ライフサイエンスコーパス: startle

1 cluding marked attenuation of light-enhanced startle.

2 s assessed by the prepulse inhibition of the startle.

3 -induced prepulse inhibition of the acoustic startle.

4 no effect on short-duration fear-potentiated startle.

5 kin conductance response or fear potentiated startle.

6 comotor activity, and prepulse inhibition of startle.

7 ression underlying short-term habituation of startle.

8 move toward light (phototax positively) when startled.

9 on available on the aged olfactory system is startling.

10 hreat memory, measured with fear-potentiated startle 7 days after acquisition, is attenuated by 60%

11 -cells abolishes short-latency tail-elicited startles [8, 9], we hypothesized that M-cell activity wa

12 Startling acoustic stimuli (SAS) can accelerate reaction

13 ned movements can be rapidly released when a startling acoustic stimulus (SAS) is presented immediate

14 Simultaneous measurements of startle amplitude and freezing time were used to assess

15 We found an increase in startle amplitude and plasma corticosterone levels 30 mi

16 caused a moderate hearing loss, the acoustic startle amplitude at the super-threshold level was signi

17 in the elevated plus maze or basal acoustic startle amplitude.

18 are represented in such natural sounds, with startle and burrowing behaviors.

19 , which has been associated with exaggerated startle and deficient sensorimotor gating.

20 Abnormal information processing of acoustic startle and depressive-like behaviors are also observed.

21 d auditory processing, with reduced acoustic startle and distorted auditory brainstem responses.

22 search in the past decades on habituation of startle and other escape responses, the underlying neura

23 ensitization of BLA manifested as heightened startle and PPI deficits in response to subsequent subth

24 stive association (p < 10(-6)) with baseline startle and PPI in the discovery cohort.

25 and environmental contributions to baseline startle and PPI showed a substantial single nucleotide p

26 a Spectrum project was assessed for baseline startle and PPI.

27 ygenic score for schizophrenia with baseline startle and PPI.

28 on genetic variants associated with baseline startle and PPI; 2) estimate the single nucleotide polym

29 exposure) on amygdala systems that modulate startle and prepulse inhibition (PPI), an operational me

30 e that could underlie certain core deficits (startle and prepulse inhibition) that are observed in po

31 e present study, we used elevated plus-maze, startle and prepulse inhibition, open field, and novel o

32 ated with HDAC4 expression, fear-potentiated startle and resting-state functional connectivity of the

33 lementary roles in facilitating the acoustic startle and visceromotor reflexes.

34 n addition to the characteristic 'stiffness, startles and stumbles' of hyperekplexia, apnoea attacks

35 voked by predictable shock (fear-potentiated startle) and by the context in which the shocks were adm

36 ng (measured by prepulse inhibition (PPI) of startle) and mismatch negativity (MMN).

37 ching sad and amusing emotional films, being startled); and (iii) to examine the ability of patients

38 odify anxiety-related phenotypes (avoidance, startle, and conditioned fear), we induced transient for

39 arly microsurgical approaches demonstrated a startling array of regenerative and morphogenetic proces

40 such as grooming, nest building and acoustic startle as early as 1-2 months of age.

41 xercising mice demonstrated reduced acoustic startle, attenuated stress induced hyperthermia, and a b

42 Upon repeated exposures, this olfactory startle attenuates with the characteristics of habituati

43 efCS presented 6 seconds after the US caused startle attenuation (Study2 and 3) and positively valenc

44 termination elicit appetitive responses like startle attenuation.

45 ay that is essential for the M-cell-mediated startle behavior in larval zebrafish.

46 The neural circuit underlying the C-start, a startle behavior in which the fish forms a "C"-shaped bo

47 cue of major aspects of adult locomotion and startle behavior required octopamine, but a complementar

48 fiber neurons help activate M-cell-mediated startle behavior.

49 of older fathers had reduced exploratory and startle behaviors and exhibited similar brain DNA methyl

50 cover a mechanism for generating alternative startle behaviors; local sensory inputs drive inhibitory

51 activity, Rtkn2 for intensity of reaction to startle, Bmp2 for wound healing, Il15 and Id2 for severa

52 increased long-duration anxiety-potentiated startle but had no effect on short-duration fear-potenti

53 at some species can perform a second type of startle called the S-start [5-7].

54 PPI was measured in startle chambers 30 min after injection.

55 ticulospinal Mauthner cells (M-cells) of the startle circuit have been considered to be dedicated to

56 We find that pappaa is expressed by startle circuit neurons, and expression of wild-type but

57 the Mauthner cells (M-cells) in the goldfish startle circuit, which receive visual and auditory input

58 (M-cell), the decision-making neuron of the startle circuit.

59 These findings suggest that startle circuits are particularly sensitive to forebrain

60 Progress in DNA sequencing has revealed the startling complexity of cancer genomes, which typically

61 A startle cue decreased intracortical inhibition, but not

62 ad similarly shorter reaction times during a startle cue in all motor tasks.

63 tasks, reaction times were shorter during a startle cue while performing a power grip but not index

64 An acoustic startle cue, a stimulus that engages the reticular syste

65 An acoustic startle cue, which engages the reticular system, suppres

66 Skin conductance and startle data served as objective psychophysiological ind

67 l biology has been catapulted forward by the startling development of reprogramming technology.

68 e is known about circular granular ratchets, startling devices able to convert vertical vibrations in

69 yRs) have been linked to human hyperekplexia/startle disease and autism spectrum disorders.

70 dysfunction underlies neuromotor deficits in startle disease and autism spectrum disorders.

71 Hyperekplexia or startle disease is a rare clinical syndrome characterize

72 Hyperekplexia or startle disease is a serious neurological condition affe

73 Hereditary hyperekplexia or startle disease is characterized by an exaggerated start

74 Hyperekplexia or startle disease is characterized by an exaggerated start

75 a1 subunit mutation (Q177K) in a novel mouse startle disease mutant shaky Structural data suggest tha

76 rapidly emerging as a second major cause of startle disease.

77 the GlyT2 gene as the second major cause of startle disease.

78 mechanism by which GlyR dysfunction induces startle disease.

79 mechanism by which GlyR dysfunction induces startle disease.

80 s disruption triggers a paediatric and adult startle disorder, hyperekplexia.

81 There was a startling diversity within and among species in the type

82 ed PPI disruption without affecting baseline startle; dorsal striatal amylin infusions had no effect.

83 We measured fear-potentiated startle during fear conditioning and extinction in women

84 or agonist quinpirole attenuated potentiated startle during morphine withdrawal.

85 all known beta-lactam-based antibiotics with startling efficiency.

86 riables included slopes for fear-potentiated startle (electromyography) and self-reported risk rating

87 ixed stressors did not affect crash rates in startling events, suggesting that the coping mechanism's

88 e Drosophila larval sensorimotor decision to startle, explore, or perform a sequence of the two in re

89 From an evolutionary perspective the startle eye-blink response forms an integral part of the

90 This startling finding suggests that M. tuberculosis may gain

91 dvantage of fish C-start escape responses by startling fish toward their strike--often aiming for the

92 uced hyperthermia, and a blunted increase in startle following mCPP administration when compared with

93 Using the fear potentiated startle (FPS) procedure, we examined the effects of fear

94 The startling gist is that even though the atoms have no dip

95 ts of a genetic screen to identify olfactory startle habituation (OSH) mutants.

96 transient CRFOE during development decreased startle habituation and prepulse inhibition, and increas

97 or synaptic depression presumably underlying startle habituation in rats, using patch-clamp recording

98 ome sequencing, that identified 14 zebrafish startle habituation mutants including mutants of the ver

99 eizure susceptibility and decreased acoustic startle habituation.

100 GlyRs that are responsible for a hereditary startle-hyperekplexia disease.

101 cal syndrome characterized by an exaggerated startle in response to trivial tactile or acoustic stimu

102 tagion and a time-setting effect following a startle in this species.

103 g abilities, as measured by fear-potentiated startle, in adult monkeys that had received neonatal neu

104 However, startle-induced astrocytic Ca(2+) signals did not preced

105 A 14-month-old child developed startle-induced episodes of generalized rigidity and myo

106 Ca(2+) signals did not precede corresponding startle-induced hemodynamic changes.

107 G protein-coupled receptor activation and by startle-induced neuromodulatory responses.

108 ases in startle reactivity and reductions in startle inhibition independently of predator stress in b

109 Prepulse inhibition (PPI) of startle is being explored both as an indicator of target

110 Tests included measures of acoustic startle magnitude and habituation, PPI, MMN, autonomic i

111 Removal of BACE1 affected startle magnitude, balance beam performance, pain respon

112 it/hyperactivity disorder (ADHD) symptoms on startle measures were examined.

113 tates were indexed by translational acoustic startle measures.

114 ume novel, palatable foods and to approach a startling object.

115 One of the more startling outcomes of whole genome DNA sequencing has be

116 135 were assessed using the fear-potentiated startle paradigm to assess fear-related phenotypes of PT

117 ons, decreasing latency time in the acoustic startle paradigm, and decreasing the reinforcement of re

118 r, assessed via a loss of gap detection in a startle paradigm.

119 ackground noise gap detection in an acoustic startle paradigm.

120 block of action potentials traveling in the startle pathway caused by identified inhibitory interneu

121 ceptor function, is responsible for a lethal startle phenotype in a novel spontaneous mouse mutant sh

122 sufficient to induce enduring alterations in startle plasticity and anxiety, while forebrain CRFOE du

123 insic and extrinsic modulatory mechanisms in startle plasticity and sensorimotor gating.

124 of the serotonin 5-HT5A receptor in goldfish startle plasticity and sensorimotor gating.

125 ity in males but did not change avoidance or startle plasticity.

126 Low-GSK did not affect startle potentiation across conditions.

127 eliefCS immediately following the US-induced startle potentiation and negative valence (Study1); 3 se

128 , apomorphine injection was shown to relieve startle potentiation during nicotine withdrawal and cond

129 unpredictable threat (anxiety) but increased startle potentiation during the predictable condition (f

130 High-GSK had no effect on startle potentiation during unpredictable threat (anxiet

131 t with previous findings, alprazolam reduced startle potentiation during unpredictable threat but not

132 anxiety, elevated physiological arousal, and startle potentiation), 20.9% of the patients escaped fro

133 imulus, US) provoke defensive responses like startle potentiation, while stimuli associated with pain

134 to warn of a chemical defence and others, to startle predators.

135 ocomotor hyperactivity; sensorimotor gating (startle prepulse inhibition) was unaffected.

136 hreatening and neutral events while acoustic startle probes were presented and eyeblinks (orbicularis

137 showed that SB-699551 also reduced baseline startle rates (i.e., without prepulse).

138 periments showed a dose-dependent decline in startle rates in prepulse conditions.

139 hyperekplexia characterized by a generalized startle reaction and agoraphobic behavior, our data prov

140 dexed by skin conductance (experiment 1) and startle reactions (experiment 2).

141 It also mediates fast startle reactions triggered by the Mauthner cell.

142 CRHOEdev induced robust increases in startle reactivity and reductions in startle inhibition

143 vestigated whether OXT affects modulation of startle reactivity by aversive social stimuli as well as

144 ere operationally defined as the increase in startle reactivity during short- and long-duration threa

145 xtual fear learning in females and increased startle reactivity in males but did not change avoidance

146 ycloserine augmentation reduced cortisol and startle reactivity more than did alprazolam or placebo,

147 significant group differences were found in startle reactivity or habituation measures.

148 ales nor females exhibited any impairment in startle reactivity or prepulse inhibition.

149 aine users (DCU) display alterations of PPI, startle reactivity, and habituation.

150 bition of the acoustic startle reflex (PPI), startle reactivity, and spontaneous alternation, but did

151 subjects, PPI of acoustic startle response, startle reactivity, habituation, ADHD symptoms, and coca

152 depressogenic effects), emotion-potentiated startle reactivity, impulsivity (linked with suicidal be

153 PRETATION: Bivalent vaccination has led to a startling reduction in vaccine and cross-protective HPV

154 Recently prepulse inhibition of the acoustic startle reflex (ASR) became a popular technique for tinn

155 impaired prepulse inhibition of the acoustic startle reflex (PPI), startle reactivity, and spontaneou

156 O mice displayed marked deficits in acoustic startle reflex amplitude, as well as significant sensori

157 atients far exceeded control participants in startle reflex and autonomic reactivity during idiograph

158 iate PD/AG phenotypes demonstrated increased startle reflex and increased fear network, as well as ge

159 Using the acoustic startle reflex as a model of anxiety-like behavior in ra

160 d skin conductance), and potentiation of the startle reflex before and during exposure of the behavio

161 Prepulse inhibition (PPI) of the startle reflex has been suggested as a candidate endophe

162 expression levels and attenuated PPI of the startle reflex in healthy control subjects.

163 The auditory evoked startle reflex is a conserved response resulting in neur

164 ct seems unaffected in HSP patients, because startle reflex onsets were normal.

165 was evaluated with a gap detection acoustic startle reflex paradigm, while hearing status was assess

166 n lifting by the tail and lacked an enhanced startle reflex response that are characteristic of other

167 Prepulse inhibition (PPI) of the acoustic startle reflex was tested in healthy individuals (n=690)

168 the auditory brainstem response and acoustic startle reflex, yet tone detection behavior was nearly n

169 and anxiety were assessed using the acoustic startle reflex.

170 ning and prepulse inhibition of the acoustic startle reflex.

171 thdrawal was measured by potentiation of the startle reflex.

172 ange in aversive states is measured with the startle reflex.

173 re, measured as potentiation of the acoustic startle reflex.

174 lexia, which is characterised by exaggerated startle reflexes, muscle hypertonia and apnoea.

175 ive into microglia form and function reveals startling regional heterogeneity in number, morphology,

176 y functional calculations indicate that this startling regioselectivity is driven by dispersion inter

177 hocks were administered (anxiety-potentiated startle), respectively.

178 -like behavior as measured using potentiated startle responding does not emerge spontaneously during

179 and blunted circadian variations in baseline startle responding.

180 ffecting the magnitude or habituation of the startle response (all p > 0.13).

181 tion of the zebrafish (Danio Rerio) acoustic startle response (ASR).

182 morphisms may predispose to PD by increasing startle response and agoraphobic cognitions.

183 the histamine H1 antagonist meclizine on the startle response and PPI were investigated in healthy ma

184 he pwi phenotype includes a reduced auditory startle response and reduced visual evoked potentials, s

185 the safety signal to reduce the potentiated-startle response and to extinguish the fear response whe

186 e placebo group, as demonstrated by acoustic startle response and US expectancy ratings.

187 ic surge accompanied by an inhibition of the startle response as predicted by the animal model.

188 as measured by the amplitude of the acoustic startle response before and after noise exposure in a se

189 vapor, Drosophila show an olfactory-mediated startle response characterized by a transient increase i

190 e exhibit reduced initiation of the acoustic startle response consistent with hearing impairment, sug

191 the lowest cortisol reactivity and smallest startle response during virtual reality scenes.

192 male and female mice and decreased acoustic startle response in a sex-dependent manner.

193 CVS did not enhance the startle response in cycling females.

194 ted to one basic motor output and the C-type startle response in fish.

195 d whether either determines the precision of startle response initiation is not known.

196 Therefore, the startle response is the most likely evolutionary origin

197 dependent changes in timing and precision of startle response latencies.

198 e been proposed as evolutionary ancestors of startle response neurons of the mammalian reticular form

199 open field and elevated zero maze and shock-startle response of 12-month-old wild-type mice injected

200 n PPI without affecting the magnitude of the startle response or other physiological variables.

201 tipsychotics and causes a deficient acoustic startle response similar to that observed in schizophren

202 impairs prepulse inhibition of the acoustic startle response suggesting an important behavioural rol

203 ve neuromodulation, manifest in a diminished startle response suppression by hedonic stimuli.

204 smaller prepulse inhibition of the acoustic startle response than goal trackers, suggesting a reduce

205 his patient developed a profound accentuated startle response that did not have a corresponding elect

206 In prepulse inhibition (PPI), the startle response to a strong, unexpected stimulus is dim

207 impairments in motor coordination, increased startle response to acoustic stimuli and hypersociabilit

208 y related to the Lebinthini show an acoustic startle response to high-frequency sounds that generates

209 ative valence (Study1); 3 seconds later, the startle response was slightly less potentiated and the r

210 is defined as a reduction in magnitude of a startle response when a startling stimulus is preceded b

211 elevations could be evoked when inducing the startle response with unexpected air puffs.

212 tremor, and seizures (1 case with prominent startle response).

213 e burying task, elevated zero maze, acoustic startle response, and forced swim test.

214 ts prepulse inhibition (PPI) of the acoustic startle response, and patients with schizophrenia exhibi

215 as prepulse inhibition (PPI) of the acoustic startle response, are playing an increasingly important

216 e disease is characterized by an exaggerated startle response, evoked by tactile or auditory stimuli,

217 e disease is characterized by an exaggerated startle response, evoked by tactile or auditory stimuli,

218 This startle response, in which the first movement creates an

219 iated with micro-environmental plasticity of startle response, including Drosophila Hsp90, setting th

220 orphants had no FM1-43 dye uptake and lacked startle response, indicating hair cell dysfunction and g

221 Startle response, PPI, heart rate response, galvanic ski

222 tivity, respiration, tremors, body tone, and startle response, revealed normal responses for Chrna2-n

223 lant-naive control subjects, PPI of acoustic startle response, startle reactivity, habituation, ADHD

224 and applied it to three quantitative traits (startle response, starvation resistance, and chill coma

225 Measures included acoustic startle response, US expectancy, blood glucose levels, a

226 this compound tended to reduce the acoustic startle response, which is consistent with an anxiolytic

227 nxiety-like behaviors, and impaired acoustic startle response, which is distinct from the phenotype o

228 roduce persistent elevations in the acoustic startle response, which may reflect anxiety-like signs i

229 reactivity was strongly associated with the startle response, which was also associated with hypervi

230 Prepulse inhibition (PPI) of the acoustic startle response-a measure of sensorimotor gating-is hig

231 udied using prepulse inhibition (PPI) of the startle response.

232 ed interference of positive emotion with the startle response.

233 closely apposed to neurons that initiate the startle response.

234 maze and open field tests, and increased the startle response.

235 ide), on prepulse inhibition of the acoustic startle response.

236 d tasks and recording of emotion-potentiated startle response.

237 normalize, along with partial rescue of the startle response.

238 t and deficits in prepulse inhibition of the startle response.

239 the afferent neurons (S-cells) mediating the startle response.

240 is prepulse inhibition (PPI) of the acoustic startle response.

241 rited disease associated with an exaggerated startle response.

242 to antipsychotics, and an abnormal acoustic-startle response.

243 tion of predators and facilitate an acoustic startle response.

244 atory behavior characteristic of an acoustic startle response.

245 s; investigator ratings; PPI of the acoustic startle response; and autonomic, endocrine, and adverse

246 ted in the hindbrain to initiate C-type fast startle responses (C-starts).

247 primary SLCs and less frequent, long-latency startle responses (LLCs).

248 Here, we examined short-latency startle responses (SLCs) in larval zebrafish and tested

249 other motor activities, as well as acoustic startle responses all reveal a more slowly developing ph

250 cs and field potential parameters of C-start startle responses allowed for discrimination between sho

251 cs and field potential parameters of C-start startle responses allowed for discrimination between sho

252 in healthy male subjects with high baseline startle responses and low PPI levels.

253 The prepulse inhibition of startle responses by a weaker preceding tone, the inhibi

254 fearful faces, intact modulation of acoustic startle responses by fear-eliciting scenes, and a normal

255 response magnitude and levels of exaggerated startle responses in daily life in PTSD participants (t

256 iciency and exaggerated acoustic and tactile startle responses in mice bearing point mutations in alp

257 measured by inhibitory avoidance, increased startle responses in prepulse inhibition tasks, and incr

258 Latencies of startle responses in sternocleidomastoid and tibialis an

259 ents in the open field test, higher baseline startle responses in the course of the prepulse inhibiti

260 han 90 ms) and the frequent co-expression of startle responses in the neck and eye muscles, it has be

261 subcellular astrocyte calcium imaging during startle responses in vivo.

262 Intranasal OXT potentiated acoustic startle responses to negative stimuli, without affecting

263 We evoked startle responses via activation of Channelrhodopsin (Ch

264 Enhanced acoustic startle responses were observed among injected compared

265 chanism that can serve to precisely initiate startle responses when speed is critical for survival.

266 erekplexia is a syndrome of readily provoked startle responses, alongside episodic and generalized hy

267 For speed of initiation of startle responses, FSL would be the more advantageous me

268 uency discrimination, prepulse inhibition of startle responses, or fear conditioning with pure tones.

269 e immediately before the main pulse inhibits startle responses, though the mechanism for this remains

270 ise acts as a cue that attenuates subsequent startle responses.

271 encoding for rapid and precise initiation of startle responses.

272 encoding for rapid and precise initiation of startle responses.

273 impaired learning and memory and exaggerated startle responses.

274 lfactory-driven chemotaxis and touch-induced startle responses.

275 fety learning, with 22.5% of the variance in startle retention accounted for by REM sleep.

276 i larval inner ear was near normal, acoustic startle stimuli evoked smaller postsynaptic responses in

277 Control subjects responded to a startle stimulus similarly across tasks.

278 complete chronic cervical SCI responded to a startle stimulus, a test that engages the reticulospinal

279 on in magnitude of a startle response when a startling stimulus is preceded by a weaker "prepulse." P

280 oluntary release of a planned movement via a startling stimulus that engages the reticulospinal tract

281 ment an average of 71.7 +/- 2.7 ms after the startling stimulus.

282 fect of exercise was assessed using acoustic startle, stress-induced hyperthermia, and a challenge wi

283 oth by a standard pattern of responding to a startling stressor and also contagion.

284 g of tasks owing, among other things, to its startling structural and functional complexity and its r

285 t cysteine residues are very rare and rather startling structural features which play a variety of fu

286 elevate anxiety-like behavior in an acoustic startle task.

287 essed in the elevated-plus maze and acoustic startle test, including marked attenuation of light-enha

288 eld and pre-pulse inhibition of the acoustic startle tests and are significantly more sensitive to th

289 he bright coloration of butterflies; do they startle the bat, giving the moth a momentary advantage i

290 edented reemergence of Zika virus (ZIKV) has startled the world with reports of increased microcephal

291 uld be countered by sudden disturbances that startled them into a net, such as when we dropped a net

292 h PTSD symptoms (N=187) and fear-potentiated startle to a safety signal (N=135).

293 Eels were 50% less likely and 25% slower to startle to an 'ambush predator' and were caught more tha

294 and gap-prepulse inhibition of the acoustic startle to assess tinnitus, we recorded spontaneous acti

295 ar environment of budding yeast undertakes a startling transition upon glucose starvation in which ma

296 ontrol, daily mild stress exposure (acoustic startle), voluntary consumption of moderate-level alcoho

297 n with low estrogen levels, fear-potentiated startle was higher during extinction in the PTSD group c

298 Changes in prepulse inhibition of startle was tested after MK-801 (n = 6), NVP-AAM077, and

299 ovian conditioned stimulus (fear-potentiated startle) was enhanced.

300 tor (CRF)-dependent mechanism] that regulate startle, which is exaggerated in PTSD.