ライフサイエンスコーパス: step

1 emistry (selective beta-hydrogen elimination step).

2 essitating a mediator of the third enzymatic step.

3 o test, c index, and clinical weight at each step.

4 l approach that clusters k-mers as the first step.

5 of the carboxyl proton to water in the same step.

6 one year from adjustment of their treatment step.

7 nformation obtained from a single analytical step.

8 at low pressure minimize losses in the FAIMS step.

9 ated C-H activation is the turnover-limiting step.

10 pecies and require an additional viral lysis step.

11 d long-RNAs, in a single library preparation step.

12 des the critical O-O bond reductive cleavage step.

13 h are required in the transitional pronation step.

14 lms can be tuned by the number of deposition steps.

15 rotocol by eliminating two PAGE purification steps.

16 ssembly with no chromatographic purification steps.

17 libration data through all data manipulation steps.

18 ut need for separate work-up or purification steps.

19 +/-)-vindeburnol from tryptamine in only two steps.

20 edure involves multiple washing and transfer steps.

21 elasticum, all showing similar ORT formative steps.

22 of (-)-himalensine A has been achieved in 22 steps.

23 or the reaction barriers of the two reaction steps.

24 rical properties, without any postprocessing steps.

25 o study the regioselectivity of the addition steps.

26 t energy recovery from nitrogen (N) in three steps: (1) ammonium oxidation to nitrite; (2) denitrific

27 The framework includes the following steps: (1) ensuring adequate financial investment in sca

28 The synthetic procedure involved two key steps: (1) the reaction of vinyl magnesium bromide with

29 tants such as E159A are enhanced in release (step 4) of cyt c from the HCCS active site; thus, we ter

30 -fold greater on POD1 [mean difference 843.3 steps (95% CI 219.5-1467.1)] and POD2 [mean difference 1

31 .5-1467.1)] and POD2 [mean difference 1099.4 steps (95% CI 282.7-1916.1)] There was no between-group

32 In a second step, a second antibody to ERBB2 quantitatively detects

33 and (2) changes in the magnitude of step to step adjustments in postural sway and lateral foot place

34 cients of independent predictors at the last step after checking for collinearity, likelihood ratio t

35 tial proton-coupled electron transfer (PCET) steps along a pathway of redox active amino acids (Y122b

36 This step, among others, afforded critical functionality to c

37 a from a patient's smartphone, specifically, step and global position system data, to quantify physic

38 s found to be involved in the phase transfer step and in the stereoinduction process, as expected, bu

39 ies agree on the nature of the rate-limiting step and provided close results for the reaction barrier

40 A key hydrindanone was prepared in three steps and 48% overall yield from cyclohex-2-en-1-one.

41 ng thymocytes to traverse through maturation steps and in regulating the expression of most Tcf1 targ

42 oordination numbers, such as found at atomic steps and surface defects, is firmly established.

43 bulk carbon nitride, was fabricated by a one-step approach.

44 Derivatization, extraction and rinsing steps are not required to separate the analytes from the

45 n the base stacking of pairs in dinucleotide steps, arising from energetically favorable stacking of

46 l solutions in significantly lower number of steps as compared to exhaustive search.

47 Finally, minimal use of intermediary steps as well as direct, late stage C-7 hydroxylation pr

48 infrared excitation and many tedious washing steps, as the free dye molecules are physically located

49 atment with two different sample preparation steps assisted by ultrasound energy, the proposed method

50 cal and functional coupling of recombination steps at the DNA level with specific organizational feat

51 -molecule microscopy to directly observe the stepping behavior of kinesin-1 and -2 family motors with

52 Ambient ionization ameliorates these slow steps by reducing or even eliminating sample preparation

53 We also added scripts and a step-by-step tutorial for visualizing each dataset at th

54 c group animal models and provide extensive, step-by-step tutorials that demonstrate how to fit such

55 Co-based catalysis proceeds through five steps: C-H bond activation; C-C coupling via a concerted

56 Our scheme is based on a two-step calculation in which a linear-response TDDFT calcul

57 hetized mice we first show that simple light steps can excite a subset of VPM neurons.

58 Specifically, these steps cause increased film thickness, which diminishes p

59 Second, the projection step comes first, implying all subsequent tasks are more

60 e via pathways involving fewer hydroxylation steps compared to HO(*) or CO3(*-).

61 ic wettability are synthesized through a one-step compartmentalized growth of a mesoporous organosili

62 We present a novel two-step computational approach for identification of master

63 The factors and steps controlling postinfection CD8(+) T cell terminal e

64 The direct and single-step conversion of benzene, ethylene, and a Cu(II) oxida

65 trochemical device for spontaneous or single step conversion of biomass into electricity, based on th

66 Step count was at least 2-fold greater on POD1 [mean dif

67 dicted by the HLCA and PEI models, the first-step decision dynamics were initially biased toward the

68 for a 2-step decrease in VH demonstrated a 2-step decrease (40% in Group 1 and 46.1% in Group 2).

69 5% of patients who had the potential for a 2-step decrease in VH demonstrated a 2-step decrease (40%

70 rocessing, gene filtering, and normalization steps designed to facilitate downstream analysis of larg

71 rmine the clinical efficacy of fosfomycin as step-down oral therapy to treat complicated urinary trac

72 h the indication and failure of a medication step-down treatment.

73 generating sparse targets in a 2D space with steps drawn from a Levy distribution with the exponent v

74 Crushing is a key step during olive oil extraction.

75 overcome potential problems with individual steps during the synthesis.

76 A step-economical access to polysubstituted aminoimidazole

77 s a result in the development of more highly step-economical syntheses, a synthesis that combines hig

78 es, a synthesis that combines high levels of step economy with high levels of efficiency and scalabil

79 ile surface defects (i.e., few to multilayer step edges) give rise to a morphology-dependent (i.e., h

80 tral and peripheral stalks affects c-subunit stepping efficiency.

81 st product dissociation, and that isoprenoid stepping ensures short transit times.

82 lergenic milk protein products using the two-step enzymatic modification method involving thermolysin

83 The traditional stepped field CCS method performs with a relative standa

84 ions and AFM data indicate a transition to a step-flow growth mode.

85 HCV-associated liver fibrosis is a critical step for end-stage liver disease progression.

86 Host-to-host transmission is a critical step for infection.

87 ates the strand information in the alignment step for more accurate quantification.

88 ion is predicted to be the turnover-limiting step for one substrate, and this is facilitated by solve

89 ose that such clustering is a useful initial step for other assembly pipelines.

90 ensor in the first domain is a rate limiting step for release of the inactivation domain, and highlig

91 sphere adsorption complex may be a necessary step for the redox transformation via catalytic or direc

92 saccharide idraparinux was synthesized in 23 steps for the longest linear route, with a 1.7% overall

93 This novel approach enables the one-step formation of CsPbI3/PEDOT composite, which could be

94 This represents an important step forward for mapping genes involved in complex disea

95 ven approach in designing DPT protocols is a step forward in improving DPT standardization, starting

96 This represents a significant step forward in the chemical knowledge of this material.

97 recovery from noise exposure is an important step forward in understanding NIHL.

98 Overall, our findings have proved a major step forward to accurately modeling multisolute adsorpti

99 show that microFIPs represent a significant step forward toward the development of implantable drug-

100 tes for these reactions are generated in 1-3 steps from commercially available materials, and product

101 amin antibiotics that proceeds in 6-8 linear steps from simple chemical building blocks.

102 -lactams, are also prepared in two- to three-steps from the versatile 2-hydroxy-5,6,7,7a-tetrahydro-3

103 ich incorporates the alkanethiol in a second step, gives rise to a heterogeneous distribution of olig

104 In a second step, gray scales, iodine deposition, and Hounsfield uni

105 st resting state, and turnover-rate limiting step has been examined.

106 Targeting this trafficking step has therapeutic promise, but the mechanism of traff

107 ynthesized by a stereoselective route in six steps; however, both alpha and beta epimers could be obt

108 had no impact on the ability to achieve >/=2-step improvement in DRSS score.

109 to host receptors is an early and essential step in bacterial colonization, and the nature of adhesi

110 A critical step in creating an artificial photosynthesis system for

111 xpression patterns of snoRNAs is the initial step in determining their functional significance in age

112 appear possible, suggesting this is a first step in developing a simple way of controlling plastic f

113 ylic acid synthase gene, the first committed step in ethylene biosynthesis compared with wild type.

114 cells (HSCs) in response to injury is a key step in hepatic fibrosis, and is characterized by trans-

115 ext of cell-to-cell transmission, a critical step in HTLV-1 transmission and pathogenesis.

116 ne A4 hydrolase (LTA4H) catalyses the distal step in LTB4 synthesis and hence inhibitors of this enzy

117 The ultimate step in lysine biosynthesis, the NAD(+)-dependent dehydr

118 ion of tru1 in axillary branches, a critical step in mediating the effects of domestication by tb1.

119 uncertain origin, served as an intermediary step in MV reversion to normal microvessels.

120 activated phosphate release, the biochemical step in myosin's ATPase cycle associated with force gene

121 inal nitride from coordinated ammonia, a key step in NH3 oxidation.

122 xylesterases is considered the rate-limiting step in polyester biodegradation.

123 nzyme catalyzing the first and rate-limiting step in sphingolipid biosynthesis: the condensation of s

124 , in response to heat and salt is a critical step in the assembly of elastic fibers in vivo, precedin

125 ndent transaminase BioA catalyzes the second step in the biosynthesis of biotin in Mycobacterium tube

126 Enumerating the losses at each step in the care cascade enables appropriate targeting o

127 The turnover-limiting step in the catalytic cycle for hydroboration of the int

128 ignature of kinetics of the force-generating step in the cross-bridge cycle.

129 h greater specificity against hRRM1 is a key step in the development of more effective treatments for

130 the existence of cross-seeding as a crucial step in the formation of the yeast prion [PSI (+)], form

131 phytoplankton in the surface ocean is a key step in the global carbon cycle, with almost half of mar

132 smigration across vessel walls is a critical step in the innate immune response.

133 he maternal decidua appears to be an initial step in the maternal component of the disease as well as

134 Support is included for the key step in the process, reduction of U(VI) to U(V) .

135 Translation initiation is a key step in the regulation of gene expression.

136 ation through ubiquitination is an important step in the regulation of glucose metabolism.

137 to the conclusion that the rate-determining step in the stereomutation of such piperidines is the pi

138 Here, we undertake a first step in this direction by focussing on the pressure-driv

139 As a first step in this direction, we investigate here the properti

140 A critical step in this process is the activation of naive B cells

141 t to evoke painful thermal TCE, an essential step in transforming transient afferent nociceptive sign

142 eurochemistry to perception provides a vital step in understanding population variability in sensory

143 The reflectance compensation step in VD calculation significantly improved repeatabil

144 as the combination of at least two reaction steps in a single reaction vessel without isolation of t

145 s of small molecules on specific microscopic steps in Abeta42 aggregation.

146 f compounds that target specific microscopic steps in Abeta42 aggregation.

147 decay-promoting factor influencing multiple steps in AGO2-miRNA-mediated mRNA decay.

148 Critical steps in forming the vertebrate limb include the positio

149 ly considered to be one of the most critical steps in hapten-specific antibody production.

150 One of the most crucial steps in high-throughput sequence-based microbiome studi

151 Early steps in infection include release of the capsid into th

152 We propose that HID-1 influences early steps in LDCV formation by controlling dense core format

153 Exploratory research into the critical steps in metal-organic framework (MOF) activation involv

154 ays distinct roles in two sequential priming steps in mouse adrenal chromaffin cells.

155 Although several steps in MPO biosynthesis and processing have been eluci

156 he canonical CTD, which orchestrates various steps in mRNA synthesis.

157 east facilitated the characterization of key steps in Muta1 transposition.

158 essed RNA binding protein vital for multiple steps in RNA metabolism.

159 roteolytic and lipolytic phenomena, decisive steps in such a ripening process, could be monitored thr

160 bination of interventions targeting multiple steps in the continuum is needed to achieve the full ben

161 These cells allowed completion of steps in the HIV-1 life cycle through integration but su

162 in degradation/hemozoin formation, essential steps in the Plasmodium life cycle, are targets of exist

163 More data are needed to inform next steps in the responsible stewardship of this process, fr

164 We examined the individual steps in the transport cycle by recording transporter-as

165 d -negative cells, without any amplification step, in less than 2h.

166 iggered by allergen exposure through several steps including release of IL-33, which promotes cytokin

167 architecture comprising a periodic array of step-index waveguides is reported.

168 A two-step integrated protocol creates a more rapid autoinduct

169 The second step involved anti-valgus osteotomy of the right tibial

170 The first step involves a change in the distance between the benze

171 erence, suggesting that the rate-determining step is associated either with the mobilization of pi-bo

172 n of the intermediates, whereby at least one step is catalyzed by an enzyme.

173 nm long origami lever to an applied voltage step is less than 100 mus, allowing dynamic control of t

174 This latter step is reliant on active caspase-1, pannexin-1, and P2X

175 he theoretical discussion, the rate-limiting step is the diffusion through the coating; therefore, th

176 A common analysis step is to annotate such genomic regions to genomic anno

177 esults have shown that SWASV with extraction step is very sensitive method for the determination of v

178 linical management practices initiated under STEP led to a decade-long decline in the incidence level

179 n in driving gradual chromatin compaction by step-like and slow "creeping" dynamics consistent with a

180 such up-regulations may represent the early steps linked to termination of diapause programming.

181 nsposon Analysis in Yeast (SATAY) allows one-step mapping of all genetic loci in which transposons ca

182 discuss the results in the context of a four-step mechanism for HCCS, whereby HCCS mutants such as E1

183 hosphorylation occurs via a noncanonical two-step mechanism in which 1) the cyclin-dependent kinase a

184 om the studies, we uncover a sequential, two-step mechanism of cellular reprogramming in which repres

185 ylation and kinase activity serve as a multi-step mechanism to coordinate cell motility during migrat

186 A two-step mechanism was elucidated through detailed kinetic a

187 We used a two-step Mendelian randomization approach to assess whether

188 The two-step meta-analysis did not reveal evidence of heterogene

189 Each of these steps might be addressed algorithmically using various c

190 echanisms of 20 OMPs during the methanogenic step of AD with a focus on the role of acetate kinase (A

191 phatase, an enzyme which catalyses the final step of gluconeogenesis and glycogenolysis.

192 for hexokinase-2, which catalyzes the first step of glycolysis, was significantly lower expressed in

193 ochelatase, the enzyme involved in the final step of heme synthesis, is deficient in these patients.

194 Here, we provide first insight into the key step of MSP-mediated phosphotransfer in a eukaryotic sys

195 H) mouse model of DWMI activates the initial step of the ISR.

196 versification mechanisms that exist at every step of the protein biosynthesis pathway, such as altern

197 stly impair the EF-G-catalyzed translocation step of the two tRNALys and the slippery codons from the

198 The key step of this approach is an epimerization of C5 by an el

199 dhypocotyl, whose expansion drives the final step of this developmental transition under optimal cond

200 cell trafficking by promoting the diapedesis step of transendothelial migration in a alpha4 integrin-

201 re piwi-interacting RNAs requires a critical step of trimming piwi-interacting RNA intermediates to a

202 positive end-expiratory pressure titration (steps of 2 cm H2O starting from >/= 26 cm H2O).

203 aled or revealed, enabling catalysis of both steps of a tandem reaction process.

204 at could be involved in critical yet missing steps of astaxanthin biosynthesis, including ABC transpo

205 ning a detailed understanding of the initial steps of CO2 electroreduction on copper surfaces, the be

206 tochastic model accounting for the essential steps of conversion showed excellent agreement with the

207 ities and forms a starting point for further steps of data analytics and modeling of biological dynam

208 As estimating Km and kcat requires multiple steps of data manipulation, we developed a computational

209 We used these measurements to quantify 6 steps of oxygen transport and utilization (the O2 pathwa

210 The steps of the silylation mechanism may follow either an i

211 The elucidation of the elementary steps of this process will aid the design of new catalyt

212 as major cellular compartments for the early steps of TLR9 activation in dendritic cells (DCs).

213 ly required for visualizing distinct kinetic steps of transcription on a single-copy gene in vivo.

214 nt morphology may be computed in a series of steps, one of which is partly independent from syntactic

215 er that during large magnitude earthquakes a step-over along the fault zone results in the vertical d

216 With the observations, we built a three-step prediction model, namely RPI-Bind, for the identifi

217 ply that SERINC5 restricts HIV-1 fusion at a step prior to small pore formation by selectively inacti

218 course is sigmoidal, signaling an activation step, prior to turnover.

219 r preference as an IV method, we propose a 2-step procedure with which to estimate a valid treatment

220 The two-step process has been achieved at 1,300 degrees C/900 de

221 This one-pot, two-step process occurs in minutes and enables the synthesis

222 s caused a transition from a one-step to two-step process.

223 We established a multi-step protocol involving protein immobilization, sialic a

224 ing a positive shift of the potential of the step-related peak on Pt(553).

225 thway, enzymes involved in late biosynthetic steps remain uncharacterized.

226 In a first step, reproduction of patient anatomy was tested by prin

227 ly disentangle these models, we design a two-step reward-based decision paradigm and implement it in

228 In this work, we present an eight-step route to 5-hydroxymethylcytidine (hm(5)rC) phosphor

229 These observations imply that pre-excision step(s) during OGG1 initiated BER evoked by ROS facilita

230 predicts that a 1-point difference on this 5-step scale would be detectable with 12 subjects in each

231 phene-based electrochemical biosensor for on-step, sensitive and low cost detection of beta-lactoglob

232 Using this method, a single-step separation factor up to 261 was obtained for the se

233 ong the step weaken the OH adsorption at the step sites, causing a positive shift of the potential of

234 The one-step spin-coating process of perovskites is investigated

235 aturated aqueous solutions in three distinct steps: spinodal decomposition into solute-rich and solut

236 (2+) cation occurs readily in a one-pot, two-step stoichiometric reaction at room temperature to form

237 lem for static networks, but this is a first step study to explore designing surveillance systems for

238 xhibiting CO binding stronger than the (211) step surface.

239 but not patient self-reported, estimates of steps taken per day correlated with smartphone data (sur

240 From 2-step testing, all glutamate dehydrogenase (GDH)-positive

241 significantly more, but slower and shorter, steps than did CIPN- (all P < .05).

242 embrane is coupled to an energy transduction step that could thermodynamically drive proton pumping i

243 Co Prism is obtained in one self-assembly step that organizes six total building blocks, two CoTPy

244 They mediate the priming step that renders synaptic vesicles fusion-competent, an

245 nd alcohol) and (ii) the washing and elution steps that are required to remove these reagents and rel

246 atient with HFpEF, identifying the defective steps that impair each one's exercise capacity (peak Vo2

247 ew therapeutics for depression, and the next steps that need to be made to facilitate this translatio

248 Thus, intracellular sorting steps that occur after receptor internalization by endoc

249 ty Index score, the highest asthma treatment step, the greatest variability in FEV1 over time, and th

250 In the second step, the trisaccharide is specifically hydrolyzed by tr

251 ide range from 20 to 1000 nm followed by one-step thermal activation.

252 acetic acid and a centrifugation/filtration step to decrease turbidity are not required, thus reduci

253 e patients access health services is a first step to planning for the placement of services to meet p

254 stance, and (2) changes in the magnitude of step to step adjustments in postural sway and lateral fo

255 osanoic acids caused a transition from a one-step to two-step process.

256 l comparative study represents a fundamental step to understand the spin dynamics of potential molecu

257 It utilizes two steps to estimate the conditional essentiality for each

258 limited by the number of evolution interval steps to which the number of scans, the acquisition time

259 This paper proposes a first step toward an alternative computational framework in wh

260 As a next step toward an understanding of the mechanism by which I

261 Identification of the linkage is a first step toward identifying the linking enzyme and potential

262 ltransferase 1 (POMGNT1) catalyzes the first step toward other various glycan structures present on a

263 Bittner and colleagues describe a promising step toward solving this problem by identifying and desc

264 alidation of oncogenic drivers are essential steps toward advancing cancer precision medicine.

265 These data are important first steps toward implementation of precision head and neck o

266 Current experiments are taking the first steps toward noise-resilient logical qubits.

267 Although the first steps toward potential therapies have been taken, there

268 i for cannabis dependence is among the first steps toward understanding the biological contributions

269 This constitutes a first step towards a fully integrated system for rapid label-f

270 to excellent yield, and represents the first step towards a general transition metal catalysed synthe

271 ference of non-canonical pairs, an important step towards accurate prediction of the full tertiary st

272 e results show that this strategy is a first step towards developing "activator drugs" for a large nu

273 a non-RNA-guided Cas9 endonuclease and first step towards eliminating the ribose dependency of Cas9 t

274 These strategies present a critical step towards harnessing the myriad of potential applicat

275 maintaining structural stability is the key step towards high-voltage operation of layered-cathode m

276 ences in threat response would be a valuable step towards improving our understanding of anxiety diso

277 shed, Canver et al. have now taken the first steps towards addressing these issues by increasing scre

278 We also added scripts and a step-by-step tutorial for visualizing each dataset at the single

279 animal models and provide extensive, step-by-step tutorials that demonstrate how to fit such models i

280 This sample concentration step typically occurs after metabolite extraction, when

281 The second step uses the correlation between residuals of the linea

282 This step was also devised to dual-labeling of PCR products w

283 For this purpose, the target capturing step was designed by functionalization of 3-aminopropylt

284 apore Tuberculosis (TB) Elimination Program (STEP) was set up in 1997, and the better surveillance an

285 The co-adsorbed alkali cations along the step weaken the OH adsorption at the step sites, causing

286 Key steps were a palladium-catalyzed C(sp3)X-C(sp3)ZnX Negis

287 20 mg, and the following LLT intensification steps were applied: uptitration to atorvastatin, 80 mg;

288 ecific inhibitors, we demonstrated that both steps were critical in the deleterious effect of IL-1bet

289 The clean-up step which employed chitosan proved to be effective, sin

290 computationally intensive and time consuming steps, which are not ideally suited for real-time molecu

291 he cognate codon-anticodon helix, initiating step-wise 'latching' of the decoding centre.

292 ct directly with a wide range of arenes in a step-wise and controlled manner.

293 MO cool phases during the LIA, followed by a step-wise increase from 1910 to present levels-unprecede

294 These are arguments to consider a step-wise pathophysiology for these diseases, with thera

295 l of scientific rigor toward a well-planned, step-wise sequence of preclinical and clinical studies,

296 tial acylation, alkylation, or glycosylation step with an amine-mediated glycosylation of the boronic

297 drogel can be programmed by the pre-swelling step with different masks to encode the buckling directi

298 ith the more specific KalbTG and in a second step with the less specific MTG from Streptomyces mobara

299 approaches, such as a facile remote C-H HAT step, with that of transition-metal-catalyzed chemistry

300 IV/AIDS Strategy goals 2 through 4 including steps within each goal.