ライフサイエンスコーパス: stem cell self-renewal

1 n of cell cycle, senescence, DNA damage, and stem cell self-renewal.

2 e G1-S transition to promote rapid embryonic stem cell self-renewal.

3 n increased cell proliferation and decreased stem cell self-renewal.

4 lators in many cellular processes, including stem cell self-renewal.

5 d identify miR-99 as a critical regulator of stem cell self-renewal.

6 central mechanism of organ size control and stem cell self-renewal.

7 fy peptide surfaces that sustain pluripotent stem cell self-renewal.

8 roliferation, differentiation, and embryonic stem cell self-renewal.

9 e functions, including organ development and stem cell self-renewal.

10 niche cells to control germ line and somatic stem cell self-renewal.

11 enitor cells, may also be crucial for cancer stem cell self-renewal.

12 rated by Wnt signaling are proliferation and stem cell self-renewal.

13 critical for the regulation of hematopoietic stem cell self-renewal.

14 gulation previously shown to be critical for stem cell self-renewal.

15 e receptors that are essential for embryonic stem cell self-renewal.

16 ly re-isolated, providing evidence of muscle stem cell self-renewal.

17 at such regulation is required for germ line stem cell self-renewal.

18 e required for maintaining cell identity and stem cell self-renewal.

19 epigenetic cellular memory, pluripotency and stem cell self-renewal.

20 gesting that mago nashi is not necessary for stem cell self-renewal.

21 ignaling pathway that has been implicated in stem cell self-renewal.

22 nical Wnt signaling pathway, which regulates stem cell self-renewal.

23 -chromosome inactivation, tumorigenesis, and stem cell self-renewal.

24 f-renew, and are a model system for studying stem cell self-renewal.

25 light on the molecular mechanisms underlying stem cell self-renewal.

26 he testis and is required for spermatogonial stem cell self-renewal.

27 tic mechanisms that govern tissue repair and stem cell self-renewal.

28 l mouse mutant luxoid affects adult germline stem cell self-renewal.

29 ing genes in stem cells in order to maintain stem cell self-renewal.

30 nt signaling to ensure a balanced control of stem cell self-renewal.

31 testis act as a cellular niche that supports stem cell self-renewal.

32 pate in basic stem cell functions, including stem cell self-renewal.

33 K-STAT pathway, thereby defining a niche for stem cell self-renewal.

34 Notch signaling in regulating hematopoietic stem cell self-renewal.

35 determines the efficiency of mouse embryonic stem cell self-renewal.

36 of genes involved in fetal hematopoiesis and stem cell self-renewal.

37 d a key transcription factor for pluripotent stem cell self-renewal.

38 ant for normal mammary gland development and stem cell self-renewal.

39 ent creates an essential "niche" to maintain stem cell self-renewal.

40 p to further dissect the networks underlying stem cell self-renewal.

41 gulates organ size, tissue regeneration, and stem cell self-renewal.

42 bitors, suggesting an autocrine mechanism of stem cell self-renewal.

43 atin-modifier proteins that is essential for stem cell self-renewal.

44 ay to identify regulators of human embryonic stem-cell self-renewal.

45 roduction of oocytes by maintaining germline stem cells self-renewal.

46 cytosine (5-hmC) and increased hematopoietic stem cell self-renewal accompanied by defective differen

47 ic deregulations, and impairs haematopoietic stem-cell self-renewal activity and regenerative potenti

48 t signaling pathways that regulate mammalian stem cell self-renewal, adhesion, and migration.

49 s abnormalities including a severe defect in stem cell self-renewal, alterations in thymocyte maturat

50 olecular mechanisms governing spermatogonial stem cell self renewal and hierarchical differentiation.

51 nscription factors such as Oct4 that control stem cell self renewal and multipotency.

52 a new avenue for investigating mechanisms of stem cell self-renewal and achieving clinically signific

53 Conversely, Yap overexpression increases stem cell self-renewal and blocks terminal differentiati

54 ological processes associated with embryonic stem cell self-renewal and cell fate determination.

55 nanog, and sox-2, which are associated with stem cell self-renewal and developmental potential.

56 Stem cell self-renewal and differentiation along neurona

57 the transcriptional changes associated with stem cell self-renewal and differentiation and followed

58 r stem cells in functional assays for cancer stem cell self-renewal and differentiation and form uniq

59 ors, are known to influence murine embryonic stem cell self-renewal and differentiation behavioral re

60 in the cell and molecular biology of neural stem cell self-renewal and differentiation between inver

61 The search for genes that regulate stem cell self-renewal and differentiation has been hind

62 Although the principles that balance stem cell self-renewal and differentiation in normal tis

63 ory networks that control the switch between stem cell self-renewal and differentiation in the germli

64 The signals that regulate stem cell self-renewal and differentiation in the lung r

65 The balance between stem cell self-renewal and differentiation is controlled

66 Neural stem cell self-renewal and differentiation is orchestrat

67 isms that ensure the correct balance between stem cell self-renewal and differentiation is poorly und

68 However, the mechanism that regulates Leydig stem cell self-renewal and differentiation is unknown.

69 ional role of matrix mechanics in regulating stem cell self-renewal and differentiation processes.

70 Although biochemical signals that modulate stem cell self-renewal and differentiation were extensiv

71 ll understanding of the networks controlling stem cell self-renewal and differentiation, however, has

72 tissue development and homeostasis depend on stem cell self-renewal and differentiation, the mechanis

73 the mechanisms underlying human pluripotent stem cell self-renewal and differentiation.

74 gene expression, cell cycle progression, and stem cell self-renewal and differentiation.

75 stem cells are vital for proper control over stem cell self-renewal and differentiation.

76 naling pathway is a key player in regulating stem cell self-renewal and differentiation.

77 ree toward understanding the coordination of stem cell self-renewal and differentiation.

78 nce of translational repression in balancing stem cell self-renewal and differentiation.

79 ays an important role in mammalian germ line stem cell self-renewal and differentiation.

80 plays an essential role in regulating adult stem cell self-renewal and differentiation.

81 actor Prospero, regulates the choice between stem cell self-renewal and differentiation.

82 s, including spermatogenesis, metabolism and stem cell self-renewal and differentiation.

83 ttractive system to study how niches control stem cell self-renewal and differentiation.

84 largely unknown how DNA damage affects both stem cell self-renewal and differentiation.

85 g of molecular controls of the hematopoietic stem cell self-renewal and differentiation.

86 le is known about Mediator function in adult stem cell self-renewal and differentiation.

87 the transcriptional regulation of epidermal stem cell self-renewal and differentiation.

88 genetics plays critical roles in controlling stem cell self-renewal and differentiation.

89 ate normal developmental processes including stem cell self-renewal and differentiation.

90 echanism for controlling the balance between stem cell self-renewal and differentiation.

91 k factors that influence the balance between stem cell self-renewal and differentiation.

92 ral stem cells (neuroblasts) are a model for stem cell self-renewal and differentiation; they divide

93 However, Tspan3 deletion impaired leukemia stem cell self-renewal and disease propagation and marke

94 OXB4 has been shown to enhance hematopoietic stem cell self-renewal and expansion ex vivo and in vivo

95 regulator of essential mechanisms governing stem cell self-renewal and fate decisions through transc

96 tral role in controlling the balance between stem cell self-renewal and fate determination by regulat

97 entire process of neurogenesis, from neural stem cell self-renewal and fate determination to neurona

98 lium provides a unique model to study neural stem cell self-renewal and fate determination.

99 s are implicated in regulating pluripotency, stem cell self-renewal and fate specification.

100 g hematopoietic stem cell (HSC) and leukemic stem cell self-renewal and functions in the context of t

101 Bmi1 is implicated in the control of stem cell self-renewal and has been shown to regulate ce

102 l during development that may participate in stem cell self-renewal and hematopoietic differentiation

103 Nanog facilitates embryonic stem cell self-renewal and induced pluripotent stem cell

104 Balancing stem cell self-renewal and initiation of lineage specifi

105 that stem cell-niche adhesion is crucial for stem cell self-renewal and is dynamically regulated.

106 Wnt/beta-catenin can promote stem cell self-renewal and is dysregulated in colon carc

107 respectively, elucidates new key players in stem cell self-renewal and leukemic transformation.

108 At the heart of stem cell self-renewal and lineage commitment decisions

109 key known transcription factors which govern stem cell self-renewal and lineage commitment decisions.

110 Both stem cell self-renewal and lineage differentiation are c

111 e an attractive model in which to study both stem cell self-renewal and lineage differentiation at th

112 the DNA damage-mediated disruption of adult stem cell self-renewal and lineage differentiation, and

113 However, regulation of stem cell self-renewal and maintenance of its potentiali

114 ely 10-15 somatic cells that is required for stem cell self-renewal and maintenance.

115 iation 4 (ID4) is a key regulator of mammary stem cell self-renewal and marks a subset of BLBC with a

116 urther dissecting the signalling pathways of stem cell self-renewal and may help develop more effecti

117 relevant to the regulation of hematopoietic stem cell self-renewal and megakaryocytopoiesis in the b

118 tion coordinately to regulate haematopoietic stem cell self-renewal and mobilization.

119 onserved pathway that promotes hematopoietic stem cell self-renewal and multipotency by limiting stem

120 ling has been found to be a key regulator of stem cell self-renewal and myogenesis in normal skeletal

121 show here that Wnt7a is essential for neural stem cell self-renewal and neural progenitor cell cycle

122 recent advances in the regulation of neural stem cell self-renewal and neurogenesis by microRNAs.

123 ox 2 (Sox2), a well established regulator of stem cell self-renewal and neurogenesis.

124 y postnatal lethality with defects in neural stem cell self-renewal and neuronal/glial cell fate spec

125 amily of RNA binding proteins act to promote stem cell self-renewal and oppose cell differentiation p

126 c transcription factors play a major role in stem cell self-renewal and pluripotency, their integrati

127 enetics of ECs will reveal genes involved in stem cell self-renewal and pluripotency.

128 adult stem cells and progenitors by altering stem cell self-renewal and proliferation.

129 urine development and its role in regulating stem cell self-renewal and proliferation.

130 m low to moderate ROS levels is required for stem cell self-renewal and proliferation.

131 We conclude that Brat suppresses neuroblast stem cell self-renewal and promotes neuronal differentia

132 sashi-2 (Msi2) RNA-binding protein maintains stem cell self-renewal and promotes oncogenesis by enhan

133 as a major regulatory pathway in controlling stem cell self-renewal and quiescence.

134 feration, migration, invasion, angiogenesis, stem cell self-renewal and regulation of other tumor sup

135 r Arf from Bmi-1(-/-) mice partially rescued stem cell self-renewal and stem cell frequency in the CN

136 neuroblasts are a model system for studying stem cell self-renewal and the establishment of cortical

137 ower in unearthing new molecules that govern stem cell self-renewal and tissue-regenerative potential

138 hways therefore confer temporal changes upon stem cell self-renewal and tumor suppressor mechanisms.

139 t polycomb repressive complexes also control stem cell self-renewal and tumorigenesis, but so far, no

140 ranscriptional regulation plays key roles in stem cell self-renewal and tumorigenesis.

141 of the Notch signaling pathway and mediates stem cell self-renewal and vascular development.

142 the tissue type, the Wnt pathway can promote stem cell self-renewal and/or direct lineage commitment.

143 mi-1 often overexpressed and participated in stem cells self-renewal and tumorigenesis initiating of

144 utionized our understanding of regeneration, stem cell self-renewal, and cancer; yet models for direc

145 ological processes, including embryogenesis, stem cell self-renewal, and postnatal survival.

146 role of miRs in reprogramming and embryonic stem cell self-renewal, and specifically addresses the r

147 that mTORC1 non-cell-autonomously regulates stem-cell self-renewal, and highlight a significant role

148 cal amount of Oct-3/4 is required to sustain stem-cell self-renewal, and up- or downregulation induce

149 C), but the signaling pathways that regulate stem cell self-renewal are largely unknown.

150 The mechanisms that control adult neural stem cell self-renewal are still largely unknown.

151 significant role in enhancing hematopoietic stem cell self-renewal as well as the production and dif

152 ed cells that inhibit stem-cell division and stem-cell self-renewal, as documented in the olfactory e

153 ient stem cells continued to show defects in stem cell self-renewal assays, suggesting a requirement

154 Asxl2 was required for normal haematopoietic stem cell self-renewal, Asxl2 loss promoted AML1-ETO leu

155 ystem is a good model to study mechanisms of stem cell self-renewal because of the well defined cultu

156 The network also controls embryonic stem cell self-renewal but is associated with distinct e

157 adaptor protein LNK suppresses hematopoietic stem cell self-renewal, but its presence and role in the

158 Kruppel-like factor 5 regulates pluripotent stem cell self-renewal, but its role in somatic stem cel

159 Hmga2 thus promotes fetal and young-adult stem cell self-renewal by decreasing p16(Ink4a)/p19(Arf)

160 find that linc-RoR maintains human embryonic stem cell self-renewal by functioning as a sponge to tra

161 roles in cellular proliferation and regulate stem cell self-renewal by maintaining expression of key

162 Thus, although it promotes stem cell self-renewal by repressing a bam-dependent pro

163 Stem cell self-renewal can be specified by local signals

164 cription factor is an important regulator of stem cell self-renewal, cancer cell survival, and inflam

165 e immunity, the regulation of autophagy, and stem cell self-renewal capacity, where evidence suggests

166 lator in embryonic development that controls stem cell self-renewal, chromatin organization, and the

167 Stem cell self-renewal depends on their ability to divid

168 cell autonomous changes, including increased stem cell self-renewal, differential capacity to generat

169 d on the role of Activin/Nodal signalling in stem cell self-renewal, differentiation and proliferatio

170 hese findings connect sexual identity to the stem cell self-renewal/differentiation decision and high

171 Precise regulation of stem cell self-renewal/differentiation is essential for

172 nes without any drug selection, but enforced stem cell self-renewal divisions can have adverse conseq

173 eins are essential for germline development, stem cell self-renewal, epigenetic regulation, and trans

174 n/ERalpha signalling promotes haematopoietic stem-cell self-renewal, expanding splenic haematopoietic

175 Comparison of GSC regulators with neural stem cell self-renewal factors identifies common and cel

176 Despite expressing stem cell self-renewal factors, intermediate progenitor

177 Ps by attenuating their genomic responses to stem cell self-renewal factors.

178 ll lineages that depend on a balance between stem cell self-renewal for continuity and the formation

179 Thus, Bmi-1 dependence distinguishes stem cell self-renewal from restricted progenitor prolif

180 during evolution and play essential roles in stem cell self-renewal, gametogenesis, and RNA interfere

181 ith or without homeobox B4 (HOXB4), a potent stem cell self-renewal gene.

182 gnals that emanate from the niche to specify stem cell self-renewal have been identified.

183 Its specific role in mouse epiblast stem cell self-renewal, however, remains poorly understo

184 Retinoic acid (RA) has been linked to stem cell self-renewal in adults and also participates i

185 irst class of genes known to be required for stem cell self-renewal in diverse organisms.

186 also be involved in the regulation of adult stem cell self-renewal in mammals, including humans.

187 gene shown to be required in germ cells for stem cell self-renewal in mammals.

188 own or ROR overexpression leads to increased stem cell self-renewal in mammary stem cells.

189 a fragment of collagen VI alpha3, increased stem cell self-renewal in mammosphere assays and Wnt sig

190 orphan nuclear receptor TLX regulates neural stem cell self-renewal in the adult brain and functions

191 r Wnt signaling as an important regulator of stem cell self-renewal in the developing brain.

192 d DOM control germline stem cell and somatic stem cell self-renewal in the Drosophila ovary, respecti

193 eir effect on long-term, but not short-term, stem cell self-renewal in vitro.

194 l diversity during development and regulates stem-cell self-renewal in Drosophila and mammals.

195 g molecular mechanisms, like those governing stem-cell self-renewal in general, remain poorly underst

196 ryonal cells and suggest that OCT4 maintains stem cell self-renewal, in part, by recruiting PRC compl

197 gulates the expression of genes critical for stem cell self-renewal, including NOTCH1, and may be lin

198 Pbx1 is required to maintain stem cell self-renewal, including that of mesenchymal st

199 ue to decreased differentiation and enhanced stem cell self-renewal induced by Notch1.

200 nificantly inhibit VEGF secretion, decreased stem cell self-renewal, inhibited tumor growth, and incr

201 Nin regulates neural stem cell self-renewal, interkinetic nuclear migration,

202 The molecular mechanism underlying stem cell self-renewal is a fundamental question in stem

203 hat deregulation of pathways responsible for stem cell self-renewal is a likely requirement for carci

204 lization of small molecules in modulation of stem cell self-renewal is a promising approach to expand

205 Here we evaluated whether hematopoietic stem cell self-renewal is affected by the Notch pathway.

206 Stem cell self-renewal is controlled by concerted action

207 Stem cell self-renewal is controlled by concerted action

208 Because abnormal stem cell self-renewal is frequently observed during tum

209 Stem cell self-renewal is intrinsically associated with

210 Stem cell self-renewal is tightly controlled by the conc

211 erstanding how extrinsic signaling regulates stem cell self-renewal, little is known about how cell-a

212 e employment of gut epithelia as a niche for stem cell self-renewal may provide a mechanism for direc

213 The stem cell self-renewal mediated by SALL4 is linked to ep

214 These findings provide new insights into stem cell self-renewal mediated by SALL4 via epigenetic

215 ciated with (1) embryonic development and/or stem cell self renewal (MSX, MEIS, ID, Hes1, and SIX hom

216 The regulation of stem cell self-renewal must balance the regenerative nee

217 evelopment of exogenous molecules to control stem cell self-renewal or differentiation has arrived at

218 strate plays a key role in the regulation of stem cell self-renewal or differentiation.

219 Activation in transformed cells of normal stem cells' self-renewal pathways might contribute to th

220 cancers may develop through dysregulation of stem-cell self-renewal pathways.

221 induction of autophagy; augmentation of GBM stem cell self-renewal; possible implications of GBM-end

222 cell functions and are required to maintain stem cell self-renewal potential.

223 ocampal NSPCs can provide insight into basic stem cell self-renewal principles important for tissue h

224 evealed a loss of the hematopoietic/leukemic stem cell self-renewal program and an increase in the di

225 machinery can play a key role in regulating stem cell self-renewal, proliferation, differentiation a

226 Embryonic stem cell self-renewal properties are attributed to crit

227 d that by providing a humanized environment, stem cell self-renewal properties were better maintained

228 the role for post-transcriptional control in stem cell self-renewal, provide mechanistic insight on A

229 We found that the stem cell self-renewal regulator SOX2 is a novel target

230 The determinants of normal and leukemic stem cell self-renewal remain poorly characterized.

231 e that TLX, an essential regulator of neural stem cell self-renewal, represses the expression of miR-

232 The piwi family genes are crucial for stem cell self-renewal, RNA silencing, and translational

233 KDM2B (also known as FBXL10) controls stem cell self-renewal, somatic cell reprogramming and s

234 re a powerful model system for investigating stem cell self-renewal, specification of temporal identi

235 the genes have been implicated in vertebrate stem cell self-renewal, suggesting that this core set of

236 e recently described ability of p53 to limit stem cell self-renewal suppresses tumorigenesis in acute

237 lts elucidate a new role for beta-catenin in stem cell self-renewal that is independent of its transc

238 cation of conditions and factors involved in stem cell self-renewal, the foundation of spermatogenesi

239 en shown to be required for postnatal neural stem cell self-renewal, the role of trxG genes remains u

240 ays a critical role in tooth development and stem cell self-renewal through beta-catenin.

241 Here we show that GV represses melanoma stem cell self-renewal through inhibition of SOX2.

242 maintaining stem cell identity and governing stem cell self-renewal through transcriptional repressio

243 promoter in response to signals stimulating stem cell self-renewal, through activation of the mitoge

244 tem cell function and their consequences for stem cell self-renewal, tissue homeostasis, and regenera

245 However, the progression from stem cell self-renewal to overt signs of early different

246 s define a blueprint for the transition from stem cell self-renewal to terminal differentiation.

247 enriched in the prostate, promoting prostate stem cell self-renewal upon proteolytic activation via a

248 Niches regulate lineage-specific stem cell self-renewal versus differentiation in vivo an

249 as a model to understand how the balance of stem cell self-renewal versus differentiation is achieve

250 Regulation of stem cell self-renewal versus differentiation is critica

251 Stem cell self-renewal versus differentiation is regulat

252 rocess may be favored by cytokines promoting stem cell self-renewal versus differentiation.

253 the different signaling pathways involved in stem cell self-renewal versus lineage-specific different

254 Expression of BMI1, a known regulator of stem cell self-renewal, was modulated by miR-200c.

255 Significantly for the maintenance of stem cell self-renewal, we detected a reduction in the e

256 nsight into mechanisms controlling embryonic stem cell self-renewal, we explore the molecular and cel

257 Asxl1 deletion reduces hematopoietic stem cell self-renewal, which is restored by concomitant

258 ed that Bmi1 promotes cell proliferation and stem cell self-renewal with a correlative decrease of p1

259 In the epidermis, a tissue that balances stem cell self-renewal with differentiation, H3K27me3, o

260 have a loss of maintenance of spermatogonial stem cell self-renewal without a block in normal spermat

261 (SEZ) leads to persistently enhanced neural stem cell self-renewal without sign of exhaustion.