ライフサイエンスコーパス: stearoyl-CoA desaturase

1 ich include ATP citrate lyase, ACC, FAS, and stearoyl-CoA desaturase.

2 ine motif required for catalytic activity in stearoyl-CoA desaturase.

3 oenzyme A synthase, fatty acid synthase, and stearoyl-CoA desaturase.

4 atory element binding protein (SREBP1c), and stearoyl-CoA desaturase.

5 se 1 (ACC1), fatty acid synthase (FASN), and stearoyl CoA desaturase 1 (SCD1)] to AML and eBL cell li

6 pression of key lipogenic enzymes, including stearoyl CoA desaturase 1 (SCD1/SCD).

7 P-2 (vesicle-associated membrane protein 2), stearoyl CoA desaturase 1, and cAMP-specific phosphodies

8 In contrast, the stearoyl-CoA desaturase 1 (in lipogenesis) mRNA was up-r

9 Herein, we demonstrate that inhibition of stearoyl-CoA desaturase 1 (SCD-1) halts the biosynthesis

10 glucose tolerance, and reduced expression of stearoyl-CoA desaturase 1 (SCD-1).

11 f the mice with a disruption in the gene for stearoyl-CoA desaturase 1 (SCD1) (SCD1-/-) is deficient

12 e model, here we show that expression of the stearoyl-CoA desaturase 1 (Scd1) gene is downregulated i

13 r strategies to combat this growing problem, stearoyl-CoA desaturase 1 (SCD1) inhibition has been pro

14 Mice with a targeted disruption of the stearoyl-CoA desaturase 1 (SCD1) isoform are protected a

15 We analyzed the changes in stearoyl-CoA desaturase 1 (SCD1) mRNA to further define

16 SREBPs (1a and 2) led to elevated mRNAs for stearoyl-CoA desaturase 1 (SCD1), an isoform that is det

17 r Xenopus kinesin-like protein 2 (TPX2), and stearoyl-CoA desaturase 1 (SCD1), significantly reduced

18 ChREBP overexpression induced expression of stearoyl-CoA desaturase 1 (Scd1), the enzyme responsible

19 Stearoyl-CoA desaturase 1 (SCD1), the key enzyme involve

20 oupling of fatty acid synthase activity from stearoyl-CoA desaturase 1 (SCD1)-mediated desaturation.

21 n as well as reduction in mRNA expression of stearoyl-CoA desaturase 1 and genes associated with fatt

22 that mice with a targeted disruption in the stearoyl-CoA desaturase 1 gene (SCD1-/-) have increased

23 The lipogenic enzyme stearoyl-CoA desaturase 1 is highly induced in SIRT3KO m

24 Therefore, stearoyl-CoA desaturase 1 may play an unexpected role in

25 seen with genetic deletion or inhibition of stearoyl-CoA desaturase 1 promotes inflammation, TLR4 hy

26 ohydrate response element-binding protein or stearoyl-CoA desaturase 1 resulted in lethality on high

27 ary cell line that overexpressed transfected stearoyl-CoA desaturase 1, a rate-limiting enzyme in the

28 pression, most notably reduced expression of stearoyl-CoA desaturase 1, a rate-limiting enzyme in the

29 n of SFA in the body is tightly regulated by stearoyl-CoA desaturase 1, an enzyme that converts endog

30 crophage LXR/RXR target genes, we identified stearoyl-CoA desaturases 1 and 2 (Scd1 and Scd2), and su

31 Recent evidences suggest that stearoyl-CoA-desaturase 1 (SCD1), the enzyme involved in

32 evidenced by downregulation of both hepatic stearoyl CoA desaturase-1 and fatty acid synthase.

33 was also a significant downregulation of the stearoyl CoA desaturase-1 gene, which has been associate

34 ed hyperleptinemia without downregulation of stearoyl CoA desaturase-1 or fatty acid synthase and by

35 MP-activated kinase (AMPK) and reduced liver stearoyl-CoA desaturase-1 (SCD-1) activities.

36 several accessory lipogenic enzymes, such as stearoyl-CoA desaturase-1 (SCD-1) and long chain free fa

37 Central leptin also repressed stearoyl-CoA desaturase-1 (SCD-1) RNA and enzymatic acti

38 sed the mRNA levels for fatty acid synthase, stearoyl-CoA desaturase-1 (SCD-1), and epidermal fatty a

39 ting a high activity of the lipogenic enzyme stearoyl-CoA desaturase-1 (SCD-1), has been shown to be

40 RNA levels and enzymatic activity of hepatic stearoyl-CoA desaturase-1 (SCD-1), which catalyzes the b

41 Stearoyl-CoA desaturase-1 (SCD1) catalyzes de novo synth

42 Stearoyl-CoA desaturase-1 (SCD1) catalyzes the synthesis

43 Stearoyl-CoA desaturase-1 (SCD1) catalyzes the synthesis

44 cell death effect ORCTL3 targets the enzyme stearoyl-CoA desaturase-1 (SCD1) in fatty acid metabolis

45 Stearoyl-CoA desaturase-1 (SCD1) is the rate-limiting en

46 Genetic or pharmacological inhibition of stearoyl-CoA desaturase-1 (SCD1), the enzyme that conver

47 tic expression of lipogenic genes, including stearoyl-CoA desaturase-1 (SCD1).

48 hannels and to decreased hepatic activity of stearoyl-CoA desaturase-1 (SCD1).

49 tty acid (FA) synthesis with the activity of stearoyl-CoA desaturase-1 (SCD1).

50 activate transcription of the genes encoding stearoyl-CoA desaturase-1 and -2, thereby markedly enhan

51 erides or in the exercise-suppressed hepatic stearoyl-CoA desaturase-1 and peroxisome proliferator-ac

52 r-activated receptor gamma2 (PPARgamma2) and stearoyl-CoA desaturase-1 and up-regulated PPARalpha ind

53 We identify stearoyl-CoA desaturase-1 as a MSI1 target, revealing a

54 n in wild-type mice increased PPARgamma2 and stearoyl-CoA desaturase-1 mRNA and hepatic triglyceride

55 yl-CoA carboxylase, fatty acid synthase, and stearoyl-CoA desaturase-1 were all elevated markedly, as

56 yl-CoA carboxylase, fatty-acid synthase, and stearoyl-CoA desaturase-1 were increased in apoB/BATless

57 d-type mice, with the induction of the Scd1 (stearoyl-CoA desaturase-1) gene preceding that of other

58 e, glycerol-3-phosphate acyltransferase, and stearoyl-CoA desaturase-1) showed a complete failure of

59 y acid synthase, acetyl-CoA carboxylase, and stearoyl-CoA desaturase-1, were reduced in ob/ob-PPARgam

60 Previous studies using stearoyl-CoA desaturase-1-deficient (SCD1-deficient) mic

61 We previously identified stearoyl-CoA desaturase 2 (SCD2) as a new member of the

62 This approach identified stearoyl-CoA desaturase 2 (SCD2) as a new SREBP-regulate

63 Of 24 enzymes screened, stearoyl-CoA desaturase 2 (SCD2) was found to be uniquel

64 Why, then, is stearoyl-CoA desaturase a highly regulated enzyme?

65 secondary analysis, each SD increase of log-stearoyl-coA desaturase activity (16:1n-7/16:0 ratio) wa

66 Peroxisome proliferators induce stearoyl-CoA desaturase activity (EC 1.14.99.5) in liver

67 ester transfer protein and indexes of plasma stearoyl-CoA desaturase activity (SCD).

68 -binding cassette transporter A1 (ABCA1) and stearoyl CoA desaturase, and expression of these genes i

69 Lipocalin 2, haptoglobin, serum amyloid A3, stearoyl-CoA desaturase, and 11beta-hydroxysteroid dehyd

70 the molecular mechanism for the induction of stearoyl-CoA desaturase by peroxisome proliferators.

71 Stearoyl-CoA desaturase catalyzes the rate-limiting step

72 We also found the expression of Stearoyl-CoA desaturase, Desat1 mRNA significantly highe

73 acyl-CoA oxidase (F08A8.1 and F08A8.2), and stearoyl-CoA desaturase (fat-7).

74 Stearoyl-CoA desaturase gene 1 (scd1) mRNA levels were i

75 ) and other fatty acids on the expression of stearoyl-CoA desaturase gene 1 were investigated in full

76 ouse model with a targeted disruption of the stearoyl-CoA desaturase gene-1 (SCD1-/-) have revealed t

77 ce was identified at the N-terminus of mouse stearoyl-CoA desaturase I (SCD I) comprised of (30)KVKTV

78 tin in the cytoplasm of basal sebocytes, and stearoyl CoA desaturase in the cytoplasm of basal and lu

79 ly advances concerning the important role of stearoyl-CoA desaturase in metabolism.

80 onse-element-binding protein-1 (SREBP-1) and stearoyl-CoA desaturase in the immortalized sebaceous gl

81 ineralization of CVCs, whereas inhibition of stearoyl-CoA desaturase induced mineralization.

82 ssion of galectin-12, resistin, SREBP-1, and stearoyl-CoA desaturase mRNAs in SZ95 sebocytes.

83 III; medium chain acyl-CoA dehydrogenase; or stearoyl-CoA desaturase mRNAs.

84 Analysis revealed that four of the genes [stearoyl-CoA desaturase; NADH-ubiquinone oxidoreductase

85 erilipin-5, adipose triglyceride lipase, and stearoyl-CoA desaturase protein was higher in the NWA gr

86 were examined to investigate TR4 target gene stearoyl-CoA desaturase (SCD) 1 regulation.

87 saturase (D5D), Delta6 desaturase (D6D), and stearoyl-CoA desaturase (SCD) activity and T2D risk.

88 Stearoyl-CoA desaturase (SCD) catalyzes the rate-limitin

89 h arachidonic acid resulted in a decrease in stearoyl-CoA desaturase (Scd) enzyme activity and scd1 m

90 There are four known stearoyl-CoA desaturase (SCD) enzyme isoforms in mouse a

91 Here, we have shown that repression of stearoyl-CoA desaturase (SCD) enzymes, which regulate th

92 T3-L1 preadipocyte cells are correlated with stearoyl-CoA desaturase (SCD) expression (mRNA and prote

93 f fatty acid uptake and synthesis and higher stearoyl-CoA desaturase (SCD) expression, Ncb5or(-/-) li

94 Stearoyl-CoA desaturase (SCD) is a central lipogenic enz

95 Stearoyl-CoA desaturase (SCD) is a key regulator of memb

96 Stearoyl-CoA desaturase (SCD) is a microsomal enzyme req

97 Stearoyl-CoA desaturase (SCD) is a regulatory enzyme inv

98 Stearoyl-CoA desaturase (SCD) is an integral membrane pr

99 Stearoyl-CoA desaturase (SCD) is an integral membrane pr

100 Stearoyl-CoA desaturase (SCD) is conserved in all eukary

101 Stearoyl-CoA desaturase (SCD) is the rate-limiting enzym

102 Stearoyl-CoA desaturase (SCD) is the rate-limiting enzym

103 Remarkably, liver stearoyl-CoA desaturase (Scd) mRNA expression was by far

104 Stearoyl-CoA desaturase (SCD) synthesizes oleate necessa

105 esis: four desaturases were induced, and one stearoyl-CoA desaturase (SCD) was strongly repressed.

106 The regulation of stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in

107 vo lipogenesis, such as fatty-acid synthase, stearoyl-CoA desaturase (SCD)-1, and apoB.

108 atty acid metabolism, including induction of stearoyl-CoA desaturase (SCD)-1, which converts saturate

109 protease exhibits substrate selectivity for stearoyl-CoA desaturase (SCD).

110 The lipogenic gene stearoyl-CoA desaturase (SCD)1 appears to be a promising

111 Stearoyl-CoA desaturase (SCD)1 catalyzes the rate-limiti

112 s carried out by the oxygen-consuming enzyme stearoyl-CoA desaturase (SCD)1.

113 Lipid metabolites of stearoyl-CoA-desaturase (SCD) activity were associated w

114 or depletion of the lipid metabolism enzymes stearoyl-CoA-desaturases (SCD) and S-adenosyl methionine

115 sion, its expression was compared to that of stearoyl CoA desaturase (Scd1) in B6 mice exposed to die

116 scle carnitine palmitoyl-transferase (MCPT), stearoyl CoA desaturase (SCD1), and fatty acid transloca

117 fatty-acid synthase, acetyl-CoA carboxylase, stearoyl-CoA desaturase, squalene synthase, farnesyl-pyr

118 Moreover, expression of stearoyl-CoA desaturase, the enzyme required for the gen