ライフサイエンスコーパス: stemness

1 ll functions (which are collectively termed 'stemness').

2 ancreatic cancer by regulating ER stress and stemness.

3 lling in regulation of HSC proliferation and stemness.

4 h Miz1-dependent gene repression to maintain stemness.

5 arcinomas and is associated with cancer cell stemness.

6 ated with cancer progression and cancer cell stemness.

7 in somatic cells to maintain spermatogonial stemness.

8 hlight ABCG2 as a potential driver of glioma stemness.

9 through the induction of cell plasticity and stemness.

10 as a key molecule that controls cancer cell stemness.

11 h Oct4, Nanog, Klf4 and c-Myc to control ESC stemness.

12 ed for the maintenance of breast cancer cell stemness.

13 gulates PAF and decreases breast cancer cell stemness.

14 s PAF induces the loss of breast cancer cell stemness.

15 xpression of SUMO E1 or E2 increases CC cell stemness.

16 (~2.0 x 10(7) cells/ml) without the loss of stemness.

17 maturation and secretion as well as loss of stemness.

18 ong-term dormancy, treatment resistance, and stemness.

19 is and can also inhibit apoptosis and confer stemness.

20 ent to establish the functional hallmarks of stemness.

21 w carcinoma cells with enhanced motility and stemness.

22 cteristics such as invasion, metastasis, and stemness.

23 al for regulating niche size and maintaining stemness.

24 phenotype by regulating genes that establish stemness.

25 ithin tissue hierarchies and integrated with stemness.

26 of miR-205 markedly diminished breast cancer stemness.

27 covered that Qki is a major regulator of NSC stemness.

28 contribute to breast cancer progression and stemness.

29 F-II can induce Nanog expression and promote stemness.

30 atastrophe, multinucleation, and the loss of stemness.

31 cancer stem-cell marker and driver of cancer stemness.

32 cts human colorectal cancer invasiveness and stemness.

33 acquire mobility and traits associated with stemness.

34 f RS-hAFSCs to revert to an earlier state of stemness.

35 s and early-stage breast cancer invasion and stemness.

36 Inflammatory mediators may induce tumor cell stemness.

37 EMT and the acquisition of cell motility and stemness.

38 specific pathways driving CSC emergence and stemness.

39 presses PUMA in these cells, promoting tumor stemness.

40 our understanding of cellular plasticity and stemness.

41 oss-of-DUSP2-induced tumor growth and cancer stemness.

42 with, and necessary for, maintenance of NPC stemness.

43 epithelial-mesenchymal transition (EMT) and stemness acquisition in NE differentiated prostate cance

44 of electrophysiology-mediated regulation of stemness acquisition, proliferation, differentiation, an

45 hibits epithelial-mesenchymal plasticity and stemness activities in vitro and markedly reduces tumor

46 y organized and well characterized model for stemness analysis.

47 e in the expression of genes associated with stemness and an increase in the expression of genes asso

48 iptional signature associated with a loss of stemness and cell cycle deregulation.

49 a distinct profile of genes critical to BTIC stemness and cell cycle progression.

50 to loss of epithelial traits, an increase in stemness and cell plasticity, and the acquisition of mor

51 as a novel molecular circuit regulating the stemness and chemoresistance of hepatic Lgr5(+) CICs and

52 3A as a critical regulator of ovarian cancer stemness and cisplatin resistance by inducing the expres

53 , we determined whether KDM1A modulates GSCs stemness and differentiation and tested the utility of t

54 lays a fundamental role in the regulation of stemness and differentiation of somatic stem cells.

55 ed with genes for a specific task related to stemness and early differentiation.

56 al node in a molecular network that controls stemness and EMT in glioblastoma, suggesting S100A4 as a

57 r factor involved in the control of cellular stemness and epithelial-mesenchymal transition (EMT).

58 ting a coupled mechanism that enables cancer stemness and immune escape.

59 tment size at the expense of partial loss in stemness and incomplete differentiation and the activati

60 ctional level, and cells displayed decreased stemness and increased drug sensitivity.

61 knockdown of KDM1A using shRNA-reduced GSCs stemness and induced the differentiation.

62 In summary, by approximating both stemness and intra-tumour heterogeneity, signalling entr

63 that KCTD12 is a novel regulator of CRC cell stemness and may serve as a novel prognostic marker and

64 Present work indicates that stemness and metastasis are a two-way street: Sox2, a ma

65 es a long observed genomic alteration to PCa stemness and metastasis.

66 development and emphasize the importance of stemness and microRNA-mediated processes in the origins

67 reversible pulpitis (I-DPSCs), which possess stemness and multidifferentiation potentials similar to

68 signalling pathway in regulating cancer cell stemness and open a new therapeutic avenue to target ste

69 AEC) to investigate epigenetic mechanisms of stemness and pluripotency in lung cancers.

70 otypical inheritance is under the control of stemness and potentially provides a platform for asymmet

71 els in the IE1-positive tumors, upregulating stemness and proliferation markers in vivo.

72 ronment created by myofibroblasts impact the stemness and proliferation of normal ductal epithelial c

73 in addition to its known roles in promoting stemness and proliferation, PRC2 may inhibit immune surv

74 gastric cancer cells, which regulate cancer stemness and promote tumorigenesis.

75 atopoiesis by simultaneously preserving HSPC stemness and promoting MyePro proliferation.

76 ed CPCs have increased senescence, decreased stemness and reduced capacity to proliferate or to diffe

77 r regulator of epidermal biology, sustaining stemness and renewal capacity of the proliferating kerat

78 5 target gene BMI1 has been shown to promote stemness and self-renewal and to vary inversely with CDX

79 th thapsigargin caused a similar decrease in stemness and showed synergistic activity with gemcitabin

80 High levels of OTUD1 inhibit cancer stemness and shut off metastasis.

81 Our findings illuminate mechanisms of cancer stemness and suggest new cancer therapy regimens.

82 anner under conditions that promote GBM cell stemness and that miR-296-5p inhibits GBM cell stemness

83 educed the expression of genes that regulate stemness and the epithelial to mesenchymal transition an

84 is study is to compare the proliferation and stemness and the MSC-specific and mineralized tissue-spe

85 our results indicate that it is required for stemness and the preservation of neurogenic potential in

86 cription factor critical for maintaining the stemness and the self-renewal ability of CSCs, resulting

87 emness and that miR-296-5p inhibits GBM cell stemness and their capacity to self-renew as spheres and

88 by which MaSC and MaTIC EMT programs promote stemness and thereby support mammary tissue outgrowth an

89 We also observed a decrease in markers of stemness and traced the growth effects of MPC expression

90 the connecting mechanism between cancer cell stemness and tumor initiation.

91 table molecular circuit by which glioma cell stemness and tumor-propagating capacity are regulated.

92 2, and Pou5F1, resulting in increased cancer stemness and tumorigenic potential.

93 ignaling pathways in the development of EMT, stemness and ultimately tumor progression.

94 cancer cells (PGCCs) acquired embryonic-like stemness and were capable of tumor initiation raised two

95 ells that display stem-like characteristics (stemness) and play unique roles in tumor propagation, th

96 , including angiogenesis, proliferation, and stemness, and a minor subpopulation (19%) with many over

97 lthy mitochondria to maintain quiescence and stemness, and becomes increasingly necessary with age to

98 is central to tissue development, epithelial stemness, and cancer metastasis.

99 mia that combine the phenotypes of dormancy, stemness, and chemo-resistance.

100 in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition, is up-r

101 epithelial-mesenchymal transition, invasion, stemness, and growth of cancer cells.

102 n DNA replication, cell cycle, biosynthesis, stemness, and invasiveness.

103 ling is essential for tissue development and stemness, and its deregulation has been observed in many

104 regulating inflammation, cell proliferation, stemness, and miR-122 loss.

105 and with increased signatures of EMT, cancer stemness, and poor prognosis.

106 cell biology features including morphology, stemness, and proliferative behavior.

107 SOX2, a master transcriptional regulator of stemness, and recruits it to the promoter of Hedgehog (H

108 r cells has been associated with metastasis, stemness, and resistance to therapy.

109 nt anti-proliferative effects, inhibition of stemness, and suppression of FGFR/RTK signaling in ErbB2

110 AFs constitute a supporting niche for cancer stemness, and targeting this paracrine signalling may pr

111 nswered questions: how do PGCCs acquire such stemness, and to which stage of normal development do PG

112 elated to epithelial-mesenchymal transition, stemness, and Wnt signaling.

113 mant state by inducing senescence, reducing "stemness," and activating dormancy-associated p38 MAPK s

114 ectly drive tumor growth by promoting cancer stemness, angiogenesis, stroma deposition, epithelial-to

115 ile those for cell cycle, proliferation, and stemness are significantly up-regulated.

116 reveal adaptive aspects of pancreatic cancer stemness arising from driver populations of CSCs that mi

117 These data demonstrate targeting cancer stemness as a novel approach to develop the next generat

118 ociated with expression of genes controlling stemness as well as milk synthesis.

119 Notch signaling promotes the maintenance of "stemness" as well as the expansion of self-renewing HSCs

120 Stemness, as "self-renewal and multipotency," seems not

121 Itpkb(-/-) HSC downregulated quiescence and stemness associated, but upregulated activation, oxidati

122 Similarly, a stemness-associated gene set identified clones with dive

123 macroH2A1 increased expression of a panel of stemness-associated genes and drove hyperactivation of t

124 ed miR-424 regulates numerous EMT and cancer stemness-associated genes, including TGFBR3, whose downr

125 correlated positively with the expression of stemness-associated markers and regulators.

126 gnaling, which facilitates malignant hepatic stemness; because of its absence from normal human tissu

127 to apoptosis (c-KIT and Bcl2), and enhanced stemness (beta-catenin and Lef1).

128 I (EGFRvIII) has been associated with glioma stemness, but the direct molecular mechanism linking the

129 ritical stem cell determinant that maintains stemness by repressing differentiation-promoting factors

130 -mesenchymal transition, invasion and cancer stemness, by interacting with p53 to suppress p53-mediat

131 tes Sox2 expression, a master driver of cell stemness, by modifying chromatin architecture at the Sox

132 se-lacking organism, indicating that loss of stemness can be regarded as a conserved, telomerase-inde

133 in vivo engraftment rates and maintained the stemness characteristics of hMSC compared with hMSCs-alo

134 ly decreased gene expression associated with stemness, chemoresistance and epithelial-mesenchymal tra

135 ed KANSL2 levels, linking these two genes to stemness control in GBM cells.

136 We also discuss how TSCM cell stemness could be leveraged therapeutically to enhance t

137 ibitors modulate several pathways related to stemness, differentiation and apoptosis.

138 s a variety of cellular processes, including stemness, differentiation, and proliferation.

139 Expression of genes involved in stemness, differentiation, and the epithelial to mesench

140 er levels of key regulators of keratinocytes stemness, differentiation, and the viral life cycle, res

141 ng tool to provide or deliver cues to retain stemness, direct differentiation, promote reprogramming,

142 thereby preserving phenotypic properties of "stemness." Early cardiac aging with a decline in cardiac

143 hat the tailored scaffolding maintained hMSC stemness, engraftment, and led to robust motosensory imp

144 emonstrated increased expression in IL-6 and stemness factor Bmi1, but reduced level of metastasis-su

145 data provide evidence that DEPTOR is a novel stemness factor that promotes pluripotency and self-rene

146 dentified ZEB1 binding sites within the LIF (stemness factor) promoter region, and demonstrate LIF re

147 ght control of the expression of several key stemness factors, particularly Nanog and Oct4 transcript

148 ough Sox2-dependent transcription of EMT and stemness factors.

149 om early, low-density lesions displayed more stemness features, migrated more and founded more metast

150 ker highly expressed in a subset of HCC with stemness features.

151 differentiation defects and reacquisition of stemness features.

152 r cell dedifferentiation with acquisition of stemness features.

153 tly enhanced expression of genes controlling stemness features.

154 and cancer stemness properties, can inhibit stemness gene expression and block spherogenesis of or k

155 secretion, cytolytic capacity, expression of stemness gene signature, and decreased TGF-beta signalin

156 sition (EMT) markers and upregulation of the stemness gene SOX2 was linked to acquisition of stem cel

157 sorted cells exhibit a higher expression of stemness genes and self-renewal potential; and as few as

158 binds to and potentiates transactivation of stemness genes critical for leukemogenicity including Me

159 15 mediates the repression of cell cycle and stemness genes downstream of CDX1.

160 mote colon cancer stemness via regulation of stemness genes that negatively affects patient outcome.

161 depletion in metastatic cells downregulated stemness genes, attenuated sphere formation and reduced

162 Moreover, such stemness-high cancer cells are resistant to conventional

163 xpression and block spherogenesis of or kill stemness-high cancer cells isolated from a variety of ca

164 nt cancer cells, termed cancer stem cells or stemness-high cancer cells, that are highly tumorigenic

165 em cells must proliferate while maintaining 'stemness'; however, much remains to be learned about how

166 minin in the regulation of PDGFRbeta(+) cell stemness, identify an innovative target for future drug

167 as a previously unknown strategy to maintain stemness in 3D.

168 romote epithelial-mesenchymal transition and stemness in breast cancer cells-mechanisms critical to t

169 involving TAZ and LM511 that contributes to stemness in breast cancer.

170 or Sox2 is a master regulator that maintains stemness in embryonic stem cells and neural stem cells.

171 we report a role for KANSL2 in regulation of stemness in glioblastoma (GBM), which is characterized b

172 oxia mediated oncogenic signaling as well as stemness in pancreatic cancer.

173 enchymal transition, migration, invasion and stemness in pancreatic neuroendocrine tumour (panNET) an

174 regulates cell proliferation, apoptosis, and stemness in response to a wide range of extracellular an

175 elps glioma stem cells (GSCs) maintain their stemness in suboptimal environments outside their niches

176 degradability affect the maintenance of NPC stemness in the absence of differentiation factors.

177 temness, yet it is unclear how CSCs maintain stemness in the suboptimal environment outside their nic

178 y, decreased GIC sphere size, expansion, and stemness in vitro.

179 a enhances their survival, proliferation and stemness in vitro.

180 nabled us to identify putative regulators of stemness in vivo.

181 S preserves characteristics associated with "stemness" in CPCs and antagonizes myocardial senescence

182 reveal that interleukin-22 can also promote "stemness" in human colorectal cancer via transcription f

183 ntrols expression of NOTCH3, a key driver of stemness, in KRAS-mediated lung adenocarcinoma (LADC).

184 inhibitor orlistat significantly diminished stemness, in part due to induction of endoplasmic reticu

185 tracellular matrix formation, migration, and stemness, including TNC, PTPRZ1, FAM107A, HOPX, and LIFR

186 ited signatures of immune evasion, increased stemness, increased calcium signaling, transformation, a

187 ntial for tumor initiation, maintenance, and stemness independent of its EMT-inducing activity.

188 that the performance of cell stiffness as a stemness indicator is on par with the performance of Del

189 phosphorylated proteins in modulating cancer stemness induced by gemcitabine exposure based on PPIs m

190 to HIF2alpha destabilization, loss of glioma stemness, inhibition of tumour growth, and a more favour

191 neity and the limited efficacy of individual stemness inhibitors in cancer treatment.

192 ignancies, reveal that senescence-associated stemness is an unexpected, cell-autonomous feature that

193 In some but not all tissues, stemness is associated with quiescence.

194 Cancer cell stemness is dynamically influenced by epigenetic mechani

195 re pluripotent factor system to regulate ESC stemness is little known.

196 ng, an essential pathway for maintaining HCC stemness, is required for EpCAM(+) HCC spheroid formatio

197 stically, miR-128-3p induces mesenchymal and stemness-like properties through downregulating multiple

198 A disproportionate stemness load, caused by integrated transgenes, affects

199 stiffness from approximately 0.5 to 50 kPa, stemness maintenance did not correlate with initial hydr

200 ng proved to be a generalizable strategy for stemness maintenance in 3D.

201 and downregulates the expression of a cancer-stemness marker CD44 and other stemness markers, includi

202 ioma stemlike cells that EGR1 contributes to stemness marker expression and proliferation by orchestr

203 of the IGF1 receptor (IGF1R) responsible for stemness marker expression.

204 unterparts and expressed lower levels of the stemness marker LIN28.

205 Moreover, the expression of epithelial stemness marker SOX2 was altered in the palatal shelves

206 , the identified protein could constitute a "stemness marker" of the normal cell and a possible targe

207 ation of RISC and it correlates with loss of stemness markers and activation of early cell differenti

208 ncreased spheroid formation and the level of stemness markers and self-renewal capacity in human brea

209 issues for suitable implants using molecular stemness markers are confounded by the poorly understood

210 t target GLUL, pharmacological target FGFR4, stemness markers EPCAM and KRT19 and immune checkpoint P

211 t expression levels of KANSL2 correlate with stemness markers in GBM stem-like cell populations.

212 ishes the increase in expression of CRC cell stemness markers induced by the down-regulation of KCTD1

213 ls on a biophysical basis, the biomechanical stemness markers presented here may enable the rapid pur

214 -phase progression, diminished expression of stemness markers, and up-regulation of p53 and p16.

215 C), where they colocalize with the other GBM stemness markers, CD133, Nestin, and Sox2.

216 n of a cancer-stemness marker CD44 and other stemness markers, including Nanog, Oct-4, and c-Myc, in

217 Mechanistically, KCTD12 suppresses CRC cell stemness markers, such as CD44, CD133 and CD29, by inhib

218 In cancer cells, a gain of stemness may have profound implications for tumour aggre

219 ne expression profile, as an estimate of the stemness of a tumour sample.

220 ellular domain induced genes associated with stemness of cell columns, myc and VE-cadherin, in Notch1

221 hich are key guardians of the quiescence and stemness of CML LSCs.

222 ibition of expression of IRE1alpha decreased stemness of colon cancer stem cells (CSCs) and attenuate

223 ane induces cell differentiation and loss of stemness of CSCs leading to effective elimination of thi

224 ficient to inhibit the growth, survival, and stemness of GSCs and also sensitized them to temozolomid

225 IB suppresses EMT and stemness of HNSCC cells through inhibition of Twist1-med

226 a is sufficient to repress Hh signaling, the stemness of MaSCs, and the tumor-forming potential of Ma

227 7) is a pluripotent factor essential for the stemness of mouse ESCs.

228 cription factor, is required to maintain the stemness of nephron progenitor cells.

229 lead to the conclusion that IGF-II promotes stemness of NSCs via the IR-A and not through activation

230 important for maintaining the integrity and stemness of NSCs, which is critical for their ability to

231 Moreover, gemcitabine can promote the stemness of pancreatic cancer cells.

232 The embryonic-like stemness of PGCCs was associated with nuclear accumulati

233 ss specific characteristics able to maintain stemness of resident and exogenous stem cells.

234 are known to be critical for maintaining the stemness of stem cells through autocrine signaling.

235 is, epithelial-to-mesenchymal transition and stemness of the epithelial cancer cells in vivo.

236 ht a novel role for Sall1 in maintaining the stemness of the progenitor cell pool by restraining thei

237 ociated loci in ES cells, Esrrb sustains the stemness of TS cells by direct binding and regulation of

238 f chromatin remodeling, preservation of the "stemness" of the cell, and cell differentiation.

239 53(-/-) background helps NSCs maintain their stemness outside the SVZ in Nes-CreER(T2); Qk(L/L); Pten

240 ular zone (SVZ) niches but fails to maintain stemness outside the SVZ.

241 ed gene set identified clones with divergent stemness pathway activation within the same tumor.

242 temporal features of lineage-status but also stemness, plasticity in transitional states and differen

243 in MYC-pathway targets, thereby maintaining stemness programs and inhibiting expression of early lin

244 s to establish which receptor(s) mediate the stemness promoting actions of IGF-II on mouse subventric

245 Blocking such stemness-promoting pathways in conjunction with establis

246 anism that extrinsically confers cancer cell stemness properties and affects patient outcome.

247 ferent subtypes of late-stage cancer vary in stemness properties and whether or not these subtypes ar

248 d not upregulate CD73 expression but induced stemness properties drastically improved the antitumor e

249 echanistic insights into how HCMV/IE control stemness properties in GBM cells.

250 , the Lin28B-Let7 pathway not only regulated stemness properties in OSCC but also determined the effi

251 -specific demethylase 1 (LSD1) regulates the stemness properties of CICs.

252 ur study uncovers REST in regulating EMT and stemness properties of NE PCa cells and suggests that RE

253 ene transcription driven by Stat3 and cancer stemness properties, can inhibit stemness gene expressio

254 ria, and these are important for maintaining stemness properties.

255 the division properties of glioma cells with stemness properties.

256 subpopulations versus subpopulations without stemness properties.

257 ssive pathways and through the conferment of stemness properties.

258 have been shown to display "tumor-initiating/stemness" properties, including the expression of CIC-as

259 er show a link between proliferation and the stemness property of lens epithelial cells, controlled b

260 redict that targeting self-renewal, the key 'stemness' property unique to CICs, may represent a new p

261 Here, we report that the stemness regulator Sox2 is a new, clinically important t

262 is is critical for RAS-induced expression of stemness regulators and maintenance of a cancer initiati

263 atin landscape and activate transcription of stemness regulators.

264 nt miRNAs and also reveal a novel epigenetic stemness-regulatory mechanism in which a double-negative

265 We also observed a continuum of stemness-related expression states that enabled us to id

266 enchymal transition (EMT), the expression of stemness-related genes, cell migration and invasiveness.

267 alleled by decreased expression of c-Myc and stemness-related genes.

268 ded a PAM50-intrinsic subtype classifier and stemness-related genes.

269 t by reducing early apoptosis and preserving stemness-related properties of PDGFR-beta(+) MSCs, inclu

270 diminishes ALDH(+) subpopulations, decreases stemness-related transcriptional factor expression, and

271 er, the regulatory mechanisms of cancer cell stemness remain elusive.

272 gene-induced signaling pathways with EMT and stemness remain largely elusive.

273 the mechanism(s) connecting EMT programs to stemness remain unclear.

274 dramatically enhances and represses CRC cell stemness, respectively, as assessed in vitro and in vivo

275 gulation is hypothesized to account for the 'stemness' - self-renewal and pluripotency - shared betwe

276 epithelial cells and activate properties of stemness show the sophisticated relationship between H p

277 Functional regulators of stem cell (stemness) signaling pathways in human cancers have broug

278 ger HFSC aging, characterized by the loss of stemness signatures and by epidermal commitment.

279 er de-activation, and consequent loss of HSC stemness signatures.

280 enes belonging to hematopoietic and leukemic stemness signatures.

281 lts demonstrate novel methods and markers of stemness that facilitate physical isolation, study, and

282 asmic proteins to the periphery impacts cell stemness, the response to cytotoxicity, proliferation, c

283 wn to increase distant metastases and cancer stemness through activation of SDF-1/CXCR4 and AP-1 path

284 ndent inflammatory environment that imparted stemness to nonstem cancer cells, induced multidrug resi

285 ption factor and EMT-inducing gene, promotes stemness traits and chemoresistance in mammary epithelia

286 is a more potent mediator of Foxq1-promoted stemness traits than PDGFRalpha.

287 l transition that subsequently confer cancer stemness traits to susceptible cells.

288 thelial cells acquire migratory/invasive and stemness traits upon conversion to the mesenchymal pheno

289 r in vitro with respect to self-replication, stemness traits, and multipotency.

290 correlates with effects on expression of the stemness transcription factor POU5F1.

291 ling via a pathway involving p38MAPK and the stemness transcription factor Smad3, which promotes CML

292 downregulation, COX-2 overexpression, cancer stemness, tumor growth, and drug resistance.

293 glioma which when deleted leads to increased stemness, tumorigenicity and shortened patient survival.

294 evelopmental transitions in animals, such as stemness versus differentiation and juvenile versus adul

295 Thus, IL-22(+) cells promote colon cancer stemness via regulation of stemness genes that negativel

296 ived prostaglandin E2, which promoted cancer stemness via the EP2/EP4 signaling pathways.

297 y mechanisms responsible for integrating the stemness with drug resistance remain poorly understood.

298 ng cascades and markers implicated in cancer stemness with higher angiogenic potential and tumorigeni

299 en re-expansions, providing evidence of true stemness within the T cell memory compartment.

300 tem cells (CSCs), require niches to maintain stemness, yet it is unclear how CSCs maintain stemness i