ライフサイエンスコーパス: starting point

1 procedures to assure critical steps was the starting point.

2 hrough rapid optimization of a weakly potent starting point.

3 its own history, background, and a definite starting point.

4 druggable targets may represent a promising starting point.

5 information about total displacement from a starting point.

6 or the compound of interest is required as a starting point.

7 dged by approaches that leverage mRNA as the starting point.

8 ain were explored, mostly motivated from two starting points.

9 Bacillus stearothermophilus enzyme served as starting points.

10 en, paclitaxel, codeine, and fluorouracil as starting points.

11 convergent adaptations from distinct genomic starting points.

12 subsequently expanding over 500 km from its starting point [7-11].

13 Using the identified compounds as a starting point a substructure directed search against CH

14 tronic transition begin with two alternative starting points: a Peierls MIT driven by instabilities i

15 el746-750) selective EGFR inhibitor (2) as a starting point, activities against the single mutants (L

16 pecotamide 5 was identified as an attractive starting point after a high-throughput screen (HTS) for

17 we aim to give the users of these methods a starting point and perspective from which to view the ke

18 Our study provides a starting point and resources, including an open-access m

19 al design strategy using known inhibitors as starting points and introducing structural features acco

20 lution crystal structures providing chemical starting points and structural models for the developmen

21 (similar diversities reached from different starting points), and divergence in shaping the present-

22 disclosed indazole series of inhibitors as a starting point, and using X-ray crystallography and solu

23 nown antibacterial agents and the HTS active starting point, (b) the probability of plasma protein bi

24 diversities reached via changes from similar starting points), convergence (similar diversities reach

25 erity, level of control and phenotype is the starting point for a comprehensive treatment strategy.

26 s substrate reduction activity and marks the starting point for a crystallographic pulse-chase experi

27 correlated novelties, our results provide a starting point for a deeper understanding of the adjacen

28 tion or non-native association and provide a starting point for a detailed atomic-level understanding

29 mone receptor 1 (MCHr1) antagonists were the starting point for a drug discovery program that culmina

30 lizing the simple benzofuran template 7 as a starting point for a fragment growing approach was pursu

31 nd NTPase assays are expected to provide the starting point for a further search of possibilities for

32 Our results provide a starting point for a future process in which tens of tho

33 antagonist called NIBR127 (2) was used as a starting point for a medicinal chemistry campaign, which

34 We anticipate our research to be a starting point for a more comprehensive evaluation invol

35 Such, this contribution may serve as a starting point for a more detailed investigation of the

36 The peptides therefore represent a promising starting point for a new class of substrate-competitive

37 ncentrations in rats, providing an excellent starting point for a proof-of-principle study.

38 of the zirconium catalyst and serves as the starting point for a theoretical study of the catalytic

39 Taken together, necrosis represents the starting point for a vicious cycle including the uptake

40 operties indicating that it may serve as the starting point for an attenuated vaccine.

41 slope-to-amplitude ratio (TS/A) was used as starting point for an ECG-based [K(+)] estimate (KECG).

42 DCP3 is intended to be a model starting point for analyses at the country level, but co

43 metabolite (+)-pleuromutilin has served as a starting point for antibiotic development.

44 The quality framework developed can be the starting point for any Total Diet Study centre and can b

45 We believe this approach should be the starting point for autologous cellular therapies using '

46 The most interesting hit was taken as starting point for chemical modification applying a liga

47 FNTM is an ideal starting point for clinical and translational researcher

48 antics, this has important implications as a starting point for clinical care pathways and inclusion

49 ncer Institute remains rightly viewed as the starting point for clinical PDT in modern medicine.

50 These five recommendations provide a starting point for clinicians and patients to make decis

51 The findings are an important starting point for clinicians considering the introducti

52 ital objects, the tree provides a compelling starting point for community contribution.

53 These results provide a starting point for compiling a mammalian nervous system

54 d a strategy that uses natural products as a starting point for complex molecule synthesis.

55 ling may invalidate the standard single-site starting point for considering magnetism, and can lead t

56 EUHC) with 218 interventions that provides a starting point for country-specific analysis of prioriti

57 , although wiring topography could provide a starting point for decoding at a very early stage in dev

58 Therefore, this work represents a starting point for designing effective incentives to red

59 ing molecules that target them, as well as a starting point for determining the organization of the e

60 common to water, this platform is a logical starting point for developing a multimatrix monitor.

61 zole macrocyclic depsipeptide structure as a starting point for developing new KDACIs with increased

62 These findings provide an important starting point for developing nonhuman primate models to

63 on VCaP xenografts and thus it may serve as starting point for developing novel AR pan-antagonists.

64 n mice than piperine and thus may serve as a starting point for developing novel GABAAR modulators.

65 s identified here can potentially serve as a starting point for development of GluD2-selective ligand

66 These proof-of-concept results provide a starting point for development of therapeutic Pin1-FOXM1

67 thal concentrations, hence providing a novel starting point for discovery of custom designed engineer

68 were scrutinized, tabulated, and used as the starting point for discussions at a roundtable panel mee

69 f antibiotic resistance (AR), and provides a starting point for distinguishing AR that can be impacte

70 mental currency in the field and provide the starting point for downstream biological analysis.

71 files have recently been illustrated to be a starting point for drug repositioning.

72 ding this changing landscape is an essential starting point for effective allocation of both domestic

73 We anticipate that our approach will be a starting point for elaborate studies of the population d

74 These structures provide an essential starting point for elucidating the complex gating mechan

75 y invertebrate phylum has been proposed as a starting point for evolving vertebrates.

76 Examples from ants provide a starting point for examining more generally the fit betw

77 ion to metabolic liver disease and provide a starting point for expanding the toolbox of reactivity-b

78 rs for helicases, and 9 could be a promising starting point for exploring molecular probes to elucida

79 n enzyme orthosteric sites offers a rational starting point for FBDD.

80 of isoquinoline ethyl urea 13 as a promising starting point for fragment evolution.

81 ets, suggesting that this scaffold is a poor starting point for fragment-based drug discovery.

82 anticipate that our findings will serve as a starting point for functionalization at inert C-H bonds

83 These findings are anticipated to be a starting point for further discoveries of therapeutic bo

84 cterial chemotype thus offers an interesting starting point for further investigations of the potenti

85 lpyridin-2-one scaffold offers an attractive starting point for further lead optimization.

86 It may also be used as a starting point for further numerical optimization algori

87 This molecule served as a starting point for further optimization and generation o

88 were found that together provide a promising starting point for further optimization as antibacterial

89 compound 14 (GSK'481), makes it an excellent starting point for further optimization into a RIP1 clin

90 nds have been highlighted, providing a solid starting point for further optimization.

91 This unique profile constitutes the starting point for further pharmacological studies to as

92 tes near the Fermi edge, which was used as a starting point for further selection of suitable MOFs.

93 pted to other imaging modalities and forms a starting point for further steps of data analytics and m

94 lity and function and that it can serve as a starting point for further structural analyses of the HO

95 tially explicit data set may also serve as a starting point for further studies aiming at determining

96 t near or within the BCRP block, providing a starting point for future breakpoint mapping using addit

97 odology can identify such sites, providing a starting point for future drug design efforts.

98 e-sensing and phosphatase activity provide a starting point for future experiments to investigate the

99 nd provides, for the first time, a promising starting point for future studies correlating molecular

100 pe of maize primary roots and thus provide a starting point for gaining a better understanding of the

101 used a DOPA-containing sequence motif as the starting point for generation of a further library of ov

102 lation within the spinal cord constitute the starting point for handedness, implying a fundamental sh

103 These results provide a starting point for high-temperature, anhydrous proton co

104 r synergy model, deeming them as a promising starting point for hit-to-lead development.

105 tuted 2-(3-aminophenyl)oxazolopyridines as a starting point for hit-to-lead medicinal chemistry.

106 lidates the utility of network analysis as a starting point for identifying strategies for the synthe

107 aracterized interaction site provide a novel starting point for inhibitor design targeting AbDsbA.

108 identification of amino imidazoles, a robust starting point for initiating a hit-to-lead medicinal ch

109 These summary dose data provide a starting point for institutional evaluation of CT radiat

110 n addition, the lead compound can serve as a starting point for lead optimization toward the goal of

111 oisoquinoline pharmacophore as an attractive starting point for lead optimization.

112 onomically verified dataset provides a valid starting point for macroecological and evolutionary stud

113 divergences observed between provinces are a starting point for macroevolutionary divergences between

114 Depolymerization is an important starting point for many lignin valorization strategies,

115 ecognition of protein structural fold is the starting point for many structure prediction tools and p

116 ss future rice crop conditions and provide a starting point for marker-assisted selection for plastic

117 essible states of the nucleosome must be the starting point for mechanistic models regarding these es

118 ibitors known today, may serve as a suitable starting point for medicinal chemistry programs aided by

119 inherent to GHMT reprogramming and provide a starting point for optimization of CM subtype-specific r

120 This fragment is an excellent starting point for optimization through rational structu

121 DNA markers described in this paper are the starting point for pedigree based selection of cultivars

122 PC6-selective inhibitors and may represent a starting point for pharmacological TRPC6 modulation with

123 study design selection framework provides a starting point for planning vaccine safety evaluations u

124 cs, drawn from existing data that can form a starting point for policy makers to identify the structu

125 are amyloidotic disease, and also presents a starting point for possible application within other amy

126 e and dementia and potentially may provide a starting point for prevention and treatment.

127 w structural leads and provide the necessary starting point for projected efforts to determine the PK

128 dation profiles of the compounds; thus, as a starting point for PROTAC development, both the target l

129 f the inhibitor, which serves as a promising starting point for rational drug design.

130 cture derived from the interaction provide a starting point for rational drug design.

131 These results provide a starting point for reexamining the connectional organiza

132 eir importance for OsMTP11 function and is a starting point for refining transporter activity/specifi

133 res (PDBs: 4PR6, 4PRF) provide a more robust starting point for research on the dynamics and catalyti

134 strians evacuating a room and might become a starting point for researchers working in a wide variety

135 r understanding of EHF pathophysiology and a starting point for researching new potential targets for

136 IL-10.GAG complex structure and provides the starting point for revealing the biological significance

137 luding 31 seeds--individuals selected as the starting point for sampling because they were well conne

138 s transition of the mutant were then used as starting point for sampling of the free-energy surface o

139 n serine protease inhibitor, as an excellent starting point for SAR profiling.

140 However, health provides a critical starting point for scaling up, given its reach to pregna

141 This tutorial review is a reference and a starting point for scientists and clinicians working or

142 ucture of Delta-3 a H(4+) 4 Cl(-) provides a starting point for speculation regarding transition-stat

143 ys that differ from host organisms and are a starting point for structural and functional studies of

144 arge and lipophilic binding site and are the starting point for structure-based inhibitor design.

145 rience condensed in this article is a useful starting point for students wishing to organise their ow

146 ing the horizontal transfer of these loci, a starting point for studies aimed at understanding the ev

147 Taken together, these results provide a starting point for studying the implications of WDR prot

148 We anticipate our findings to be a starting point for studying the posttranscriptional regu

149 This knowledge is a promising starting point for sustainable breeding strategies for f

150 synthesis of talcarpine (26) and provides a starting point for synthesis of macroline-related alkalo

151 ants of plant root colonization and offers a starting point for targeted improvement of the colonizat

152 Our results provide a starting point for technologies enabling direct, rapid,

153 The results provide a starting point for the broader use of 2-aza-Cope reactiv

154 "chiral pool terpenes") has long served as a starting point for the chemical synthesis of complex nat

155 of the previously reported DDD85646 (1) as a starting point for the design of a class of potent, brai

156 ng at the catalytic site of hRRM1 provides a starting point for the design of a unique class of hRR i

157 o IgE-FcepsilonRI complexes, and represent a starting point for the design of promising hypoallergens

158 2 diabetes mellitus, as well as a promising starting point for the design of structural analogs with

159 ating contamination pathways, this work is a starting point for the design of two-stage biomimetic pl

160 g a urea zinc-binding motif were used as the starting point for the development of a novel class of h

161 ions of N1-Src and C-Src in neurons and is a starting point for the development of a small molecule i

162 2,4-oxazolidinediones appear to be a viable starting point for the development of an alternative cla

163 ine inhibitor of RSK kinases, as a promising starting point for the development of chemical probes ta

164 ve compound Ac-LAE-ep represents a promising starting point for the development of compounds that dis

165 Apelin-36-[L28C(30kDa-PEG)] provides a starting point for the development of diabetes therapeut

166 , the described scaffolds represent a viable starting point for the development of druglike Hsp70 inh

167 On the other hand, it may serve as starting point for the development of dual targeting lig

168 s, native-like trimers represent a promising starting point for the development of HIV-1 vaccines aim

169 phthalene-2,3-dicarboxamide , could serve as starting point for the development of improved and more

170 nto the reactivation mechanism and provide a starting point for the development of improved antidotes

171 roles of mouse TAAR1 and could represent the starting point for the development of more potent and se

172 that this proof-of-principle data will be a starting point for the development of new possible strat

173 uggest that gladiolin may represent a useful starting point for the development of novel drugs to tac

174 cterial culture broth extracts have been the starting point for the development of numerous therapeut

175 This compound represents a solid starting point for the development of potent and selecti

176 identifies a promising MMP-14 inhibitor as a starting point for the development of protein-based anti

177 lt may be useful for the juice industry as a starting point for the development of tasty quince juice

178 haracterization and can serve as a promising starting point for the discovery of new antimelanoma the

179 The structure provides a starting point for the elucidation of the mechanism by w

180 tion for the treatment of AML and provides a starting point for the further development of Myb-inhibi

181 urther biochemical activities or used as the starting point for the investigation of motor-mediated m

182 Together, our data provide the rationale and starting point for the screening of small molecule chape

183 The study serves as a starting point for the solid-state tuning of the supramo

184 elop and employ provide a potentially useful starting point for the statistical inference of brain ne

185 MPPNs provide not only a starting point for the structural analysis of membrane p

186 We anticipate our discovery to be a fresh starting point for the study on the roles of MOCOS in br

187 AK1 and DRAK2 inhibitors that can be used as starting point for the synthesis of chemical tool compou

188 sociated regions should provide an important starting point for the translational community in search

189 for signal readouts, establishes a valuable starting point for the use of porous polymeric materials

190 The starting point for the workshop was the recent reports f

191 This, therefore, provides a starting point for therapeutic inhibition of the Ras-Ral

192 As a starting point for these covalent inhibitors, reported E

193 These vectors provide a starting point for transsynaptic tracing in most vertebr

194 modification and is therefore an attractive starting point for understanding control of Tau's inhibi

195 her a mean-field description is a reasonable starting point for understanding experimental glass form

196 Our results provide a starting point for understanding gene regulation by bifu

197 gene regulation in yeast, which serves as a starting point for understanding long-distance gene regu

198 rolled studies in vitro provide an excellent starting point for understanding regulation of 20S core

199 These insights also provide a starting point for understanding the types of subsequent

200 nofibers to enable adhesion, and serves as a starting point for unraveling the molecular architecture

201 the versatility of the API and to provide a starting point for users.

202 ase protein targets and potentially serve as starting points for a new therapeutic approach to the tr

203 ncy-approved but repurposed drugs, providing starting points for anti-onchocerciasis drug development

204 Therefore, MBX2329 and MBX2546 represent new starting points for chemical optimization and have the p

205 e in the activity of PdO catalysts and offer starting points for computational design of materials wi

206 challenges and opportunities in their use as starting points for designing natural product-inspired T

207 We identify chemical starting points for designing new chemical probes of orp

208 The compounds described are valuable starting points for discovery of selective bromodomain i

209 activities represent potentially attractive starting points for divergent evolution in the laborator

210 t both as tools to understand biology and as starting points for drug leads, but not every active mol

211 (RIP) and crosslinking and IP (CLIP) are key starting points for evaluating the molecular roles of th

212 usly occupying both S1 and S1' are promising starting points for fragment-growing strategies.

213 nti-HCV activity and therefore are promising starting points for further structural optimization and

214 erred in compounds that represent attractive starting points for future optimization.

215 ction and response rates to this therapy and starting points for generating BD2-selective BET inhibit

216 coded chemical library screening to identify starting points for inhibitor lead optimization.

217 ive regulators of HIV replication, providing starting points for investigating new cellular factors.

218 stable enzyme active sites will be fruitful starting points for investigations of non-natural P450 c

219 g new antifungal leads reported as promising starting points for optimization projects are published.

220 o achieve 3Rs in animal research--to provide starting points for potential interventions that can pre

221 DRP structural diversity, providing suitable starting points for seeding phage display experiments.

222 to be involved in TLE are the most frequent starting points for seizures in patients in the model.

223 at bioactive natural products are attractive starting points for such libraries because of their stru

224 h dual asexual/sexual activity, representing starting points for target identification and candidate

225 ersatile hubs in sequence space as potential starting points for the acquisition of new functions.

226 esent novel inhibitor scaffolds and are good starting points for the design of potent MBL inhibitors.

227 tors, MBX2254 and MBX2270, that can serve as starting points for the development of an anti-EBOV ther

228 The 1,8-naphthyridones emerged as valid starting points for the development of innovative agents

229 eened a library of 490 fragments to identify starting points for the development of new inhibitors of

230 itis-associated hearing loss that reveal new starting points for the development of otoprotective the

231 and asexual parasites and provide a tool and starting points for the discovery and development of tra

232 The PDEdelta inhibitors provide promising starting points for the establishment of new drug discov

233 enzymatic source of cAMP production, are key starting points for understanding cAMP compartments and

234 ayed by MHC class I molecules are attractive starting points for vaccine development because they ind

235 that this review can serve both as a useful starting-point for researchers who are new to these topi

236 This article represents a starting point from which diagnostic and management deci

237 This structure provides a starting point from which to design highly specific myos

238 clei that fall between these extremes is the starting point from which to determine the physiological

239 The present study provides a starting point from which we can define the role of pote

240 nge in social health, both in terms of their starting points (ie, baseline scores) and their rates of

241 Astragalin-6-glucoside can serve as a starting point in the design of specific inhibitors for

242 The starting point in the exercise is the one-dimensional (1

243 ered sepsis mortality, and found three major starting points in a combined temporal sepsis network: A

244 c natural products could be used not only as starting points in drug design but also as tools to stud

245 the current adult NHL response criteria as a starting point, international pediatric NHL response cri

246 xins with naturally unlinked components as a starting point is advantageous because it allows for the

247 haliana) are top-down assembled, whereby the starting point is the annotated genome, in particular, t

248 Although an LS coupling scheme is a useful starting point, it is not sufficient to describe the com

249 Regardless of starting point, lactate-switch communities followed comp

250 into B-cell clones and identification of the starting point of a B-cell clonal lineage, the initial V

251 adjustments, as reflected by changes in the starting point of evidence accumulation, are responsible

252 es capable of binding phosphate could be the starting point of new novel technological approaches tow

253 This agitator represents the starting point of the allosteric signal propagation path

254 The starting point of the approach is a Bayesian clustering

255 -core, the latter should be the evolutionary starting point of the molecule, i.e. it should represent

256 -saccade process, in turn, helped to set the starting point of the next within-saccade process.

257 s with a spatial sequence, flashing only the starting point of the sequence triggers an activity wave

258 nually inserted into the minor groove as the starting point of the simulations.

259 functional unit of organisms, represents the starting point of this review.

260 The starting point of this study of through-space substituen

261 crucial because such configurations serve as starting points of folding studies, and thus can affect

262 d by parallel slices, and the offsets in the starting points of the 1D slices can predict the measure

263 ch processes when the target is far from the starting point, or when relative to the starting point t

264 As a starting point, research is needed to assess rates of ED

265 et, little is known about the performance of starting points (seed nodes) for diffusion.

266 ers in the ensemble and can provide a better starting point than majority voting for estimating the m

267 a rise-to-threshold decision process with a starting point that reflected expected state-dependent t

268 Here, using as a starting point the crystal structures of human MGL (hMGL

269 the starting point, or when relative to the starting point the target is upstream, we show that for

270 sing the gene and its link to phenotype as a starting point, the BIGSdb database, which powers the Pu

271 We investigate this problem using, as a starting point, the C. elegans LIM homeodomain transcrip

272 gy is the generation of a library of design 'starting points' through the discovery and characterizat

273 osals enumerated here will serve as a useful starting point to address these challenges.

274 using a stochastic metacommunity model as a starting point to bridge community and disease ecology p

275 W. smithii provides a unique starting point to determine if there are universal nonbi

276 nature of FRET analyses, but also provides a starting point to develop more realistic in silico appro

277 arboring common genetic risk variants as the starting point to discover novel insights into disease p

278 t with this review, we provide a forum and a starting point to discuss the idea that catalytic functi

279 Our results provide a starting point to dissect spatiotemporal Rho GTPase sign

280 These studies will serve as a starting point to explore the nonlinear dynamics of atri

281 The SlitOBPs identified here provide a starting point to facilitate functional studies of insec

282 s plausible deletion precursors, providing a starting point to identify the molecular mechanisms of m

283 Standardization of treatments is the starting point to redefine the treatment paradigm from a

284 This study provides a starting point to study how RGB cone-specific transcript

285 during this form of cell death, providing a starting point to study iron signaling in living systems

286 the HIF signalling cascade and an attractive starting point to the development of potential new thera

287 tal structure, these data offer an important starting point to understand the molecular details of hi

288 These investigations are a starting point to unraveling the complex arena of vlncRN

289 ly occurring ligands can serve as structural starting points to explore the biologically relevant che

290 t antigens in PAH lung immune complexes as a starting point toward resolving these issues to better i

291 ition of the human microbiome, and provide a starting point toward understanding the complex interact

292 as the ones presented here, provide valuable starting points toward insecticides and are complementar

293 Our starting point was a fragment hit, which was optimized i

294 Using liver biopsy as a starting point, we analyzed the development of end-stage

295 viously reported tertiary sulfonamide 1 as a starting point, we engineered structural modifications t

296 Using a monomerised RadA as our starting point, we have adopted two parallel and mutuall

297 Using the X-ray crystal structure as a starting point, we have modeled the motions of a DNA dup

298 he consensus substrate-peptide sequence as a starting point, we optimized the length and rigidity of

299 As a starting point, we used parthenolide, an agent shown to

300 that if evolution had begun from a different starting point within the network of sequences encoding