ライフサイエンスコーパス: stepwise

1 between two stimulus mixtures can be altered stepwise.

2 ently cyclize to give tetrahydroindolizines (stepwise 1,3-dipolar cycloadditions with 3) and cyclopro

3 a concerted [4+2] Diels-Alder reaction or a stepwise [6+4] cycloaddition followed by a Cope rearrang

4 This phase 2 study evaluated stepwise (9-28-112 mug/d with weekly dose increases; n =

5 s of this family of RTs ensure its rapid but stepwise accumulation in plant populations experiencing

6 multistep clonal evolution characterized by stepwise accumulation of successive alterations affectin

7 Resistance was achieved by the stepwise acquisition of coat protein mutations.

8 ing these associations and shed light on the stepwise acquisition of this genetic toolkit during plan

9 morphology reveals a previously unrecognized stepwise acquisition of typical caecilian cranial apomor

10 ne transfer and gene duplication allowed the stepwise acquisition of virulence factors in pathogenic

11 y functional theory show that ICDs involve a stepwise addition, forming an intermediate stabilized ca

12 agrams revealed a change in mechanism from a stepwise addition-elimination (TEWT) to a lower energy c

13 Here we report a stepwise addition/elimination reaction in the SP hydroly

14 dient is established that contributes to the stepwise aminolysis rate differences and enhanced select

15 y Ru(III) is energetically favorable by both stepwise and concerted pathways.

16 DFT calculations of stepwise and concerted reaction pathways are used to rat

17 n/d or placebo from 4 to 6 mo of age, with a stepwise and fixed gluten increase until age 10 mo and u

18 We report the stepwise and quantitative transformation of the Zr6(mu3-

19 reflux are most effectively diagnosed with a stepwise approach incorporating empiric treatment and an

20 her stand-alone PVI (PVI-only approach) or a stepwise approach of PVI followed by complex fractionate

21 x ablative approach of stand-alone PVI and a stepwise approach of PVI plus complex fractionated atria

22 The stepwise approach takes advantage of simple, versatile,

23 ents of the US biosimilars program involve a stepwise approach that relies heavily on analytical meth

24 label data from multiple sources, we used a stepwise approach to derive the added sugar content of 1

25 dherence to the World Health Organization's "STEPwise Approach to Surveillance" framework for populat

26 approach was used (pulmonary vein isolation/stepwise approach).

27 dies underscore the importance of a thorough stepwise approach, including consideration of the time-d

28 sful in this endeavor, using a comprehensive stepwise approach, leading to a wealth of findings.

29 iable analyses were evaluated using backward stepwise approach.

30 mainstay of asthma therapy and are used in a stepwise approach.

31 Our results revealed a stepwise assembly mechanism by monomer addition and doma

32 Overall, here we propose a stepwise assembly mechanism detailing the synergistic ac

33 phabeta-half, which led to the proposal of a stepwise assembly mechanism of the M-cluster in the two

34 mal assembly pathway allowed us to develop a stepwise assembly model for the eight pieces of the larg

35 tudies have suggested that proteins fold via stepwise assembly of structural units named 'foldons' th

36 ibosomal subunit and propose a model for the stepwise assembly of the large-subunit ribosomal RNA (rR

37 Using a new in vivo assay, we find that a stepwise assembly pathway produces the two species of bu

38 We report a stepwise assembly strategy for the integration of metal-

39 F-UreG complex exists in plants and show its stepwise assembly.

40 how that oligomerization of HsRAD51 leads to stepwise, but stochastic unwrapping of the DNA from the

41 its cysteine (Cys) thiol group, followed by stepwise catalyzed degradation and eventual elimination

42 udies of the reaction pathway suggest that a stepwise, cationic Diels-Alder cycloaddition is operativ

43 eptor precursor cells were generated using a stepwise cGMP-compliant 3D differentiation protocol.

44 ffice (n=6), by assessing which markers were stepwise changed from no SI to high SI to suicide comple

45 th time, and calculations suggest that these stepwise changes can result from arrival of individual i

46 individual bacterial flagellar motors under stepwise changes in external osmolarity.

47 tes of ion incidence, detector currents show stepwise changes with time, and calculations suggest tha

48 progress signals seem essential for aligning stepwise choices with internal plans.

49 ram first uses UV-vis spectra for an initial stepwise classification of flavonoids into classes and t

50 The stepwise classification strategy to identify classes sig

51 trix stability was directly assessed using a stepwise collagen extraction assay and fibrotic septae m

52 1) by drilling or 2) by drilling followed by stepwise condensation with tapered osteotomes.

53 We found that, compared to stepwise conditional multiple-SNP analysis, SOJO provide

54 Stepwise conversion of floral organs into leaves in the

55 in Sec31 also bind to Sec23, suggesting that stepwise COPII coat assembly will ultimately displace TA

56 A palladium-catalyzed one-pot stepwise coupling-annulation reaction of 2-chloroqunolin

57 We used stepwise Cox regression and the Kaplan-Meier method to a

58 Stepwise current decreases were observed for the prior t

59 heir catalytic cycles involve a concerted or stepwise cyclization mechanism has not been addressed ex

60 Both concerted and stepwise cycloadditions are predicted, depending on the

61 ethyl to ethyl, propyl, and butyl produced a stepwise decrease in potency.

62 A-sequencing, optimal competence conditions, stepwise deletions and marker-less genome editing, we fo

63 antibody panel and laboratory procedure was stepwise designed to measure minimal residual disease (M

64 ally designed mutations, we demonstrate that stepwise destabilization of the talin rod R3 subdomain d

65 tions was investigated, yielding products of stepwise desubstitution.

66 this protocol, we describe our procedure in stepwise detail to allow efficient completion of both th

67 ia the inducible costimulator ICOS fuels the stepwise development of follicular helper T cells (TFH c

68 chemotherapy, little is known regarding the stepwise development of the tumor microenvironment.

69 Significant stepwise differences in metabolite concentrations were s

70 Stepwise dimension reduction and texture feature selecti

71 the endosome, particles undergo a series of stepwise disassembly events.

72 reaction for which CSNAr is favoured over a stepwise displacement.

73 A stepwise dissociation-recombination mechanism was found

74 l venetoclax, starting at 20 mg per day with stepwise dose ramp-up over 5 weeks to 400 mg per day.

75 nstituents of the mobile phase were modified stepwise during analysis, this did not overtly interfere

76 h the idea that the catalytic RNA core forms stepwise during the B to B(act) transition and is likely

77 re of past sea-level rises (i.e., gradual or stepwise) during deglaciation is critical for informing

78 concerted pathway can never compete with the stepwise electron-first mechanism (ETPT) when neat water

79 vergeneralized "sophomore textbook" image of stepwise electrophilic attack on the alkene and subseque

80 ple logistic regression models with backward stepwise elimination (Proc Logistic procedure in SAS).

81 or substrate recognition and demonstrate the stepwise elongation of cellulose.

82 Venetoclax was dosed daily using a stepwise escalation to target doses (200-600 mg) and the

83 The phenol oxidation occurs via a stepwise ET-PT mechanism with kET = 2.7 x 10(7) s(-1) an

84 These genera document the stepwise evolution of the aculiferan body plan from form

85 array library design, parallel screening and stepwise evolution, to discover novel peptide hotspots.

86 These results highlight a plausible stepwise evolutionary trajectory for cold adaptations ac

87 We apply this method to stepwise evolve peptide binders to streptavidin, a prote

88 ved as the glycan antennae were shortened by stepwise exoglycosidase treatments; this trend was consi

89 The stepwise expansion of both pyrroline moieties in near-pl

90 s by mimicking embryonic development through stepwise exposure to morphogens, or by conversion of one

91 4-day fasting mimicking diet (FMD) induces a stepwise expression of Sox17 and Pdx-1, followed by Ngn3

92 with the likelihood of a major response in a stepwise fashion (0, 7.5%; 1, 12.7%; 2, 16.9%; 3, 35.7%;

93 columnar and layered branching patterns in a stepwise fashion from mid-metamorphosis onwards.

94 signed 19 new specific primers anchored in a stepwise fashion in order to detect all alleles present.

95 ads beta-strands into the lipid bilayer in a stepwise fashion or catalyzes the insertion of pre-folde

96 f liver disease and cirrhosis increased in a stepwise fashion with increasing body surface area affec

97 ariance models (ANCOVA) was constructed in a stepwise fashion.

98 A hybrid biomarker developed using a stepwise feature selection method could classify the leg

99 y a [2 + 2] cycloaddition, which takes place stepwise, first by formation of cyclopropyl gold(I) carb

100 An identical sample volume was imaged stepwise, first under oxidizing and reducing atmospheres

101 suggests that quantized native structure and stepwise folding coevolved in ancient repeat proteins an

102 Risk for all outcomes increased stepwise for each additional risk factor not at target.

103 two reaction pathways, one concerted and one stepwise, for the production of each enantiomer of the d

104 healthy dogs, as plasma glucose was lowered stepwise from 280 mg/dL to 80 mg/dL, progressively more

105 ayer of the cubic mesophase can be ramped up stepwise from less than a milligram per milliliter to te

106 pin the design of small molecules capable of stepwise functionalization, of which there are notably f

107 gically synchronously with the initiation of stepwise global cooling, glaciation of Antarctica and ar

108 A novel stepwise heat treatment yields significant improvement i

109 Multistage, stepwise HIV testing and treatment procedures can result

110 Stepwise humanisation has also allowed us to elucidate t

111 CO-derived COOH groups undergoing subsequent stepwise hydrogenation with CO as reductant.

112 Thus, stepwise immunization initiates CD4bs-bnAb responses, bu

113 Thereafter, a stepwise implementation phase was initiated directed tow

114 This was a before and after stepwise implementation study of conservative oxygenatio

115 A stepwise increase in 28-day mortality was associated wit

116 ted along the wire axis, the wires exhibit a stepwise increase in conductance and oscillatory thermop

117 We observed a stepwise increase in median colon tumor numbers as the d

118 Kaplan-Meier analysis revealed a stepwise increase in mortality between the different sco

119 However, there was a stepwise increase in the hazard of death with higher qua

120 rrocene methanol was being oxidized produced stepwise increases in current as observed by amperometry

121 This association was dose dependent, with stepwise increases in tuberculosis disease risk with eac

122 get metabolite analyses revealed significant stepwise increases of sarcosine, glycine, and choline ti

123 Using GS-knockout/liver and control mice and stepwise increments of enterally infused ammonia, we sho

124 vity, we further show that detoxification of stepwise increments of intravenously (jugular vein) infu

125 The stepwise infection of flower organs and mimicry of ovary

126 that sodium ions undergo occupancy-dependent stepwise insertion into the core of porphyrin-like tetra

127 dothelial cadherin (VE-cadherin), we provide stepwise instructions for mechanogenetic control of rece

128 gradable blends, strategically involving the stepwise integration of elongational shear and high-pres

129 LT2 genome through a process we term SIRCAS (stepwise integration of rolling circle amplified segment

130 uced within three days, without the need for stepwise intermediate plasmid production.

131 e NH4 PbI3 non-perovskite thin film converts stepwise into a dense, ultrasmooth, textured CH3 NH3 PbI

132 en-9-ones have been developed via in situ or stepwise intramolecular heteroannulation of newly synthe

133 logical, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL d

134 endent of ring size, all macrocycles exhibit stepwise, light-induced, ring-opening reactions (DHA-DHA

135 Stepwise Linear Discriminant Analysis (SLDA) showed that

136 erformed using univariable and multivariable stepwise linear regression models, taking family structu

137 A stepwise linear regression was performed to identify fac

138 Results from stepwise logistic regression analysis showed that five b

139 system phenotypes remained significant in a stepwise logistic regression model and showed significan

140 Stepwise logistic regression revealed the following fact

141 We performed a stepwise logistic regression to develop a multivariate r

142 Stepwise logistic regression was used to compare factors

143 modeled in a derivation cohort, and backward stepwise logistic regression was used to identify factor

144 Bidirectional stepwise logistic regression was used to identify factor

145 Using forward stepwise logistic regression, we built a predictive mode

146 th within 14 days of LVAD were assessed with stepwise logistic regression.

147 diction analyses that used forward selection stepwise logistic regression.

148 ogether with other potential predictors in a stepwise logistic regression.

149 A stepwise management approach is advocated for patients w

150 We offer recommendations for the stepwise management of calcium channel blocker toxicity.

151 cooperative (strong anion then weak acid) or stepwise manner (weak acid then strong anion).

152 g, VHF-to-DHA, ring closures also occur in a stepwise manner and are systematically found to proceed

153 hod that reduces the degrees of freedom in a stepwise manner and leads to a dynamic flux distribution

154 ing to a subset of late-expressed genes in a stepwise manner by initial positive feedback regulation

155 e of the enzyme fuel cell was increased in a stepwise manner by the charge pump from 330mV to 3.1V, a

156 eously once per week, but was decreased in a stepwise manner due to toxic effects to a final starting

157 essibility of these regions is acquired in a stepwise manner during development and changes little af

158 he orderly process of brain development in a stepwise manner to further our understanding of neurodev

159 AGE: Rubisco activase of plants evolved in a stepwise manner without losing its function to adapt to

160 The translocation of DNA occurs in a stepwise manner, and at both sites where DNA enters and

161 In both groups, treatment was escalated in a stepwise manner, from no treatment, to adalimumab induct

162 solution, aggregation proceeded in a highly stepwise manner, in which the individual domains (N term

163 A) cycloisomerization reaction proceeds in a stepwise manner-i.e., via a diradical intermediate.

164 ) elevations, CaMKII activity increased in a stepwise manner.

165 r process, and temperature may increase in a stepwise manner.

166 lowering end-expiratory airway pressure in a stepwise manner.

167 heavy and Ig light chain loci rearrange in a stepwise manner.

168 to learn to pull a string when trained in a stepwise manner.

169 cles, that can be used on blood samples in a stepwise manner.

170 NAc-PP-Und to form the intact RU-PP-Und in a stepwise manner.

171 functional constraints on plastid genes in a stepwise manner.

172 for non-surgical peri-implantitis combining stepwise mechanical debridement measures with adjuvant P

173 for non-surgical peri-implantitis combining stepwise mechanical debridement measures with adjuvant p

174 This stepwise mechanism could be bypassed by seeding, which p

175 sm in gas phase and in apolar solvents but a stepwise mechanism in polar solvents.

176 rate constant calculated by eq 1 suggests a stepwise mechanism in which the initial nucleophilic att

177 A stepwise mechanism involving short-lived zwitterion inte

178 the delicate nature of the concerted versus stepwise mechanism of inverse electron-demand Diels-Alde

179 The stepwise mechanism of the reduction shows similarities t

180 f acetylenes, the obtained results suggest a stepwise mechanism through a 3-azatriene.

181 of H2F and hydride transfer to C6 occur in a stepwise mechanism.

182 um solvent kinetic isotope effects suggested stepwise mechanisms with thiolate attack on NO2-CLA as r

183 In stepwise mechanisms, the first step of the reaction is a

184 me measures were developed in a standardized stepwise method, starting with the identification of ite

185 A stepwise methodology is also described to choose between

186 r follicle stem cell (HFSC) aging causes the stepwise miniaturization of hair follicles and eventual

187 reveal that Pol II backtracking occurs in a stepwise mode where two intermediate states are involved

188 rease in ECV, 95% CI, 1.25-2.45; P = .001 in stepwise model) whether grouped with patients at risk fo

189 We used stepwise modeling to generate a model for subphenotype i

190 As an initial proof of concept, we developed stepwise multiple linear regression (MLR) models for spe

191 Stepwise multiple linear regression was used to derive a

192 The score was developed using a stepwise multivariable regression analysis.

193 6; 95% CI, 1.05-1.75; P = .02), confirmed in stepwise multivariate analysis (interaction P = .04).

194 d fluoroquinolone resistance through precise stepwise mutations in bothparCandgyrA, and putative comp

195 Notably, stepwise neoplastic transformation is accompanied by a g

196 This study describes a stepwise optimization of DFG (1-deoxy-1-fructosylglycine

197 additional covariates evaluated by using the stepwise option for the selection.

198 erivatives have been shown to undergo either stepwise or concerted PCET, where the latter process is

199 enables a selective alcohol epimerization by stepwise or reversible oxidation and reduction.

200 volutionary processes into account through a stepwise or simultaneous method.

201 In the absence of stromal cells, the stepwise order of rearrangements is blocked so that IgLl

202 d with C-Cl breakage) in alkanes compared to stepwise OS-SET (SET to a pi* orbital followed by C-Cl c

203 In the early stage of the reaction, the stepwise oxidation results in the formation of phenO, wh

204 We find that the stepwise pathway is the relevant pathway in the producti

205 A stepwise pathway wherein the MK-cinchona enolate (enolat

206 ess and provide no evidence of a competitive stepwise pathway.

207 strates from acetyl carbazole proceeds via a stepwise pathway.

208 by Biotype versus healthy controls showed a stepwise pattern of GMD reductions as follows: Biotype1,

209 The stepwise pattern of virus replication and dissemination

210 stributed across boundaries and find a clear stepwise pattern.

211 confronted with the intensity of the common stepwise pharmacotherapy, and the concurrently included

212 Stepwise photobleaching of SpoIVFB fused to a fluorescen

213 Stepwise photobleaching showed that CaMKII formed oligom

214 lar Friedel-Crafts-type reactions, allow the stepwise planarization of the hexaarylborazine precursor

215 ECM) remodeling through its availability and stepwise polymerization for fibrillogenesis.

216 The stepwise preparation of the biomimetic surface was chara

217 Cooling of atomic gases to perform backward stepwise privacy-preserving feature selection.

218 lar carcinoma (HCC) typically results from a stepwise process characterized by the development of pre

219 sity functional theory calculations reveal a stepwise process involving activation of the diazo compo

220 es of HCC development likely involved in the stepwise process of HCC development.

221 Gene expression analysis supports a stepwise process of maturation, highlighted by temporall

222 Pluripotency enhancer selection is a stepwise process that also begins early in reprogramming

223 Stress granule disassembly is also a stepwise process with shell dissipation followed by core

224 Reprogramming is a stepwise process with well-defined stages of initiation,

225 not well described as either a concerted or stepwise process, and dynamical effects influence the id

226 found previously, MukB DNA condensation is a stepwise process.

227 These findings elucidate the stepwise processes regulated by Rasip1 through downstrea

228 Stepwise processing of amelogenin by MMP-20 in the CS-AM

229 Possible roles for the stepwise progression of this patterning program are disc

230 tion of biosynthetic processes rather than a stepwise progression.

231 A key feature of this method is a stepwise QM/MM approach that allows accuracy to be achie

232 We report the stepwise, quantitative transformation of Ce(IV)6(mu3-O)4

233 s) of patients with persistent AF undergoing stepwise radiofrequency ablation.

234 ditional patients were treated with a weekly stepwise ramp-up in doses as high as 400 mg per day.

235 n of MoO3 solid precursors to sub-oxides and stepwise reactions with Se vapor to finally form MoSe2 .

236 emistry of the bimetallic complex shows four stepwise redox events, indicating significant intramolec

237 m of our study was to evaluate the effect of stepwise-reduced doses on objective and subjective image

238 king replication links by reconnection while stepwise reducing the topological complexity.

239 the isotonic velocity transient following a stepwise reduction in force from the isometric peak forc

240 We retrospectively simulated the stepwise reduction of (18)F-FDG doses of 19 patients (me

241 Here we used a forward stepwise regression algorithm to build a classifier of b

242 NPs) within some of these genes and multiple stepwise regression analysis including other independent

243 Stepwise regression assessing variables affecting the li

244 In stepwise regression models, mayonnaise was the leading p

245 A stepwise regression procedure selected the following var

246 Stepwise regression was used to determine variables pred

247 Stepwise regressions identified tau in MTL regions known

248 ol in vivo, which is likely due to sustained stepwise release of active triptolide within cancer cell

249 urally, exoglycosidases were used to achieve stepwise removal of individual saccharide units from the

250 ysis describes the energetic profile for the stepwise removal of three H atoms from [Mo-NH3](+) and f

251 , and the absence of methods that enable the stepwise replacement of the Escherichia coli genome with

252 phenyl substituents previously prepared by a stepwise route.

253 space as opposed to experimentally suggested stepwise sampling.

254 onitored to develop LUR models by supervised stepwise selection of GIS predictors.

255 strains typically develop resistance through stepwise selection of multiple drug-resistance mechanism

256 dictor selection was performed via a forward stepwise selection process.

257 rognostic index was built by Cox regression (stepwise selection) using data from 401 patients enrolle

258 Based on multivariable Cox models and stepwise selection, the 3 most discriminating variables

259 By performing functional prediction and stepwise selection, we identified two independent SNPs (

260 n situ transmission electron microscopy, the stepwise self-assembly dynamics of hydrophobic gold NPs

261 ies, such as template-directed synthesis and stepwise self-assembly, this design enables the formatio

262 aightforward and effective approach based on stepwise, sequentially directed disulfide bond formation

263 In the caudorostral dimension, stepwise serial projections convey information through t

264 , HCF, riboflavin, RF) were characterized by stepwise shifting the "voltage window" (ranging between

265 tein, allowing the preparation of a range of stepwise-smaller nanodiscs (6- to 8-nm diameter) to over

266 anges in mean blood pressure (BP) induced by stepwise sodium nitroprusside (SNP) and phenylephrine (P

267 nd that PANX1 activation involves sequential stepwise sojourns through multiple discrete open states,

268 We show here the first full stepwise solid phase peptide synthesis of mambalgin-1 an

269 m dodecyl sulfate (SDS) decellularization or stepwise, solubilization-based antigen removal using ami

270 erive a mechanistic framework to explain the stepwise spacer integration process and the leader-proxi

271 ards and a novel chemometric model that uses stepwise strategy and projected distance resolution (PDR

272 riphosphate hydrolysis cycle that results in stepwise substrate translocation.

273 ated conditional conformational sampling via stepwise synthesis and assembly of foldon units that min

274 Here following a stepwise synthesis and self-assembly approach, pentagona

275 eir linear precursors, prepared by microwave stepwise synthesis.

276 This includes a stepwise system of quality controls and user-friendly da

277 Individuals were exposed to a stepwise temperature increase from 15 degrees C to 25 de

278 l bifunctional porous catalysts, through the stepwise template removal and chemical functionalization

279 ion battery electrodes obtained by replacing stepwise the oxygen atoms with sulfur atoms in the carbo

280 be functionalized with thiolated DNA through stepwise thiolyne chemistry using UV light irradiation.

281 In turn, HCHO reacts with olefins stepwise to aromatic molecules on Bronsted acid sites.

282 25 degrees oscillation amplitude), while the stepwise trajectories show only a chaotic pattern and le

283 functional theory calculations reveal that a stepwise transfer mechanism is dominant in the tautomeri

284 hydrogen content, the macrocycles undergo a stepwise transition from a cylindrical to conical shape.

285 simulation (simulation cohort) that applied stepwise treatment intensification algorithms in those w

286 Stepwise treatment of implants was performed with ultras

287 Stepwise treatment of implants was performed with ultras

288 GdL) provides a slow pH drop that allows for stepwise triggering of peptide components into essential

289 h Twinkle as well as events corresponding to stepwise unwinding and annealing.

290 in the presence of strong base results in a stepwise unzipping of the polymer chain to yield the cor

291 hes, the desired conjugates were constructed stepwise using solid-phase synthesis starting from immob

292 Logistic regression with stepwise variable selection was used to determine predic

293 developed four dietary interventions with a stepwise variance in concordance with the WHO healthy ea

294 of the pertinent electrochemistry (including stepwise versus concerted carbon-halogen bond cleavage,

295 Stepwise volumetric reductions (ADHD+ODD < ADHD-only < c

296 than two different reaction pathways (i.e., stepwise vs concerted).

297 rchical complexity of An-materials was built stepwise, which was only feasible due to preparation of

298 a small contribution as evolution proceeded stepwise with incremental increases in sensitivity.

299 Additionally, a stepwise zero-inflated negative binomial model was used

300 SNARE assembly occurs by stepwise zippering of the vesicle-associated SNARE (v-SN