ライフサイエンスコーパス: stiffening

1 , such as degradation, matrix deposition, or stiffening.

2 s accompanied by segmental infrarenal aortic stiffening.

3 ol1a2, leading to medial fibrosis and aortic stiffening.

4 in the form of hoop reinforcement and strain stiffening.

5 tion, or extracellular matrix deposition and stiffening.

6 nflammation and mechanical stretch in aortic stiffening.

7 eukin 17a were also protected against aortic stiffening.

8 t HSP27 or alphaB-crystallin suppressed this stiffening.

9 x adhesions, including integrin-induced cell stiffening.

10 destly favorable effect on age-associated LV stiffening.

11 of protein chains, which mediate the capsid stiffening.

12 othelial function and contribute to arterial stiffening.

13 impair vascular function and cause vascular stiffening.

14 onus and corneal ectasia by inducing corneal stiffening.

15 ponsiveness to vasoconstrictors and vascular stiffening.

16 instead delays the occurrence of the strain stiffening.

17 enic differentiation is favoured for earlier stiffening.

18 hibitor on pulmonary vascular remodeling and stiffening.

19 levels (P < 0.001) in the eyes with corneal stiffening.

20 erm (days-to-weeks) cell response to dynamic stiffening.

21 e, such as increased fat depots and arterial stiffening.

22 sponse to morphological changes and membrane stiffening.

23 post-LASIK keratectasia by means of corneal stiffening.

24 y associated with risk of progressive aortic stiffening.

25 of focal adhesions and adaptive cytoskeletal stiffening.

26 HFpEF is associated with ventriculoarterial stiffening.

27 stimulated fibrous ECM deposition and tissue stiffening.

28 creasing adherent area does not lead to cell stiffening.

29 on generally resulted in body shortening and stiffening.

30 esponse to morphological change and membrane stiffening.

31 ng evidence for a significant role for polar stiffening.

32 motility and proliferative responses to ECM stiffening.

33 geing is associated with marked large artery stiffening.

34 of cellular ageing, is linked with arterial stiffening.

35 focal adhesion maturation, and intracellular stiffening.

36 first: blood pressure elevation or arterial stiffening.

37 ng, thickening of dermal fibrils, and tissue stiffening.

38 ibit nonlinear elasticity, undergoing strain stiffening.

39 ular resistance, and arterial remodeling and stiffening.

40 ven though conventional wisdom only suggests stiffening.

41 d and is characterized by progressive matrix stiffening.

42 used by endothelial dysfunction and arterial stiffening.

43 calponin exhibited a delayed onset of strain stiffening (10.0% without calponin, 14.9% with calponin)

44 plications including structures with tunable stiffening, 3D structures with gradient and programmable

45 putational model, we recently predicted that stiffening a large anterior infarct anisotropically (in

46 ement analysis to explore the role of strain stiffening, a characteristic mechanical property of coll

47 We conclude that titin-based cardiac myocyte stiffening acutely after MI is partly mediated by interl

48 to detect diminished or accentuated corneal stiffening after CXL.

49 ide resulted in significantly higher corneal stiffening after CXL.

50 ition of LOX-dependent subendothelial matrix stiffening alone suppressed HG-induced retinal EC activa

51 quantum-mechanical calculations that strain-stiffening also occurs, surprisingly, in simple inorgani

52 Strain-stiffening--an increase in material stiffness at large s

53 kers of aging, and impact age-related tissue stiffening and atherosclerotic changes.

54 ver, temporal relationships between vascular stiffening and blood pressure elevation have not been fu

55 ccelerated in response to microenvironmental stiffening and can be inhibited by softening.

56 eposition, whereas PLOD2 is required for ECM stiffening and collagen fiber alignment.

57 ichostatin A treatment also resulted in cell stiffening and decreased migratory ability in KFs.

58 Stiffening and decreased viscosity of the TM at high sti

59 Aging incurs aortic stiffening and dilation, but these changes are less pron

60 noncooperative process, which results in DNA stiffening and DNA folding depending on protein concentr

61 1 clusters, there is an increase in cellular stiffening and enhanced RhoA signaling compared with ICA

62 ed tumor progression by reducing the stromal stiffening and epithelial contractility induced by loss

63 of the arms (widening or raising) and legs (stiffening and extending or tucking up) during Approach

64 ECs adherent on collagen display divergent stiffening and focal adhesion growth compared with ECs o

65 erstanding the fundamental science of strain-stiffening and incorporating this concept into the desig

66 rformed to quantify arterial and ventricular stiffening and interaction in 461 participants without h

67 ich is hypothesized to induce early vascular stiffening and may be promoted by macrophage-mediated ma

68 onstructed that incorporated stretch-induced stiffening and multidirectionality of the collagen fiber

69 Matrix stiffening and myofibroblast resistance to apoptosis are

70 ng of vFLIP or IKKbeta is localized twisting/stiffening and not large-scale rearrangements.

71 idant stress to immune activation and aortic stiffening and provide insight into the systemic inflamm

72 Aortic stiffening and reduced nitric oxide (NO) availability ma

73 therapeutic interventions that limit aortic stiffening and related cardiovascular disease events.

74 s collagen cross-linking and leads to tissue stiffening and scar formation.

75 wever, our system is capable of both dynamic stiffening and softening.

76 is maintained; these results indicate strain stiffening and/or dependence of mechanotype on deformati

77 These data suggest that targeting intimal stiffening and/or the EC response to intima stiffening c

78 induced vascular T-cell infiltration, aortic stiffening, and collagen deposition.

79 n, extracellular matrix (ECM) production and stiffening, and contraction due to the expression of smo

80 be responsible for valvular cusp retraction, stiffening, and formation of calcified nodules.

81 ure; prevented vascular inflammation, aortic stiffening, and hypertension; and prevented DC and T cel

82 estyles lead to cardiac atrophy, ventricular stiffening, and impaired diastolic function.

83 In fact, vessel wall stiffening, and microcirculatory endothelial dysfunction

84 disease, the valve cusps undergo retraction, stiffening, and nodular calcification.

85 ern diet (WD) for 16 weeks results in aortic stiffening, and that these abnormalities were prevented

86 e peripheral airways and early onset of lung stiffening are often difficult to detect.

87 anisms of its actions on cusp retraction and stiffening are unclear.

88 We show that initial stress stiffening arises from acceleration of strained filament

89 and t-ferulic acids indicates that the wall stiffening arises from cross-linkage to cell wall polyme

90 These findings implicate BM stiffening as a critical determinant of HG-induced retin

91 oduces the novel concept of segmental aortic stiffening as an early pathomechanism generating aortic

92 Aortic stiffening, assessed by carotid-femoral pulse wave veloc

93 ine blood samples exhibited significant cell stiffening at 500 mug/mL iron dextran loading concentrat

94 Moreover, the worm exhibits dramatic stiffening at higher stresses-behavior that is also inde

95 ally soft response followed by strong strain-stiffening at large extensions.

96 ast, lamin A/C levels control nuclear strain stiffening at large extensions.

97 g softening at a yield point and substantial stiffening at large strain until failure--as being cruci

98 t contracture formation is not the result of stiffening at the cellular level, but stiffening of the

99 lied stress, which is consistent with stress stiffening behavior of cells.

100 ess is not explained by the nonlinear strain-stiffening behavior of the material alone and is likely

101 xonal microtubule bundles in tension display stiffening behavior similar to a power-law relationship

102 iological tissue, exhibit a nonlinear strain-stiffening behavior when subjected to large deformations

103 al hemodynamic shear stress and blood vessel stiffening both significantly influence the arterial end

104 age of 36 years predicted change in arterial stiffening by a mean age of 43 years, but not the revers

105 tion of the collagen I/III ratio and cardiac stiffening by excess n-6 PUFA represent a novel pathway

106 of the control of extracellular matrix (ECM) stiffening by the mechanosensitive microRNA-130/301 fami

107 ological and X-ray diffraction measurements, stiffening can be attributed to a mobile nematic directo

108 cross-links, we demonstrate that the strain stiffening can be caused by two distinctly different mec

109 cs and determine whether exertional arterial stiffening can be mitigated by inorganic nitrite.

110 riplet enables the replication of the strain-stiffening characteristics of jellyfish, lung, and arter

111 in the mouse myocardium, leading to cardiac "stiffening" characterized by impaired transmitral flow i

112 stiffening and/or the EC response to intima stiffening clinically may improve vascular health.

113 lthough SScPAH did not have greater vascular stiffening compared with IPAH, RV contractility was more

114 -dependent, indicating that anterior stromal stiffening contributes the most to mechanical outcome.

115 Left ventricular (LV) stiffening contributes to heart failure with preserved e

116 Our data suggest that organ stiffening cooperates with TGF-beta to induce fibrosis i

117 This stiffening counterbalances the natural tendency of the D

118 , dynamic-LH binding/unbinding reduces fiber stiffening dramatically (by a factor of almost 5, as mea

119 of the intact airway, accounting for strain-stiffening due to collagen recruitment (a large componen

120 properties of the macrofibrils dominate the stiffening due to the progressive setting up of the cyst

121 revealed a profound effect of cell membrane stiffening during deoxygenation, with granular RBC shape

122 The stiffening effect of CXL has made it a promising alterna

123 The phosphorylation extension and stiffening effect provides a peptide-scale physical inte

124 We find that divalent ions produce a fiber stiffening effect that competes with, but does not overs

125 ays) and matrix fiber realignment and strain stiffening enables the cells to polarize and develop con

126 , we review the cross talk among vessel wall stiffening, endothelial contractility, and vascular dise

127 ctions can alter stem cell perception of the stiffening extracellular microenvironment.

128 dynamic catch', characterized by abrupt bond stiffening followed by the formation of catch bonds, whe

129 cyte stretch, fibroblast stretch, and matrix stiffening following MI may separately regulate differen

130 Both molecular systems show torsional stiffening for increasing rotation angle, but the elasti

131 lear localization of YAP/TAZ, and subsequent stiffening (from ca. 3.5 to 28 kPa) increased the cell a

132 y mediators and often results in ventricular stiffening, functional deterioration, and development of

133 pose that these cells, via vacuolization and stiffening, gave rise to the chordate notochord.

134 As LV stiffening has been implicated in the pathophysiology of

135 ding stroke, myocardial infarction, arterial stiffening, heart failure, and renal insufficiency.

136 ibit plasticity in Cdc42-mediated mechanical stiffening, histone 3 lysine residue 9 (H3K9) methylatio

137 Together, these data suggest that stiffening hydrogels may be more faithful models for stu

138 Here, we used visible light-mediated stiffening hydrogels to investigate cell mechanotransduc

139 ffer a means to prevent accelerated arterial stiffening in adulthood and related cardiovascular seque

140 apeutic target of aortic fibrosis and aortic stiffening in diabetes mellitus.

141 h may play an important role in the observed stiffening in glucose-treated elastin.

142 These results suggest that LV stiffening in healthy ageing occurs during the transitio

143 passive-force levels characterize diastolic stiffening in heart-failure patients, and it is critical

144 inflammation, mechanical stretch, and aortic stiffening in hypertension remains undefined.

145 ts might underlie susceptibility to arterial stiffening in male and female Dahl salt-sensitive rats.

146 dence that elevated BP precedes large-artery stiffening in middle-aged adults.

147 ed these activities and prevented cells from stiffening in response to forces on E-cadherin.

148 spreading on post arrays as demonstrated by stiffening in response to jasplakinolide and the abrogat

149 s formed, cell spreading as well as cellular stiffening in response to mechanical force.

150 al LARG regulating leukocyte behavior and EC stiffening in response to tractional forces generated by

151 te the potential predictive role of vascular stiffening in the early detection of atherosclerosis.

152 p38 prevented angiotensin II-induced aortic stiffening in vivo.

153 ing other hallmark cellular responses to ECM stiffening including cell spread area, stress fiber form

154 ressure associated with age-related arterial stiffening increases risk for Alzheimer dementia but the

155 We hypothesized that aortic stiffening increases this previously ignored component o

156 Corneal stiffening index (CSI) was introduced as a metric to com

157 Interestingly, stiffening inhibits fibroblast spreading through either

158 n also suppress extrinsic effects by greatly stiffening interface bonding.

159 Responses of the endothelium to stiffening involve integration of mechanical cues from v

160 We propose that stiffening is a consequence of active myosin-driven cell

161 We argue that this stiffening is a consequence of local aggregations of fib

162 Accelerated arterial stiffening is a major complication of diabetes mellitus

163 Matrix stiffening is a prominent feature of pulmonary fibrosis.

164 ins, we demonstrate that frequency-dependent stiffening is associated with the striated sheet matrix

165 The early mechanical stiffening is concomitant to an increase in diameter of

166 Carotid stiffening is considered a key element in the pathogenes

167 Thereafter, this LV stiffening is followed by LV volume contraction and remo

168 Elastomer stiffening is influenced by liquid crystal content, the

169 Cell-induced stiffening is limited to a factor 3 even though fibrin g

170 n after MI, suggesting that MI-induced titin stiffening is mediated by elevated levels of the cytokin

171 n, it remains unknown whether age-related LV stiffening is merely a reaction to arterial stiffening o

172 , we demonstrated that subendothelial matrix stiffening is necessary and sufficient to promote EC act

173 e, and growing evidence suggests that matrix stiffening is particularly decisive during development,

174 An important regulator of sarcomeric stiffening is the sarcomeric protein titin.

175 (i.e., helices A-C and F), and a comparable "stiffening" is observed for residues in the DNA recognit

176 ng of the heart's matrix with collagenase or stiffening it with enzymatic crosslinking suppresses bea

177 Frequency-dependent stiffening largely disappeared in all three TM mutations

178 he following: vascular dysfunction; arterial stiffening; left ventricular hypertrophy; and worsened m

179 that operate during material deformation and stiffening make stretchability and conductivity fundamen

180 In addition, monitoring segmental aortic stiffening may aid the identification of patients at ris

181 apies targeting load-independent ventricular stiffening may be effective to treat and prevent age-ass

182 ss or the endothelial cell response to tumor stiffening may help restore vessel structure, minimize m

183 but direct vascular inflammation and aortic stiffening may play a role.

184 The detrimental effects of aortic stiffening may result in brain damage as well as heart f

185 This remarkable strain-stiffening mechanism offers fundamental insights for und

186 l twin-boundary dominated indentation strain-stiffening mechanism that produces a large strength enha

187 ture or constituents, suggesting a universal stiffening mechanism.

188 orsal doming" are thought to facilitate this stiffening mechanism.

189 e, can affect the transition between the two stiffening mechanisms and, as such, control the dominant

190 providing a fundamental understanding of the stiffening mechanisms of Pf-infected RBCs, our simulatio

191 usions, known as "knobs," introduce multiple stiffening mechanisms through composite strengthening, s

192 ity lies in the existence of two fundamental stiffening mechanisms.

193 H-NS DNA-stiffening mode caused by nucleoprotein filament formati

194 ed ECM production; and 3) progressive matrix stiffening, modeling the mechanical effects of infarct s

195 ay contribute to the rapid mechanical tissue stiffening occurring in many diseases, including cancer

196 Interventional stiffening of AAA-adjacent aortic segments (via external

197 efect-driven' hypothesis, we clearly observe stiffening of C-S-H with increasing Ca/Si in the range 0

198 ulation of type II fibres and a decrease and stiffening of connective tissue.

199 ises from competition between passive strain-stiffening of ECM and force generation by ASM yielding a

200 The extraordinary stiffening of Fe3C arises from the strain-induced revers

201 lity given the known effects of large artery stiffening of left ventricular pulsatile load.

202 ment detachment kinetics, and strain-induced stiffening of motor-cargo linkages.

203 as a muscle contractant, but it also causes stiffening of mutable connective tissue in the body wall

204 temperature changes underpin the macroscopic stiffening of nanocomposites.

205 n of strain-concentrating defects and to the stiffening of nanoscale components at high strains, such

206 Controlled stiffening of normal human red blood cells (RBCs) in dif

207 hich promotes the spreading of cells and the stiffening of nuclei as both actomyosin assembly and nuc

208 Here, we show that the nonlinear stiffening of reconstituted type I collagen networks is

209 cts (>200%; Pinteraction <0.001), indicating stiffening of RV sarcomeres.

210 plied to study the morphologies and membrane stiffening of sickle RBCs.

211 We found a substantial stiffening of single filaments above a characteristic tr

212 Finite-element analysis reveals that early stiffening of the aneurysm-prone aortic segment leads to

213 We observe stiffening of the aorta in regulator of G protein signal

214 Marked stiffening of the aorta is associated with reduced wave

215 Stiffening of the aortic wall is a phenomenon consistent

216 around the inclusions cause the softening or stiffening of the biological membranes.

217 We find reversible local stiffening of the cell during growth, and show that the

218 degree of strain-induced fiber alignment and stiffening of the collagen matrices.

219 amellar stresses; and 3), the passive strain-stiffening of the cytoskeleton.

220 We propose a model in which stiffening of the damaged ends by the repair complex, co

221 ologic range of ECM stiffness and found that stiffening of the ECM leads to both cell cycling and cel

222 ult of stiffening at the cellular level, but stiffening of the ECM with increased collagen and an inc

223 ive extracellular matrix deposition leads to stiffening of the heart, which can eventually lead to he

224 sedentary ageing leads to marked atrophy and stiffening of the heart, with substantially reduced card

225 onal stability of the duplex and the related stiffening of the heterocyclic bases and the sugar-phosp

226 he pathogenesis of malaria is largely due to stiffening of the infected red blood cells (RBCs).

227 pectrins in the cytoskeletal network and the stiffening of the iRBCs.

228 od of 2 months revealed a marked age-related stiffening of the lens nucleus.

229 The related stiffening of the material follows a power law, typical

230 OX-induced collagen cross-linking results in stiffening of the matrix both in vitro and in vivo.

231 ional changes that result in fluidization or stiffening of the melt can be induced by crystal growth

232 cess adhesive energy combined with the local stiffening of the membrane, which occurs in a narrow ran

233 that binding to actin leads to an allosteric stiffening of the motor-lever junction.

234 on in heart failure patients is evident from stiffening of the passive properties of the ventricular

235 addition, our analysis reveals an unexpected stiffening of the polar regions of the stomata complexes

236 explained by the occurrence of electrostatic stiffening of the polymer chains at large charge densiti

237 We hypothesized that disproportionate stiffening of the proximal aorta as compared with the ca

238 Stiffening of the proximal aorta is strongly associated

239 utions from increased collagen and intrinsic stiffening of the RV cardiomyocyte sarcomeres.

240 To investigate the contribution of stiffening of the sarcomere (the contractile apparatus o

241 Significant stiffening of the sclera follows exposure to moderate IO

242 d that implementation of frequency-dependent stiffening of the TM in the OHC attachment region facili

243 cell to adhesion structures and facilitates stiffening of the vessel wall, regulating blood flow ret

244 ns as an energy source, and Ca(2+)-dependent stiffening of titin stretched during eccentric muscle co

245 approach minimized the impact of chest wall stiffening on alveolar recruitment without causing hemod

246 Scleral hypercompliance may precede stiffening or be a unique response to minimal chronic IO

247 stiffening is merely a reaction to arterial stiffening or caused by other processes.

248 n the complete cohort and progressive aortic stiffening over 30 months in a subgroup of 93 patients.

249 ess relaxation is to rapidly diminish strain stiffening over time.

250 rts the experimental observation that radial stiffening plays a very limited role in stomatal opening

251 ng started later in life fails to reverse LV stiffening, possibly because of accumulation of irrevers

252 model, we demonstrate that segmental aortic stiffening precedes aneurysm growth.

253 Recent evidence shows that arterial stiffening precedes the onset of high blood pressure; ho

254 n fibers, responses to applied force, strain stiffening properties of the aligned fibers, aspect rati

255 The mechanical stiffening range of approximately 58 kHz and a more than

256 he increase in Ees was reflective of passive stiffening rather than enhanced systolic function.

257 Moreover, endothelial stiffening reduces nitric oxide production, which promot

258 plus modeling lead us to propose that polar stiffening reflects a mechanical, pectin-based pinning d

259 We speculate that this stiffening reflects the development of particle clusters

260 We show that in the strain-stiffening regime with typical physiological and experim

261 ended on IOP and the spatial distribution of stiffening relative to the cone location.

262 develop vascular collagen deposition, aortic stiffening, renal dysfunction, and hypertension with age

263 ice eliminated vascular inflammation, aortic stiffening, renal dysfunction, and hypertension; however

264 mportantly, this softening is contrary to TM stiffening reported in glaucomatous human eyes.

265 connection between attenuated stiffness and stiffening response and the increased invasion capacity

266 We further show that the stiffening response mimics the effect of an external str

267 e for the solid-like behavior and the stress-stiffening response of the soma, whereas neurofilaments

268 n decreased stiffness and loss of the normal stiffening response to force applied on integrins.

269 hat result in increased cell stiffness and a stiffening response.

270 hat alpha-SMA inhibition following substrate stiffening resulted in attenuated stellate cell activati

271 diseased lung tissue and determined that ECM stiffening resulted in mechanoactivation of the transcri

272 we demonstrate quantitatively that arterial stiffening seems sufficient to explain age-related emerg

273 Microscopy observations show that this stiffening sets in when the cells spread and apply tract

274 provided experimental evidence that corneal stiffening significantly increases GAT and Tono-Pen read

275 Unlike Fe3C, no new bond forms in Al3BC3 but stiffening still occurs because strong repulsion between

276 ed on the period of culture, before or after stiffening, such that adipogenic differentiation is favo

277 These results indicate that ECM stiffening sustains vascular cell growth and migration t

278 Lankan CKDu is associated with less arterial stiffening than defined causes of CKD.

279 ), we identify progressive structural aortic stiffening that precedes the onset of arterial hypertens

280 uced membrane disruptions while mechanically stiffening the associated complexes under the applied me

281 packing interactions within the receptor and stiffening the detergent micelle.

282 ered the cuticle biomechanical properties by stiffening the elastic and viscoelastic phase and by red

283 recipitated by infarction through bulking or stiffening the infarct region.

284 There is some evidence to suggest that stiffening the peripapillary sclera may be protective ag

285 would improve LV function, whereas isotropic stiffening, the focus of previous studies and therapies,

286 Network stiffening, therefore, contributed less to crumb firmnes

287 eter-deliverable soft hydrogels with in vivo stiffening to enhance therapeutic efficacy achieve these

288 regimes that exhibit cell softening or cell stiffening to varying degrees.

289 iopolymer networks have shown similar strain-stiffening trends regardless of the differences in their

290 Stiffening under dynamic compression has not been previo

291 fferent scales to maintain reversible stress stiffening up to large strains.

292 l structure and hydrolysis triggers filament stiffening upon disassembly.

293 have shown softening via photodegradation or stiffening via secondary cross-linking; however, our sys

294 For each dog, corneal stiffening was induced in one eye with glutaraldehyde/ph

295 ogenic differentiation is favoured for later stiffening, whereas osteogenic differentiation is favour

296 w-driven fibrous ECM accumulation and tissue stiffening, while the addition of lysophosphatidic acid

297 The vessel wall experiences progressive stiffening with age and the development of cardiovascula

298 Inorganic nitrite mitigates arterial stiffening with exercise and improves hemodynamics, indi

299 roves hemodynamics, indicating that arterial stiffening with exercise is at least partially reversibl

300 study tested the hypothesis that CXL-induced stiffening would be proportional to the collagen autoflu