ライフサイエンスコーパス: start from

1 products was the major or sole reaction path starting from 1,1- or 1,2-bis(2-nitroaryl)ethenes.

2 Starting from 1,2-dihydropyridines bearing a ring trimet

3 Starting from 1,2-dihydropyridines with trimethylsilylme

4 ce of two parallel paths of ring contraction starting from 1-isoquinolylcarbene; path a via ring expa

5 t the presence of bacteria at concentrations starting from 10(1) colony forming units (CFU)mL(-1) in

6 be obtained by a nonstereoselective approach starting from 2'-F U.

7 tion of substituted aryl dihydronaphthalenes starting from 2-allylbenzaldehydes via Grignard 1,2-addi

8 Starting from 2-deoxy-d-ribose, the product is obtained

9 chieved by a lithiation/elimination sequence starting from 2-fluoro-SF5-benzene.

10 Starting from 2-hydroxy-1,4-naphthoquinone (lawsone), we

11 crassipes (water hyacinth), was synthesized starting from 2-methoxynaphthalene in 11 steps and with

12 rom 50 mg/day) or 20 mg/day of aripiprazole (starting from 2.5 mg/day).

13 al gavage to leptin (db/db) mice for 5 weeks starting from 3 weeks of age, and to HF diabetic mice in

14 zo[h]chromeno[3,4-b][1,6]naphthyridin-6-ones starting from 3-amino-2H-chromen-2-one, again in high yi

15 r the synthesis of benzothieno[3,2-b]indoles starting from 3-nitrobenzothiophene.

16 emories as silencing COMT Val overexpression starting from 30 days after the initial aversive conditi

17 ent with specific GSK3 inhibitor (L803-mts), starting from 4 hours after 600 mg/kg dose of APAP, resu

18 ozotocin (STZ) in C57BL/6J mice for 13 weeks starting from 4 weeks of age.

19 bes annulation reactions in one or two steps starting from 5-aminoimidazole-4-carbonitriles 1-8 in mo

20 Starting from 5-min time slices, we uncover dynamic soci

21 target doses of 600 mg/day of quetiapine-ER (starting from 50 mg/day) or 20 mg/day of aripiprazole (s

22 Lactate levels in the culture medium starting from 50microM with production rates of 5microMh

23 ng on misorientation angles and type of GBs, starting from 53 Omega mum for low-mismatch angles in tw

24 nd a moderate dystrophic pattern was evident starting from 6 months of age.

25 ne propeller with a D3-symmetry was obtained starting from 7,8-dibromo[5]helicene by Yamamoto nickel(

26 When starting from 7-chloro-substituted 2,3,4-benzothiadiazep

27 We start from a sample of 143 patients characterised throug

28 nical challenges of making measurements that start from a single molecule of DNA, and then explore ho

29 e spatial distribution of the molecules that started from a given pixel.

30 flexibility of the target protein and can be started from a seed to mimic R-group strategy or fragmen

31 Starting from a careful analysis of the surface electros

32 Importantly, starting from a charge-neutralized scaffold facilitated

33 Starting from a chiral furanone, the nitrone-olefin [3 +

34 cis-DHQ) classes of alkaloids are developed, starting from a common chiral nonracemic bicyclic lactam

35 s of pyrimidine and 8-oxo-purine nucleotides starting from a common prebiotic precursor that yields t

36 sition metal compounds is usually considered starting from a description of isolated ions, as exact a

37 Starting from a differentially protected trimannopyranos

38 rices tested, matrix effects were negligible starting from a dilution factor of 100, enabling, thus,

39 Starting from a general C2-amination strategy, subsequen

40 Hence, starting from a heterogeneous population, we applied wit

41 Starting from a historical overview of the development o

42 ccount for the separation of the two domains starting from a homogeneous array of cells, and thus for

43 Starting from a known inhibitor, in the first and second

44 Starting from a library of natural products, we combined

45 Starting from a minimal case with spins of dimension 6 a

46 Starting from a potent lead, permeability and selectivit

47 thout requiring phthalazinone ring synthesis starting from a prefunctionalized arene.

48 Starting from a previous series of benzoic acid esters,

49 Starting from a progenitor collection of 39,918 mutants,

50 Here, starting from a promising lead, a small series of novel

51 Starting from a query sequence or structure, the server

52 Starting from a query sequence, ThreaDomEx first threads

53 In contrast, we performed de novo selections starting from a random library and generated nanostructu

54 -alstoscholarisine B and C were accomplished starting from a readily available indole-2-acetic ester

55 Starting from a ruthenium alkylidene complex, competitio

56 Starting from a sequence, it first generates full-length

57 Starting from a sequential structure-based virtual scree

58 Starting from a series of 1,5-diarylimidazoles with micr

59 Starting from a set of 727842 compounds, 28 molecules we

60 rm electrophilic trifluoromethylselenolation starting from a simple and easily accessible reagent, na

61 ifformine, each in less than 10 linear steps starting from a single delta-lactam building block, is r

62 FoXS computes a population-weighted ensemble starting from a single input structure by fitting to a S

63 Starting from a source population deep in the Middle Ple

64 Starting from a structure of the wild-type protein with

65 Here we show that, starting from a suite of biosynthetic enzymes, catalysts

66 lop an untargeted normal phase LC-MS method, starting from a targeted method already validated for th

67 Starting from a terminal alkyne the iteration cycle cons

68 Starting from a time series of images collected for the

69 The algorithm starts from a greedy assignment and improves it through

70 s the F23G24A25I26L27 region of hIAPP, which starts from a random coil structure, evolves into ordere

71 However, when the reaction starts from a terminal alkyne as under the practical cir

72 work of a transparent theoretical model that starts from a well-known partial differential equation t

73 New C(sp(3))-C(sp(2)) bonds are forged starting from abundant and inexpensive natural amino aci

74 ,4-dihydrocoumarin framework are constructed starting from acyclic precursors.

75 route for substituted 2,3-benzodiazepines 1, starting from aldehyde 4, was developed with excellent o

76 by cycloaromatization and cycloisomerization starting from alkynes.

77 o new oxazolo[3,2-d][1,4]oxazepin-5(3H)-ones starting from alpha-bromoamido alcohols and Michael acce

78 eterocycles such as pyrazines and imidazoles starting from alpha-diketones using phosphine supported

79 re we describe a medicinal chemistry program starting from amicarbalide that led to two compounds wit

80 re template based on a close homolog than to start from an active template based on a distant homolog

81 edict an active conformation it is better to start from an inactive structure template based on a clo

82 The tricarbocyclic scaffold was assembled starting from an easily accessible A ring building block

83 Starting from an established sensor format where aggrega

84 nt magnetoresistive (GMR) biosensor platform starting from an initially double-stranded DNA target.

85 N phases at the extremities of the channel, starting from an initially single N phase, by generating

86 Starting from an orally available compound with demonstr

87 we provide a survey of data analysis methods starting from an overview of basic statistical technique

88 ts in the field of lithium-sulfur batteries, starting from an overview of their electrochemistry, tec

89 Starting from an unbiased protein microarray screen, we

90 for weak selection to favor cooperation when starting from any configuration containing any number of

91 The uptake of Fe(II) showed a sharp edge starting from approximately pH 6.5 with 95%-100% uptake

92 isease and all-cause deaths were ascertained starting from ARIC visit 4 until 2010.

93 sing a one-pot microwave-assisted synthesis, starting from arsenic (III) oxide.

94 ate below approximately 10(-10) and that can start from as little as 50 pg DNA.

95 e, with two or more peptides per protein and starting from as little as 200 mul of plasma.

96 Tetracyclic, planar products were prepared starting from assembly of the suitably substituted couma

97 Starting from assumptions about disease biology and epid

98 to produce a micronized potassium bitartrate starting from available commercial products, since the d

99 We start from basic mechanics principles on the effects of

100 In particular, starting from basic concepts in polymer physics, we deri

101 is of functionalized imidazo[2,1-b]thiazoles starting from benzaldehydes, 2-aminothiazoles, and alkyn

102 Starting from benzo-[b]-thiophene-2-boronic acid (BZB),

103 Starting from bicyclic beta-amino acid 3 or 5, strategie

104 yelsamine D, prepared via an optimized route starting from Boc-dopamine, with paraformaldehyde afford

105 alpha-glucosidase inhibitor, was carried out starting from butadiene monoepoxide through a synthetic

106 deletion increased in size over a succession starting from camelid viruses via old human viruses to c

107 th IV fluids, inotropes, and RBC transfusion starting from cardiopulmonary bypass and ending 8 hours

108 Starting from chemical-specific transcriptional networks

109 diplopyrone was achieved in 17 linear steps starting from cis-1,4-butene-diol.

110 t the same time to reactive gradual closure, starting from class-by-class, then grades and finally th

111 ed in 13 steps and an overall yield of 1.75% starting from commercially available (E,E)-farnesol.

112 ion inhibitor, has been achieved in 12 steps starting from commercially available 1,4-dioxaspiro[4.5]

113 re of the indole alkaloid aspidophytine (2), starting from commercially available and inexpensive 3-a

114 he synthesis of polysubstituted naphthalenes starting from commercially available isovanillin and its

115 Starting from commercially available substrates and reag

116 achieved in six steps and 14% overall yield starting from commercially available tyrosol.

117 Starting from complex climate models, a key difficulty i

118 Starting from compound 1, an isoxazole compound with pot

119 Starting from computational calculations describing the

120 Starting from d-glucose, we developed a divergent synthe

121 teps and 17% yield (longest linear sequence) starting from d-mannose and (S)-propylene oxide as the s

122 After ablation of mature NK cells, starting from day 15 after HSCT and favored by the high

123 icle was given via an intranasal route daily starting from day 3.

124 tional squaramides have been easily prepared starting from diamines derived from natural amino acids

125 each saw similar patients, their nosologies started from different first principles: symptomatic pre

126 Starting from different NMR-derived structures, mutants

127 Starting from dimethyl (E)-2-{[(1-tert-butoxycarbonyl)-1

128 Mammalian chromosome replication starts from distinct sites; however, the principles gove

129 and-based production of functional biologics starting from DNA sequence information.

130 ulted in the highest bacterial load observed starting from early adulthood.

131 al processes declines progressively with age starting from early adulthood.

132 s were synthesized in a single assembly step starting from easily accessible ligands and Pd(II) catio

133 preparation of 2,6-disubstituted piperidines starting from easily accessible pro-chiral ketoenones.

134 ental mAbs by differential protein A elution starting from either a) purified parental mAbs, b) in-su

135 ey aspect of the present protocol is that we start from elemental selenium; isolation and handling of

136 eroid-based hepatic differentiation protocol starting from embryoid bodies of hiPSCs (hiPSC-EBs) for

137 (SP)-[(16)O,(17)O,(18)O]phosphoenol pyruvate starting from enantiomerically pure (R)-2-chloro-1-pheny

138 Starting from ether-containing aminoalkyne substrates, a

139 ion has been recapitulated in the laboratory starting from extant enzymes.

140 Starting from Fmoc-tyrosine phosphate and phenylalanine

141 All simulations were started from fully extended polypeptide chains, and no e

142 In this work, we start from fundamental physics in the form of the Bethe

143 Starting from fundamental multiple scattering theory it

144 Starting from fundamental physics principles, recent pro

145 nce to 6-substituted 2-pyrones was developed starting from furfuryl alcohol, a renewable resource mad

146 Airway obstruction was seen, starting from generation 6 and increasing to 40 to 50% o

147 We analyze graphene-based devices starting from graphene synthetic strategies, functionali

148 ratory pressure titration (steps of 2 cm H2O starting from >/= 26 cm H2O).

149 w that palm site inhibitors block initiation starting from GTP but not when starting from pGG.

150 with the longest linear sequence of 19 steps starting from hexanal.

151 Starting from hits identified in a high-throughput scree

152 Starting from HTS hit 5, IDO-1 inhibitor 6 (EOS200271/PF

153 w current areas of emphasis in ASD research, starting from human genetics and exploring how mouse mod

154 Starting from hundreds of genomes, we are interested in

155 Starting from hydroxy- or methoxyisatin, the synthesis f

156 tructed stepwise using solid-phase synthesis starting from immobilized primary amines.

157 chemical reactions leading to InP formation starting from InCl3 and tris(dialkylamino)phosphines.

158 f hemoglobin level was <7.5 g per deciliter, starting from induction of anesthesia) or a liberal red-

159 Starting from inexpensive levoglucosan, most reactions w

160 C and two C-N bond forming events in one pot starting from inexpensive starting material in ambient r

161 ns of international scientific collaboration starting from initial results described by literature in

162 rocurement of organs from executed prisoners starting from January 2015.

163 ne can be synthesized by the same method but starting from l-tartaric acid.

164 Their synthesis starts from l-lactic acid-derived propargyl alcohol, whi

165 The synthesis starts from l-xylose and key steps include the stereospe

166 Starting from large phage display libraries of single-ch

167 efficacious GPR4 antagonist 13 was developed starting from lead compound 1a.

168 Starting from M, a photocycle branching occurs involving

169 Controlling polymer composition starting from mixtures of monomers is an important, but

170 Using IMS MS, the entire series starting from mono- up to octasialylated GGs was detecte

171 ions up to 25% solids via a one-pot approach-starting from monomers-that combines polymerization-indu

172 eceptor, AR) in a primed conversion strategy starting from mouse fibroblasts, resulting in prostate t

173 bers of clinical-grade tumor-redirected TSCM starting from naive precursors.

174 itions, using an industrial-scale operation, starting from naturally contaminated raw materials.

175 Starting from no information on amino acid similarity, w

176 Starting from North America, USA300 spread globally, inc

177 taining 2-mercaptoethylamine was synthesized starting from O-propyloxime-N-propoxy bacteriopurpurinim

178 of the allosteric "NMR toolbox" is provided starting from one of the simplest models of allostery (i

179 Starting from one-dimension, now, we all are moving towa

180 By starting from optically pure N-protected trifluoromethyl

181 The synthetic strategy starting from ortho-substituted benzene units to constru

182 Starting from our previously discovered RNAP inhibitors,

183 Starting from our recently reported 4,5,6,7-tetrahydrobe

184 ll yield, by a three-step synthesis sequence starting from p-substituted acetophenones.

185 synthesis of Pd-Au bimetallic nanoparticles starting from palladium nanocube seeds.

186 ck initiation starting from GTP but not when starting from pGG.

187 Starting from Planck and Einstein, several authors have

188 the direct construction of an aromatic core starting from polyunsaturated systems is yet a less expl

189 re extensive after 15 days of treatment that started from postnatal day 1.

190 ord neural progenitor cells and the pipeline starting from preclinical studies to the designs of phas

191 Moreover, starting from products bearing a phenyldimethyl silyl su

192 synthesized via a two-stage domino strategy starting from propargyl ethers of 2-halo phenol derivati

193 The third approach starting from R-mandelic acid, involving the RCM reactio

194 we report the total synthesis of stolonidiol starting from (R)-(+)-limonene.

195 Diels-Alder and selenocyclization reactions, starting from (R)-citronellal and propylene oxide.

196 Here we demonstrate that, starting from random connectivity and modifying a small

197 Starting from randomization, the rate of event-free surv

198 mild cyclodehydration-aromatization reaction starting from readily available amides.

199 n-4(3H)-ones were synthesized in high yields starting from readily available benzyl alcohols and o-am

200 ss a variety of unusual deoxy amino l-sugars starting from readily available l-rhamnose and l-fucose

201 salts in high yields and excellent purities starting from readily available methyl ketones, malononi

202 al simulations of early black hole formation starting from realistic cosmological conditions.

203 Starting from recently proposed kernels on the discrete

204 15 were prepared in a chiral-pool synthesis starting from (S)- or (R)-aspartate.

205 process, [Pd]-catalyzed direct carbonylation starting from simple and commercially available iodo are

206 yliodonium reagent to generate triarylamines starting from simple anilines, representing an atom-econ

207 od for the synthesis of o-hydroxyazobenzenes starting from simple azoarenes.

208 eaction for the synthesis of diverse indanes starting from simple cinnamic acid esters is described.

209 is of substituted indenones was accomplished starting from simple o-iodoketones and aldehydes.

210 When starting from sterically hindered terpenes, allenylphosp

211 olecule-molecule interaction strengths (i.e. starting from strong directional multiple H bonds up to

212 Starting from styrene derivatives, it was possible to pr

213 l waves." They also suggest that these waves start from subunits CCT6 and CCT8 (or CCT3 and CCT6) and

214 mus all-atom molecular dynamics simulations starting from tetrameric transmembrane helical bundles o

215 chieved through the corresponding steps that start from the gem-diolate and formate.

216 We start from the observation that the most widely used tec

217 4:2:4, and 3:2:5 (MnO2: La2O3: Pt) which is start from the side of the electrolyte.

218 Started from the development of simple solid microneedle

219 As exemplified, we started from the integrated disposal of hot steel slags,

220 It started from the masking of nucleoside monophosphate and

221 It started from the observation of strong circular dichrois

222 nalyses revealed that the mineralization had started from the outside, then proceeded inward, suggest

223 nt, two different approaches were used, both starting from the (-)-quinic acid.

224 In this study, starting from the (4-(4-chlorobenzoyl)piperidin-1-yl)(4-

225 Starting from the assumption that opportunely designed c

226 Starting from the basic concepts behind the on-surface s

227 [(18)F]29 was prepared starting from the bromo precursor (53).

228 itors of the CD40-CD40L interaction designed starting from the chemical space of organic dyes.

229 of the sea gooseberry, Pleurobrachia bachei, starting from the cleavage stages to posthatching larvae

230 have many concentric layers, and are created starting from the core and proceeding outwards.

231 ients before and during patient recuperation starting from the early febrile to the defervescence and

232 ylakoid connections have a helical character starting from the early stages of appressed membrane for

233 ted method to produce oleacein in good yield starting from the easily available oleuropein is here pr

234 igned an outdoor longitudinal one-year study starting from the egg stage.

235 Starting from the expression of heat capacity which incl

236 Pain levels were reduced starting from the first day in the test group and from t

237 Mice exhibited timed-switching behavior starting from the first few test trials, and their perfo

238 Starting from the first TA synthesis in 1981, this revie

239 (Cosmics Leaving OUtdoors Droplets) chamber, starting from the formation of molecular clusters.

240 Starting from the highest ranked gene, we progressively

241 Starting from the hypothesis that nuclear factors that b

242 The overall protocol, starting from the immobilization of the template onto th

243 osecond-scale molecular dynamics simulations starting from the inactive state of D3R in complex with

244 Starting from the initial lead 4-phenylthiazole 18, a mo

245 oinduced structural changes in the foldamer, starting from the initial ultrafast isomerization of the

246 vel dual MNK1 and 2 and BCR-ABL1 inhibitors, starting from the known kinase inhibitor 2.

247 Starting from the many-body expansion of the interaction

248 roaches can be examined at different levels, starting from the most fundamental, i.e., the genome, an

249 , double bond, or thiol precursor) moieties, starting from the native lipid A isolated from Escherich

250 ed the enzymatic sequence of redox reactions starting from the nonadride 5.

251 Starting from the old idea of perception as probabilisti

252 n (SP-PCR) to form the array of PCR products starting from the oligonucleotide primers.

253 significant healing of erosions and plaques starting from the peripheral aspect within 1 to 2 weeks

254 Starting from the previously identified 3-cyano-4,6-diph

255 who carry the Huntington's disease mutation, starting from the prodromal period prior to motor diagno

256 in five linear steps and 53% overall yield, starting from the readily available 3-chloro-1-phenylpro

257 In this study, starting from the recently reported x-ray structure at p

258 Starting from the recently solved crystal structure of H

259 Starting from the reported aminopiperidyl pan PIM kinase

260 The RON3 gene was map-based cloned starting from the ron3-1 leaf mutant and found to be a u

261 Starting from the same monoboronic ester intermediates,

262 Ulcer size was reduced starting from the second day in test group and from the

263 suggest a pattern of sequential divergence, starting from the separation of A. aphrophilus and A. ac

264 tudied at different stages of HIV infection, starting from the seronegative phase.

265 Here, starting from the simplest periodic origami pattern that

266 formation and progression of tumors in situ, starting from the single-cell level longitudinally over

267 ids, a unique class of functional molecules, starting from the smallest triphyrins(1.1.1) via [18]por

268 e is no bottom-up, dynamical account of how, starting from the solitary ancestor, the first groups or

269 Starting from the state-of-the-art of organosulfur ligan

270 Herein, starting from the structural similarity of a potent G4 l

271 nded vigilance for multiple mental disorders starting from the time of the cancer diagnostic workup.

272 ion systems requires an integrated approach, starting from the treatment of water prior to entering t

273 responses of living systems to perturbations starting from the underlying molecular interactions.

274 lop a new model of the self-assembly process starting from the underlying physical interaction betwee

275 ng to two novel families of polyheterocycles starting from the versatile chromone-based Michael accep

276 equired to generate cruciferous phytoalexins starting from the well-studied glucosinolate pathway.

277 The HGE starts from the 3' end of intron 19 and extends into int

278 ive configuration of natural products, which starts from the molecular formula and uses a combination

279 Mechanistically, the growth of the GNP corks starts from the nucleation and welding of gold seeds on

280 ally has a circular periphery and the growth starts from the periphery as a membrane invagination, wh

281 Our procedure starts from the results of kinetic experiments that meas

282 ospectively followed for 5 years until 2013, starting from their first prescription of tamoxifen or a

283 he effects of ribonucleotides incorporation, starting from their impact on DNA structure and conforma

284 The development of organisms starting from their zygotic state involves a tight integ

285 Starting from these principles, this article discusses t

286 In contrast to classical approaches starting from thiols or their derivatives, our TrNSO-bas

287 Starting from this and in order to increase bioaccessibi

288 Starting from this baseline, we estimate that between 20

289 Starting from this gap in the literature, we seek to pro

290 Starting from three clinical vignettes representing two

291 long-term outcomes compared with group PLT (starting from time of LT) (OS 54%/54% vs. 73%/63%, P = 0

292 quiterpene quinol dasyscyphin E was achieved starting from trans-communic acid.

293 C-O, C-N, and C-C) under mild conditions and starting from unsaturated substrates.

294 Starting from vanillin, the synthetic sequence comprises

295 ine the properties of their binding peptides starting from various experimental data.

296 to a variety of SF5CF2-substituted compounds starting from vinyl ethers and SF5CF2C(O)Cl.

297 nd make consistent the HPO terms predictions starting from virtually any flat learning method.

298 Starting from weakly binding fragments, we describe a st

299 Starting from whole-mount expression images for close to

300 Starting from wild-type sequences, 3D models are constru