ライフサイエンスコーパス: starvation

1 M1-like polarizing conditions (hypoxia serum starvation).

2 hase cyclin, cyclin E1 (CCNE1), during serum starvation.

3 the food of the day and are at daily risk of starvation.

4 olic process which provides nutrients during starvation.

5 &7 also support root meristem growth under N starvation.

6 to induce fragmentation of ER tubules during starvation.

7 ated under conditions of nutrient and oxygen starvation.

8 metabolic flexibility to survive periods of starvation.

9 ruginosa is tightly organized under nitrogen starvation.

10 gene induction and survival during phosphate starvation.

11 to identify changes as the cells died due to starvation.

12 n SLC7A11-overexpressing cells under glucose starvation.

13 eation length, thus coined the term, nucleus starvation.

14 on nucleoid dynamics and organization during starvation.

15 ation capacity and the metabolic response to starvation.

16 ENND3), is phosphorylated and activated upon starvation.

17 active and resistant to serum and amino acid starvation.

18 the anti-tumour effect of serine and glycine starvation.

19 were measured over a time course of nitrogen starvation.

20 it is expressed during ammonium run-out and starvation.

21 sensitive to hydrogen peroxide and nutrient starvation.

22 tected in autophagosomes induced by nutrient starvation.

23 bolism, in particular induced lipolysis upon starvation.

24 n promotes cancer cell survival upon glucose starvation.

25 modification in response to acute periods of starvation.

26 mania to survive prolonged periods of purine starvation.

27 stic with other TAG inducing stimuli such as starvation.

28 subsequently undergo apoptosis due to IL-15 starvation.

29 for the removal of proteasomes upon nitrogen starvation.

30 hopping time' model of RelA activity during starvation.

31 ed for cellular survival under conditions of starvation.

32 HMG-CoA synthase 2 increased with prolonged starvation.

33 integrating responses to salt stress and Pi starvation.

34 protein synthesis in response to amino acid starvation.

35 sfer lipids to mitochondria during phosphate starvation.

36 ated by SUMO, but this was attenuated during starvation.

37 osira pseudonana on a time-course of silicon starvation.

38 constituents and is systemically induced by starvation.

39 ternal transfer, changes in food sources and starvation.

40 rmination factor Nab3 in response to glucose starvation.

41 cold stress, and reduced ability to survive starvation.

42 contribute to autophagosome formation during starvation.

43 esis induced by lysosome alkalizers or serum starvation.

44 liver autophagy and metabolic adaptation to starvation.

45 hed Rpd3L complex recruitment in response to starvation.

46 riacylglycerol (TAG) in response to nutrient starvation.

47 nders cancer cells more resistant to glucose starvation.

48 e distribution and spacing relax deeper into starvation.

49 nsistent with historical studies on maternal starvation.

50 romotes completion of cell cycle exit during starvation.

51 d type in response to phosphorus or nitrogen starvation.

52 bidopsis mutant, hps10 (hypersensitive to Pi starvation 10), which is morphologically normal under Pi

53 These findings show that during amino acid starvation a primary role of aaRS quality control is to

54 Between 1 and 3 h after nitrogen starvation, a minority of cells have divided, yet the to

55 In the case of starvation, a signaling cascade involving AMPK and histo

56 Amino acid starvation activates the protein kinase Gcn2p, leading t

57 ted but KCR8-16 mice rapidly transitioned to starvation after mild metabolic challenges.

58 Together with the universal starvation alarmone (p)ppGpp, polyP has an additive effe

59 Likewise, subjecting cells to nitrogen starvation also elevates the level of Ras1 phosphorylati

60 More gradual glucose starvation, amino acid deprivation or rapamycin did not

61 Under conditions of stress and starvation, an NAP called Dps (DNA-binding protein from

62 of mSTAT3 inhibition are enhanced by glucose starvation and by increased reliance of cancer cells and

63 experience continuous erosion under sediment starvation and climate change in the next decades of thi

64 Deltas are widely threatened by sediment starvation and climate change.

65 Mutant cells lacking polyP elongate during starvation and contain more than one origin.

66 Leptin levels fall during starvation and elicit adaptive responses in many other p

67 Agrp neurons that are normally activated by starvation and evoke intense hunger-display electrical a

68 ng energy-avid adaptive immunity in times of starvation and exerting a paradoxical effect in overnutr

69 erious eating disorder characterized by self-starvation and extreme weight loss.

70 cid response, leading ultimately to nutrient starvation and GIC cell death.

71 gRP)-expressing neurons are activated during starvation and have been implicated in leptin-associated

72 , indicated a phenotype more akin to that of starvation and intestinal malabsorption.

73 ho2 is dispensable for survival in phosphate starvation and is only partially required for inducing P

74 abolite patterns were distinct from nitrogen starvation and other abiotic stresses commonly used to i

75 A key integrator of the cell's responses to starvation and other stresses is amino-acid-dependent me

76 GM-strains of Bacteroides to survive thymine starvation and overcome it through the exchange of genet

77 diated adaptation to food availability after starvation and physical exercise and played an important

78 of tumor and T cells to adapt to tryptophan starvation and provide important insights into the poor

79 otroph Methyloprofundus sedimenti to methane starvation and recovery was characterized.

80 nding of methanotrophic responses to methane starvation and recovery, and lays the initial groundwork

81 PCs diminished cardiomyocyte viability under starvation and simulated ischaemia.

82 s of both 5-InsP7 and ATP decrease upon [Pi] starvation and subsequently recover during Pi replenishm

83 autophagosomes under conditions of nutrient starvation and that the mature Red Blood Cells of some R

84 EB R4 neurons increases dramatically during starvation and that this increase is abolished in the SL

85 artially decoupled lipogenesis from nitrogen starvation and unleashed the lipogenic potential of Y. l

86 namic roles of GlnB and GlnK during nitrogen starvation and upshift.

87 nd GPD3 were shown to be induced by nutrient starvation and/or salt stress.

88 reases carbon costs during periods of carbon starvation, and (3) promote biotic attack due to low tis

89 thogenic enterococci to survive desiccation, starvation, and disinfection in the modern hospital, for

90 f activity in the reactors though was due to starvation, and final removal rates did not differ betwe

91 tresses, including zinc deficiency, nitrogen starvation, and inhibition of carbon concentration/fixat

92 ratios remain unchanged during acute glucose starvation, and intact AMP-binding sites on AMPK are not

93 for GlnK as a buffer of nitrogen shock after starvation, and provides a further functional link betwe

94 Starvation arouses evolved protective mechanisms includi

95 gest that this response occurs under proline starvation as well.

96 Nitrogen starvation, as well as direct inhibition of the master n

97 tion of the photosynthetic apparatus to iron starvation at three levels: (1) directly, via posttransc

98 During periods of starvation, ATXN2 is transcriptionally induced and local

99 y contributors to PINK1/Parkin mitophagy and starvation autophagy.

100 ablished cytoprotective role during nutrient starvation, autophagy protects cells from detachment-ind

101 During amino acid starvation, bacterial cells rapidly synthesize the nucle

102 metabolism transcripts that are induced by P starvation but misregulated in the psr1 mutant.

103 -PABP1 association is not specific to energy starvation but represents a common stress response.

104 rigger for archaellum expression is nutrient starvation, but although some components are known, the

105 is also required for detection of amino acid starvation by Gcn2p.

106 on blunted neurite formation evoked by serum starvation by signaling mechanisms involving Galpha12/13

107 vents, such as traumatic stress, illness, or starvation, can influence us through molecular changes t

108 Nitrogen starvation caused an accumulation of ribosomes on 5' lea

109 Upon SAM depletion by methionine starvation, cells induce MAT2A expression by enhanced sp

110 severe energy depletion (serum plus glucose starvation), changes in the autophagic flux (as assessed

111 nd for its modulation in response to glucose starvation, characterized by a rapid drop followed by sl

112 muscle cells under normal and hypoxia serum starvation conditions) and in vivo experiments in precli

113 ck development in the defective strain under starvation conditions, but is also required for Pxr to p

114 ber of key pathways are affected by nitrogen starvation conditions, including central carbon metaboli

115 to limit host damage to only the most severe starvation conditions, providing insight into one potent

116 energy homeostasis and cell viability under starvation conditions, suggesting that REGgamma-proteaso

117 Finally, our results suggested that under starvation conditions, the levels of alphaSNAP, although

118 clock was affected by glucose; compared with starvation conditions, the period was longer and the osc

119 l RNA preservation during prolonged nutrient starvation conditions.

120 acids may act to support mTORC1 activity in starvation conditions.

121 e proposed nutritional role of the PPS under starvation conditions.

122 it can obtain iron during growth under iron starvation conditions.

123 ase in the viability of cardiomyocytes under starvation conditions.

124 conditions inside glycosomes in response to starvation conditions.

125 ally interact under continuous nitrate and N-starvation conditions.

126 agic flux was increased in ARSACS HDFs under starvation conditions.

127 tary bee, Osmia lignaria We demonstrate that starvation cues metamorphosis in O. lignaria and that a

128 In the presence of exogenous glucose, starvation decreased the Crabtree effect in Huh7 and C2C

129 ive-while the rest died on Mount Sinjar from starvation, dehydration, or injuries during the ISIS sie

130 ribosomal protein (RP) mRNAs whereas glucose starvation destabilized RP transcripts through Hog1.

131 phylum wherein a progenitor cell that faces starvation differentiates to form a dormant spore.

132 In response to starvation, diploid cells of Saccharomyces cerevisiae un

133 While serine starvation dramatically decreased ATP levels, this was a

134 acute need to produce autophagosomes during starvation drives the interaction of Sec24 with Atg9 to

135 or growth in long days and for prevention of starvation during twilight is discussed.

136 Using both starvation experiments and mass balance models, it was f

137 regulon during the early stages of nitrogen starvation for the model cyanobacterium Synechocystis sp

138 ria have evolved strategies to overcome iron starvation, for example, by stealing iron from the host

139 However, starvation halts growth, thereby decreasing productivity

140 Notably, glutamine starvation has a synergistic effect with cisplatin, a co

141 lated M. tuberculosis was similar to that of starvation, hypoxia, stationary phase, or nonreplicating

142 LS), is also secreted by yeast upon nutrient starvation in a Grh1- and ESCRT-I-, -II-, and -III-depen

143 int in the root developmental response to Pi starvation in Arabidopsis thaliana Our results also show

144 gal species and can be maximized by nutrient starvation in batch culture.

145 We show here that during periods of acute starvation in Caenorhabditis elegans larvae, the master

146 daf-16/FoxO is required to survive starvation in Caenorhabditis elegans, but how daf-16IFox

147 tions, we studied the autophagic response to starvation in eight affected SPG11 cases and control fib

148 Both miR395 and NtaSULTR2 respond to sulfate starvation in tobacco.

149 biosynthetic building blocks in response to starvation, in contrast to findings in other cell types.

150 crete cellular shifts in response to methane starvation, including changes in headgroup-specific fatt

151 Serine starvation increased the methionine/S-adenosyl methionin

152 t cells with copper overload, whereas copper starvation increased tryptase content.

153 a primarily nuclear protein, which promotes starvation-independent, basal autophagy.

154 necessary and sufficient for both amino-acid starvation induced mono-ADP-ribosylation and subsequent

155 nase activity is more potent, and amino acid starvation induced more rapid ATG13 and ULK1 translocati

156 The starvation-induced aggregation of the social amoeba Dict

157 NSCLC cells rendered them resistant to serum starvation-induced apoptosis.

158 er GABARAP from the centrosome occurs during starvation-induced autophagosome biogenesis, but how cen

159 tream signals that regulate the induction of starvation-induced autophagy are clearly defined.

160 This competition resulted in impairment of starvation-induced autophagy in cells expressing mutant

161 Rab12 functions in the initiation of starvation-induced autophagy, and our previous work reve

162 Starvation-induced autophagy, which is regulated by becl

163 have named Zonda, is critically required for starvation-induced autophagy.

164 omes and autolysosomes during both basal and starvation-induced autophagy.

165 GTA is distinct from starvation-induced autophagy.

166 fyve activity protects Ras-mutant cells from starvation-induced cell death and supports their prolife

167 nders cancer cells more sensitive to glucose starvation-induced cell death and, conversely, that SLC7

168 ability of P. aeruginosa to resuscitate from starvation-induced dormancy and that HPF is the major fa

169 These include novel glucose starvation-induced downstream transcripts for the transl

170 ption factor regulating the expression of Pi starvation-induced genes.

171 In this study, we analysed starvation-induced gluconeogenesis and ketogenesis in mo

172 Initially, starvation-induced intracellular signals direct changes

173 ed autophagy is necessary and sufficient for starvation-induced LD biogenesis.

174 lipids (approximately 70%), in contrast to N starvation-induced LDs, which contain approximately 60%

175 Here, we show that P starvation-induced lipid and starch accumulation is inhi

176 plays an important role in the initiation of starvation-induced macroautophagy (autophagy) and is act

177 d expression of archaellum components during starvation-induced motility in Sulfolobus acidocaldarius

178 SIRT1 phosphorylation is required for energy starvation-induced PABP1-SIRT1 association, PABP1 deacet

179 We found that nitrogen starvation-induced proteasome autophagy is independent o

180 TMEM55B or JIP4 depletion abolishes starvation-induced retrograde lysosomal transport and pr

181 In this work, the starvation-induced Ser/Thr protein kinase ArnS (Saci_118

182 ns revealed these neurons to be required for starvation-induced sleep suppression.

183 ed RNA/DNA binding protein, as essential for starvation-induced sleep suppression.

184 esults suggest a possible mechanism by which starvation-induced stress response factors may prime qui

185 Early starvation-induced substitution of phospholipids in the

186 PD3 GPDH isoforms are important for nutrient starvation-induced TAG accumulation but have distinct me

187 ients and repopulate polysomes after a short starvation-induced translational block, indicating their

188 ion of these OH-interface residues abrogates starvation-induced up-regulation of autophagy but does n

189 airs rapamycin- and torin 1-induced, but not starvation-induced, autophagy.

190 Moreover, energy starvation induces an AMPK-directed SirT7 phosphorylatio

191 Second, continued PA production in later starvation induces expression of PLD-targeting microRNA

192 Starvation induces liver autophagy, which is thought to

193 Arg starvation induces p300 dissociation, allowing histone H

194 Arg starvation induces PHD2 and HDAC2 interaction which is s

195 We further show that glucose starvation induces SLC7A11 expression through ATF4 and N

196 of these motifs could be bound by a nitrogen starvation-inducible RING-domain protein termed RING-GAF

197 When challenged with starvation, insufficient energy reserves attenuate gonad

198 From our experiments, we conclude that Pi starvation interferes with salt responses mainly at the

199 Methane starvation is associated with a significant increase in

200 Thymine starvation is exceptional, because it kills cells rapidl

201 Resistance to Arg starvation is often developed through reactivation of AS

202 e known, the regulatory cascade triggered by starvation is poorly understood.

203 Amino acid starvation is sensed by depletion of the aminoacylated t

204 Here, we show that thymine starvation leads to accumulation of both single-stranded

205 Conversely, TORC1 inactivation upon starvation leads to the inactivation of PP2A-B55(Pab1) t

206 em to lose their ability to resuscitate from starvation, leaving intact nondividing cells.

207 nduction of primary cilia formation by serum starvation led to a two-fold reduction in ciliogenesis i

208 Phosphate starvation led to gradual increase in Pro content in wil

209 but not deacylated tRNAPhe during amino acid starvation, limiting Gcn2p kinase activity and suppressi

210 , restricting access to forage, resulting in starvation, lower survival and fecundity.

211 aspect of the cellular adaptive response to starvation, mediated by LDs.

212 We hypothesized that starvation-mimicking signaling compounds secreted from t

213 Drugs that mirror the cellular effects of starvation mimics are considered promising therapeutics

214 ution under basal conditions and, soon after starvation, nucleates in endoplasmic reticulum-associate

215 thetases may be important for survival under starvation/nutrient limitation conditions.

216 exponential growth (unstressed) and nitrogen starvation (nutritional stress), and both in the presenc

217 how that repression of this pathway by sugar starvation occurs downstream of the hypoxia-dependent st

218 king inositol, and were mirrored by inositol starvation of an ino1Delta mutant.

219 pogenic activity and LD sizes during glucose starvation of HeLa cells and transforming growth factor

220 , we address this issue and show that copper starvation of mast cells causes increased granule matura

221 urther direct drought effects such as carbon starvation (only in HYBRID4) or hydraulic failure are us

222 ze is reduced 3-fold in response to nutrient starvation or accumulation of the alarmone ppGpp, a glob

223 under stress conditions, such as amino acid starvation or aminoacyl-tRNA depletion due to a high lev

224 survival under stressful conditions, such as starvation or antibiotic stress.

225 vation of autophagosome formation, either by starvation or by inhibition of the mammalian target of r

226 Upon mTORC1 inactivation, either by starvation or by inhibitor, recycling receptors and plas

227 ulated following TFEB and TFE3 activation by starvation or cholesterol-induced lysosomal stress.

228 y is not robustly upregulated in response to starvation or mammalian target of rapamycin inhibition,

229 t of rapamycin inhibition by either nutrient starvation or use of an active site inhibitor reduces Sk

230 uch as during periods of prolonged exercise, starvation, or absence of dietary carbohydrates.

231 Starvation, or caloric restriction, is known to activate

232 atments induce apoptosis, others induce cell starvation, or oncosis.

233 In S. cerevisiae, the phosphate starvation (PHO) responsive transcription factors Pho4 a

234 peptides and amino acids, response to sulfur starvation, potentially NADPH-producing pathways involvi

235 indings uncover a signaling cascade by which starvation promotes autophagy through OGT phosphorylatio

236 hage growth locus protein A (MglA)-stringent starvation protein A (SspA) complex and the DNA-binding

237 o analysis showed that the E. coli stringent starvation protein A (SspA) shares sequence and structur

238 ilencing is controlled by HIF-1alpha and Arg starvation-reactivated ASS1 is associated with HIF-1alph

239 In cells, methionine starvation reduces SAM levels below this dissociation co

240 Instead, nutrient starvation regulates the lysosomal concentrations of the

241 Glutamine starvation rendered tumour cells more resistant to Chk1

242 Serum starvation resembles the growth factor deprivation chara

243 work demonstrates that daf-16/FoxO promotes starvation resistance by shifting carbon metabolism to d

244 bditis elegans, but how daf-16IFoxO promotes starvation resistance is unclear.

245 enormous information available for phosphate starvation response (P0), very few information is availa

246 The loss of PON2 initiates the cellular starvation response and activates AMP-activated protein

247 novel insight into the B. subtilis phosphate starvation response and implicate WTA hydrolase activity

248 ster maintenance robustly activates the iron-starvation response and, in combination with inhibition

249 nown to bind to Zn(II) and can induce a zinc starvation response in bacteria.

250 nule biogenesis is an ancient and ubiquitous starvation response in bacteria.

251 polyP production and triggers the phosphate starvation response via the PHO pathway.

252 us cellular processes are triggered by the P starvation response, a tightly regulated process in plan

253 n reprogramming, an evolutionarily conserved starvation response, has been hijacked by microenvironme

254 Originally characterized as a hormonal and starvation response, we now know that autophagy has a mu

255 s (MYB)-type transcription factors PHOSPHATE STARVATION RESPONSE1 (PHR1) and PHR1-LIKE1 (PHL1) were i

256 i mutant lacking the transcription factor Pi Starvation Response1 (PSR1).

257 by Pi deficiency was influenced by PHOSPHATE STARVATION RESPONSE1, the main transcription factor regu

258 roles in translational accuracy and nutrient starvation responses during protein translation.

259 d to pathogenesis, translational repression, starvation responses, and ribosome turnover.

260 nd metabolite profiling revealed enhanced Pi starvation responses, such as up-regulation of multiple

261 with transcription factors to regulate P(i) starvation responses.

262 ced DNA damage and reversal of the glutamine starvation restored the sensitivity of tumour cells to C

263 followed a two-stage pattern where nitrogen starvation resulted in a 2.5-fold increase followed by a

264 -type plants under conditions inducing sugar starvation results in a weak induction of alcohol dehydr

265 receptor signalling in the hypothalamus and starvation sensing in mice.

266 gonadal steroid and circadian cues, but the starvation-sensitive input that inhibits this circuit du

267 ived cell lines are respiration-impaired and starvation-sensitive.

268 etabolism, the data suggest that indole is a starvation signal in V. campbellii.

269 med nutrient can paradoxically sustain brain starvation signals, and identify a biological factor req

270 Upon energy starvation, SIRT1 interacts with and deacetylates PABP1

271 lated genes in pap7-1 mutants reflecting the starvation situation of the albino seedlings.

272 The nutrient starvation-specific unconventional secretion of Acb1 in

273 Light triggers a rapid removal of the starvation state and the establishment of PIN1 polar mem

274 ncluded that the ppGpp(0) mutant reacts upon starvation stress by elongation and desaturation of fatt

275 ons, but how cells generate acetyl-CoA under starvation stress is less understood.

276 s hair cell fate while alleviating phosphate starvation stress.

277 er basal conditions and in response to serum starvation, suggesting that, under conditions of severe

278 he main regulator of the response to sulfate starvation, SULFATE LIMITATION1 (SLIM1) belongs to the f

279 Importantly, acute amino acid starvation suppressed intestinal inflammation via a mech

280 n elongation rate as shown by our amino-acid starvation/surplus studies.

281 ophagy supports nucleotide pools and thereby starvation survival.

282 Under N starvation, TCP20-NLP6&7 heterodimers accumulate in the

283 romal fibroblasts and epithelial cells under starvation that could be exploited therapeutically to ta

284 o promote distinct phenotypes in response to starvation, the ileS(T233P) strain was observed to exhib

285 Upon nutritional starvation, the master regulator of meiosis Mei2 inactiv

286 for targeting Arg auxotrophic tumors by Arg starvation therapy.

287 (5-InsP7) as follows: during a period of Pi starvation, there is a decline in cellular [ATP]; the un

288 d/or LC-MS over time courses during nitrogen starvation to address the roles of catabolic carbon recy

289 for membranes to form autophagosomes during starvation to maintain homeostasis leads to a dramatic r

290 to intracellular stress events ranging from starvation to pathogen invasion, the cell activates one

291 Protein starvation triggered branch-specific plastic changes in

292 In Pseudomonas putida biofilms, nutrient starvation triggers c-di-GMP hydrolysis by phosphodieste

293 In fission yeast, glucose starvation triggers lncRNA transcription across promoter

294 Nutrient starvation usually halts cell growth rather than causing

295 ive regulator of autophagy during amino acid starvation, via its target kinase Ypk1, by repressing th

296 Long-term starvation was characterized by a profound increase in c

297 However, Chlamydia can experience amino acid starvation when the human host cell in which the bacteri

298 ions of dietary restriction or growth factor starvation, where PI3K/mTOR signalling is decreased, mat

299 feeding gravid state and a period of forced starvation while they brood developing young inside thei

300 Finally, we show that combining GLN starvation with pro-oxidants selectively kills GLN addic