ライフサイエンスコーパス: steroidal

1 Abiraterone, a steroidal 17alpha-hydroxylase/17,20-lyase (CYP17A1) inhi

2 Two additional subclasses were prepared: bis(steroidal)-4,7-ACQ derivatives and bis(4,7-ACQ)cholate d

3 ty and is structurally similar to endogenous steroidal 5alpha-reductase substrates, such as testoster

4 oline (HHII) scaffold as a surrogate for the steroidal A-B ring system is described.

5 ucocorticoid receptor antagonism by studying steroidal active antagonists such as RU-38486 (1).

6 an 100 Food and Drug Administration-approved steroidal agents are prescribed daily for indications in

7 products, are glycosides of triterpenoid or steroidal aglycones (sapogenins).

8 onally defined a novel pharmacophore for the steroidal agonist site.

9 even the best clinically approved synthetic steroidal agonists are prone to cross-reactivity and off

10 Compared with steroidal agonists for the androgen receptor (AR) (e.g.

11 Steroidal alkaloid analysis employed silica gel-coated T

12 A steroidal alkaloid batrachotoxin (BTX) causes persistent

13 terribilis frogs sequester lethal amounts of steroidal alkaloid batrachotoxin (BTX) in their skin as

14 terpenoid found in apples) and tomatidine (a steroidal alkaloid derived from green tomatoes).

15 -Cortistatin A (dCA), an analog of a natural steroidal alkaloid from a marine sponge, inhibits Tat-me

16 Batrachotoxin (BTX), a steroidal alkaloid, and pyrethroid insecticides bind to

17 fic tropane (l-hyoscyamine, scopolamine) and steroidal alkaloids (alpha-solanine, alpha-chaconine) in

18 Batrachotoxins are neurotoxic steroidal alkaloids first isolated from a Colombian pois

19 resin acids, mefenamic acid, oxybenzone, and steroidal alkaloids in the bile or plasma, and there wer

20 samples of 2 and 3 with those of appropriate steroidal analogues [e.g., petromyzonol sulfate (PS, 1,

21 e a less detrimental effect on bone than non-steroidal anastrozole.

22 Systemic therapy includes steroidal and non-steroidal anti-inflammatory agents, di

23 This first comparison of steroidal and nonsteroidal classes of aromatase inhibito

24 ophore that, over some 20 years, have led to steroidal and nonsteroidal drugs in numerous preclinical

25 al function and the electronic properties of steroidal and nonsteroidal estrogens by analysis of the

26 new rational template for drug discovery of steroidal and nonsteroidal glucocorticoids that can be s

27 d work to date underlying the development of steroidal and nonsteroidal receptor ligands, including t

28 In this study, we show that although the steroidal and nonsteroidal SERDs target ERalpha for degr

29 The LBD responds to classic steroidal and nonsteroidal small ligands; both may selec

30 We describe two structurally similar 4-aza-steroidal androgen receptor (AR) ligands, Cl-4AS-1, a fu

31 We report the synthesis of novel steroidal androgen receptor ligands comprising 11beta-al

32 Although steroidal antagonists such as spironolactone and epleren

33 The non-steroidal anti-androgen bicalutamide may offer an equiva

34 Alcohol, exercise or non-steroidal anti-inflamatory drugs (NSAID) are frequently

35 netic pathway and uniquely revealed that non-steroidal anti-inflammatories (NSAIDs) rank just as high

36 ant concentrations of ibuprofen (IBF), a non-steroidal anti-inflammatory agent and prevalent environm

37 e-1IC50/anti-cyclooxygense-2IC50>1) than non-steroidal anti-inflammatory agent ibuprofen (0.44) descr

38 rugs can easily be conjugated to another non-steroidal anti-inflammatory agent, leading to easy synth

39 Non-steroidal anti-inflammatory agents (NSAIDs) are associat

40 ocognitive sequelae from irradiation and non-steroidal anti-inflammatory agents can restore neurogene

41 Non-steroidal anti-inflammatory agents inhibit the productio

42 Systemic therapy includes steroidal and non-steroidal anti-inflammatory agents, disease-modifying ag

43 Treatment is with non-steroidal anti-inflammatory agents, four to six weeks of

44 urogenesis through the administration of non-steroidal anti-inflammatory agents.

45 s currently on the market, including the non-steroidal anti-inflammatory blockbuster drug celecoxib.

46 Define the effectiveness of a topical non-steroidal anti-inflammatory drug (NSAID) added to topica

47 Treatment with a NO-donating non-steroidal anti-inflammatory drug (NSAID) alleviates this

48 se (GERD), Barrett's esophagus (BE), and non-steroidal anti-inflammatory drug (NSAID) bleeding prophy

49 The unprecedented polymorphism of the non-steroidal anti-inflammatory drug (NSAID) flufenamic acid

50 In the non-steroidal anti-inflammatory drug (NSAID) group, patients

51 Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that independen

52 ow that inhibition of endogenous PGE2 by non-steroidal anti-inflammatory drug (NSAID) treatment in mi

53 Non-steroidal anti-inflammatory drug (NSAID) treatment suppr

54 h or standard doses compared with remote non-steroidal anti-inflammatory drug (NSAID) use or celecoxi

55 mine-gallic acid hybrid molecule against non-steroidal anti-inflammatory drug (NSAID)-induced gastrop

56 The non-steroidal anti-inflammatory drug aspirin and its metabol

57 Tolfenamic acid (TA) is a non-steroidal anti-inflammatory drug associated with anti-tu

58 t unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen.

59 investigated potential therapy with the non-steroidal anti-inflammatory drug ibuprofen.

60 The non-steroidal anti-inflammatory drug sulindac decreases size

61 Flufenamic acid (FFA) is a non-steroidal anti-inflammatory drug that has been long used

62 Pretreatment with the non-steroidal anti-inflammatory drug, 2-cyano-3,12-dioxoolea

63 lumiracoxib (59 events [0.65%]) and the non-steroidal anti-inflammatory drugs (50 events [0.55%]; ha

64 ations was 1.09% (95% CI 0.82-1.36) with non-steroidal anti-inflammatory drugs (64 events) versus 0.2

65 Aspirin and other non-steroidal anti-inflammatory drugs (NSAID) probably decre

66 ose and regularity of aspirin use, other non-steroidal anti-inflammatory drugs (NSAID), and the effec

67 Certain non-steroidal anti-inflammatory drugs (NSAIDs) (e.g., rofeco

68 that underlie the antitumour activity of non-steroidal anti-inflammatory drugs (NSAIDs) against color

69 Non-steroidal anti-inflammatory drugs (NSAIDs) are among the

70 Non-steroidal anti-inflammatory drugs (NSAIDs) are among the

71 2 selective inhibitors and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) are associate

72 Non-steroidal anti-inflammatory drugs (NSAIDs) are known gam

73 Non-steroidal anti-inflammatory drugs (NSAIDs) are used to m

74 As an additional pharmacologic approach, non-steroidal anti-inflammatory drugs (NSAIDs) can reduce gi

75 Non-steroidal anti-inflammatory drugs (NSAIDs) damage the ga

76 selective inhibitors versus traditional non-steroidal anti-inflammatory drugs (NSAIDs) has not been

77 Zinc chelation and non-steroidal anti-inflammatory drugs (NSAIDs) have been exp

78 for reducing gastrointestinal effects of non-steroidal anti-inflammatory drugs (NSAIDs) have been sub

79 Non-steroidal anti-inflammatory drugs (NSAIDs) have been wid

80 Previous studies have shown that non-steroidal anti-inflammatory drugs (NSAIDs) have signific

81 sis (FASS) for the determination of five non-steroidal anti-inflammatory drugs (NSAIDs) in bovine mil

82 Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclo

83 Topically administered non-steroidal anti-inflammatory drugs (NSAIDs) inhibit perio

84 trials demonstrate that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) markedly redu

85 opreventive effect for aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) on colorectal

86 inically important errors: non-selective non-steroidal anti-inflammatory drugs (NSAIDs) prescribed to

87 Nitric oxide (NO)-donating non-steroidal anti-inflammatory drugs (NSAIDs) represent a p

88 Furthermore, topical application of non-steroidal anti-inflammatory drugs (NSAIDs) significantly

89 Non-steroidal anti-inflammatory drugs (NSAIDs) use in the ye

90 Interestingly, the use of non-steroidal anti-inflammatory drugs (NSAIDs) was not assoc

91 respectively), while anti-infectives and non-steroidal anti-inflammatory drugs (NSAIDs) were frequent

92 Activity clustering showed that non-steroidal anti-inflammatory drugs (NSAIDs) were signific

93 statin drugs, low-dose aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs), and even fis

94 al trials have suggested that the use of non-steroidal anti-inflammatory drugs (NSAIDs), including as

95 Both the use of non-steroidal anti-inflammatory drugs (NSAIDs), such as indo

96 Non-steroidal anti-inflammatory drugs (NSAIDs), the most wid

97 reasing prevalence of individuals taking non-steroidal anti-inflammatory drugs (NSAIDs), there is con

98 of these drugs compared with traditional non-steroidal anti-inflammatory drugs (NSAIDs).

99 nsteroidal anti-inflammatory drugs (NSAIDs), steroidal anti-inflammatory drugs (SAIDs), immunosuppres

100 gs in four therapeutic areas: analgesia (non-steroidal anti-inflammatory drugs [NSAIDs]), diabetes (m

101 This might be a result of the use of non-steroidal anti-inflammatory drugs and rheumatoid agents

102 Although Helicobacter pylori and use of non-steroidal anti-inflammatory drugs are common causes, dem

103 optimal, but combinations of opioids and non-steroidal anti-inflammatory drugs are helpful.

104 tive blood loss after tonsillectomy when non-steroidal anti-inflammatory drugs are used.

105 Non-steroidal anti-inflammatory drugs are widely used for th

106 t individuals taking aspirin and related non-steroidal anti-inflammatory drugs have reduced risk of l

107 Non-steroidal anti-inflammatory drugs inhibit PG synthesis v

108 lation of serine 121 in cells exposed to non-steroidal anti-inflammatory drugs leads to HSP90 dissoci

109 ve consistently demonstrated that common non-steroidal anti-inflammatory drugs may protect against th

110 A subset of non-steroidal anti-inflammatory drugs modulates the gamma cl

111 vity by the administration of PTH and/or non-steroidal anti-inflammatory drugs or COX-2 selective inh

112 e of such therapies precluded the use of non-steroidal anti-inflammatory drugs or other enzyme inhibi

113 ics, antimotility agents, narcotics, and non-steroidal anti-inflammatory drugs should not be given to

114 statin, antihypertensive medications and non-steroidal anti-inflammatory drugs therapy) as well as 4

115 Selective COX-2 inhibitors are non-steroidal anti-inflammatory drugs which directly target

116 ion in ulcer complications compared with non-steroidal anti-inflammatory drugs without an increase in

117 nesthetics, ketamine, acetaminophen, and non-steroidal anti-inflammatory drugs) analgesic drugs can m

118 diuretics, antivirals, methotrexate, and non-steroidal anti-inflammatory drugs) is organic anion tran

119 tack therapies (eg, simple analgesics or non-steroidal anti-inflammatory drugs) or specific agents wi

120 Unlike antipyretic non-steroidal anti-inflammatory drugs, APAP elicits hypother

121 omplications compared with non-selective non-steroidal anti-inflammatory drugs, but evidence is limit

122 and analgesic properties to traditional non-steroidal anti-inflammatory drugs, but with significantl

123 cancer, and is a key molecular target of non-steroidal anti-inflammatory drugs, compounds that reduce

124 Other agents, such as aspirin, other non-steroidal anti-inflammatory drugs, COX-2 inhibitors, ret

125 tments have been suggested, ranging from non-steroidal anti-inflammatory drugs, drugs for neuropathic

126 ecretase modulators (GSMs), such as some non-steroidal anti-inflammatory drugs, is a promising therap

127 n pharmacotherapies, which have included non-steroidal anti-inflammatory drugs, must take into accoun

128 inhibitor lumiracoxib compared with two non-steroidal anti-inflammatory drugs, naproxen and ibuprofe

129 d PUD was associated with current use of non-steroidal anti-inflammatory drugs, oral steroids or acid

130 In this study we evaluate the effect of non-steroidal anti-inflammatory drugs, such as indomethacin

131 d placebo-controlled trials, traditional non-steroidal anti-inflammatory drugs, such as naproxen, dic

132 Non-steroidal anti-inflammatory drugs, which inhibit the cyc

133 s the principal target for the action of non-steroidal anti-inflammatory drugs.

134 a target for the development of specific non-steroidal anti-inflammatory drugs.

135 ioselective oxidation of several anionic non-steroidal anti-inflammatory drugs.

136 esults against gastric damage induced by non-steroidal anti-inflammatory drugs.

137 he potential role of these drugs as oral non-steroidal anti-inflammatory therapy for asthma and COPD

138 double endocrine targeting approach with the steroidal anti-oestrogen fulvestrant in combination with

139 therapy merits discussion as an alternative; steroidal antiandrogen monotherapy should not be offered

140 Cyproterone acetate (CPA) is a steroidal antiandrogen used clinically in the treatment

141 rapy may be discussed as an alternative, but steroidal antiandrogens should not be offered as monothe

142 tained within this class of molecules is the steroidal antiestrogen ICI182,780 (faslodex), recently a

143 cleavage of all its substrates, certain non-steroidal antiinflammatory drugs (NSAIDs) have been show

144 nd isolates at 100 mug/mL was similar to non-steroidal antiinflammatory drugs aspirin, ibuprofen and

145 ablished anticoagulants like heparin and non-steroidal antiinflammatory drugs may have a solid basis.

146 he polycyclic domain of advanced and complex steroidal architectures.

147 To compare time to progression (TTP) with a steroidal aromatase inhibitor (AI) atamestane (ATA) comb

148 double-blind clinical trial to evaluate the steroidal aromatase inhibitor exemestane as extended adj

149 omised trial that compared the switch to the steroidal aromatase inhibitor exemestane with continuati

150 e) Flutamide + ATD (androgen antagonist plus steroidal aromatase inhibitor); or (f) dihydrotestostero

151 Exemestane, a steroidal aromatase inhibitor, reduced invasive breast c

152 ive breast cancer that has progressed on non-steroidal aromatase inhibitors (NSAIs) is unclear.

153 serves bone in postmenopausal women, but non-steroidal aromatase inhibitors accelerate bone loss and

154 renders the beta-clamshell structure of this steroidal bile acid transport protein unfolded.

155 LCA is an endogenous steroidal bile acid, variously reported to have both car

156 Previous work has shown that certain steroidal bis-(N-phenyl)ureas, derived from cholic acid,

157 ails of the structure determination of these steroidal bis-sulfates [petromyzosterol disulfate (PSDS,

158 New chemical entities, steroidal C-17 benzoazoles (5, 6, 9 and 10) and pyrazine

159 t of diosgenin and several structure-related steroidal compounds on the growth of faecal anaerobes is

160 nal theory (DFT) calculations to suggest non-steroidal compounds selective for CYP17A1.

161 ns of mixtures of laser dyes and mixtures of steroidal compounds were performed to illustrate the cap

162 ost important phase II metabolic reaction of steroidal compounds.

163 e two species' spores respond differently to steroidal compounds.

164 gordonii and found to have homologies to the steroidal core of cardiac glycosides.

165 The ability to quickly set this steroidal core with preinstalled functional handles and

166 electivity and fewer side effects than their steroidal counterparts.

167 1,3-Dienes derived from steroidal D-ring C 17-ketones undergo Ni(II)-catalyzed h

168 The stereoselective construction of C20 in steroidal derivatives by a highly diastereoselective Ir-

169 Bile salts act as steroidal detergents in the gut, and could also interact

170 Steroidal dexamethasone is as effective as non-steroidal

171 , fast, and reliable biochemical read out of steroidal drug pharmacodynamics could enable a rapid and

172 We found that many steroidal drugs (such as dexamethasone and cortisone) an

173 rmones testosterone and estradiol as well as steroidal drugs.

174 straightforward access to geometrically pure steroidal enol tosylate and enol triflate intermediates

175 d applications include allylic oxidations of steroidal enones.

176 These results show that beta-LGND2, a non-steroidal ERbeta selective agonist, could be a useful th

177 halogenated estrogens made up 60-70% of the steroidal estrogen load on a molar basis.

178 Four steroidal estrogens (17beta-estradiol, estrone, estriol,

179 n in vitro ER activity and concentrations of steroidal estrogens after correcting for the in vitro po

180 Steroidal estrogens are potent endocrine-disrupting chem

181 tion reagents to enhance the sensitivity for steroidal estrogens in liquid chromatography electrospra

182 The biological function of steroidal estrogens is related to their electronic prope

183 tipes) were exposed to solutions of singular steroidal estrogens or to the estrogenic extract of an a

184 Of the hormone analytes, steroidal estrogens were more abundant than androgens or

185 Phytoestrogens were often more abundant than steroidal estrogens, but contributed minimally toward to

186 t known to increase in vivo potency in other steroidal estrogens, into the (17alpha,20E)-21-(trifluor

187 ed site-specific C-H oxyfunctionalization of steroidal ethers with periodate or bromate as terminal o

188 ed 1,2-dioxines along with a 1,3-dialkyl and steroidal example, with yields ranging from moderate to

189 bitors (AIs) letrozole, anastrozole, and the steroidal exemestane were approved in the U.S. in the la

190 nonsteroidal (letrozole and anastrozole) and steroidal (exemestane) aromatase inhibitors may allow tr

191 ar affinity towards other hormones of the E2 steroidal family and excellent discrimination against po

192 ng squaramide groups in axial positions on a steroidal framework.

193 tors 7E and 7Z, consisting of two androstane steroidal frameworks linked by the D rings by triple bon

194 The steroidal glucocorticoid antagonist mifepristone has bee

195 atory drugs may offer a safer alternative to steroidal glucocorticoids in the treatment of inflammato

196 cs in wild tomato unreveal potential role of steroidal glyco-alkaloids and phenylpropanoids during ea

197 of both acetylcholinesterase activity and a steroidal glycoalkaloid with anticholinesterase activity

198 d from alpha-tomatine, an anticholinesterase steroidal glycoalkaloid.

199 triggered metabolic changes were active from steroidal glycol-alkaloid (SGA), lignin and flavonoid bi

200 A steroidal glycoside with anorectic activity in animals,

201 h as vitamin D analogs and various antitumor steroidal glycosides.

202 had a profile similar to that of a classical steroidal GR agonist.

203 Trenbolone acetate (TBA) is a high-value steroidal growth promoter often administered to beef cat

204 ceptors in lung cancer progression, and this steroidal growth-stimulatory pathway may be promoted by

205 ounds-all of which are spiroketal-containing steroidal heterodimers-that inhibit the proliferation of

206 In plants, the steroidal hormone brassinosteroid (BR) regulates numerou

207 expression induction after exposure to other steroidal hormones (11-ketotestosterone approximately te

208 n of endocrine-disrupting chemicals, such as steroidal hormones and 4-nonylphenol, that can disrupt e

209 es, personal care products, pharmaceuticals, steroidal hormones, and pesticides.

210 Small lipophilic molecules such as steroidal hormones, retinoids, and free fatty acids cont

211 important group of molecular fossils is the steroidal hydrocarbons (steranes), which are the diagene

212 alts that vary in the number and position of steroidal hydroxyl groups and the presence and type of s

213 eroidal dexamethasone is as effective as non-steroidal ibuprofen for preventing or controlling postop

214 Five new steroidal imidazoles, amaranzoles B-F, were isolated fro

215 The steroidal inhibitor exemestane is partially non-cross-re

216 ndrosta-1,4-diene-3,17-dione) is a synthetic steroidal inhibitor of the aromatase reaction that catal

217 ence of either abiraterone, a first-in-class steroidal inhibitor recently approved by the US Food and

218 cellent discrimination against potential non-steroidal interfering agents.

219 duction of these enones gave the pentacyclic steroidal ketones 2 alpha,3beta- (8) and 2 alpha,3 alpha

220 Withaferin A (WA), a C5,C6-epoxy steroidal lactone derived from a medicinal plant (Withan

221 Withaferin A (WA) is a steroidal lactone purified from medicinal plant "Indian

222 thesize a large array of biologically active steroidal lactone triterpenoids called withanolides.

223 Withaferin A (WFA) is a steroidal lactone with antitumor effects manifested at m

224 28-Homobrassinolide (HB), a steroidal lactone with potent plant growth-promoting pro

225 Here we show that Withaferin A (WA), a steroidal lactone, causes a change in NEMO's interaction

226 e have purified physapubescin, a predominant steroidal lactone, from medicinal plant Physalis pubesce

227 itis elegans nuclear receptor DAF-12 and its steroidal ligand directly activate promoters of let-7 mi

228 t of dihydrotestosterone (DHT, an endogenous steroidal ligand for the AR).

229 was activated in vivo by inclusion of a non-steroidal ligand in the diet, the expression of the mRNA

230 At nanomolar concentrations, these steroidal ligands (called dafachronic acids) bind and tr

231 is a great interest in the discovery of non-steroidal ligands able to bind to the ligand-binding dom

232 ful scaffold to generate novel and selective steroidal ligands for GP-BAR1.

233 ved neuroendocrine pathways that converge on steroidal ligands of the nuclear receptor DAF-12, a homo

234 mpanies have been developing a series of non-steroidal ligands that consist of different chemical sca

235 OR7D4, and in vivo olfactory perception of 2 steroidal ligands--androstenone and androstadienone--che

236 F-12 function is regulated by bile acid-like steroidal ligands; however, tools for investigating thei

237 a series of recently published studies, the steroidal lipid, cholesterol, has emerged as a clinicall

238 teins occurred when 25-OH-cholesterol or non-steroidal LXR agonists (GW3965, TO-901317) were used.

239 gesterone acetate to mimic the decidualizing steroidal milieu of the luteal phase and early pregnancy

240 Steroidal mineralocorticoid receptor (MR) antagonists ar

241 he renoprotective effects of Ly, a novel non-steroidal mineralocorticoid receptor (MR) blocker, throu

242 ound to improve discrimination against other steroidal molecules and to improve colorimetric sensitiv

243 similar blood pressure (BP) reduction as the steroidal MR antagonist eplerenone, providing proof-of-c

244 entified as having comparable potency to the steroidal MR antagonist eplerenone.

245 This effect, however, was restricted to steroidal MR antagonists as a nonsteroidal MR antagonist

246 Therefore, the endogenous steroidal Na/K-ATPase inhibitor, marinobufagenin, is syn

247 rine-derived highly potent antiproliferative steroidal natural product, and nine closely related anal

248 The total synthesis of the highly degraded steroidal natural product, aplykurodinone-1 (1), has bee

249 of new synthetic disconnections in preparing steroidal natural products.

250 a novel approach to terminate the action of steroidal neuromuscular blockers (sugammadex).

251 ms very tight complexes in a 1: 1 ratio with steroidal neuromuscular blocking agents.

252 e been designed that selectively encapsulate steroidal neuromuscular blocking agents.

253 The steroidal neurotoxin (-)-batrachotoxin functions as a po

254 Sugammadex encapsulates steroidal NMBAs.

255 relationship study provided a new potent and steroidal nonestrogenic inhibitor of 17beta-HSD1 named 3

256 nd intensity variance in perception of these steroidal odours.

257 ICI 182 780 is a pure steroidal oestrogen receptor (ER) antagonist that blocks

258 e effect profiles versus currently available steroidal oral contraceptives.

259 Here we describe GDC-0810, a novel, non-steroidal, orally bioavailable selective ER downregulato

260 This suggests a role for a non-steroidal ovarian factor on adult female VZ cell prolife

261 nkeys, but in contrast to currently approved steroidal PR agonists, it did not suppress estradiol lev

262 teroids of either enantiomeric series, these steroidal products have been selectively functionalized

263 (50) value of 0.1 nm, comparable with potent steroidal progestins such as medroxyprogesterone acetate

264 th a higher relative affinity than reference steroidal progestins.

265 lin (SHBG) is believed to play a key role in steroidal radiopharmaceutical delivery to target tissues

266 It is increasingly accepted that steroidal receptor co-regulators may also function in th

267 It is increasingly accepted that steroidal receptor coregulators may also function in the

268 orphan nuclear receptor and demonstrate that steroidal regulation of reproduction, from biology to mo

269 are more photostable but also maintain their steroidal ring structure and therefore may retain some b

270 Containers 1a-1e bind the steroidal ring system and aromatic moieties of insoluble

271 ogues possessing a framework that mimics the steroidal ring system.

272 Collectively, these results indicate that steroidal sapogenins may be a novel class of prebiotics

273 alysis showed that the prebiotic activity of steroidal sapogenins might require structural elements o

274 Diosgenin, a steroidal saponin present in fenugreek (Trigonella foenu

275 Existing techniques presently used for Yucca steroidal saponin quantification remain either inaccurat

276 Our results reveal for the first time, steroidal saponins from S. paniculatum and the antiulcer

277 d does not over- or under-estimate levels of steroidal saponins.

278 andard of saponins, to quantify the group of steroidal saponins.

279 7A1 inhibitor, abiraterone, which contains a steroidal scaffold similar to the endogenous CYP17A1 sub

280 n of polycyclic molecules including modified steroidal scaffolds as well as challenging-to-synthesize

281 Using non-steroidal scaffolds is expected to enable the design of

282 Non-steroidal selective-AR modulator, GTx-026, which selecti

283 gnancy C. sordellii infections suggests that steroidal sex hormones might regulate its capacity to ge

284 Steroidal sex hormones play an important role in the neu

285 ology for the development of a novel A,B-cis steroidal skeleton system containing a C3-C9 single bond

286 natural products characterized by an unusual steroidal skeleton, which have been found to inhibit dif

287 signaling, we report discovery of novel non-steroidal small-molecule compounds that activate the vit

288 Our study reinforces the concept that steroidal sodium channel agonists bind in the inner pore

289 Glucocorticoids, which are steroidal stress hormones, have a broad array of biologi

290 for hormone-independent tumors, such as the steroidal STX140 and nonsteroidal counterparts, acting i

291 A variety of Delta(5)-steroidal substrates are selectively oxidized to the cor

292 the role of SHBG in radiotracer delivery of steroidal systems to target tissues.

293 tanyl acetate resulted in a 1:1 mixture of a steroidal tetrahydrofuran and a steroidal tetrahydropyra

294 mixture of a steroidal tetrahydrofuran and a steroidal tetrahydropyran.

295 ed defensive glands on its neck that contain steroidal toxins known as bufadienolides.

296 Cardenolides are remarkable steroidal toxins that have become model systems, critica

297 in toad-free regions are left undefended by steroidal toxins.

298 rols, brassinosteroid phytohormones, and non-steroidal triterpenoids.

299 A key feature of the nanoporous steroidal urea (NPSU) structure is that groups at either

300 uloskeletal conditions and analgesic and non-steroidal use.