ライフサイエンスコーパス: steroid

1 out being influenced by the chirality of the steroid.

2 ar inflammation that resolved with a topical steroid.

3 cophenolate mofetil-based regimen along with steroid.

4 Ozonation further removed the steroids.

5 upplying deficient ADAMTS13, with or without steroids.

6 en, reflect abnormal responsivity to ovarian steroids.

7 ons on both the A and D ring when converting steroids.

8 s by decreasing the koff rates of any of the steroids.

9 active autoimmune disease requiring systemic steroids.

10 , alphaalphaalpha-steranes, and monoaromatic steroids.

11 isol against a background of closely related steroids.

12 ), high doses of calcineurin inhibitors, and steroids.

13 differ in their cellular response to ovarian steroids.

14 P = 0.001) compared with those remaining on steroids.

15 cipants who filled prescriptions for topical steroids.

16 trol, despite lower dose maintenance inhaled steroids.

17 limus and mycophenolate mofetil with/without steroids.

18 imbalances in cortical levels of neuroactive steroids.

19 re elderly in CD and were on higher doses of steroids.

20 st international cohort of 108 patients with steroid 11beta-hydroxylase deficiency CAH.

21 ytochrome P450 (P450, CYP) 21A2 is the major steroid 21-hydroxylase, converting progesterone to 11-de

22 ustine (22% versus 0%; P < 0.001), high-dose steroids (57% versus 21%; P = 0.001), or purine analogs

23 Steroid 5alpha-reductase type 3 congenital disorder of g

24 Prolonged high-dose anabolic-androgenic steroid (AAS) use has been associated with psychiatric s

25 iduals have used illicit anabolic-androgenic steroids (AAS), but the long-term cardiovascular associa

26 abeling reagent and used to identify peptide-steroid adducts in MS1 spectra via the stable heavy isot

27 Peptide-steroid adducts were not identified in MS2-based databas

28 Osteoporosis induction in a sheep model by steroid administration combined with ovariectomy recapit

29 However, less is known about the effects of steroid administration in other types of muscular dystro

30 ge (PLEX; yes = PLEX(+) , no = PLEX(-) ) and steroids administration timing (prophylactically [proST]

31 cate that dosing frequency of glucocorticoid steroids affects muscle remodeling in non-Duchenne muscu

32 ay 10, whereas patients in arm 2 received no steroids after the intraoperative bolus.

33 tary, aqueous formulation of the neuroactive steroid, allopregnanolone.

34 report, we demonstrate that two cardiotonic steroids already in use in humans, digoxin and digitoxin

35 ctive axis is primarily regulated by gonadal steroid and circadian cues, but the starvation-sensitive

36 The steroid and the hydroxyarylmethylamino moieties are esse

37 e modify several natural products, including steroids and a vitamin E derivative, indicating the appl

38 thermore, this severe asthma is resistant to steroids and characterized by mixed TH2 and TH17 respons

39 he cytosol; 24 h exposure to arylmethylamino steroids and G6PD inhibitors revealed oxidation of mitoc

40 ; for combined first-line immunotherapy with steroids and intravenous immunoglobulins vs. late immuno

41 ndings, resolution was achieved with topical steroids and lubrication, whereas some patients who deve

42 Participants using long-term oral steroids and participants unable to be tested using spir

43 wn as 3alpha-androstanediol, are neuroactive steroids and positive GABAA receptor allosteric modulato

44 rious forms of ketones and aldehydes such as steroids and sugars.

45 e respiratory symptoms resistant to systemic steroids, and 1 patient died of severe interstitial lung

46 light on the mechanism of action of topical steroids, and demonstrates the critical role of endogeno

47 colitis include 5-aminosalicylic acid drugs, steroids, and immunosuppressants.

48 d that high viral load, receipt of high-dose steroids, and myeloablative conditioning were associated

49 High viral load, high-dose steroids, and myeloablative conditioning were associated

50 oms requiring either antibiotics or systemic steroids, and severe events by the need for hospitalizat

51 and patient out-of-pocket costs for topical steroids, and to model potential savings that could resu

52 reaction conditions, including beta-lactam-, steroid-, and sugar-derived ones, leading to desired qui

53 Cationic steroid antimicrobial 13 (CSA13) shares cationic nature

54 ular dystrophy are paradoxical because these steroids are also known to trigger muscle atrophy.

55 Steroids are polycyclic compounds that share tetracyclic

56 on to complex molecular architectures (e.g., steroids) are documented.

57 tic agents, we here identify arylmethylamino steroids as potent compounds and characterize more than

58 upports further investigation of neuroactive steroids as potential anticonvulsant compounds for refra

59 l organ involvement, or the ability to taper steroids, at 14, 28, and 56 weeks.

60 pable of lyase activity with the 17alpha-OOH steroids because it can achieve an appropriate conformat

61 G is predicted to have enzymatic function in steroid biosynthesis, cholesterol biosynthesis and thyro

62 Eight steroid bis-sulfates were synthesized in high purity in

63 ommon medications such as antihistamines and steroids can have undesirable long-term side-effects and

64 ntine perivascular enhancement responsive to steroids (CLIPPERS) is a central nervous system inflamma

65 comparable in size to those produced by the steroids clobetasol and dexamethasone.

66 Although steroid concentrations are low in Swiss rivers, the poss

67 copper and O2 promoted the hydroxylation of steroid-containing ligands.

68 A synthetic derivative of the cardiotonic steroid convallotoxin was even more potent than digoxin

69 heterogeneous catalysts for the synthesis of steroid derivatives, outperforming the bulk (Zr)UiO-66(N

70 ary glands when used with small doses of the steroid, dexamethasone, and promotes the tissue healing

71 To study how steroids directly affect the podocytes in the treatment

72 art of the International Consortium for Rare Steroid Disorders, we have diagnosed and followed the la

73 ed to increased odds of being able to reduce steroid dose by 50% or greater at 14 weeks.

74 ositive outcome associated with intermittent steroid dosing in LGMD 2B and 2C muscle.

75 Herein, we assessed the efficacy of steroid dosing on sarcolemmal repair, muscle function, h

76 l for clinical diagnostics and production of steroid drugs and insecticides.

77 Beyond steroids, effective treatment options are limited.

78 A third steroid, estrone (E1), also can occur at high concentrat

79 hed for gestational age, sex, race, prenatal steroid exposure, and delivery mode.

80 t controlling fertility and are regulated by steroid feedback.

81 The exploitation of pregnenolone steroid for benzoquinolines and terephthalaldehyde for b

82 ive patients (8%) were treated with systemic steroids for immune-related AEs.

83 To compare standard and frequent topical steroids for postsurgical macular edema (ME).

84 sociated lymphoid tissue (MALT) lymphoma and steroids for prolonged cough.

85 rimary outcome for this analysis was 3-month steroid-free clinical remission at 1 year after HSCT (Cr

86 therapy using a stringent primary endpoint (steroid-free clinical remission for 3 months with no end

87 At 1 year after HSCT, 3-month steroid-free clinical remission was seen in 13 (38%, 95%

88 ution of the most affordable generic topical steroid from the corresponding potency class may reduce

89 lt from substitution of the cheapest topical steroid from the corresponding potency class.

90 iastereoselective synthesis of cis and trans steroid-fulleropyrrolidines hybrids by reaction of N-met

91 he use of intravitreal of sustained-released steroid had not been mentioned to date.

92 eotide probes consist on anabolic androgenic steroid haptens (AAS) covalently linked to specifically

93 re, we demonstrate a key requirement for the steroid hormone 20-hydroxyecdysone (20E) in the maintena

94 at constitutively produce the salt-retaining steroid hormone aldosterone and cause millions of cases

95 of neuroblast proliferation/quiescence and a steroid hormone cue that is required for temporal transc

96 pressed glucocorticoid receptors (GRs), this steroid hormone has pleiotropic effects on many cell typ

97 rone (DHEA) is the most abundant circulating steroid hormone in humans, produced by the adrenals, the

98 x 10(-8)), implicating genes involved in sex steroid hormone pathways (FN1, CCDC170, ESR1, SYNE1 and

99 pared within the subgroups defined by cancer steroid hormone receptor status (ER and/or PR positive v

100 otein ZNF764 acts as an enhancer for several steroid hormone receptors, and haploinsufficiency of thi

101 tial mechanism leading to this dimorphism is steroid hormone regulated synthesis of transcripts encod

102 Therefore, we examined ovarian steroid hormone regulation of GPR64 expression in the mu

103 We investigated the role of steroid hormone signaling in the brain on distinct featu

104 r specific genes with important roles in sex steroid hormone signalling and function, and offer uniqu

105 Estradiol (E2) is a steroid hormone that negatively affects muscle growth in

106 The steroid hormone-activated glucocorticoid receptor (GR) r

107 lts indicate that short-term treatments with steroid hormones are sufficient to alter both Lep transc

108 nd songbirds is linked to the actions of sex steroid hormones during ontogeny but also in adulthood i

109 a new signaling pathway in the regulation of steroid hormones in the uterus, and to overcome P4 resis

110 esponsible for tissue resistance to multiple steroid hormones including glucocorticoids observed in a

111 Steroid hormones mediate critical lineage-specific devel

112 Steroid hormones produce adverse effects on biota as wel

113 Here, we explored whether steroid hormones to which human spermatozoa are exposed

114 ferred to clinically as corticosteroids) are steroid hormones with potent anti-inflammatory and immun

115 l plasticity is linked to the actions of sex steroid hormones, but the precise mechanisms are unclear

116 ity, with low levels of gonadotropic and sex steroid hormones, small testes or ovaries, impaired sper

117 The phenotype depends on sex-steroid hormones: dihydrotestosterone treatment of gonad

118 Among these steroids, however, only allopregnanolone (5-15 mg/kg, IP

119 demonstrates the critical role of endogenous steroid in maintaining both inflammatory and differentia

120 dly generate a potent anti-neuroinflammatory steroid in response to peripheral activation of the immu

121 estrogens, the occurrence and ecotoxicity of steroids in aquatic environments is poorly known.

122 ven the extensive involvement of neuroactive steroids in psychopathology, we hypothesized that the be

123 ate metabolites of seven anabolic-androgenic steroids in urine.

124 cognitive and behavioral effects of ovarian steroids in women, and may provide a neurogenetic framew

125 nsitivity and detection limit for all of the steroids included in the survey.

126 Here, we analyzed 33 steroids, including estrogens, androgens, progestins, an

127 Steroid-induced diabetes is the most common form of drug

128 yte-specific RANKL/OPG ratio showed that the steroid-induced osteoporosis in its late progressive pha

129 The steroid influences the spatial organization of GPCRs wit

130 L-22), and hormonal modulation including sex steroid inhibition and growth hormone administration.

131 and ovariectomy with dietary limitation and steroid injection.

132 ct infections and ovalbumin-induced, severe, steroid-insensitive allergic airway disease (SSIAAD) in

133 velop representative mouse models of severe, steroid-insensitive asthma and to use them to identify p

134 Steroid-insensitive asthma is associated with respirator

135 However, steroid-insensitive patients with eosinophil-enriched in

136 ith discrimination >95% achieved between the steroids investigated.

137 core scaffold, and selective detection of a steroid is challenging owing to their structural similar

138 of PLEX and (2) caution on the early use of steroids is suggested because their prophylactic use to

139 ith lack of compressive symptoms, a trial of steroids is worthwhile.

140 However, it is not known whether neuroactive steroid levels are abnormal at the extremes of the weigh

141 arian steroids, yet they appear with ovarian steroid levels indistinguishable from those in women wit

142 pitated either by an acute change in ovarian steroid levels or by stable levels above a critical thre

143 Steroid levels show variation among the RA patients acco

144 ations in 5alphaR isoenzymes and neuroactive steroid levels; then, we assessed whether the behavioral

145 models to understand the brain synthesis of steroids like estrogens and the implications for neurobi

146 Glucocorticoid steroids, like prednisone, are known to delay loss of am

147 Anabolic steroids marketed as bodybuilding supplements typically

148 uggesting that the intravitreal injection of steroid may benefit in certain patients.

149 RATIONALE: Sex steroids may play a role in plaque composition and in st

150 s FLS2 and BRI1, which activate immunity and steroid-mediated growth, respectively.

151 50 (P450, CYP) 17A1 plays a critical role in steroid metabolism, catalyzing both the 17alpha-hydroxyl

152 of multiple enzymes potentially involved in steroid metabolism.

153 ([M + 2Na - H](+)) of isobaric and coeluting steroid metabolites allowed their rapid (8 min) qualitat

154 gnal-to-noise ratios for the doubly sodiated steroid metabolites in unspiked urine (>250%) by the red

155 or additional tool for identification of the steroid metabolites is based on the observations of diff

156 Bis-sulfates of 23 steroid metabolites were synthesized and their MS behavi

157 strongly associated with decreased androgen steroid metabolites, with all reaching metabolome-wide s

158 ations, we present evidence that the ovarian steroid/Meth responsive cells in the MePD are necessary

159 ce that CNI-sparing/minimization strategies, steroid minimization or renin-angiotensin-aldosterone sy

160 Together these steroids modify the course of brain development by alter

161 Elucidating the cellular mechanisms by which steroids modulate brain development provides valuable in

162 First-line immunotherapy consisted of steroids (n = 61/74; 82%), intravenous immunoglobulins (

163 il count (EOS) in 36 patients with allergic, steroid-naive asthma and in 34 healthy controls.

164 The aim of this study was to assess whether steroid-naive asthma modulates hemostasis.

165 Even in subjects with mild steroid-naive asthma, differences in the bronchial micro

166 bronchial epithelial brushings from healthy, steroid-naive asthmatic and steroid-treated asthmatic su

167 One hundred twenty-seven steroid-naive children with the first severe wheezing ep

168 Neuroactive steroids (NAS) increased fluorescence of GABAAR expressi

169 ich could include ruxolitinib, chemotherapy, steroids, no treatment, or other standard interventions)

170 he ligand entry mechanism for members of the steroid nuclear hormone receptor family (androgen recept

171 odds ratio = 9.52; P = 0.001), and high-dose steroids (odds ratio = 5.05; P = 0.01) retained signific

172 roduction of highly functionalized synthetic steroids of varying substitution and stereochemistry rem

173 eroids were compared to those taking topical steroids only.

174 CAPT should be delayed if receiving systemic steroids or antihistamines.

175 ents requiring treatment [antibiotics and/or steroids or hospitalization] in the year before enrollme

176 0; 95% CI, 0.07-0.55) and more likely to use steroids (OR, 5.04; 95% CI, 1.91-13.31).

177 Anecdotal use of topical steroid oral prophylaxis has been reported in patients w

178 Patients' out-of-pocket spending for topical steroids over the same period was $333.7 million.

179 rences versus vehicle values were limited to steroids (P < .0001).

180 , and S100As) were similarly reduced only by steroids (P < .001).

181 Steroids (particularly clobetasol) restored epidermal hy

182 he establishment and sustained growth of the steroid pharmaceutical industry, the production of highl

183 Unlike benzodiazepines, neuroactive steroids potentiate a wider-range of GABAA receptors.

184 Most topical steroids prescribed were generic drugs.

185 recessive Mendelian disorder of aberrant sex steroid production.

186 n 2 (AF2) surfaces of both receptors driving steroid receptor co-activator-1 (SRC1) interaction.

187 rene-tolerant transcription factor (Met) and steroid receptor coactivator (SRC), would be expressed c

188 eciphered a previously unappreciated role of Steroid receptor coactivator 1 (SRC1) in defining the li

189 ement binding protein binding protein (CBP), steroid receptor coactivator 1 (SRC1), and protein argin

190 The steroid receptor coactivator 3 (SRC-3) is overexpressed

191 lpha), which requires co-activators, such as steroid receptor coactivator-1 (SRC-1), to facilitate th

192 sly shown that the transcriptional regulator steroid receptor coactivator-2 (SRC-2) controls activati

193 Estrogen receptor (ER) recruits steroid receptor coactivator-3 (SRC-3) primary coactivat

194 (20-45 min), p300 is recruited to ERalpha by steroid receptor coregulators (SRCs) for enhancer matura

195 However, steroid receptor ligand-binding domains (LBDs) are inher

196 We will review how steroid receptor-dependent genomic signaling is affected

197 ysis on the intranuclear dwell times of four steroid receptors and a number of known cofactors.

198 itin ligase function that targets, e.g., the steroid receptors for proteasomal degradation.

199 Therapy for steroid-refractory acute graft-versus-host disease (SR-a

200 limomab vs usual care in adult patients with steroid-refractory acute GVHD.

201 function links thrombotic microangiopathy to steroid-refractory graft-versus-host disease (GVHD) afte

202 er intragraft CYP3A5 mRNA levels compared to steroid-refractory patients (n = 42) in AR (P = 0.006).

203 ermittent, rather than daily, glucocorticoid steroid regimen promotes sarcolemmal repair and muscle r

204 ession of ESC/E(Z) complex genes (an ovarian steroid-regulated gene silencing complex) in untreated L

205 igin of acute respiratory distress syndrome, steroids, renal failure and need for vasopressors).

206 c airway inflammation, disease severity, and steroid resistance in human asthma correlate with NLRP3

207 Steroid resistance is dependent on fungus-induced TH17 r

208 b, and the STAT5 inhibitor pimozide reversed steroid resistance of BAL ILC2s.

209 We sought to assess steroid resistance of human blood and airway ILC2s from

210 fluid TSLP levels correlated (r = 0.74) with steroid resistance of ILC2s.

211 n (pSTAT) 3, and pSTAT5, molecules linked to steroid resistance.

212 tic patients with increased TSLP levels were steroid resistant, which was reversed by clinically avai

213 fferences between steroid-sensitive (SS) and steroid-resistant (SR) asthmatics.

214 Treatment of steroid-resistant acute graft-versus-host disease (GVHD)

215 r IL-27 significantly suppressed RSV-induced steroid-resistant airway hyperresponsiveness and airway

216 rophil depletion suppressed IL-1beta-induced steroid-resistant airway hyperresponsiveness.

217 nfection-mediated, ovalbumin-induced severe, steroid-resistant allergic airway disease.

218 The causes of steroid-resistant asthma are multifactorial and result f

219 RATIONALE: Severe, steroid-resistant asthma is the major unmet need in asth

220 d IL-1beta responses in experimental severe, steroid-resistant asthma were examined using a highly se

221 e NLRP3 inflammasome and IL-1beta in severe, steroid-resistant asthma.

222 oorly understood, and are unknown in severe, steroid-resistant asthma.

223 ys during airway inflammation and identify a steroid-resistant cascade of Wnt5a, Tgm2, and LTs, which

224 The underlying mechanisms associated with steroid-resistant exacerbations remain largely unknown.

225 pressed IL-1beta responses and the important steroid-resistant features of disease in mice, whereas I

226 s) play essential roles in the generation of steroid-resistant inflammation and AHR secondary to alle

227 Steroid-resistant nephrotic syndrome (SRNS) causes 15% o

228 Steroid-resistant nephrotic syndrome (SRNS), a heterogen

229 a primary adrenal insufficiency syndrome and steroid-resistant nephrotic syndrome caused by loss-of-f

230 Steroid-resistant nephrotic syndrome is characterized by

231 -term renal outcome in children with primary steroid-resistant nephrotic syndrome.

232 term outcome, respectively, in children with steroid-resistant nephrotic syndrome.

233 This is the first study in children with steroid-resistant NS who underwent kidney transplantatio

234 a large minority of patients with CRS have a steroid-resistant phenotype, identification of which wil

235 Production of IFN-gamma and IL-27 was steroid-resistant, and neutralization of IFN-gamma or IL

236 t association between Treg cells and skin or steroid response, whereas a larger increase in CD4+ coun

237 opment of asthma and may be eosinophilic and steroid-responsive or neurogenic and non- inflammatory.

238 Moreover, steroid-responsive patients (n = 64) expressed significa

239 Here we identify a steroid-responsive subset of neurotensin (Nts)-expressin

240 a diazirine in either the 7 position of the steroid ring (LKM38) or the aliphatic tail (KK174), we m

241 activated carbon, were analyzed to study the steroid's behavior during treatment.

242 o identify immunological differences between steroid-sensitive (SS) and steroid-resistant (SR) asthma

243 Collectively, these data demonstrate that steroid-sensitive mPOA neurons encode ethologically rele

244 n of airway hyperresponsiveness and restored steroid sensitivity to allergic airway disease.

245 ent on fungus-induced TH17 responses because steroid sensitivity was restored in IL-17rc(-/-) mice.

246 The synthetic neuroactive steroid SGE-516 is a potent positive allosteric modulato

247 li, thus providing mechanistic insights into steroid signaling in Drosophila ovulation.

248 including matrix metalloproteinases (Mmps), steroid signaling, and adrenergic signaling.

249 2) None of the genes related to steroid signaling, that are modulated in eutherian speci

250 d prednisolone, suggesting the potential for steroid sparing activity.

251 Steroid sparing was significant.

252 of gammaT supplements as a complementary or steroid-sparing treatment for asthma.

253 However, steroid specificity of ABHD2 has not been evaluated.

254 olyamine metabolites and decreased levels of steroids, sphingomyelins, and phosphatidylcholines disti

255 ysis of a small panel of clinically relevant steroids, spiked within various complex biological matri

256 Neuroactive steroids such as allopregnanolone may be potential thera

257 Glucocorticoid steroids such as prednisone are prescribed for chronic m

258 e of glucocorticoid (Gc) therapy; a class of steroids that are activating ligands for the glucocortic

259 dicare and out-of-pocket spending on topical steroids that is driven by higher costs for generics.

260 Glucocorticoids (GC) are the primary steroids that regulate inflammation and have been exploi

261 influence the response to antimicrobial and steroid therapies and the risk of lung infection.

262 treated effectively with aggressive topical steroid therapy and lubrication.

263 The patient was discharged and given steroid therapy for presumed IgG4-related disease.

264 Individuals receiving steroid therapy had significantly higher levels of Asper

265 rhea associated with combined antibiotic and steroid therapy in critically ill patients not fitting i

266 consistent evidence for the value of adding steroids to IVIG.

267 her a child's AD required the use of topical steroids, topical calcineurin inhibitors, or other medic

268 of the mesoporous SiO2 , is demonstrated for steroid transformations.

269 gs from healthy, steroid-naive asthmatic and steroid-treated asthmatic subjects.

270 els were higher in neutropenic versus CGD or steroid-treated lungs.

271 neither was detected in serum/BALF of CGD or steroid-treated mice.

272 ational follow-up of the Multicenter Uveitis Steroid Treatment (MUST) randomized clinical trial compa

273 The Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study was a

274 Conversely, weekly steroid treatment in mdx mice improved muscle function a

275 We compared weekly versus daily steroid treatment in mouse models of acute muscle injury

276 The positive effects of chronic steroid treatment in muscular dystrophy are paradoxical

277 ed genetic predisposition to the response to steroid treatment of acute allograft rejection.

278 V acute graft-versus-host disease related to steroid treatment shows a trend toward a protective effe

279 on with progressive symptoms despite ongoing steroid treatment.

280 PLEX and steroids treatment as time-dependent covariates were ent

281 nd after 2 weeks of systemic glucocorticoid (steroid) treatment to identify immunological differences

282 rse-effect profile than conventional topical steroid treatments or other medical or surgical therapie

283 osphere formulations encapsulating the model steroid triamcinolone acetonide (Tr-A) were implanted su

284 The women with PMDD manifested ovarian steroid-triggered behavioral sensitivity during a hormon

285 xamethasone and possibly contributing to the steroid-unresponsive nature of these eosinophilic patien

286 Higher steroid usage was noted in the CMV positive group compar

287 i-inflammatory drug (NSAID) added to topical steroid use after uncomplicated phacoemulsification for

288 s at HT (OR, 1.5; 95% CI, 1.0-2.19), chronic steroid use at HT (OR, 1.5; 95% CI, 1.0-2.2), and treatm

289 Chronic steroid use usually involves once-daily dosing, although

290 moking, hypertension, diabetes, and systemic steroid use.

291 tosterone concentrations since levels of the steroid were controlled by subcutaneous implants, thus s

292 Steroids were administered in 77.7% of patients.

293 topical NSAIDs filled in addition to topical steroids were compared to those taking topical steroids

294 17alpha-hydroperoxy (OOH) derivatives of the steroids were used as oxygen surrogates.

295 ids, with a relative concentration of 74.0%; steroids, with a relative concentration of 9.8%; and dit

296 renes, polycyclic aromatic hydrocarbons, and steroids, with subtle differences in the structure of su

297 , develop delayed graft function, or undergo steroid withdrawal.

298 active antibody, delayed graft function, and steroid withdrawal; in these groups, cytolytic induction

299 gs from substitution of the cheapest topical steroid within the corresponding potency class were $944

300 and stimulated by administration of ovarian steroids, yet they appear with ovarian steroid levels in