ライフサイエンスコーパス: stiff

1 n stoichiometry in MSCs versus osteogenesis (stiff).

2 lls located in tumor regions predicted to be stiff.

3 ment, which is predicted to be exceptionally stiff.

4 while that of bovine rhodopsin is rigid and stiff.

5 aminar material properties were compliant or stiff.

6 igidities ranging from very flexible to very stiff.

7 by solution processing, is known to be very stiff.

8 stiffest (16.3 MPa) and the medial was least stiff (1.4 MPa).

9 8.3 MPa) and the anterior superior was least stiff (1.4 MPa).

10 To study 3D migration under confinement in a stiff (1.77 MPa) environment, we use soft lithography to

11 We find that amyloid materials are very stiff (10(9) Pa).

12 ctile force and strong directional motion on stiff (12 kPa) surfaces.

13 kPa), but not on very soft (1 kPa) and very stiff (3.6 GPa) substrates.

14 ions of high cell pre-stress with culture on stiff (7.5 kPa) polyacrylamide gels (with or without tra

15 ction functionally belongs to the relatively stiff A-band region of titin.

16 lacement of the viscera within an unyielding stiff abdominal wall may compromise the perfusion of the

17 ticity of the intima of compliant, young, or stiff, aging arteries.

18 Aeroelastic flutter is intrinsic to stiff airfoils such as feathers and thus explains tonal

19 it charge transport can render the materials stiff and brittle.

20 nfigurations - the structures are relatively stiff and can carry load in each - without any mechanica

21 ransduced normal airway epithelial cells had stiff and dyskinetic cilia beating patterns compared to

22 A stiff and healable polymer is obtained by using the dyna

23 that the ILK-mediated phenotypes induced by stiff and hypoxic microenvironments are regulated by PI3

24 Here we report that stiff and hypoxic microenvironments promote the developm

25 centrations drives ssDNA to a unique, highly stiff and more compact state.

26 oA to induce the formation of a mechanically stiff and rounded metaphase cortex.

27 elow the physiological level, the MLF became stiff and shrank considerably.

28 mozygote individuals, whose cilia retained a stiff and slowed beat.

29 We find that a combination of stiff and soft materials at an 80:20 ratio enables musse

30 vealed a quite heterogeneous distribution of stiff and soft regions, resembling that of typical compo

31 lations suggest that cadherin-23 repeats are stiff and that either removing Ca(2+) or mutating Ca(2+)

32 bes the flutter phenomenon observed in both "stiff" and "flexible" materials for flow driven energy h

33 thermally driven shape fluctuations at bare (stiff) and decorated (compliant) boundaries, thereby pro

34 The as-prepared polymer is very strong and stiff, and can bear a load of more than 450 times its we

35 vorable profile of a more compliant and less stiff aorta.

36 The abdominal skin was thinner and less stiff as compared to back skin.

37 different intracellular forces when grown on stiff as compared to soft substrates.

38 Whereas billfish bone material is as stiff as mammalian bone (unlike the bone of other fishes

39 .e. they are disordered azimuthally although stiff axially.

40 essential for cochlear amplification in the stiff basal turn, possibly through maintaining cochlear

41 rdiomyocytes, which become hypertrophied and stiff because of low nitric oxide and cyclic guanosine m

42 ound to increase in size even when the BM is stiff because of pressure induced by growing tumor clust

43 ed loads, such as those exerted by wind, the stiff behaviour of silk under small deformation, before

44 lassical view of DNA posits that DNA must be stiff below the persistence length [<150 base pairs (bp)

45 as bone, silk or nacre are often built from stiff blocks bound together using thin interfacial soft

46 A stiff BM promotes invasiveness because at early stages t

47 The filaments, arranged in stiff bundles by fascin, are constrained to point toward

48 We find that stiff but well distributed networks of plates are requir

49 pleomorphic adenoma was also interpreted as stiff by elastosonography suggesting that the elastosono

50 pfp-1 was localized at the interface between stiff byssus and the soft tissue by immunochemical stain

51 ckle cells, and even to interactions of soft/stiff cancer cells with macrophages.

52 of hypophosphorylation of titin; and 5) both stiff cardiomyocytes and interstitial fibrosis contribut

53 ring the 24-y study than did those with less stiff carotid arteries, as defined on the basis of the h

54 inite element modeling studies showed that a stiff cell cortex could explain the results.

55 nt cells is tantamount to the shaping of the stiff cell wall that surrounds them.

56 iers and exit the separation device, whereas stiff cells remain trapped.

57 and metastatic propensity flowed out, while stiff cells remained trapped.

58 directed migration, whereas the surrounding stiff cells show little net migration.

59 We show that follicular dendritic cells are stiff cells that promote strong B cell pulling forces an

60 sensors with growing (soft) cells and fixed (stiff) cells, and through analytical modeling, we derive

61 Structural reinforcement of the wall by stiff cellulose microfibrils is central to contemporary

62 cell wall is a composite material containing stiff cellulose microfibrils that are embedded within a

63 xternal fields can be bound permanently into stiff chains through electrostatic or van der Waals attr

64 l; and 3) transpulmonary open lung approach, stiff chest wall.

65 st wall; 2) conventional open lung approach, stiff chest wall; and 3) transpulmonary open lung approa

66 echanical mapping reveals the formation of a stiff coiled filamentous structure underneath the capsid

67 ibuted to the reconfigurable 3D network from stiff collagen nanofibers and flexible proteoglycans.

68 hrough Src, PI3K, and Rac1, and increasingly stiff collagen promoted dispersive epithelial cell invas

69 teeth, protein and chitin fibers establish a stiff compact outer shell enclosing a less compact core.

70 compared to a single-level hierarchy and the stiff constituent, respectively.

71 Expansion on stiff culture substrates activates pro-fibrotic cell pro

72 in poorly performing molecular diodes, while stiff, densely packed SAMs result in well-performing mol

73 This sensitization was reversed when the 'stiff' differentiated nucleus was softened and was enhan

74 itioning of fluorophores on the surface of a stiff DNA nanorod can produce 216 distinct barcodes that

75 rotational and linear joints that integrate stiff double-stranded DNA components and flexible single

76 rdering in aqueous solutions of monodisperse stiff double-stranded DNA fragments is known not to occu

77 hosphatidylcholine liposomes, it is twice as stiff, due to membrane-attached protein components.

78 anical dosing of hMSCs cultured on initially stiff (E ~ 10 kPa) and then soft (E ~ 2 kPa) phototunabl

79 boundary are concentrated in the relatively stiff ECM fibers and are propagated farther in a fibrous

80 Further investigation revealed that a stiff ECM increased Robo1 levels by down-regulating miR-

81 onectin fibrillogenesis, and production of a stiff ECM with oriented fibers.

82 ustaining proliferation and migration within stiff ECM.

83 This stiff, elastic response required the presence of vimenti

84 tin type III-like (FN-III) domains provide a stiff elasticity.

85 bstrates for globally deformable yet locally stiff electronics.

86 r, the arrangement of soft/flexible and hard/stiff elements into particular geometries can permit sur

87 junction between the OSCP and the apparently stiff, elongated alpha-helical b-subunit and associated

88 -triggered differentiation of cells grown on stiff, endosteum-like matrix, but not soft, marrow-like

89 ops (4L) were deleted to obtain an unusually stiff engineered FhuA DeltaC/Delta4L nanopore.

90 older adults, the large-arterial wall is not stiff enough in youth to alter BP levels during young ad

91 wever, whether the bacterial cytoskeleton is stiff enough to affect the overall mechanical rigidity o

92 For materials stiff enough to withstand deformation related to cellula

93 ike chain, we predict that it functions as a stiff entropic spring linking the bending protofilaments

94 Exposure to a stiff environment leads cells to establish a mechanical

95 These results shed light on the role of stiff epithelial cells that neighbor individual cancer c

96 and secrete and concomitantly reorganise the stiff extracellular matrix (ECM).

97 The stiff extracellular matrix also limits drug penetration

98 e and invade in Boyden chambers, to create a stiff extracellular matrix in mice, to cross-link secret

99 ith confinement of all of the cells within a stiff extracellular matrix.

100 The use of few stiff fibers to control the deformation of dielectric el

101 oblast population, and may contribute to the stiff fibrotic microenvironment through their own stiffn

102 Here we study voltage-driven dynamics of the stiff filamentous virus fd with experiments and simulati

103 The thermal motion of stiff filaments in a crowded environment is highly const

104 me of implantation (early), or after 4 wk of stiff fixation (delayed).

105 antly up-regulated when VICs are cultured on stiff gels or tissue culture polystyrene compared with f

106 t less cell-to-cell noise than homogeneously stiff gels.

107 bility to sense substrate stiffness for very stiff gels.

108 ional high-throughput printing strategies on stiff, glass substrates and non-covalent attachment meth

109 A stiff guidewire and a large sheath distorted the anatomy

110 ers of 0.89 mm (0.035 inch) for standard and stiff guidewires and 0.36 mm (0.014 inch) for micro guid

111 vary widely in mechanics from soft brain and stiff heart to rigid bone [2].

112 eased plasma volumes and significantly heavy stiff hearts.

113 Microtubules, the dynamic, yet stiff hollow tubes built from alphabeta-tubulin protein

114 By contrast, on a stiff hydrogel matrix, hESCs show elevated integrin-depe

115 re induced by interactions with TGF-beta1 or stiff hydrogels are accompanied by the accumulation of e

116 ysical forms-viscoelastic solutions, soft or stiff hydrogels, electrospun fibers, non-woven meshes, m

117 erse temperature dependence of the KIE are a stiff hydrogen bond, which corresponds to a high-frequen

118 eme limits of molecular confinement, where a stiff inorganic phase confines the polymer chains to dim

119 For some conditions, such as deep and stiff lamina, the association between LCD and SCE was st

120 seizures, and a wide-based, spastic, and/or stiff-legged gait.

121 soft like fat, which bears little stress, or stiff like bone, which sustains high stress, but whether

122 yses of macrophages on soft (like marrow) or stiff (like solid tumors) collagenous gels demonstrated

123 tion that mimicked the early-onset twisting, stiff limbs and tremor that is observed in dystonia, a d

124 y 50% toughness enhancement is achieved in a stiff load-bearing polymer network, demonstrating the ut

125 oalesces into longitudinal bundles, giving a stiff, low-DNA-density ellipsoid.

126 um is a transparent hydrogel consisting of a stiff lower layer and a compliant upper layer.

127 s the phenotype under conditions of fibrotic/stiff lung.

128 ositive cases (12% of cases) included 9 with stiff-man syndrome (4 classic; 5 variant; 66% were gluta

129 Reports of pediatric-onset stiff-man syndrome (SMS) are rare.

130 se research in this area, the synthesis of a stiff material with intrinsic self-healing ability remai

131 We previously reported that stiff materials promote nuclear localization of the Yes-

132 re to evaluate the Young's modulus of highly stiff materials with greater accuracy than previously po

133 entury's robotic systems have been made from stiff materials, and much of the developments have pursu

134 Compared to "stiff" materials, which has a flow velocity-independent

135 e high epithelial STAT3 activity and develop stiff, matricellular-enriched fibrosis associated with h

136 Stiff matrices also increased co-localization of prolact

137 f the spectrum of prolactin signals and that stiff matrices and prolactin interact in a feed-forward

138 tin actions and activation of STAT5, whereas stiff matrices promoted protumorigenic outcomes, includi

139 In stiff matrices, prolactin increased SRC family kinase-de

140 and is recruited to cell-ECM contacts within stiff matrices.

141 ling from a soft matrix can substitute for a stiff matrix in stimulating spreading, stress fibre form

142 By contrast, MSC cultured on a stiff matrix secreted prosaposin that promoted prolifera

143 levels, whereas differentiation into bone on stiff matrix was enhanced by high lamin-A levels.

144 ic and basal-like tumor cells, fostered by a stiff matrix, and critical for tumor cell invasion in ou

145 the tendency of cells to crawl from soft to stiff matrix, and durotaxis of primary mesenchymal stem

146 MIIA appeared diffuse and mobile, whereas on stiff matrix, MIIA was strongly assembled in oriented st

147 On a stiff matrix, MSC cultured with conditioned media from m

148 Moreover, stiff matrix-activated ERK increased the protein level a

149 Klf5 or forced expression of Klf4 inhibited stiff matrix-induced cell spreading and proliferation, s

150 e down-regulation of Klf4 when cells were on stiff matrix.

151 emerging only as cells migrate from soft to stiff matrix.

152 lpha expression from hepatocytes cultured on stiff matrix.

153 Stiff mechanical restraint led to formation of an extens

154 iloxane) of a soft inclusion surrounded by a stiff medium.

155 s crystal lattice and remaining a strong and stiff metal.

156 enchymal transition (EMT) to the profibrotic stiff microenvironment and myofibroblast accumulation in

157 Cs in an active state and a tumour-favouring stiff microenvironment.

158 Stiff microenvironments also promoted tumor formation an

159 and its specialized membrane is covered with stiff, microscopically small, domed hairs.

160 ger hind limbs, extended limb posture, and a stiff midfoot, suggesting improved, human-like economy,

161 on are fundamental properties of elastically stiff molecular materials and are assumed to be the same

162 orks as a route for rational design of ultra-stiff molecular solids.

163 The stiff MR imaging guidewire provided the best support for

164 compliant N2BA isoform at the expense of the stiff N2B isoform in HF and CHF mice.

165 ly designed DNA strands self-assemble into a stiff "nanomold" that contains a user-specified three-di

166 rometre-sized particles that are coated with stiff, nanoscale spikes and exhibit long-term colloidal

167 s consist of natural rubber impregnated into stiff natural fiber fabrics, including cotton, hemp, and

168 responds to DNA shape and deformability-the stiff, naturally straight double-helical structure-rathe

169 ogic symptoms (in 48%), nausea (in 39%), and stiff neck (in 29%).

170 lst communities associated meningitis with a stiff neck, in practice responses focused on ability to

171 strointestinal symptoms, and three (11%) had stiff neck.

172 cal mismatch between soft neural tissues and stiff neural implants hinders the long-term performance

173 ells is dramatically enhanced by surrounding stiff nontransformed cells compared with single cells or

174 Stiff nonviable cells directed through the channel are c

175 is induced by the transient crowding of the stiff nuclei of the surrounding nontransformed cells, wh

176 of pressure modulated adhesion between flat, stiff objects and elastomeric surfaces with sharp featur

177 Synthetic nanoparticles and other stiff objects injected into a blood vessel filled with r

178 er cells have longer transit times than less stiff ones and that cell size significantly influences t

179 Stiff or "hard" lesions were suspected of being malignan

180 endothelial cells (ECs) on collagen-coupled stiff or compliant polyacrylamide ECMs to examine the ef

181 inless flexible normal variant of growth, to stiff or painful manifestations of tarsal coalition, col

182 y an enhanced rate of collisions between the stiff particles and the deformable red blood cells.

183 In humans, a high ABI indicates stiff peripheral arteries and is associated with cardiov

184 4 of 34 patients [71%]) and in patients with stiff person syndrome (20 of 28 patients [71%]).

185 ssociated with autoimmune diseases including Stiff Person Syndrome (SPS) and Type 1 diabetes (T1D).

186 Stiff person syndrome (SPS) is a rare neurological disea

187 Stiff person syndrome (SPS) is characterized by muscle s

188 In stiff person syndrome (SPS), an antibody-mediated impair

189 GAD) are well documented in association with stiff person syndrome (SPS).

190 Twenty-eight patients with stiff person syndrome and GAD65-Abs served as controls.

191 n a retrospective cohort of 56 patients with stiff person syndrome and related syndromes.

192 Stiff person syndrome represents a novel indication for

193 Nine patients (26%) had coexisting stiff person syndrome symptoms.

194 ts with CA and 17 samples from patients with stiff person syndrome).

195 o-antibody target in human hyperekplexia and stiff person syndrome, respectively.

196 itis with rigidity and myoclonus, and two as stiff person syndrome; five had a limbic encephalitis or

197 previously reported cases had more frequent stiff-person syndrome (74% vs 13%; P = .001) and better

198 with epilepsia partialis continua), four had stiff-person syndrome (one with seizures and limbic invo

199 Stiff-person syndrome (SPS) is characterised by progress

200 ts suffering from type 1 diabetes as well as stiff-person syndrome (SPS), a disorder that affects the

201 viously reported) included presentation with stiff-person syndrome and the presence of a thymic tumor

202 was a classic PNS, if it was different from stiff-person syndrome or cerebellar ataxia (odds ratio,

203 dystonia (NMDAR antibodies), the spectrum of Stiff-person syndrome/muscle rigidity (glutamic acid dec

204 Conversely, stiff pili are much more likely to make contact with the

205 it the bacteria to short jumps forward while stiff pili enable much greater displacements.

206 o found to vary greatly between flexible and stiff pili.

207 ibroblast phenotype of VICs much better than stiff plastic plates.

208 duced bone formation by 75% in comparison to stiff plate controls.

209 ayer, composed of cyclic ether groups with a stiff polycyclic main chain, serves as a grafted polymer

210 During stiff priming, miR-21 levels were gradually increased by

211 Knocking down miR-21 once by the end of the stiff-priming period was sufficient to erase the mechani

212 Mimicking in vivo stimulation, we used stiff probes to displace individual hair bundles at phys

213 validation, we apply the present scheme to a stiff problem of hypersonic gas flows around a 2D cylind

214 anism with a fast chemical process remains a stiff problem.

215 ntar soft tissues to convert the foot into a stiff propulsive lever.

216 living cells, arising from polymerization of stiff protein filaments against a comparably soft membra

217 The core of dynamically stiff regions exhibits dense connectivity, which is cons

218 d on hydrogels with higher concentrations of stiff regions in a dose-dependent manner.

219 s, directional migration from softer to more stiff regions of a substrate, has been observed for a va

220 the spatial organization of the mechanically stiff regions was altered from a regular to randomized p

221 this process, through the construction of a stiff, rounded metaphase cortex [5-7].

222 , for other conditions, such as for thin and stiff sclera, the association was opposite to the tauten

223 Simulations also studied the stiff, secondary structure elasticity of the I65-I70 cha

224 re to beyond 800 degrees C, by interspersing stiff, self-assembled vertical columns of Sm(2)O(3) thro

225 Programmable stiff sheets with a single low-energy folding motion hav

226 pha-helical region is found to be remarkably stiff, similar only to structural proteins forming viral

227 n regimes not possible by using conventional stiff skin layers.

228 Recently, stiff skin syndrome (SSS) and a group of syndromes known

229 is of pathological skin fibrosis, we studied stiff skin syndrome (SSS), a rare but tractable Mendelia

230 ng cells in different physical environments, stiff, soft, or suspension, induced a phenotypic switch

231 d using the method of lines with appropriate stiff solvers.

232 netriscarboximides were parallel arranged by stiff spacers where exciton interactions could be contro

233 When half-sarcomeres were linked to stiff springs (so that they did not shorten appreciably

234 omal regions have been described in two Iowa Stiff Stalk (SS) inbreds.

235 B73 is a founder of the Stiff Stalk germplasm pool, while PH207 is a founder of

236 ble the six chromosomal regions from the Non-Stiff Stalk maize inbred W22 from a single DNA sequence

237 We illustrate our method by showing that E stiff stilbene (1,1'-Delta-biindan) with up to 700 pN of

238 rier of thermal isomerization of constrained stiff stilbene increase sharply as the restoring force d

239 Here, we show how a molecular force probe, stiff stilbene, simplifies force spectroscopy of localiz

240 tracellular matrix with alternating soft and stiff stripes improves current NMJ-in-a-dish models by i

241 s requires tumor cells to navigate through a stiff stroma and squeeze through confined microenvironme

242 pliant, structural "soft tissue") to bone (a stiff, structural "hard tissue").

243 forces are transmitted through mechanically stiff structures, flowing, for example, through cytoskel

244 ll line (SUM149), into enriched flexible and stiff subpopulations.

245 cultured on profibrotic conditions including stiff substrata and TGF-beta1, and analyzed in terms of

246 ells that are typically expanded in vitro on stiff substrata before reimplantation.

247 to the plasma membrane in cells cultured on stiff substrata or in collagen-rich regions of human bre

248 tion, some crawling cells when plated onto a stiff substrate will not migrate onto soft substrate, a

249 esults show that intermediate adhesion size, stiff substrate, cytoskeleton stiffening, and low-angle

250 In a stiff substrate, such motions were always observed.

251 In contrast, on stiff substrates (Young's modulus >20 kPa), traction str

252 These data suggest that stiff substrates change intercellular junction protein l

253 xial stretch, valvular interstitial cells on stiff substrates decreased their traction force (from 30

254 ed that large holes formed in endothelium on stiff substrates several minutes after neutrophil transm

255 substrates and sustained traction stress on stiff substrates suggest these may be factors governing

256 h-clamp recording were greater in neurons on stiff substrates than on soft substrates.

257 bottom effect' artefact that arises from the stiff substrates used to culture cells.

258 GF-beta1 stimulation and direct contact with stiff substrates, and spontaneously in IPF fibroblasts,

259 t FAs varied linearly with applied force for stiff substrates, and this was disrupted on soft substra

260 opagation was faster and farther reaching on stiff substrates, indicating that substrate stiffness af

261 When PI3K or AKT is inhibited on stiff substrates, myofibroblast activation is blocked.

262 of low elastic modulus were more porous than stiff substrates, suggesting that the collagen anchoring

263 ate how growing neurons may detect and avoid stiff substrates--as a mechanism involved in axonal bran

264 re heightened at synapses between neurons on stiff substrates.

265 came greater and more frequent in neurons on stiff substrates.

266 oth amplitude and frequency among neurons on stiff substrates.

267 ed recording was enhanced between neurons on stiff substrates.

268 fibers with a positive feedback loop on very stiff substrates.

269 and eliminating hole formation in HUVECs on stiff substrates.

270 eferentially migrate from less stiff to more stiff substrates; however, much of this phenomenon, term

271 Polyacrylamide gels are cast upon a stiff support with controlled topography, resulting in a

272 onses to TGF-beta In contrast to growth on a stiff surface, fibroblast growth on a soft matrix led to

273 AP localization in fibroblasts cultured on a stiff surface.

274 compliant surfaces could be recapitulated on stiff surfaces by adding small-molecule inhibitors of F-

275 l force-mediated antigen extraction, whereas stiff surfaces lead to enzyme-mediated antigen release b

276 e cytoskeleton time-scale is small (i.e., on stiff surfaces), in agreement with experiment.

277 lled stress fibers, appear preferentially on stiff surfaces, our mechanical model provides a mechanis

278 a well-established method for approximating stiff systems at a given timescale.

279 complicated wave regimes in multi-component, stiff systems by studying simplified, soft systems.

280 imescale and they are inevitably modelled by stiff systems of ordinary differential equations.

281 ed mechanical dosing on supraphysiologically stiff TCPS biases hMSCs towards osteogenic differentiati

282 sly by the combined presence of a relatively stiff temporal core that is composed primarily of sensor

283 because of its ability to self-assemble into stiff tetra-molecular parallel-stranded G-quadruplexes.

284 It is significantly harder (30%) and less stiff than calcite, and retains these properties after h

285 y and invasive potential are five times less stiff than cells with the lowest migration and invasion

286 ferentiated regenerative blastemas were less stiff than differentiated stump muscle (13.3+/-1.6 vs. 1

287 king inner nuclear membrane tethers are less stiff than wild-type nuclei and exhibit increased chroma

288 A stiff three-arm-junction DNA origami tile motif with pre

289 hat microtubule stability is diminished by a stiff three-dimensional (3D) extracellular matrix, which

290 bstrates are static and supraphysiologically stiff; thus, platforms with dynamic and reversible mecha

291 ared to parent cells grown on standard, very stiff tissue culture dishes.

292 2 kPa) depended on previous culture time on stiff tissue culture polystyrene (TCPS; E ~ 3 GPa).

293 ding sarcomere stretch and the expression of stiff titin isoforms.

294 rmore, we find that the bundle is solid, and stiff to bending, along the long axis, whereas it has a

295 that cells preferentially migrate from less stiff to more stiff substrates; however, much of this ph

296 fd is too stiff to translocate in folded configurations.

297 sembly to create a hybrid DNA gel containing stiff tubes and flexible linkers.

298 entrations of HU, DNA molecules first become stiff with a larger value of the persistence length.

299 The tubes are unexpectedly stiff, with reported Young's moduli of 19-27 GPa that we

300 rate active tensegrities that are relatively stiff yet resilient with various complexities.