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1 ibition of the proteolytic activation of the sterol regulatory element binding proteins.
2 such as Cubitus interruptus, NF-kappa B and sterol regulatory element binding proteins.
3 thus, was unable to suppress the cleavage of sterol regulatory element-binding proteins.
4 ion of lipid biosynthetic genes regulated by sterol regulatory element-binding proteins.
5 lipogenic transcription factors, especially sterol-regulatory element binding proteins.
6 ter lipid regulator the transcription factor sterol regulatory element binding protein 1 (SREBP-1) an
7 a replacement of the TMD2 with the TMD1 from sterol regulatory element binding protein 1 (SREBP-1) is
10 taine partially reduced homocysteine-induced sterol regulatory element binding protein 1 expression i
11 enzyme 1, which was not seen in the rat, and sterol regulatory element binding protein 1 was increase
12 nduces lipogenesis through the activation of sterol regulatory element binding protein 1, which is me
14 nd cholesterol synthetic pathways, including sterol regulatory element binding proteins 1 and 2 and t
15 ethanol causes fatty liver by activation of sterol regulatory element-binding protein 1 (SREBP-1) an
16 s to selectively alter expression of hepatic sterol regulatory element-binding protein 1 (SREBP-1) or
17 ntrolled via a temporal negative feedback of sterol regulatory element-binding protein 1 (SREBP-1) to
18 of hepatic CES2 stimulates lipogenesis in a sterol regulatory element-binding protein 1 (SREBP-1)-de
19 atty acid synthesis pathway by activation of sterol regulatory element-binding protein 1 (SREBP-1).
20 absorption, T39 deficiency inhibits hepatic sterol regulatory element-binding protein 1 (SREBP-1, AD
21 tified within intron 16 of the gene encoding sterol regulatory element-binding protein 1 (Srebp1), an
23 se (AMPK), which in turn directly suppresses sterol regulatory element-binding protein 1 (SREBP1)-dir
24 f LDLR expression and activity and defined a sterol regulatory element-binding protein 1 (SREBP1)-med
25 palmitoyl transferase 1, and down-regulated sterol regulatory element-binding protein 1 and fatty ac
27 1.8-fold increase in cell number), increased sterol regulatory element-binding protein 1 expression (
28 er transcriptional regulator of lipogenesis, sterol regulatory element-binding protein 1(SREBP1/SREBF
29 a, adiponectin, leptin, fatty acid synthase, sterol regulatory element-binding protein 1, glycerol ki
30 atter changes, which included higher nuclear sterol regulatory element-binding protein 1, higher Srep
31 isome proliferator-activated receptor alpha, sterol regulatory element-binding protein 1, hydroxymeth
32 ctors pancreatic and duodenal homeobox 1 and sterol regulatory element-binding protein 1, together le
33 rol-induced macrophage ABCA1 expression by a sterol regulatory element-binding protein 1-dependent me
34 xisome proliferator-activated receptor gamma/sterol regulatory element-binding protein 1/CD36 in hepa
35 up-regulation of the transcription factors, sterol regulatory element-binding proteins 1 and 2, and
36 ty of several transcription factors, notably sterol regulatory-element binding protein 1 and nuclear
37 tty acids inhibit the proteolytic release of sterol regulatory-element binding protein 1 from its mem
38 ing with the liver receptor X stimulation of sterol regulatory-element binding protein 1 gene transcr
39 Highly unsaturated fatty acids accelerate sterol regulatory-element binding protein 1 mRNA decay a
40 A(2b)AR-null mice: the transcription factor sterol regulatory element binding protein-1 (SREBP-1) an
42 fatty acid synthesis, and the expression of sterol regulatory element binding protein-1 (SREBP-1).
43 isome proliferator activated receptor alpha, sterol regulatory element binding protein-1 and carbohyd
44 isome proliferator-activated receptor alpha, sterol regulatory element binding protein-1 and the carb
45 associated with FGF21 inhibition of nuclear sterol regulatory element binding protein-1 and the expr
47 ssion while enhancing degradation of nuclear sterol regulatory element binding protein-1 through 26S
48 skeletal muscles of wild-type mice, SREBP-1 (sterol regulatory element binding protein-1) activates t
49 ression of lipogenesis/adipogenesis markers (sterol regulatory element binding protein-1, acetyl-CoA
52 We found that FXR agonists modulate renal sterol regulatory element-binding protein-1 (SREBP-1) ex
54 tor activated receptor alpha (PPARalpha) and sterol regulatory element-binding protein-1 (SREBP-1) pa
55 levels of central lipogenic genes, including sterol regulatory element-binding protein-1 (SREBP-1), f
56 a key transcription factor for lipogenesis, sterol regulatory element-binding protein-1 (SREBP-1), i
57 l at the endoplasmic reticulum, induction of sterol regulatory element-binding protein-1 cleavage, an
58 oplasmic reticulum stress markers, including sterol regulatory element-binding protein-1, and proapop
60 ndent with reduced levels of mature, nuclear sterol-regulatory element-binding protein-1 (SREBP-1), a
61 as that of membrane-bound precursor forms of sterol-regulatory, element-binding protein-1 and -2, tra
64 tion of two lipogenic transcription factors, sterol regulatory element binding protein-1a (SREBP-1a)
65 sfected Huh7.5 cells increased expression of sterol regulatory element binding protein 1c (SREBP-1c)
66 ferator-activated receptor gamma 2), SREBP1c(sterol regulatory element binding protein 1c), and ACACA
67 arising from decreased PPARalpha, increased sterol regulatory element binding protein 1c, and associ
68 cerol stores, leading to an up-regulation of sterol regulatory element binding protein 1c-mediated li
69 ibuted to the LXR-dependent up-regulation of sterol regulatory element-binding protein 1c (SREBP-1c)
71 e LXR agonist, T1317, induced mRNAs encoding sterol regulatory element-binding protein 1c (SREBP-1c)
73 nduced upon LXR activation in the absence of sterol regulatory element-binding protein 1c (SREBP-1c),
74 ever, LXR also upregulates the expression of sterol regulatory element-binding protein 1c (SREBP-1c),
75 gnificant reduction in hepatic expression of sterol regulatory element-binding protein 1c (SREBP-1c),
76 ntly high levels of lipogenic genes, such as sterol regulatory element-binding protein 1c and fatty a
77 ride abundance, and the expression of mature sterol regulatory element-binding protein 1c and fatty a
78 EBPdelta, PPARgamma, liver X receptor alpha, sterol regulatory element-binding protein 1c and of adip
79 ignificantly increased in WT mice, including sterol regulatory element-binding protein 1c target gene
80 e lipogenic transcriptional factor SREBP-1c (sterol regulatory element-binding protein 1c) and its pr
81 phoenolpyruvate carboxykinase) and SREBP-1c (sterol regulatory element-binding protein 1c) in the liv
82 ponsive element-binding protein) or SREBP1c (sterol regulatory element-binding protein 1c) regulation
83 as in the expression of fatty acid synthase, sterol regulatory element-binding protein 1c, and CCAAT/
84 ulated protein 78, C/EBP homologous protein, sterol regulatory element-binding protein 1c, and phosph
85 of ethanol involved up-regulated PGC-1beta, sterol regulatory element-binding proteins 1c and 2, ace
86 when additionally simulating the increase in sterol-regulatory element binding protein 1c (SREBP-1c)
87 zed with insulin to induce the expression of sterol-regulatory element-binding protein 1c gene (Srebp
89 XR), induced these genes via upregulation of sterol regulatory element binding protein-1c (SREBP-1c)
90 ear receptor liver X receptor (LXR)-mediated sterol regulatory element binding protein-1c (SREBP-1c)
91 R) heterodimers, which induced expression of sterol regulatory element binding protein-1c (SREBP-1c),
92 liver X receptor (LXR) and its gene target, sterol regulatory element binding protein-1c (SREBP-1c).
94 henotype with higher protein content of both sterol regulatory element binding protein-1c and acetyl
95 ty was attributable to reduced expression of sterol regulatory element binding protein-1c and its tar
96 or-activated receptor-gamma (PPAR-gamma) and sterol regulatory element binding protein-1c in WAT acco
97 iption factors such as liver X Receptor, the sterol regulatory element binding protein-1c, and the ca
98 ant increase of SCD-1 protein, activation of sterol regulatory element-binding protein-1c (SREBP-1),
100 mRNA of the lipogenic transcription factor, sterol regulatory element-binding protein-1c (SREBP-1c)
104 suppressed the insulin-induced expression of sterol regulatory element-binding protein-1c (SREBP-1c),
106 cally dependent on the transcription factor, sterol regulatory element-binding protein-1c (SREBP-1c).
107 enhanced transcription of the gene encoding sterol regulatory element-binding protein-1c (SREBP-1c).
108 in liver directly and indirectly by inducing sterol regulatory element-binding protein-1c (SREBP-1c).
109 thesis by insulin is mediated in part by the sterol regulatory element-binding protein-1c (SREBP-1c).
110 ctivating transcription of the gene encoding sterol regulatory element-binding protein-1c (SREBP-1c).
111 t through the transcription factor SREBP-1c (sterol regulatory element-binding protein-1c) and its re
113 ohydrate-responsive element-binding protein, sterol regulatory element-binding protein-1c, and liver
114 C/EBPbeta-RNAi normalized lipogenic genes sterol regulatory element-binding protein-1c, peroxisome
115 t response element consensus sequence in the sterol regulatory-element binding protein-1c (Srebp-1c)
117 ordinary differential equation model of the sterol regulatory element binding protein 2 (SREBP-2) ch
118 e scaffold in vascular endothelial cells via sterol regulatory element binding protein 2 (SREBP2).
119 d miR-33b, located within the genes encoding sterol regulatory element-binding protein 2 (SREBP-2) an
120 -1 infection of CD4(+) T cells activates the sterol regulatory element-binding protein 2 (SREBP2) tra
121 rain cholesterol synthesis by a reduction in sterol regulatory element-binding protein 2 (SREBP2)-reg
122 tronic microRNAs (miRNAs) located within the sterol regulatory element-binding protein 2 and 1 genes
123 rom in-vitro and in-vivo models suggest that sterol regulatory element-binding protein 2 is a key mol
125 r cell lines by inhibiting the activation of sterol regulatory-element binding protein 2 and downregu
126 osynthesis, and uptake of cholesterol (human sterol-regulatory element-binding protein 2, human 3-hyd
127 ant for ABCG1 to alter sterol efflux, induce sterol regulatory element binding protein-2 (SREBP-2) pr
129 holesterol synthesis, increase expression of sterol regulatory element-binding protein-2 (SREBP-2), a
130 in response to statin treatment activate the sterol regulatory element-binding protein-2 (SREBP-2), r
131 k regulation by cellular cholesterol through sterol regulatory element-binding protein-2 (SREBP-2).
132 novo sterol synthesis through activation of sterol regulatory element-binding protein-2 (SREBP-2).
133 s showed that the neurotrophins activate the sterol regulatory element-binding protein-2 (SREBP2) tha
134 demonstrated that ER stress can activate the sterol regulatory element-binding protein-2 (SREBP2), an
135 R-33a and hsa-miR-33b are located within the sterol regulatory element-binding protein-2 and -1 genes
137 icient OPC/OLs show a strong increase in the sterol-regulatory element-binding protein-2 yet are unab
138 mpacted both proteasomal gene expression and sterol regulatory element-binding protein-activated gene
139 (q) signaling cascades mediate LPA-dependent sterol regulatory element-binding protein activation and
140 blocking proteolytic processing required for sterol regulatory element-binding protein activation, we
142 fibroblasts 25-HC blocked the processing of sterol regulatory element-binding proteins and activated
143 a gene regulated by the transcription factor sterol regulatory element-binding proteins and showed th
144 se of the plasma membrane and suppression of sterol regulatory element-binding proteins and their tar
145 e 2 groups of transcription factors, such as sterol-regulatory-element binding proteins and peroxisom
146 ing the herpes simplex viral activator VP16, sterol regulatory element binding protein, and NF-kappaB
147 p, thus preventing proteolytic processing of sterol regulatory element-binding proteins; and the chol
148 orresponding transmembrane segments from the sterol regulatory element-binding protein cleavage activ
149 interactions or sterol metabolism, including sterol regulatory element-binding protein cleavage-activ
151 acyltransferase (ACAT) and for inhibition of sterol regulatory element-binding protein cleavage.
152 rease the levels of transcriptionally active sterol regulatory element binding proteins, decrease end
153 mic reticulum, and more rapid suppression of sterol regulatory element-binding protein-dependent gene
154 ranscriptional activation of target genes by sterol regulatory element-binding protein (dSREBP) is es
155 in vertebrates by stimulating the Drosophila sterol regulatory element-binding protein (dSREBP) pathw
156 es of ovarian cancer patients, regulates the sterol regulatory element binding protein-FAS and AMP-ac
157 asmic reticulum (ER) protein that transports sterol regulatory element-binding proteins from the ER t
160 homeostasis, thereby impeding activation of sterol regulatory element-binding proteins (key regulato
161 sterol homeostatic effects by suppression of sterol regulatory element-binding protein maturation and
162 thway than classic cholesterol inhibition of sterol regulatory element binding protein-mediated trans
163 site two protease (S2P)-mediated cleavage of sterol regulatory element binding proteins, membrane-bou
164 the transcriptional regulators (such as the sterol regulatory element-binding proteins, or SREBPs) a
165 oplasmic reticulum, because it activates the sterol regulatory element-binding protein pathway and in
168 Ethanol has been shown to activate SREBP-1 (sterol regulatory element-binding protein) processing th
169 cancer cells with fatostatin A, which blocks sterol regulatory element-binding protein proteolytic cl
170 ynthase promoter required a binding site for sterol regulatory element binding proteins (SRE-BP), con
172 oliferator-activator receptor alpha (PPARA), sterol regulatory element-binding protein (SREBF), and e
174 S triggers c-Jun-N-terminal Kinase (JNK) and Sterol Regulatory Element Binding Protein (SREBP) activi
175 oteins Sre1 and Scp1, orthologs of mammalian sterol regulatory element binding protein (SREBP) and Sc
179 The membrane-bound transcription factor sterol regulatory element binding protein (SREBP) is the
180 homeostasis in vertebrates is regulated by 3 sterol regulatory element binding protein (SREBP) isofor
182 res proteolytic activation of membrane-bound sterol regulatory element binding protein (SREBP) transc
183 e 5 has been shown to be an inhibitor of the sterol regulatory element binding protein (SREBP), a key
184 In fission yeast, the ortholog of mammalian sterol regulatory element binding protein (SREBP), calle
186 but inversely correlate with the activity of sterol regulatory element binding protein (SREBP), the m
190 expression of LXRalpha and its target genes sterol regulatory element-binding protein (Srebp) 1c and
191 arger organ, and adjusts gene expression and sterol regulatory element-binding protein (SREBP) activi
192 e effect of hypoxia and serum deprivation on sterol regulatory element-binding protein (SREBP) activi
193 ue oleate and have reduced expression of the sterol regulatory element-binding protein (SREBP) and it
194 w-density lipoprotein (LDL) receptor (LDLr), sterol regulatory element-binding protein (SREBP) cleava
195 ollowing two polytopic ER membrane proteins: sterol regulatory element-binding protein (SREBP) cleava
196 The oligodendrocyte-specific inactivation of sterol regulatory element-binding protein (SREBP) cleava
197 glucose uptake, promotes N-glycosylation of sterol regulatory element-binding protein (SREBP) cleava
198 se pulldown experiments with various USF and sterol regulatory element-binding protein (SREBP) deleti
202 d miR33b, intronic miRNAs located within the sterol regulatory element-binding protein (SREBP) genes,
203 Sterols mediate feedback inhibition of the sterol regulatory element-binding protein (SREBP) pathwa
208 se is a Golgi-localized complex required for sterol regulatory element-binding protein (SREBP) transc
210 rol homeostasis is tightly controlled by the sterol regulatory element-binding protein (SREBP) transc
212 ound that SRE1, a homologue of the mammalian sterol regulatory element-binding protein (SREBP), funct
215 pombe in a manner analogous to the mammalian sterol regulatory element-binding protein (SREBP)-1 and
216 ed protein kinase, and overactivation of the sterol regulatory element-binding protein (SREBP)-1-medi
217 ed by three DNA-binding proteins, designated sterol regulatory element-binding protein (SREBP)-1a, -1
218 s associated with 1) increased expression of sterol regulatory element-binding protein (SREBP)-1c and
219 tenuated in the L-S6K-KD mice with decreased sterol regulatory element-binding protein (SREBP)-1c exp
220 ysis (NCA) showed that transcription factors sterol regulatory element-binding protein (SREBP)-1c, ca
222 g reduction in the elevated level of nuclear sterol regulatory element-binding protein (SREBP)-1c, th
223 regulator of fatty acid synthesis in liver, sterol regulatory element-binding protein (SREBP)-1c.
225 lower species) are located in introns of the sterol regulatory element-binding protein (SREBP)-encodi
229 ors involved in adipose metabolism including sterol regulatory element-binding protein (SREBP-1), ins
231 three membrane-bound transcription factors: sterol regulatory element-binding proteins (SREBP)-1a, -
232 that the hypoxia significantly up-regulated sterol regulatory-element binding protein (SREBP)-1, the
233 receptor (LXR) and the transcription factors sterol-regulatory element binding protein (SREBP) and nu
235 of hypoxia-inducible factor (HIF1alpha) and sterol regulatory element-binding protein (SREBP1 and SR
236 cancer cell lines leads to activation of the sterol regulatory element-binding proteins (SREBP1 and S
237 f the lipogenic genes fatty acid synthetase, sterol regulatory element binding protein (SREBP1c), and
240 ng the vesicular transport of membrane-bound sterol regulatory element binding proteins (SREBPs) from
241 ortant role for altered lipid metabolism via sterol regulatory element binding proteins (SREBPs) has
242 id shear stress can modulate the activity of sterol regulatory element binding proteins (SREBPs) in v
243 ufficiency, Insig inhibits the activation of sterol regulatory element binding proteins (SREBPs), key
245 mammalian cells for regulated activation of sterol regulatory element binding proteins (SREBPs).
246 nd fatty acids are maintained in part by the sterol regulatory element binding proteins (SREBPs).
248 iscovered Scap, we have learned how it binds sterol regulatory element-binding proteins (SREBPs) and
249 actors such as the liver X receptors (LXRs), sterol regulatory element-binding proteins (SREBPs) and
256 Activating transcription factor 6 (ATF6) and sterol regulatory element-binding proteins (SREBPs) are
260 cholesterol and oxysterols, block export of sterol regulatory element-binding proteins (SREBPs) from
261 is controlled by the regulated transport of sterol regulatory element-binding proteins (SREBPs) from
262 e polytopic membrane protein SCAP transports sterol regulatory element-binding proteins (SREBPs) from
263 rols cholesterol homeostasis by transporting sterol regulatory element-binding proteins (SREBPs) from
264 lipid metabolism and increased expression of sterol regulatory element-binding proteins (SREBPs) in a
265 e whether there is altered regulation of the sterol regulatory element-binding proteins (SREBPs) in t
267 Here we demonstrate an essential role for sterol regulatory element-binding proteins (SREBPs) in t
269 oxycholesterol block the lateral movement of sterol regulatory element-binding proteins (SREBPs) into
270 ic genes, such as fatty acid synthase (FAS), sterol regulatory element-binding proteins (SREBPs) play
272 cholesterol-depleted cells, Scap transports sterol regulatory element-binding proteins (SREBPs) to t
273 rol-mediated inhibition of the processing of sterol regulatory element-binding proteins (SREBPs) to t
274 nding protein/ATF transcription factors, the sterol regulatory element-binding proteins (SREBPs), and
275 dation of reductase and blocks processing of sterol regulatory element-binding proteins (SREBPs), ano
276 hion by inhibiting proteolytic processing of sterol regulatory element-binding proteins (SREBPs), mem
277 um (ER) that block proteolytic activation of sterol regulatory element-binding proteins (SREBPs), mem
278 ms, both involving the proteins that control sterol regulatory element-binding proteins (SREBPs), mem
279 on that blocks the proteolytic processing of sterol regulatory element-binding proteins (SREBPs), mem
280 um (ER) that block proteolytic activation of sterol regulatory element-binding proteins (SREBPs), tra
281 the proteolytic processing of membrane-bound sterol regulatory element-binding proteins (SREBPs), tra
282 eride levels by inhibiting the processing of sterol regulatory element-binding proteins (SREBPs), tra
283 rol-repressed, consistent with regulation by sterol regulatory element-binding proteins (SREBPs), whe
284 n gene expression are often mediated through sterol regulatory element-binding proteins (SREBPs).
285 a family of transcription factors designated sterol regulatory element-binding proteins (SREBPs).
286 e regulated expression and activation of the sterol regulatory element-binding proteins (SREBPs).
287 that are transcriptionally regulated by the sterol regulatory element-binding proteins (SREBPs).
288 is a key regulator in the processing of the sterol regulatory element-binding proteins (SREBPs).
289 dent protein that inhibits the activation of sterol regulatory element-binding proteins (SREBPs).
290 ancing de novo lipogenesis by activating the sterol regulatory element-binding proteins (SREBPs).
291 0-mediated transcriptional program involving sterol regulatory element-binding proteins (SREBPs).
293 R gene promoter identified a pivotal role of sterol-regulatory element binding proteins (SREBPs), in
295 mic reticulum (ER) membranes that transports sterol regulatory element-binding proteins to the Golgi
297 llular sterol levels in cell culture via the sterol regulatory element binding protein transcription
298 fission yeast by controlling activity of the sterol regulatory element-binding protein transcription
299 rotein that blocks proteolytic activation of sterol regulatory element binding proteins, which are tr
300 reas newly described associations of CNVs in sterol regulatory element-binding protein with apolipopr
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