete groundwate

51 cereals, rice is the second most cultivated staple crop in the world.

52 Cassava is an important staple crop in tropical and sub-tropical areas.

53 Common bean (Phaseolus vulgaris L.), the staple crop of Nicaragua, provides protein and nonhaem i

54 Rice (Oryza sativa) is a staple crop that supports half the world's population an

55 wth measurements to map QTL in rice, a major staple crop.

56 ome-enabled breeding efforts to improve this staple crop.

57 chers and breeders to improve this important staple crop.

58 h, as the major nutritional component of our staple crops and a feedstock for industry, is a vital pl

59 mpacts of germplasm improvement in the major staple crops between 1965 and 2004 on global land-cover

60 ps, but enhancing the nutritional quality of staple crops can potentially offset limitations associat

61 ugarcane, jatropha, and eucalyptus, and that staple crops have lower water requirements (<7,000 m(3)h

62 The rate of annual yield increases for major staple crops must more than double relative to current l

63 re these data with two baseline scenarios of staple crops representing previous water demand.

64 thogens, causing significant yield losses on staple crops such as rice and wheat.

65 global health issue, but the iron content of staple crops such as wheat (Triticum aestivum) is diffic

66 cy in a wide variety of cereal species - the staple crops that feed the world.

67 w improved strategies for the engineering of staple crops to accumulate additional bioavailable iron

68 ransporters can be used to enhance yields of staple crops, increase nutrient content and increase res

69 ivilization(1) and has become one of world's staple crops.

70 , demand for plantain is more than for other staple crops.

71 tant viral disease affecting one of Africa's staple crops.

72 Rice is a staple diet as well as a major ingredient in many proces

73 where people must rely upon sorghum as their staple diet.

74 onsiderably in relation to the nature of the staple diet.

75 At high doses, staple dissociation increases which causes structural di

76 d tether-nucleic acid strands and additional staple elements with long nucleic acid chains, acting as

77 In one case (MAP-1) where stapling enhanced alpha-helicity in aqueous and lipid en

78 Stapling essentially prevented peptide degradation in bl

79 etween two cysteine sulfhydryl groups (i.e., staple), followed by photochemical release (i.e., unstap

80 ethnic fermented beverage, is consumed as a staple food and refreshing drink by the vast number of I

81 DOCK8-deficient patients is directed against staple food antigens but not house dust mites.

82 Rice is the most important staple food crop and a model grass for studies of bioene

83 a (Manihot esculenta Crantz) is an important staple food crop in Africa and South America; however, u

84 e genome-wide association mapping in rice, a staple food crop.

85 Despite these attributes as staple food crops and sources of high-value chemicals, D

86 y significantly to meeting future demand for staple food crops given that an 8% yield increase across

87 ach--genome elimination--for the breeding of staple food crops in Africa and South America.

88 Rice is a staple food eaten by more than 50% of the world's popula

89 Cassava is a major staple food for about 800 million people in the tropics

90 potatoes (Solanum tuberosum andigenum) are a staple food for Andean population; there is great biodiv

91 duce a stable folate in fortified noodles, a staple food for Asian populations that may require impro

92 Rice is the staple food for more than 50% of the world's population(

93 llet [Cenchrus americanus (L.) Morrone] is a staple food for more than 90 million farmers in arid and

94 Rice is a staple food for nearly half the world's population.

95 Rice is a staple food for over half of the world's population, but

96 Accelerating crop improvement in sorghum, a staple food for people in semiarid regions across the de

97 Chinese steamed bread (CSB) is a staple food in China since ancient time.

98 fruit in the world market and is consumed as staple food in many countries.

99 One popular staple food in many lands is minced meat, traditionally

100 he production of sweetpotatoes, an important staple food in Sub-Saharan Africa.

101 rom maize was efficacious when consumed as a staple food in this population and could avoid the poten

102 Sorghum has immense value as a staple food item for humans in Africa, but it is poorly

103 Rice (Oryza sativa) provides a staple food source for more than 50% of the world's popu

104 al grains in the world today and serves as a staple food source for more than half of the world's pop

105 Rice (Oryza sativa L.) is the primary staple food source for more than half of the world's pop

106 Apios (Apios americana Medik.), once a staple food source of Native American Indians, produces

107 esticated, along with its development into a staple food source, is thus essential.

108 Bread is a staple food that is traditionally made from wheat flour.

109 sub-Saharan Africa, relying on cassava as a staple food, offers invaluable opportunities to advance

110 regions where thiamine-poor white rice is a staple food.

111 poor Africans that depend upon plantain as a staple food.

112 n are agropastoralists and grow maize as the staple food.

113 rove the nutritional value of this important staple food.

114 reasing interest worldwide as an alternative staple food.

115 countries where people eat mostly rice as a staple food.

116 people who depend primarily on rice as their staple food.

117 of adults with well-characterized allergy to staple foods ('cases') and controls.

118 Analysis of 10 types of locally produced staple foods (including meat, fish, and eggs), provided

119 12-h period under an unrestricted diet with staple foods and a hypoallergenic potato-rice-diet (each

120 with micronutrient powders, fortification of staple foods and condiments, and activities to improve f

121 we determined the levels of IgE specific for staple foods and house dust mite allergens in DOCK8-defi

122 estricted a similar number of staple and non-staple foods as the low FODMAP diet; the diets had simil

123 useholds with at least one adult allergic to staple foods compared with controls.

124 Swedish adults with allergy to staple foods have higher total costs determined as direc

125 Being one of the major staple foods in the world, and an interesting model mono

126 Iodine concentration in staple foods was low, with median concentrations of 0.01

127 Iron (Fe) is an important mineral element in staple foods which is required in sufficient bioaccessib

128 The biofortification of staple foods with carotenoids provides an efficient deli

129 Rice is one of the most important staple foods worldwide, but it often contains inorganic

130 mycotoxins that contaminate a wide range of staple foods, including maize and groundnuts.

131 the iron and zinc availabilities in African staple foods.

132 calorie intake constant with replacement by staple foods.

133 ed binding mode of the peptide, in which the staple forms an alternative contact with the surface of

134 landraces of maize productive enough to be a staple grain existed in Central America by 4,300 cal B.P

135 ear when maize was productive enough to be a staple grain in the Americas.

136 tively examined intakes of carbohydrates and staple grains as well as glycemic index and glycemic loa

137 Modern gluten-containing staples had levels of TLR4-activating ATIs that were as

138 24 (7%) of 338 participants who received stapled haemorrhoidopexy and 33 (9%) of 352 participants

139 777 patients were randomised (389 to receive stapled haemorrhoidopexy and 388 to receive traditional

140 excisional surgery should be considered over stapled haemorrhoidopexy as the surgical treatment of ch

141 ical effectiveness and cost-effectiveness of stapled haemorrhoidopexy compared with traditional excis

142 raditional excisional surgery group than the stapled haemorrhoidopexy group over 24 months; mean diff

143 antly better quality of life scores than the stapled haemorrhoidopexy group.

144 EQ-5D-3L was higher for stapled haemorrhoidopexy in the first 6 weeks after surg

145 sex, and centre with an automated system to stapled haemorrhoidopexy or traditional excisional surge

146 Stapled haemorrhoidopexy was less painful than tradition

147 ive either traditional excisional surgery or stapled haemorrhoidopexy.

148 orrhoids; traditional excisional surgery and stapled haemorrhoidopexy.

149 The all-hydrocarbon staple has emerged as one such solution, conferring alph

150 The resulting stapled helix peptide potently and selectively binds to

151 describe the discovery and optimization of a stapled helix peptide that binds to the N-terminal domai

152 Stapled helix peptides can serve as useful tools for inh

153 reagents in oxidative processes has become a staple in modern organic synthesis.

154 ome sequencing is routine and will soon be a staple in research and clinical genetics.

155 Radiation is a staple in therapeutic regimens, although cells surviving

156 proof of concept, MDM2-binding peptides were stapled in parallel, directly in cell culture medium in

157 f genetically encoded, nonreducible covalent staples in a target protein scaffold using computational

158 increase in adhesion strength compared with staples in skin graft fixation, and removal force of ~4.

159 tegorise and analyse key examples of peptide stapling in terms of their synthesis and applicability t

160 ons of the molecular composition of key food staples incorporated into contemporary diets and how the

161 Fecal bacteria such as E. coli have been staple indicator organisms for over a century, however t

162 g closing metathesis to show that the closed staple is essential to the target interaction.

163 Peptide stapling is a method for designing macrocyclic alpha-hel

164 Peptide stapling is a strategy for constraining short peptides t

165 Stapling is carried out by covalently linking the side-c

166 A distinguishing feature of double-click stapling is the efficiency with which peptides bearing d

167 acids as well as a role for the hydrocarbon staple itself in target engagement.

168 This indicates that the fiber staple length and/or debris encapsulated inside the fabr

169 gonal close packing) Au9 kernel protected by staple-like motifs including one tetramer, one dimer, an

170 Two staple-like PhC identical withC-Au-C identical withCPh m

171 midal Au15 kernel, which is protected by two staple-like trimeric Au3(SR)4 motifs, two monomeric Au(S

172 e to LR, where LR included recurrence at the staple line (local progression), in the primary tumor lo

173 was most marked in 14 patients with positive staple line cytology (HR, 0.22; P = .24).

174 < 1 cm, margin-to-tumor ratio < 1, positive staple line cytology, wedge resection, nodule size > 2.0

175 Staple line disruption may still lead to sepsis, multior

176 and distance from the pylorus (DP) where the staple line is initiated.

177 No patient had a staple line leak or abscess, and the median hospital sta

178 Staple line leak rate decreased from 6.5% to 1.4%.

179 f procedure only had a significant impact on staple line leakage rate.

180 Staple line leakage, as the most frequent and most feare

181 leeve gastrectomy (LSG) including the use of staple line reinforcement (SLR), bougie size (BS), and d

182 on), in the primary tumor lobe away from the staple line, and in ipsilateral hilar nodes.

183 m the pylorus, and use of buttressing on the staple line.

184 The Staple-line Reinforcement for Prevention of Pulmonary Ai

185 The Staple-line Reinforcement for Prevention of Pulmonary Ai

186 No randomized trial evaluating alginate staple-line reinforcement has been performed to date.

187 ATA: No randomized trial evaluating alginate staple-line reinforcement has been performed to date.

188 dy was to determine the efficacy of alginate staple-line reinforcement of fissure openings as compare

189 dy was to determine the efficacy of alginate staple-line reinforcement of fissure openings as compare

190 ciency with which peptides bearing different staple linkages can be synthesized, thus allowing for mo

191 More broadly, diversity-oriented stapling may provide a promising alternative to polycati

192 demonstrated a robust and versatile peptide stapling method that could be potentially applied to bot

193 This stapling modification performed on a peptide sequence de

194 tive, unprotected peptides with a variety of stapling modifications for helix stabilization or genera

195 The Au15 kernel and trimeric staple motif are unprecedented and offer new insight in

196 Aun(SR)m (n > m) clusters that have only the staple motifs and that the nucleation process starts fro

197 Despite the presence of such diverse staple motifs, Au279S84 structure has a chiral pseudo-D3

198 Au249 core is protected by three types of staple motifs, namely: 30 bridging, 18 monomeric, and 6

199 surface is protected exclusively by -S-Au-S- staple motifs, which self-organize into five ripple-like

200 18 kernel protected by six dimeric Au2 (SR)3 staple motifs.

201 flexibility of the ligand shell composed of staple motifs.

202 ly: 30 bridging, 18 monomeric, and 6 dimeric staple motifs.

203 Aukernel bonding, in contrast to the common "staple" motifs in which the S-Aukernel bonding is domina

204 an be easily scaled up to the fabrication of staple nanofibers at rates that may exceed tens of kilog

205 The modulation transfer function (MTF) is a staple of auditory psychophysics, and has been shown to

206 Heterolytic bond scission is a staple of chemical reactions.

207 n profiling of mammalian cells is becoming a staple of many published biomedical and biological resea

208 Human tissue culture cells have long been a staple of molecular and cell biology research.

209 Although C-C bond formation has been a staple of organic synthesis, the direct transfer of prim

210 ular, while X-ray crystallography has been a staple of structural biology for more than half a centur

211 an analysis of a complete supply chain for a staple of the global diet, a loaf of bread.

212 dable sequencing of pathogen genomes - now a staple of the public health microbiology laboratory in w

213 Stapling of side chains to stabilize an alpha-helical st

214 We then synthesized stapled p53 mimetic analogues using pure hydrocarbon lin

215 id) polymeric micelle (RGD-M) that carried a stapled peptide antagonist of both MDM2 and MDMX (sPMI).

216 Our most potent stapled peptide binds to RAP1 protein with a Ki value of

217 s reactions, and a strained 14-membered ring stapled peptide by means of macrocyclic ring-closing met

218 Surprisingly, Bclw or a stapled peptide corresponding to the Bclw BH4 domain int

219 Thus, the stapled peptide has a membrane interaction behavior simi

220 Moreover, a hydrocarbon-stapled peptide that disrupts this interaction inhibits

221 Sld5 CIP, we identified an unorthodox i,i+6 stapled peptide with improved, submicromolar binding to

222 y, the solution structure of the most potent stapled peptide, DD5-o, revealed an alpha-helical confor

223 ich RAB25 is pro-oncogenic with an optimized stapled peptide, RFP14, inhibits migration, and prolifer

224 roborated by the synthesis of new classes of stapled peptides and antibody-drug conjugates.

225 Here, we investigate whether stapled peptides are intrinsically membrane permeable, b

226 re than decade-long experience in developing stapled peptides as biomedical research tools and protot

227 in Hsmr, and portend the general validity of stapled peptides as therapeutics for the disruption of f

228 estioned the mechanistic specificity of such stapled peptides based on interrogating their capacity t

229 s in vitro and in vivo proof-of-concept that stapled peptides can be developed as therapeutically rel

230 Nearly all stapled peptides caused less membrane perturbation (vesi

231 optimization, and validation of double-click stapled peptides encoding the Ctf4-interacting peptide (

232 Relative to unmodified peptides, optimized stapled peptides exhibit increased structural stability,

233 ar distribution, in evaluating and advancing stapled peptides for clinical translation.

234 over, we show that the efficiency with which stapled peptides reach the cytosol, as determined by FCS

235 Here, we show that stapled peptides targeting the interface between NCKAP1

236 rginine Arg8, and equals that of hydrocarbon-stapled peptides that are active in cells and animals.

237 design and characterization of alpha-helical-stapled peptides that bind selectively to active, GTP-bo

238 x, we have developed first-in-class triazole-stapled peptides that block the protein-protein interact

239 Hydrocarbon-stapled peptides that display key residues of the p53 tr

240 based methods to explore the chemical space, stapled peptides to regulate intracellular PPI, alternat

241 Here, we compare four amphiphilic stapled peptides with their linear counterparts in terms

242 In Stapled Peptides, amide exchange was reduced by over fiv

243 existing crystallographic data, we developed stapled peptides, referred to as WASF Helix Mimics (WAHM

244 y to accelerate the discovery of cell-active stapled peptides.

245 "Stapled" peptides are typically designed to replace two

246 h rates of proteolysis to reveal the optimal staple placement for improved drug properties.

247 sus the native peptide sequence depending on staple placement.

248 Preliminary analysis of three staple plant foods shows two- to sixfold lower land, GHG

249 780,000 y old, reflects a varied plant diet, staple plant foods, environmental knowledge, seasonality

250 By screening stapling positions in the Sld5 CIP, we identified an uno

251 The entire double-click stapling protocol can be completed in approximately 48 h

252 ds prepared from cereal grains are a dietary staple, providing a significant proportion of daily ener

253 n initially positioned within the cis-Golgi, staples remained at the cis face of the Golgi even after

254 The stapled ribosome is directed to an orthogonal mRNA, allo

255 Here, we developed hydrocarbon double-stapled RSV fusion peptides that exhibit stabilized alph

256 mucosal and endotracheal delivery of double-stapled RSV fusion peptides.

257 Intranasal delivery of a lead double-stapled RSV peptide effectively prevented viral infectio

258 Pretreatment with double-stapled RSV peptides that specifically bound to the RSV

259 This in situ stapling/screening process gave an optimal candidate tha

260 custom template strand by binding individual staple sequences to multiple locations on the template.

261 was confirmed by a crystal structure of the stapled Sld5 peptide bound to Ctf4.

262 The stapled Sld5 peptide was able to displace the Ctf4 partn

263 The yam products can serve as staple source of energy to consumers.

264 The kernel is protected by four dimeric "staples" (-SR-Au-SR-Au-SR-) and eight bridging thiolates

265 e co-replicational synthesis of scaffold and staple strands by RCA-based enzymatic reactions allows t

266 We demonstrated that the staple strands located in different areas of the structu

267 introduction of DNA origami, which uses many staple strands to fold one long scaffold strand into a d

268 Consequently, the number of folding staple strands tremendously decreases from hundreds to a

269 l and long-range structural defects (omitted staple strands) on the thermal stability of common DNA o

270 ndreds of short DNA oligonucleotides, called staple strands, to fold a long single-stranded DNA, whic

271 affold strand and >170 short oligonucleotide staple strands.

272 purification, even in the presence of excess staple strands.

273 ture by annealing it with hundreds of short 'staple' strands.

274 stacked 12 DNA quasi-rings interlinked by 30 staple-strands.

275 s can enhance harvests and are available for staples such as cooking bananas and plantains.

276 lex by using the cell-permeable, hydrocarbon-stapled synthetic peptide stapled alpha-helical peptide

277 We report a novel stapling technique based on a double strain-promoted azi

278 lleagues describe their work using a peptide stapling technique that allowed synthesis of a stable pe

279 There is an expanding repertoire of stapling techniques based on different macrocyclisation

280 Cereal grains are the common food staples that collectively provide over 50% of dietary ca

281 is shaped into desired nanostructure by DNA staples that form Holliday junctions with the template.

282 y been limited to use as intrachain covalent staples that reinforce existing structure or induce knot

283 inhibitors are thought to act as "molecular staples" that stabilize interactions between NP monomers

284 used today, is traditionally considered the staple therapy for gout and a second-line treatment for

285 tivity (determined as TM4(88-100), and then "staple" this sequence via Grubbs metathesis to produce p

286 ey elements, i.e., state-selective molecular stapling through disulfide bridges, competition binding

287 ut which cultivars of current or future food staples to incorporate into existing and future food sys

288 n tracking the fate of proteins that become 'stapled' to the walls of the Golgi yields insights into

289 roduced a method using a hydrocarbon linker (staple) to stabilize a peptide in a helical configuratio

290 ic receptor binding site, where sulfate ions staple together positively charged patches on both DCC a

291 lic [Au(I)-SR] pentamer interlocked with one staple trimer motif protecting the tetrahedral Au4 nucle

292 HBS stapled Trp peptide exhibited signs of steric hindrance

293 ain largely neglected in comparison to other staple tuber crops of tropical agricultural systems such

294 By the functionalization of one group of staple units with programmed tether-nucleic acid strands

295 ets and how the nutrient landscapes of these staples vary as a function of cultivar and food processi

296 The impact of lactam stapling was found to vary strongly with regard to the d

297 n methanol, stabilized by an unusual (i,i+3) staple which cross-links two d-amino acids.

298 We have designed a membrane 'staple', which consists of membrane-anchored repeats of

299 eratures likely affected the productivity of staple wild cereal resources.

300 T) dye pair, were incorporated into selected staples within various 2D and 3D DNA origami structures.