ライフサイエンスコーパス: steroid receptor coactivator

1 cancer and encodes a protein that acts as a steroid receptor coactivator.

2 interacts with LXXLL motifs (NR box) in p160 steroid receptor coactivators.

3 plicing in a manner differing from the other steroid receptor coactivators.

4 receptor beta (TRbeta) gene that cannot bind steroid receptor coactivator 1 (SRC-1) and Src-1(-/-) mi

5 gh inhibition of PR-dependent recruitment of steroid receptor coactivator 1 (SRC-1) and subsequent hi

6 e also demonstrate that UBCH7 interacts with steroid receptor coactivator 1 (SRC-1) and that UBCH7 co

7 cooperation of the coactivators CBP/p300 and steroid receptor coactivator 1 (SRC-1) and the p300/CBP-

8 nce analysis reveals that RAC3 is related to steroid receptor coactivator 1 (SRC-1) and transcription

9 xifen in the uterus requires a high level of steroid receptor coactivator 1 (SRC-1) expression.

10 Prominent in this diverse group is the steroid receptor coactivator 1 (SRC-1) family, which int

11 oic acid receptor, CREB-binding protein, and steroid receptor coactivator 1 (SRC-1) in cell transfect

12 Coactivation by steroid receptor coactivator 1 (SRC-1) of mCAR did not d

13 y less ability than dexamethasone to trigger steroid receptor coactivator 1 (SRC-1) recruitment and h

14 risk HPV type 16 (HPV16) E7 oncoprotein with steroid receptor coactivator 1 (SRC-1), an essential com

15 nterestingly, this domain corresponds to the steroid receptor coactivator 1 (SRC-1)-interacting domai

16 n disrupts the direct interaction of GR with steroid receptor coactivator 1 (SRC-1).

17 dynamics of estrogen receptor alpha (ER) and steroid receptor coactivator 1 (SRC-1).

18 pathways, we examined the phosphorylation of steroid receptor coactivator 1 (SRC-1).

19 d receptor-interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1).

20 2 (TIF2) and is also partially homologous to steroid receptor coactivator 1 (SRC-1).

21 coactivators, CREB-binding protein (CBP) and steroid receptor coactivator 1 (SRC-1, a member of the p

22 Coactivators, such as steroid receptor coactivator 1 (SRC-1A) and CREB (cAMP r

23 coid receptor interacting protein 1 (GRIP1), steroid receptor coactivator 1 (SRC-1a), and SRC-1e bind

24 eciphered a previously unappreciated role of Steroid receptor coactivator 1 (SRC1) in defining the li

25 tion, antibodies directed against the cloned steroid receptor coactivator 1 (SRC1) recognize ERAP160.

26 -dependent recruitment of a peptide from the steroid receptor coactivator 1 (SRC1) to the nuclear rec

27 iquitination greatly enhanced recruitment of steroid receptor coactivator 1 (SRC1), a coactivator cri

28 ement binding protein binding protein (CBP), steroid receptor coactivator 1 (SRC1), and protein argin

29 n and corresponds precisely with the minimal steroid receptor coactivator 1 (SRC1)-interacting domain

30 ion factor 1 and HNF3beta) all interact with steroid receptor coactivator 1 (SRC1).

31 Co-transfection with GRIP1 or steroid receptor coactivator 1 amplified both the positi

32 lular nuclear receptor coactivators, such as steroid receptor coactivator 1 and p300/CREB-binding pro

33 ARQ48 aggregates sequester mitochondria and steroid receptor coactivator 1 and stain positively for

34 Its competitive reversal of steroid receptor coactivator 1 enhancement of ER activit

35 ation of VDR with the coactivators GRIP1 and steroid receptor coactivator 1 in vitro but had little o

36 ed the transcriptional coactivators p300 and steroid receptor coactivator 1 less efficiently than ros

37 TCO-mediated interaction between CAR and the steroid receptor coactivator 1 or the glucocorticoid rec

38 D bound to DAC and the fourth LXXLL motif of steroid receptor coactivator 1 reveals that the GR ligan

39 ated the recruitment of TTF-1, p65, CBP, and steroid receptor coactivator 1 to the TBE region of the

40 Interestingly, the steroid receptor coactivator 1 together with ligand is a

41 by DAX-1, an SF-1 suppressor, and raised by steroid receptor coactivator 1, an SF-1 coactivator.

42 While all three coactivators ARA70, steroid receptor coactivator 1, and RAC3/ACTR can enhanc

43 ta in vitro and supported the recruitment of steroid receptor coactivator 1.

44 the ER interaction domain of the coactivator steroid receptor coactivator 1.

45 nd GW409544 and a coactivator motif from the steroid receptor coactivator 1.

46 s, transcriptional intermediary factor 2 and steroid receptor coactivator 1.

47 ch contains the nuclear receptor coactivator steroid receptor coactivator 1.

48 teraction of FXR with a peptide derived from steroid receptor coactivator 1.

49 CI, Gao and colleagues present evidence that steroid receptor coactivators 1 and 2 (SRC-1 and SRC-2)

50 Here, we evaluated the contribution of steroid receptor coactivators 1 and 2 (SRC-1 and SRC-2),

51 r, cotransfection of SNURF with prototypical steroid receptor coactivators 1, 2, and 3 that contain L

52 Also, coactivator binding studies with a steroid receptor coactivator-1 (receptor interaction dom

53 Steroid receptor coactivator-1 (SRC-1 or NCOA1) is overe

54 that includes the histone acetyltransferases steroid receptor coactivator-1 (SRC-1) and CREB binding

55 We previously isolated and identified steroid receptor coactivator-1 (SRC-1) and peroxisome pr

56 Steroid receptor coactivator-1 (SRC-1) and PPAR-binding

57 to interact with two other coactivators, the steroid receptor coactivator-1 (SRC-1) and the peroxisom

58 activated receptor binding protein (PBP) and steroid receptor coactivator-1 (SRC-1) are required for

59 mouse liver cDNA library and have identified steroid receptor coactivator-1 (SRC-1) as a PPAR transcr

60 These subclasses include members of the steroid receptor coactivator-1 (SRC-1) coactivator famil

61 25 amino acid residue fragment of the human steroid receptor coactivator-1 (SRC-1) containing one LX

62 In breast cancer, steroid receptor coactivator-1 (SRC-1) expression positi

63 Steroid receptor coactivator-1 (SRC-1) family members in

64 coactivators CREB-binding protein (CBP) and steroid receptor coactivator-1 (SRC-1) for maximal activ

65 tigated further the coactivator functions of steroid receptor coactivator-1 (SRC-1) in terms of its f

66 yzed roles of CREB-binding protein (CBP) and steroid receptor coactivator-1 (SRC-1) in TTF-1 regulati

67 Steroid receptor coactivator-1 (SRC-1) is a coactivator

68 Steroid receptor coactivator-1 (SRC-1) is a member of a

69 o part of the active receptor complex is the steroid receptor coactivator-1 (SRC-1) which interacts w

70 Steroid receptor coactivator-1 (SRC-1), a coregulatory p

71 Members of the p160 coactivator family (steroid receptor coactivator-1 (SRC-1), glucocorticoid r

72 hat interacts only with coactivators such as steroid receptor coactivator-1 (SRC-1), RU486-bound PR b

73 During the decade since the discovery of steroid receptor coactivator-1 (SRC-1), the first authen

74 lpha), which requires co-activators, such as steroid receptor coactivator-1 (SRC-1), to facilitate th

75 ude p300 and CREB-binding protein (CBP), the steroid receptor coactivator-1 (SRC-1)-related family of

76 ncluding CREB-binding protein (CBP/p300) and steroid receptor coactivator-1 (SRC-1).

77 n and can be partially overcome by exogenous steroid receptor coactivator-1 (SRC-1).

78 ires the involvement of coactivators such as steroid receptor coactivator-1 (SRC-1).

79 recently identified coactivators, including steroid receptor coactivator-1 (SRC-1).

80 entified in a number of coactivators such as steroid receptor coactivator-1 (SRC-1).

81 timulate receptor-dependent transcription is steroid receptor coactivator-1 (SRC-1).

82 rs recruit coactivator proteins, such as the steroid receptor coactivator-1 (SRC1).

83 corticosterone and the fourth LXXLL motif of steroid receptor coactivator-1 (SRC1-4).

84 r activator RNA 1 (SRA1) that is part of the steroid receptor coactivator-1 acetyltransferase complex

85 , nuclear receptor coactivators p300/CBP and steroid receptor coactivator-1 act individually as well

86 ACTR and related p160 family members (steroid receptor coactivator-1 and glucocorticoid recept

87 e interactions of hCAR with the coactivators steroid receptor coactivator-1 and glucocorticoid recept

88 rinsic activity of p160 coactivators such as steroid receptor coactivator-1 and promoted the interact

89 y between PBP and other coactivators such as steroid receptor coactivator-1 and that PBP plays a crit

90 ently identified to be highly related to the steroid receptor coactivator-1 and transcriptional inter

91 , transcriptional intermediate factor 2, and steroid receptor coactivator-1 are expressed in specific

92 e nuclear receptor interacting domain of the steroid receptor coactivator-1 as a model for exploring

93 and promoted the interaction between PR and steroid receptor coactivator-1 in a mammalian two-hybrid

94 Furthermore, coexpression of steroid receptor coactivator-1 is required for ligand-de

95 ypeptides in mammalian cells, along with the steroid receptor coactivator-1 protein (SRC-1).

96 ene and also remarkably reduces basal MR and steroid receptor coactivator-1 recruitment, unraveling a

97 GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXR

98 t insulin facilitated the recruitment of the steroid receptor coactivator-1 to the SREBP-1c promoter.

99 interaction with fatty acid metabolites and steroid receptor coactivator-1 while increasing PPARalph

100 ion of the complex between ERR gamma and the steroid receptor coactivator-1, and led to an inhibition

101 Multiple coactivators, including p300, steroid receptor coactivator-1, and p300/cAMP-response e

102 d to spironolactone, finerenone inhibits MR, steroid receptor coactivator-1, and RNA polymerase II bi

103 glucose increased PPARalpha interaction with steroid receptor coactivator-1, DNA binding, and transac

104 functional synergy of the p160 coactivators [steroid receptor coactivator-1, glucocorticoid receptor

105 to bind the IL-4 promoter in the presence of steroid receptor coactivator-1, indicating that PPARalph

106 element-binding protein-binding protein and steroid receptor coactivator-1, participate in both the

107 BD interacted with the C-terminal portion of steroid receptor coactivator-1, they did not enhance the

108 ion of the retinoid X receptor decreases the steroid receptor coactivator-1-dependent thyroid hormone

109 icoid-receptor-interactive protein-1(GRIP-1)/steroid-receptors coactivator-1 (SRC-1)) without breakin

110 ly of nuclear receptor coactivators, such as steroid receptor coactivator 1a and glucocorticoid recep

111 gate binding and dissociation of full-length steroid receptor coactivator-1a (SRC1a) from full-length

112 Herein, we demonstrate that Steroid Receptor Coactivator 2 (SRC-2) orchestrates a hi

113 of the oncogenic transcriptional coregulator steroid receptor coactivator 2 (SRC-2), also known as NC

114 rs that block the association of TRbeta with steroid receptor coactivator 2 (SRC2), we identified a n

115 ding between VDR and a fluorescently labeled steroid receptor coactivator 2 peptide was applied to di

116 corporated them into a sequence derived from steroid receptor coactivator 2, which interacts with est

117 ion between the vitamin D receptor (VDR) and steroid receptor coactivator 2.

118 t-binding protein (CREB)-binding protein and steroid receptor coactivators 2 and 3 was decreased in f

119 reviously demonstrated the potential role of steroid receptor coactivator-2 (SRC-2) as a co-regulator

120 sly shown that the transcriptional regulator steroid receptor coactivator-2 (SRC-2) controls activati

121 es and in HepG2 cells reduced recruitment of steroid receptor coactivator-2 by RORalpha at an endogen

122 Steroid receptor coactivator 3 (SRC-3) coactivator phosp

123 Steroid receptor coactivator 3 (SRC-3) is an oncogenic n

124 The steroid receptor coactivator 3 (SRC-3) is overexpressed

125 that ERK3 interacted with and phosphorylated steroid receptor coactivator 3 (SRC-3), an oncogenic pro

126 rect interaction of the liganded TRbeta with steroid receptor coactivator 3 (SRC-3), which recruits p

127 Steroid receptor coactivator 3 (SRC-3/AIB1) interacts wi

128 Steroid receptor coactivator 3 (SRC-3/AIB1/ACTR/NCoA-3)

129 e of an active complex of DNA-bound ERalpha, steroid receptor coactivator 3 (SRC-3/NCOA3), and a seco

130 Steroid receptor coactivator 3 (SRC-3/p/CIP/AIB1/ACTR/RA

131 as a model, we have investigated the role of steroid receptor coactivator 3 (SRC3) in gene activation

132 Here, we report that the ER coactivator steroid receptor coactivator 3 (SRC3) is also a coactiva

133 We have previously shown that steroid receptor coactivator 3 (SRC3) is expressed and u

134 enced by histone acetylation and require the steroid receptor coactivator 3 (SRC3), which mediates in

135 ctivation of gene expression was enhanced by steroid receptor coactivator 3 coactivator, and required

136 The steroid receptor coactivator 3 gene (SRC-3) (AIB1/ACTR/p

137 ied in breast cancer 1 (AIB1), also known as steroid receptor coactivator 3 or NCOA3, is a transcript

138 parate assays, both the recruitment of SRC3 (steroid receptor coactivator 3, a transcriptional coacti

139 gh-throughput screening to identify SMIs for steroid receptor coactivator-3 (SRC-3 or AIB1), a large

140 Here we demonstrate that reprogramming steroid receptor coactivator-3 (SRC-3) function by chang

141 Molecular Cell, Yu et al. reported that the steroid receptor coactivator-3 (SRC-3) has a novel cytop

142 ctivator amplified in breast cancer 1 (AIB1)/steroid receptor coactivator-3 (SRC-3) have been shown t

143 ent study aimed to elucidate the role of the steroid receptor coactivator-3 (SRC-3) in thyroid carcin

144 oncogene amplified in breast cancer 1 (AIB1)/steroid receptor coactivator-3 (SRC-3) induces mammary t

145 Steroid receptor coactivator-3 (SRC-3) is a coactivator

146 Here, we show that the oncogenic steroid receptor coactivator-3 (SRC-3) is a critical reg

147 Steroid receptor coactivator-3 (SRC-3) is a histone acet

148 Steroid receptor coactivator-3 (SRC-3) is a transcriptio

149 Phosphorylation and activity of the Steroid Receptor Coactivator-3 (SRC-3) is reduced upon H

150 Estrogen receptor (ER) recruits steroid receptor coactivator-3 (SRC-3) primary coactivat

151 We report here the characterization of steroid receptor coactivator-3 (SRC-3), a coactivator of

152 y also caused a failure in downregulation of steroid receptor coactivator-3 (SRC-3), a potent ERalpha

153 Steroid receptor coactivator-3 (SRC-3)/AIB1 is a member

154 The steroid receptor coactivator-3 (SRC-3, also known as pCI

155 Steroid receptor coactivator-3 (SRC-3, p/CIP, AIB1, ACTR

156 Steroid receptor coactivator-3 (SRC-3/AIB1) is a coactiv

157 Steroid receptor coactivator-3 (SRC-3/AIB1) is an oncoge

158 sphorylated alternate-spliced isoform of the steroid receptor coactivator-3 (SRC-3Delta4) bridges EGF

159 d crystallographic studies, we identify that steroid receptor coactivator-3 (SRC3) (also named as amp

160 exes did not readily recruit the coactivator steroid receptor coactivator-3 (SRC3) or ER to the PS2 p

161 ociated with the displacement of ERalpha and steroid receptor coactivator-3 from the target EBRs lead

162 shown that TR recruits the coactivator SRC3 (steroid receptor coactivator-3) and that coactivator rec

163 ceptor-associated coactivator 3 (RAC3)/AIB-1/steroid receptor coactivator-3, a nuclear coregulator an

164 Amplified in breast cancer 1 (AIB1; steroid receptor coactivator-3, p/CIP, RAC3, ACTR, TRAM-

165 Overexpression of the p160 steroid receptor coactivator ACTR is associated with bre

166 or CBP and the activation domain of the p160 steroid receptor coactivator ACTR.

167 R function by selectively competing with the steroid receptor coactivator AIB1 but not GRIP1 or SRC1

168 Overexpression and activation of the steroid receptor coactivator amplified in breast cancer

169 The steroid receptor coactivator amplified in breast cancer

170 eroid receptors, it has been identified as a steroid receptor coactivator, and was thought not to be

171 enotypes indicate that these two families of steroid receptor coactivators are not functionally equiv

172 sferase (HAT) domain, EIA-binding domain and steroid-receptor coactivator binding domains of CBP.

173 We show here that AIB1 and other steroid receptor coactivators can enhance the functional

174 xes, DRIP (VDR-interacting protein) and SRC (steroid receptor coactivator), during keratinocyte diffe

175 or complex disassembly by methylation of the steroid receptor coactivator family coactivators and p30

176 human breast tumors and belongs to the p160 steroid receptor coactivator family.

177 Both SRC-1 and TIF2 are members of the p160 steroid receptor coactivator family.

178 coactivators such as PBP and members of the steroid receptor coactivator family.

179 d coactivator 3 (RAC3), which belongs to the steroid receptor coactivator family.

180 ominent among these coactivators is the SRC (steroid receptor coactivator) family, which consists of

181 refore, SRC-3, a third member of a family of steroid receptor coactivators, has a distinct tissue dis

182 Currently, steroid receptor coactivators have been proposed to medi

183 a novel function of Cdc25B that serves as a steroid receptor coactivator in addition to its role as

184 To explore a possible role of steroid receptor coactivators in transcriptional synergi

185 the most active members inhibit the ERalpha/steroid receptor coactivator interaction with K i's in t

186 ty and the C-terminal region (containing the steroid receptor coactivator/p160-binding region and the

187 s induced by GR signaling, and the important steroid receptor coactivator PELP1 was also found to be

188 (Pol II), estrogen receptor alpha (ERalpha), steroid receptor coactivator proteins (SRC), and acetyla

189 een the AR N and C termini or recruitment of steroid receptor coactivator proteins (SRC-1 or -2), alt

190 In contrast, the steroid receptor coactivator SRC-1 increases transcripti

191 stant patients showed high expression of the steroid receptor coactivator SRC-1.

192 ctivator REGgamma directs degradation of the steroid receptor coactivator SRC-3 by the 20S proteasome

193 ctivator REGgamma directs degradation of the steroid receptor coactivator SRC-3 by the 20S proteasome

194 rence (RNAi) depletions of CYC, MET, and the steroid receptor coactivator SRC/FISC.

195 in the recruitment of RNA polymerase II and steroid receptor coactivators SRC-2 and SRC-3, and chang

196 The steroid-receptor coactivator SRC-1 is a coactivator for

197 ne (JH) receptor, Methoprene-tolerant (Met), steroid receptor coactivator (SRC) and GATAa but not ecd

198 tivators, VDR-interacting protein (DRIP) and steroid receptor coactivator (SRC) at different stages o

199 invasion, and metastasis, including the p160 steroid receptor coactivator (SRC) family composed of SR

200 The recently identified steroid receptor coactivator (SRC) family contains three

201 ne receptor (TR) include members of the p160/steroid receptor coactivator (SRC) family of proteins, p

202 ied of these coactivators are members of the steroid receptor coactivator (SRC) family, SRC-1, TIF2/G

203 other VDR coactivators such as those in the steroid receptor coactivator (SRC) family.

204 The steroid receptor coactivator (SRC) proteins are coactiva

205 the bHLH transcription factors studied, the steroid receptor coactivator (SRC) showed the most sever

206 cetyltransferase complexes, such as p300/CBP-steroid receptor coactivator (SRC), as well as the multi

207 rene-tolerant transcription factor (Met) and steroid receptor coactivator (SRC), would be expressed c

208 Genetic disruption of the steroid receptor coactivator (SRC)-1 and transcriptional

209 The steroid receptor coactivator (SRC)-1 enhances the activi

210 lencing mediator for retinoid and thyroid or steroid receptor coactivator (SRC)-1 with RARalpha versu

211 OOH-terminal interaction and are enhanced by steroid receptor coactivator (SRC)-1, whereas the bicalu

212 gamma) regulate bone metabolism, and because steroid receptor coactivator (SRC)-2 (TIF-2) enhances ER

213 Steroid receptor coactivator (SRC)-3, also called amplif

214 phosphorylation signaling pathway involving steroid receptor coactivator (Src)-mitogen-activated pro

215 eraction domains of p300/CBP, as well as the steroid receptor coactivator (SRC).

216 ne receptors involves the recruitment of the steroid receptor coactivator (SRC)/p160 coactivator LXXL

217 R FXXLF motif binding and the recruitment of steroid receptor coactivator (SRC)/p160 coactivator LXXL

218 further dissect the roles of members of the steroid receptor coactivator (SRC)/p160 family in PR-med

219 eam target of progesterone receptor (PR) and steroid receptor coactivator (SRC-1) action in the uteru

220 Both PXR and the steroid receptor coactivator (SRC-1) were found to bind

221 growth pathways on which cancer cells rely, steroid receptor coactivators (SRC-1, SRC-2, and SRC-3)

222 The three members of the p160 family of steroid receptor coactivators (SRC-1, SRC-2, and SRC-3)

223 interplay and demonstrated that it requires steroid receptor coactivators (SRC-2, SRC-3) and the med

224 rect interactions with full-length ER or the steroid receptor coactivator, SRC-1.

225 ray by immunofluorescence were two different steroid receptor coactivators (SRC1 and CBP) with acetyl

226 gate functional relationships between PR and steroid receptor coactivators (SRCs) in distinct cell ty

227 Thus far, a mechanistic role for steroid receptor coactivators (SRCs) in the progression

228 Steroid receptor coactivators (SRCs) regulate nuclear re

229 The p160 steroid receptor coactivators (SRCs) SRC-1, SRC-2 [nucle

230 Most nuclear receptors recruit steroid receptor coactivators (SRCs) to their ligand bin

231 cription factors, and their association with steroid receptor coactivators (SRCs) upon binding to DNA

232 ase 1 (CARM1/PRMT4) binds the p160 family of steroid receptor coactivators (SRCs).

233 rmone-dependent interaction with a family of steroid receptor coactivators (SRCs).

234 AR and its steroid receptor coactivators (SRCs; SRC-1, -2 and -3) w

235 The role of steroid receptor coactivators such as AIB1 in breast can

236 ranscription that is a member of a family of steroid receptor coactivators that includes SRC-1 and tr

237 ry gland development observed previously for steroid receptor coactivator type 1 (SRC-1) and SRC-3 fe

238 The in vivo biological function of a steroid receptor coactivator was assessed in mice in whi

239 SRC-3/AIB1 is a steroid receptor coactivator with potent growth-promotin

240 ruitment of yellow fluorescent protein (YFP)-steroid receptor coactivators (YFP-SRC-1 and YFP-CREB bi