ライフサイエンスコーパス: sterically demanding

1 R spectroscopic investigations show that the sterically demanding 2-methylimidazole ligand readily bi

2 e complementary strands, thereby placing the sterically demanding 8-alkoxy groups in the major or min

3 rocycle ring, employing for the first time a sterically demanding acetal, an intramolecular chemosele

4 , and in contrast to reactions with the less sterically demanding achiral NHCs, the presence of MeOH

5 olecular surface crowding and suppression of sterically-demanding adsorption modes.

6 Interestingly, more sterically demanding alcohols seem to unfold the protein

7 intramolecular hydroamination/cyclization of sterically demanding amino-olefins to afford disubstitut

8 On the other hand, sterically demanding analogues bearing ortho substituent

9 ducting the reaction at lower temperature on sterically demanding and less reactive substrates.

10 bind in a fashion analogous to that for the sterically demanding antagonist DOB-like compounds.

11 atalyst for the Buchwald-Hartwig coupling of sterically demanding aryl bromides and chlorides with st

12 Electron-rich and sterically demanding aryl bromides with substituents in

13 get step involves lead-mediated arylation of sterically demanding aryl groups and carbon acid couplin

14 ffected by the level of alkene strain, while sterically demanding azides do not hinder the reaction.

15 We report here that electron-withdrawing and sterically demanding bis(sulfonamido) ligands lead to en

16 By making use of sterically demanding boryl substituents, compounds of th

17 al design of siloxydiene component 36 with a sterically demanding bromine substituent.

18 owth of the linear BCP over that of the more sterically demanding brush BCP, which was gradually reve

19 Key steps include a sterically demanding Buchwald-Hartwig amination as well

20 Also, the sterically demanding C(alpha,alpha)-dibenzylglycine (Dbg

21 Less sterically demanding carbenes were found to be more acti

22 is introduced for the facile hydrolysis of a sterically demanding carboxamide under a mild condition.

23 emarkably, both enantiomers, which present a sterically demanding cis-1 C60 addition pattern, represe

24 Addition of a sterically demanding cyclic (alkyl)(amino)carbene (CAAC)

25 genuine viologens but reached its limit when sterically demanding diaryliodonium salts were used.

26 , we utilized a Diels-Alder reaction between sterically demanding diene 42 and nitroethylene to fix t

27 oiety of NP309 is replaced by a chloride and sterically demanding diimine ligands.

28 found to be counterproductive in the case of sterically demanding dimethyl groups and of no consequen

29 ear Pd-alkyl species is more pronounced with sterically demanding diphosphines.

30 The influence of sterically demanding dirhodium tetracarboxylate catalyst

31 s recruited to coerce the substrate into the sterically demanding, eclipsed conformation that is requ

32 Buchwald-Hartwig N,N-diarylation in a highly sterically demanding environment.

33 d D phenol triflates for introduction of the sterically demanding F and G aryl rings, and an unusuall

34 pairs, it is not only possible to polymerize sterically demanding, functionalized as well as heteroat

35 oroacetimidate donor was used to achieve the sterically demanding glycosylation of the 5-OH group of

36 The effect of sterically demanding groups at proline residues on the c

37 stal structure of collagen revealed that the sterically demanding groups point to the outside of thes

38 The tolerability of the S3 subsite for sterically demanding groups that provide potency and sel

39 As predicted by the calculations, CoCp*2+, a sterically demanding guest, significantly inhibits guest

40 id state and in solution, demonstrating that sterically demanding, in some cases pi-donating, ligands

41 -5,6-quinone diimine) has been designed as a sterically demanding intercalator targeted to destabiliz

42 ts as the "door" which permits access of the sterically demanding intercalator to the base stack.

43 Sterically demanding intercalators such as [Rh(bpy)2(chr

44 The hydroaminoalkylation of sterically demanding internal alkenes gives the direct,

45 anar chiral azolium salts that incorporate a sterically demanding iron sandwich complex is now report

46 bserved in the crystal structure of the more sterically demanding isocyanide adduct, [Ni(CNCy)(PCy2NB

47 pe ligands due to the shielding of Pd(II) by sterically demanding JackiePhos, whereas smaller ligands

48 )/ketone systems even in the presence of the sterically demanding ligand HMPA.

49 These sterically demanding ligands also accelerated the additi

50 The search for extremely sterically demanding monodentate amide ligands to access

51 The recent development of three classes of sterically demanding, monodentate amide ligands - the m-

52 remarkable substrate scope and tolerance for sterically demanding motifs, including a new variant, wh

53 Sterically demanding Ni(II) alpha-diimine precatalysts w

54 With the more sterically demanding nitrosocarbonyl mesitylene and anth

55 In contrast, sterically demanding nucleophiles add to the inside of t

56 Sterically demanding nucleophiles such as the silyl enol

57 In general, sterically demanding olefins (DEDAM, styrene) and Grubbs

58 The key to high selectivity is the use of sterically demanding P-chiral diphosphines, such as Tang

59 ents of the S3 subsite by the use of various sterically demanding P3 substituents.

60 catalytic active site to accommodate highly sterically demanding polycyclic metallocycle transition

61 n about the Ir-C(aryl) bond, a result of the sterically demanding PONOP ligand.

62 pected because the reaction of the even more sterically demanding rac-2-fluoro-2-benzyl acetic acid p

63 plasma kallikrein, while it is rejected from sterically demanding residues present in loops of the ot

64 chemists will have at some point utilized a sterically demanding secondary amide (R2 N(-) ).

65 Sterically demanding secondary phosphine substituents (A

66 Sterically demanding silyl groups, especially those boun

67 g groups in the aromatic appendage and/or by sterically demanding silyl groups.

68 des with various structural motifs including sterically demanding substituents and ordinary functiona

69 The results show that sterically demanding substituents are tolerated in the c

70 c acids which include electron-releasing and sterically demanding substituents in the structure thus

71 itrogen are superior to tertiary amines with sterically demanding substituents on nitrogen in their a

72 Sterically demanding substituents positioned ortho and (

73 increases modestly with the incorporation of sterically demanding substituents such as [CMe(3)] or [S

74 a deeper understanding of the functioning of sterically demanding substituents.

75 electron-withdrawing, electron-donating, and sterically demanding substrate combinations.

76 reased enantioselectivity and activity for a sterically demanding substrate.

77 In particular, use of either sterically demanding substrates or amino acid derivative

78 ent with the enhanced reactivity of 3 toward sterically demanding substrates.

79 ficantly more accommodating than PTP1 toward sterically-demanding substrates.

80 yield highly symmetrical boxes, we find that sterically demanding subunits produce unusual twisted bo

81 veloped as an alternate approach to the most sterically demanding systems in this series.

82 y the ansa-cyclopentadienyl ligand where the sterically demanding tert-butyl substituents and the C2

83 A catalytic amount of base, a sterically demanding triarylphosphine ligand, and a phen

84 nce of potassium at a U, K site supported by sterically demanding tris(tert-butoxy)siloxide ligands i

85 lecular compounds stabilized by a variety of sterically demanding, very often chelating, organic liga

86 Sterically demanding, water-soluble alkylphosphines have

87 The more sterically demanding Z-alkenylboron species are obtained