ライフサイエンスコーパス: stem cell niche

1 ive cells in the labial cervical loop (LaCL, stem cell niche).

2 hat influenced their ability to colonize the stem cell niche.

3 opsis procambial cells, defines the vascular stem cell niche.

4 viding targets within the neoplastic gastric stem cell niche.

5 hy such complex regulation exists within the stem cell niche.

6 lose proximity in vivo in the corneal limbal stem cell niche.

7 l differentiation to establish an epithelial stem cell niche.

8 gative progenitor cells that have exited the stem cell niche.

9 ch they derive, including the formation of a stem cell niche.

10 m and retina, as well as in the adult neural stem cell niche.

11 homing of human PAX7+ satellite cells to the stem cell niche.

12 competitive advantage for occupation of the stem cell niche.

13 ator of quiescence in the V-SVZ adult neural stem cell niche.

14 itch that modulates QC divisions at the root stem cell niche.

15 , PCs serve as a component of the intestinal stem cell niche.

16 ltipotent), and can be found in a recognized stem cell niche.

17 lically dormant state within the bone marrow stem cell niche.

18 the importance of the spatial aspects of the stem cell niche.

19 g of the central canal that is also an adult stem cell niche.

20 n is largely undefined, they may represent a stem cell niche.

21 ere they presumably hijack the hematopoietic stem cell niche.

22 ues for patterning the WUS domain within the stem cell niche.

23 na shoot apical meristem (SAM) to maintain a stem cell niche.

24 rvation in maintaining stem cells and/or the stem cell niche.

25 F-beta receptor pathway acts in the germline stem cell niche.

26 ioning of the centrosome with respect to the stem cell niche.

27 ifferentiate, and by their localization to a stem cell niche.

28 Vogt that constitute the corneal epithelial stem cell niche.

29 vely on Notch to restrict the ovary germline stem cell niche.

30 non-invasive tools with which to address the stem cell niche.

31 region essential for the specification of a stem cell niche.

32 r to regulate BMP signaling in the germ line stem cell niche.

33 rlin in controlling homeostasis of the liver stem cell niche.

34 instructs the suspensor to generate the root stem cell niche.

35 ddress fundamental questions about the adult stem cell niche.

36 Cs) that undergo neutral competition for the stem cell niche.

37 r suppressor by regulation of the intestinal stem cell niche.

38 the assembly and function of the SVZ neural stem cell niche.

39 e after excision of their tip, including the stem cell niche.

40 h1 activity improves myotube's function as a stem cell niche.

41 re known to contribute to the spermatogonial stem cell niche.

42 nd rhythmic modulation of the haematopoietic stem-cell niche.

43 Wnt and RSPO ligands in the intestinal crypt stem-cell niche.

44 reasing body of work has focused on defining stem cell niches.

45 ons during mouse corticogenesis and in adult stem cell niches.

46 s), known self-renewal regulators in various stem cell niches.

47 e in the identification of potential hepatic stem cell niches.

48 , transit-amplifying cells, and residents of stem cell niches.

49 onditions that emulate characteristics of 3D stem cell niches.

50 ronans, type III collagen, laminin) found in stem cell niches.

51 component of all organs that contributes to stem cell niches.

52 mulation, is a theme that is unique to plant stem cell niches.

53 cycling and point to a complex crosstalk in stem cell niches.

54 ly mimic the physiological complexity of the stem cell niches.

55 normal human skin at or near the established stem cell niches.

56 eration that may be conserved in other adult stem cell niches.

57 derstanding of the cellular diversity within stem cell niches.

58 actors that are considered key regulators in stem cell niches.

59 role during the establishment of vertebrate stem cell niches.

60 the HAM family is essential for all of these stem cell niches.

61 d to reproduce structures found within adult stem cell niches.

62 ly with WUS in the control of shoot and root stem cell niches.

63 deconstructing similar hierarchies in other stem cell niches.

64 nd how mesenchymal cells contribute to other stem cell niches.

65 studies of wound healing, angiogenesis, and stem-cell niches.

66 cal meristems (SAMs) of higher plants harbor stem-cell niches.

67 crucial role for this pathway in the testis stem cell niche, a true physiological function of NOTCH

68 C3-expressing subset demonstrates functional stem cell niche activity by maintaining primitive hemato

69 by somatic cells immediately outside of the stem cell niche acts locally to promote somatic differen

70 of stem cell function, and it is clear that stem cell-niche adhesion is crucial for stem cell self-r

71 dentities and stereotypical structure of the stem cell niche after irradiation, but these cells fail

72 context to study the spatial aspects of the stem cell niche and cell lineages by organizing into lay

73 duction of DE-cadherin level, GSCs leave the stem cell niche and differentiate.

74 P2-lineage progenitors reside in the adipose stem cell niche and express adipocyte progenitor markers

75 Induction by Wnt9b directs cells to exit the stem cell niche and express Wnt4, which is both necessar

76 ant role in regulating the normal colorectal stem cell niche and facilitating tumor progression.

77 acrophages are fundamental components of the stem cell niche and function coordinately to regulate ha

78 R-activated transcription factor BZR1 in the stem cell niche and high BZR1 levels in the transition-e

79 ught-after critical component of the nephron stem cell niche and hold promise for long-term culture a

80 results support a model in which leaving the stem cell niche and initiating differentiation are activ

81 required for proper regulation of the testis stem cell niche and is a potential feedback mechanism, b

82 ed cell death is limited to the meristematic stem cell niche and its early descendants.

83 tiating cells in organ primordia back to the stem cell niche and that appears to function broadly in

84 The stromal cells that comprise the stem cell niche and the signals that they generate that

85 essary to establish the boundary between the stem cell niche and the transit-amplifying region.

86 molecular contribution of vascular cells to stem cell niches and other brain regions under different

87 ative changes in tissue-specific stem cells, stem cell niches and systemic cues that regulate stem ce

88 normal skin cells that reside in established stem cell niches and that might relate to Merkel cell an

89 rogeneity of the stromal cells that comprise stem cell niches and the complexity of the signals that

90 Wrp is highly expressed in the ventricular stem cell niche, and it is a gene required for cytoskele

91 ng different cell types within an endogenous stem cell niche, and shed light on the biological functi

92 orm the critical component of a hypothalamic stem cell niche, and that local fibroblast growth factor

93 These cells form the perivascular gastric stem cell niche, and Wnt5a produced from ILCs activates

94 locations and contributions of the different stem cell niches, and mapping regulatory pathways of epi

95 The inner workings of the intestinal crypt stem cell niche are now well understood.

96 stem cells divide asymmetrically then colon stem cell niches are maintained by more than 8 stem cell

97 Unveiling the mechanisms of how stem cell niches are modulated provides clues for regene

98 Although adult stem cell niches are organized by specialized supporting

99 Stem cell niches are special microenvironments that main

100 The extrahepatic stem cell niches are the peribiliary glands deep within

101 Many stem cell niches are well defined anatomically, thereby

102 The cells of the stem-cell niche are organized into spatial domains of di

103 These results support the role of stem-cell niches as a key component for the spreading of

104 erferes with symplastic communication in the stem cell niche, as demonstrated by impaired SHORT-ROOT

105 generation, and perturbed homeostasis of the stem cell niche, as indicated by an increase in SC self-

106 The stem cell niche at the base of the intestinal crypts, as

107 yst stem cells (CySCs) cohabiting a discrete stem cell niche at the testis apex.

108 e leaves and conspicuously excluded from the stem cell niche at the tip of the shoot apical meristem

109 e rounds of regeneration, the Tbx1-deficient stem cell niche becomes progressively depleted.

110 cells (McSCs) in the hair follicle exit the stem cell niche before their initial cell division, pote

111 st synaptic regulator with an implication in stem cell niche biology.

112 Wnt signaling is a crucial regulator of the stem cell niche, but the mechanism that governs Wnt liga

113 s an important component of the adult neural stem cell niche, but whether vascular cells in neurogeni

114 h cells are nonessential constituents of the stem-cell niche, but recently their absence was reported

115 iescent stem cell state in the hair follicle stem cell niche by controlling Fgf18 expression.

116 te Wnt signaling from the perspective of the stem cell niche by expressing the pan Wnt inhibitor, Wnt

117 ined the effect of disrupting the intestinal stem cell niche by inducible deletion of the transcripti

118 matic support cells called the hub creates a stem cell niche by locally activating the Janus Kinase-S

119 We find that dysregulation of the stem cell niche by overexpression of an individual compo

120 These data suggest that defects of the stem cell niche can cause MVID.

121 132H) mutation in the major adult neurogenic stem cell niche causes a phenotype resembling gliomagene

122 e endogenous role for MSCs is maintenance of stem cell niches (classically the hematopoietic), and as

123 e a critical role for vesicle trafficking in stem cell niche competition and differentiation, and we

124 T cells (Tregs) are emerging as an essential stem cell niche component that promotes wound repair in

125 The shoot stem cell niche, contained within the shoot apical meris

126 at the molecular mechanisms involved in root stem-cell niche development in Arabidopsis thaliana are

127 e need to be able to probe the hematopoietic stem cell niche directly.

128 cating that Shp2/MAPK signaling might affect stem cell niches directly or via paneth cells.

129 the exception of neurons born from postnatal stem cell niches, do not express detectable paternal Ube

130 tion, the space of Disse may also serve as a stem cell niche during fetal hematopoiesis and constitut

131 These insights into the regulatory stem cell niche during homeostasis and post-injury regen

132 that promote differentiation or disturb the stem cell niche effectively reduced tumor invasiveness a

133 Mutations in the stem cell niche-expressed ASH1-RELATED3 (ASHR3) gene, en

134 most potent natural antiangiogenic factor, a stem cell niche factor, and an inhibitor of cancer cell

135 te to the identification of potential limbal stem cell niche factors that are promising targets for r

136 ntify secreted phospholipases A2 (sPLA2s) as stem cell niche factors with context-dependent functions

137 Thus, peripheral nerves serve as a stem cell niche for neuroendocrine system development.

138 The cells that compose the epithelial stem cell niche for skin homeostasis and regeneration ar

139 of hematopoietic stem cells, the role of the stem cell niche for stem cell aging as well as novel and

140 Identification of a stem cell niche for the OSE may have important implicati

141 We have therefore identified PSMCs as a stem cell niche for the variant Clara cells in the lung

142 In contrast, stem cell niche formation along a free-moving basal lami

143 ulating embryonic DG neurogenesis, DG neural stem cell niche formation, and maintenance.

144 When the stem cell niche forms along a rigid basal lamina, relati

145 on of a closed apical hook that protects the stem cell niche from damage [2, 3].

146 the integration of EGF signaling to regulate stem cell niche function.

147 rimary roots as well as auxin-responsive and stem cell niche gene expression in these mutants.

148 imary roots, as well as auxin-responsive and stem cell niche gene expression.

149 STATEMENT The subventricular zone neurogenic stem cell niche generates highly migratory neuroblasts t

150 lthood, the rodent subventricular zone (SVZ) stem cell niche generates new olfactory bulb interneuron

151 The stem cell niche generates signals that regulate HSC self

152 the contribution of pericytes to the neural stem cell niche has not been defined.

153 study on the Drosophila testicular germline stem cell niche has revealed that BMP signaling is local

154 While approaches to recapitulate the stem cell niche have been explored for directing stem ce

155 Recent studies of the hair follicle stem cell niche have shown that this can be achieved by

156 e in maintaining and replenishing endogenous stem cell niches have rendered them one of the most heav

157 the hematopoietic system, the ANS regulates stem cell niche homeostasis and regeneration and fine-tu

158 ng auxin distribution patterns necessary for stem cell niche homeostasis.

159 invading cells, with later development of a stem cell niche in adenocarcinomas of all stages.

160 ssociated with a decline of the affected SVZ-stem cell niche in aged mice.

161 g cells that are functionally analogous to a stem cell niche in animals.

162 The male germline stem cell niche in Drosophila houses two stem cell popul

163 uss the multiple components representing the stem cell niche in hematopoiesis and argue for a unbiase

164 alignant transformation of the hematopoietic stem cell niche in hematopoietic malignancies.

165 acrine Wnt signaling and restricts the crypt stem cell niche in intestines of mice.

166 ystem plays a central role in regulating the stem cell niche in many organs, and thereby pivotally mo

167 specific reporters in the neocortical neural stem cell niche in organotypic brain slices from embryon

168 feedback from organ primordia to control the stem cell niche in plants have also been hypothesized, b

169 Progressive activation of the mouse hepatic stem cell niche in response to ALIOS correlated with ste

170 Here we demonstrate that the aged stem cell niche in skeletal muscle contains substantiall

171 ng failure of maintaining the spermatogonial stem cell niche in somatic cells.

172 cline of the proliferative capacities of the stem cell niche in the affected subventricular zone (SVZ

173 ial cells are key cellular components of the stem cell niche in the bone marrow.

174 Blood vessels are part of the stem cell niche in the developing cerebral cortex, but t

175 ration through modulation of the mesenchymal stem cell niche in the Drosophila midgut.

176 e to AEC2s and may therefore contribute to a stem cell niche in the murine lung.

177 Establishment of a neural stem cell niche in the postnatal subependymal zone (SEZ)

178 as an important component of the epithelial stem cell niche in the rodent lung.

179 of cell division and differentiation in the stem cell niche in the root apical meristem.

180 ty delineated a potential macroscopic neural stem cell niche in the rostral end of the 3rd ventricle.

181 rgan primordia and organ boundaries from the stem cell niche in the shoot apical meristem (SAM) deter

182 ing, which defines the physical space of the stem cell niche in vivo.

183 In addition, Bmp signals characterize adult stem cell niches in other tissues where Hopx-mediated in

184 the controlled manipulation of hematopoietic stem cell niches in physiology and pathology.

185 We highlight emerging data that stem cell niches in the bone marrow are not static but i

186 In Arabidopsis, the stem cell niches in the shoot and root meristems are pro

187 ormation may be explained by the presence of stem cell niches in those areas.

188 N-521 and E-cadherin, which both localize to stem cell niches in vivo.

189 Stem-cell niches in mammalian tissues are often heteroge

190 indings, we propose that several other adult stem cell niches, including those in the blood, intestin

191 ial stratification are used to study how the stem cell niche influences epithelial morphologies.

192 Stem cell niche interactions have been studied extensive

193 have been used to identify and characterize stem cell-niche interactions and uncover new niche compo

194 effect recovery according to the dynamics of stem cell-niche interactions.

195 llular components to directly model and test stem cell-niche interactions.

196 that this can be achieved by organizing the stem cell niche into two compartments: one that engages

197 The stem cell niche is a complex local signaling microenviro

198 The muscle stem cell niche is central for regulating the activation

199 ogical conditions of the muscle in which the stem cell niche is compromised.

200 dynamic feedback principle by which the SAM stem cell niche is patterned.

201 e crosslinks and biochemical ligands as a 3D stem cell niche is reported.

202 A largely ignored component of the V-SVZ stem cell niche is the lateral ventricle choroid plexus

203 The stem cell niche is thought to provide signals that suppo

204 concepts of stem cell plasticity and of the stem cell niche is warranted.

205 Conversely, the cervical loop (stem cell niche) is expanded in Dicer1 cKO.

206 n of TNC, an extracellular matrix protein of stem cell niches, is associated with the aggressiveness

207 ic method for simulating a metapopulation of stem cell niche lineages, that is, many sub-populations

208 ing and label-retaining, whereas a different stem cell niche located at the crypt base is occupied by

209 ly members underlie the formation of diverse stem cell niche locations, and the HAM family is essenti

210 Plant meristems, like animal stem cell niches, maintain a pool of multipotent, undiff

211 The stem cell niche maintains a balance among quiescence, pr

212 mones alters the position of new tissues and stem cell niche markers.

213 ation and sub-functionalisation to different stem cell niches might relate to the success of seed pla

214 gregated to cells in a tenascin-C expressing stem cell niche model better than library-AR modified ce

215 ese analyses to integrate the available root stem-cell niche molecular mechanisms data and postulate

216 We sought to determine if somatic stem-cell niches more broadly are immune-privileged site

217 In many tissues, the stem cell niche must coordinate behavior across multiple

218 er-associated fibroblasts, the hematopoietic stem cell niche, myeloid-derived suppressor cells, and t

219 Altogether, our findings indicate that a stem cell niche need not be defined by short-range signa

220 Within the gastrointestinal stem cell niche, nerves help to regulate both normal and

221 ivated STATs are causal to tumorigenesis and stem cell niche occupancy, our results have therapeutic

222 L1 is preferentially expressed in the limbal stem cell niche of adult human cornea, we assume that CH

223 The stem cell niche of the Arabidopsis (Arabidopsis thaliana

224 al) epithelium, as a previously unrecognized stem cell niche of the OSE.

225 The stem cell niche of the ovarian surface epithelium (OSE),

226 he role of JAK-STAT signaling in the various stem cell niches of the hair follicle.

227 rganize body axes, regulate growth, maintain stem cell niches, or signal inductively across germ laye

228 involving EphA4 signaling that functions in stem cell niche organization and ultimately neuroblast m

229 ar approaches could also be applied to other stem cell/niche pairs to advance the understanding of mi

230 Copenhagen in Denmark to participate in 'The Stem Cell Niche', part of the Copenhagen Bioscience Conf

231 ed the complex molecular networks underlying stem-cell niche patterning in the A. thaliana root in te

232 of cancer stem cells and other cells of the stem cell niche, perhaps providing strategies to define

233 Multiple stem cell niches persist in specific anatomical location

234 s-mitotic divisions under the control of the stem cell niche produce nuclei that, upon leaving the ni

235 Stem cell niches provide a regulatory microenvironment t

236 Stem cell niches provide resident stem cells with signal

237 Stem cell niches provide signals that promote stem cell

238 The stem cell niche provides a supportive microenvironment t

239 The intestinal stem cell niche provides cues that actively maintain gut

240 ch in turn regulates the architecture of the stem cell niche, redox homeostasis, and neurogenesis.

241 supporting Wolbachia's targeting of ovarian stem cell niches--referred to as "niche tropism"--as a p

242 Stem cell niche refers to the microenvironment where ste

243 ligand Delta-1 (DL1), a key component of the stem cell niche, regulates human hematopoietic lineage d

244 sts include participation in the peribiliary stem cell niche, regulation of cholangiocyte proliferati

245 nks underlying conserved WUS/WOX function in stem cell niches remain unknown.

246 roenvironment called niche but the nature of stem cell niche remains poorly defined in many systems.

247 roenvironment, or "niche." In this vein, the stem cell niche represents a significant, and largely un

248 tely or permanently; defining the intestinal stem-cell niche requires clarity with respect to the Pan

249 t of all multicellular organisms; in plants, stem cell niches reside in meristems.

250 nt center (QC), and, together, they form the stem cell niche (SCN).

251 Organ formation in plants is dependent on stem cell niches (SCNs), which are located in the so-cal

252 response to stress induced by depletion of a stem cell niche signal.

253 It is unclear if stem cell niche signals coordinate fate decisions within

254 fferences in cortical cell layer patterning, stem cell niche structure, and radial cell division.

255 ion of soluble mesenchymal regulators of the stem cell niche such as Chordin.

256 unchecked, the expression of the GRFs in the stem cell niche suppresses formative cell divisions and

257 Here we identify a neural crest stem cell niche that centers around the dorsal midline w

258 ents identify an age-dependent change in the stem cell niche that directly influences stem cell quies

259 shoot apical meristem (SAM), containing the stem cell niche that gives rise to the above-ground tiss

260 promote the survival of constituents of the stem cell niche that initiate recovery.

261 1-MMP/integrin/YAP/TAZ axis operative in the stem cell niche that oversees SSC fate determination.

262 d destruction of the mitotically compromised stem cell niche that triggers its regeneration, enabling

263 Shoot apical meristems are stem cell niches that balance proliferation with the inc

264 However, the nature of the genetic regime in stem cell niches that centre on WOX gene function has be

265 by neural stem cells that are maintained by stem cell niches that preserve elements of the embryonic

266 ction model when delivered in their original stem cell niche-that is, by transplantation of the human

267 In addition to the stem cell niche, the meeting focused on a number of cutt

268 Here we demonstrate that the aged muscle stem cell niche, the muscle fibre, expresses Fgf2 under

269 Plant stem cell niches, the meristems, require long-distance t

270 In stem cell niches, the spatial extent of growth factor si

271 tic regulators for self-renewal in a dynamic stem cell niche: the developing vertebrate retina.

272 lls sustain oncogenic mutations while in the stem cell niche, they may have to leave that stem cell n

273 recreate important interactions in the liver stem cell niche, those between adult hepatocytes and liv

274 tions, and is thought to establish the shoot stem cell niche through a feedback circuit involving the

275 ncreasing stem cell engraftment by mimicking stem cell niches through ECM application.

276 Maturation of the stem cell niche thus appears to be associated with loss

277 hypoxia as a key external cue to protect the stem cell niche, thus ensuring successful rapid establis

278 stem cell niche, they may have to leave that stem cell niche to become tumor cells.

279 further show that response of the urothelial stem cell niche to infection, normally activated to rest

280 Thus, the evolution of stem cell niche topology allows complex pigment patterni

281 gestions of a contribution of Wolbachia from stem-cell niches toward vertical transmission.

282 e hair follicle and epidermis, indicated the stem cell niche was not maintained.

283 The existence of a 'stem cell niche' was first postulated by Schofield in 19

284 l-retaining cells and has been proposed as a stem cell niche, we examined the proliferative behavior

285 ical consequences of BAX/BAK deficiency in a stem cell niche, we generated Bak(-/-) mice with conditi

286 m cell system, the Drosophila spermatogonial stem cell niche, we reveal daily rhythms in division fre

287 gonadal distal tip cell (DTC), the germline stem cell niche, where it negatively regulates a DAF-3 S

288 This is especially relevant for stem cell niches, where neighbouring cells provide instr

289 , the Drosophila homolog of IGFBP7, into the stem cell niche, which blocks InR activation in CySCs.

290 the function of CD166 in stem cells and the stem cell niche, which might have implications for norma

291 are increasingly recognized as components of stem cell niches, which are best defined in the blood.

292 The Shp2 mutation also expanded Lgr5+ stem cell niches, which could be restricted by activated

293 nic animals exhibit a depleted hair follicle stem-cell niche, which further contributes to the overal

294 fills morphological criteria of a protective stem cell niche, with clump-forming cells constituting t

295 e labial incisor cervical loop or epithelial stem cell niche, with decreased expression in the differ

296 ials have been developed to recapitulate the stem cell niche within a tissue and to instruct MSC towa

297 In mammals, the stem cell niche within hair follicles is home to epithel

298 mation can differentially influence distinct stem cell niches within a tissue.

299 uniquely affects the formation of the larval stem cell niches, without altering other midgut cell typ

300 f the surrounding stem cells within the root stem cell niche, yet specific molecular players sustaini