ライフサイエンスコーパス: stiffness

1 l speed should increase with decreasing cell stiffness.

2 high thermal conductivity and low mechanical stiffness.

3 dulation of fiber size/diameter, density and stiffness.

4 performance over AI r in assessing arterial stiffness.

5 e bonds, which significantly enhance protein stiffness.

6 nt on the sarcomere length and the myofibril stiffness.

7 d mechanical influences such as local tissue stiffness.

8 n arrangement and extracellular matrix (ECM) stiffness.

9 -Shtrikman upper bounds on isotropic elastic stiffness.

10 proliferative and motility responses to ECM stiffness.

11 have been developed to characterize cellular stiffness.

12 strength, a parameter that is linked to cell stiffness.

13 velocity (aPWV), a robust measure of aortic stiffness.

14 e function of perlecan, which reduces tissue stiffness.

15 significantly increased sarcolemmal lateral stiffness.

16 affecting cell trajectories because of cell stiffness.

17 ervate, polymer properties, and the material stiffness.

18 an independent predictor of increased liver stiffness.

19 cades that are activated by increased tissue stiffness.

20 ecursors to adapt to substrates of different stiffness.

21 cells that exploits differences in cellular stiffness.

22 n the regulation of overall endothelial cell stiffness.

23 reserves CNS architecture by reducing tissue stiffness.

24 n resonating system featured by the negative stiffness.

25 tion potentials (myotonia), producing muscle stiffness.

26 rest in quantifying vascular cell and tissue stiffness.

27 al stimuli and varying surrounding substrate stiffness.

28 ocedure that leads to an increase in corneal stiffness.

29 pendent of local applied force and substrate stiffness.

30 he tip links relax, reducing the hair-bundle stiffness.

31 minished swelling, and restored basal tissue stiffness.

32 ars, 29% of the subjects had increased liver stiffness.

33 optimal, reliable estimates of global tissue stiffness, a cell must adjust its size, shape, and posit

34 ferences between morning and afternoon shear stiffness across all levels and there was very good tech

35 we measure phase disorder strength and shear stiffness across five cellular populations with varying

36 hypothesis for how alterations of cell wall stiffness affect periplasmic volume regulation.

37 er time, with a 40% reduction in the bending stiffness after 36 h.

38 al changes of actomyosin-dependent force and stiffness along the antero-posterior and dorso-ventral a

39 Stiffness also increases TCR-induced immune system, meta

40 on to single FAs in the context of substrate stiffness and actomyosin contractility.

41 d there were weak correlations between shear stiffness and age across all levels (R </= 0.32).

42 polarization is directly proportional to the stiffness and alignment of the matrix.

43 le number is accompanied by increased muscle stiffness and an increase in the number of collagen prod

44 Increased extracellular matrix stiffness and application of mechanical stretch to multi

45 tiation of encapsulated cells depends on gel stiffness and cell density.

46 bition was sufficient to decrease fibroblast stiffness and collagen expression, supporting that FAK(Y

47 Finally, substrate stiffness and cytoskeletal contractility regulated wheth

48 and this was consistent across different ECM stiffness and cytoskeletal tension states.

49 sed to quantify the variation in the lattice stiffness and Debye frequencies.

50 own about how 3D material properties such as stiffness and degradability affect the maintenance of NP

51 el responses, they result in a lower elastin stiffness and earlier collagen recruitment.

52 y, adipose tissue inflammation, and arterial stiffness and exerts a beneficial shift in gut microbial

53 Materials often exhibit a trade-off between stiffness and extensibility; for example, strengthening

54 n of interleukin-1beta reduced arterial wall stiffness and hampered aneurysm development.

55 The fibers exhibit a unique combination of stiffness and high damping capacity (60-70%), the latter

56 Results Correlations between liver shear stiffness and histologic features were higher at high fr

57 ion results in pleural thickening, increased stiffness and impaired lung function.

58 id after just 1 min) and displays decreasing stiffness and increasing fluidity toward its posterior e

59 es, when made from materials of high elastic stiffness and low density, represent some of the lightes

60 betaPS-integrin are known to promote tissue stiffness and oppose the function of perlecan, which red

61 anical strength with desired balance between stiffness and plasticity.

62 ors present in a sarcomere, such as filament stiffness and regulatory proteins.

63 dictor for VO2max even after inclusion of LV stiffness and relaxation time (beta=0.80; P<0.01).

64 distinct feature of HFpEF, independent of LV stiffness and relaxation.

65 The intrinsic stiffness and rod-like geometry of nanoscale components

66 this transition, quantities such as the edge stiffness and speed of sound can change by orders of mag

67 Results Liver stiffness and storage modulus increased with progressive

68 pore formers to evaluate the effect of shell stiffness and Tg on compressive behavior and compression

69 conformation changes depend on the substrate stiffness and the pulling force applied from the cell cy

70 The key to success is to control the stiffness and thickness ratios of the film and the subst

71 Results indicate that fiber stiffness and topography significantly influence epithel

72 organized microstructure that increases clot stiffness and triggers mechanical instability over time.

73 hibit a linear relationship between mandible stiffness and volume, as expected in isometric model sca

74 ve correlation with fibrosis score and liver stiffness) and correlated with hemoglobin A1C.

75 d, and decreases in blood pressure, arterial stiffness, and afterload as well, thereby improving sube

76 res) and hepatological (viral markers, liver stiffness, and biochemical parameters) evaluations were

77 eversed the reduction in E/A, reduced aortic stiffness, and eliminated impairment of coronary blood f

78 -beta1, and analyzed in terms of morphology, stiffness, and expression of EMT/myofibroblast markers a

79 ights on the coupling among force, substrate stiffness, and FA dynamics.

80 dverse events such as increased pain, muscle stiffness, and headache were reported 50% to 67% of the

81 he resonator to induce heat and modulate its stiffness, and hence its resonance frequencies.

82 ardiovascular autonomic neuropathy, arterial stiffness, and hypertension.

83 nown to impair T cell activity, induce actin stiffness, and inhibit cell polarization.

84 r progression, is sensitive to environmental stiffness, and many cell types exhibit a stiffness optim

85 ctoral fin shape, swimming behavior, fin ray stiffness, and mechanosensory sensitivity.

86 t modes of deformation, exceptional specific stiffness, and stiffness values that span over an order

87 idth normally thought to determine the local stiffness, and tonotopic mapping in turn, change little

88 ess, high rates of hypertension and arterial stiffness; and those without constitutive expression of

89 anisotropy within the lateral epidermis, and stiffness anisotropy within the fiber-reinforced dorso-v

90 t lamin-A,C's increase with tissue or matrix stiffness anti-correlates with lamin-B receptor (LBR), w

91 ent that spans over a 200-fold difference in stiffness, approaching the mechanical contrast observed

92 gnificantly, both disorder strength and cell stiffness are measured with the same phase imaging syste

93 ir ultrahigh strength, damage tolerance, and stiffness, are reviewed, and their potential for multifu

94 nd, in a subpopulation of patients, arterial stiffness as measured by pulse wave velocity.

95 hicknesses may be a key driver of structural stiffness, as the skin layer constituents are physically

96 ions with myocardial infarction and arterial stiffness, as well as coronary artery calcification.

97 loped fibrosis and portal hypertension (mean stiffness at 80 Hz and 48-week feeding, 0.51 kPa +/- 0.1

98 This study compared indices of arterial stiffness at rest and during exercise in subjects with H

99 The predicted failure load and stiffness at the distal radius and tibia were positively

100 e is excellent agreement on measured hepatic stiffness between 2D GRE and 2D SE-EPI MR elastography a

101 can arise from localized variations in wall stiffness between adjacent epidermal cells.

102 cell-substrate and cell-cell forces and cell stiffness both in cell pairs and sheets of cells.

103 en deposition resulted in scars with reduced stiffness but also reduced scar tensile strength.

104 fibrotic microenvironment through their own stiffness but not their collagen expression.

105 retrograde flow rate can be shifted to lower stiffness by simultaneous drug inhibition of myosin II m

106 ricular filling (r=0.67; P<0.01), but not LV stiffness constant beta (-0.34; P=0.051) or relaxation c

107 complex with the sarcomere, altering myocyte stiffness, contractility, and mechanosignalling.

108 dothelial dysfunction and increased arterial stiffness contribute to increased cardiovascular risk in

109 High cardiomyocyte stiffness contributed to stiffness of failing human myoc

110 treated cartilage gave a 5-fold increase in stiffness correlating with a 10-fold upregulation of lys

111 determinant is relative rather than absolute stiffness, creating differential resistance to isotropic

112 ) performance of specific VCTE-defined liver stiffness cutoffs as a test replacement strategy (to rep

113 ) performance of specific VCTE-defined liver stiffness cutoffs as a triage test to identify patients

114 ntour length, bending rigidity and intrinsic stiffness decreased in hypermethylated dsDNA, pointing a

115 Further, liver shear stiffness decreased with steatosis and increased with in

116 elial barrier function where increased fiber stiffness/density resulted in altered cytoskeletal struc

117 Using these nondurotactic gradient gels, stiffness-dependent hASC morphology, migration, and diff

118 more than typical variations in the material stiffness do as lipid composition is changed.

119 olid tumors) collagenous gels demonstrated a stiffness-driven, retinoic-acid-modulated upregulation o

120 t of lengthening reflects muscle short-range stiffness due to cross-bridge dynamics.

121 ivity, clinical effects, pain, early morning stiffness duration, fatigue, patient safety issues, func

122 Furthermore, the myofibril stiffness during shortening was greater than that during

123 effect; insensitivity of scales to quantify stiffness, especially in the less severely affected pati

124 Arterial stiffness, flow-mediated dilation (FMD), nitroglycerin-m

125 mmHg, P = 0.049) without impacting arterial stiffness, FMD, GMD, or NO.

126 There was no significant difference in liver stiffness for those who remained HBsAg-positive compared

127 ilutra models exhibit a six-fold increase in stiffness from expected stiffness-volume relationships c

128 lymerized hydrogel sink results in a tunable stiffness gradient at the cell-matrix interface.

129 onstrates that an extracellular-matrix-based stiffness gradient in the Drosophila egg chamber instruc

130 The stiffness gradient requires morphogen-like signaling to

131 eveals an anterior-posterior (A-P) symmetric stiffness gradient, which fails to develop in elongation

132 jaw, we report a novel approach to generate stiffness gradients in polymeric materials via incorpora

133 hat in the presence of vancomycin, cell wall stiffness gradually decreased over time, with a 40% redu

134 lly >/=50 years), lower platelets, and liver stiffness >/=12 kPa at year 5 represent the main risk fa

135 platelets at baseline and year 5, and liver stiffness >/=12 kPa at year 5 were independently associa

136 Particularly, increased matrix stiffness has profound effects on tumor growth and metas

137 of tissue material properties, in particular stiffness, has received much less attention.

138 erconnected network with exceptional elastic stiffness, higher than that of fully dense silica.

139 pposing faces along the same axis, different stiffness (i.e., soft on one face and hard on the other)

140 2D MRE can estimate hepatic stiffness in children with NAFLD.

141 cending aorta will present signs of apparent stiffness in children with PAH and that this effect may

142 and measured their contractility and passive stiffness in comparison with donor heart muscle as a con

143 ar protein CCN1/CYR61 is highly regulated by stiffness in endothelial cells.

144 Here we design ultra-low stiffness in fully dense, nanostructured metals via the

145 t target the NO pathway in reducing arterial stiffness in HFpEF.

146 (MR) elastography for measurement of hepatic stiffness in pediatric and young adult patients suspecte

147 esults from manual systems (two times larger stiffness in slow over fast muscle) and provides novel i

148 The increased stiffness in subjects without DPN might indicate that th

149 hich could be attributed to increased tissue stiffness in T1DM.

150 roaches, however, are incapable of assessing stiffness in the presence of physiological flows.

151 ship between telomere length (TL) and aortic stiffness in well-characterized, younger and older healt

152 ng the presentation of a continuous range of stiffnesses in a single well without the confounding eff

153 At 56 and 84 Hz, liver stiffness increased with age (Spearman correlation, r =

154 studies demonstrate unequivocally that titin stiffness increases upon muscle activation, but the mech

155 Stiffness increases with age during normal development a

156 ecifically, no differences were noted in the stiffness index, the primary outcome, or sensitivity sco

157 Targeting stiffness-induced changes in the vasculature, such as CC

158 transduces signals provided by extracellular stiffness into cells, regulate the activity of the core

159 nces provided substantially improved SNR and stiffness inversion confidence level in 47 patients in w

160 lecular simulations imply that its nanoscale stiffness is 'defect-driven', i.e., dominated by crystal

161 We hypothesised that skin's stiffness is a function of the thickness of its layers t

162 We demonstrate that the contact stiffness is a power law function of the normal contact

163 As tissue stiffness is a regulator of neuronal growth, our results

164 ling transition when the microscopic bending stiffness is comparable to kT, the scale of thermal fluc

165 istically significant difference in the cell stiffness is confirmed after exposure to various drugs a

166 We show that the ab-planar stiffness is independent of dreierketten chain defects,

167 This is because stiffness is insensitive to microstructure and bounded b

168 equency and amplitude dependency of the cell stiffness is investigated and statistically significant

169 n during solid tumor progression, and tissue stiffness is known to alter cell behaviors including pro

170 he performance of AI r in assessing arterial stiffness is limited.

171 The interfacial contact stiffness is obtained through an inverse identification

172 ing arguments that this broad range of local stiffnesses is a generic property of disordered fibre ne

173 the proof mass weight G, the whole system's stiffness k and the gap x2 between the proof mass and re

174 rolled attenuation parameter (CAP) and liver stiffness (LS) measured by transient elastography (TE, F

175 d on extracellular matrix with physiological stiffness (Matrigel mattress).

176 Liver stiffness (mean of means; in kilopascals) was measured b

177 Conclusion Liver shear stiffness measured with US elastography provided better

178 telet count >150 x 10(9) cells/L and a liver stiffness measurement (LSM) <20 kPa (Baveno VI criteria)

179 SE-EPI MR elastography allowed for stiffness measurement across larger areas of the liver a

180 Patients' liver stiffness measurements (LSM; kiloPascals [kPa]) at ART i

181 SVR in patients with CSPH and whether liver stiffness measurements (LSMs) can rule out the presence

182 Conclusion Tibial nerve stiffness measurements appear to be highly specific in t

183 monstrate that MR elastography-derived shear stiffness measurements are highly repeatable, weakly cor

184 ic resonance (MR) elastography-derived shear stiffness measurements of the intervertebral disc (IVD)

185 e, shape, and position to integrate multiple stiffness measurements over extended regions of space.

186 Even stiffness-mediated cell proliferation was unaffected by

187 Signaling pathways involved in stiffness-mediated podocyte behaviors are identified, re

188 On the contrary, the intrinsic stiffness of C-S-H solid is inversely correlated with th

189 d by reduced contractile force and increased stiffness of cells.

190 s based on the measurement of changes in the stiffness of DNA self-assembled monolayers anchored to m

191 High cardiomyocyte stiffness contributed to stiffness of failing human myocardium because of reduced

192 al collagen contribute to the high diastolic stiffness of failing myocardium.

193 model that predicts the interfacial contact stiffness of fractal rough surfaces by considering the e

194 barrier function on substrates mimicking the stiffness of healthy and tumor tissue.

195 We demonstrate differentiation by stiffness of individual elastic lamellae and vascular sm

196 insulitis was associated with changes in the stiffness of islets.

197 ile, adipose tissue inflammation, and aortic stiffness of LCR rats.

198 ture in which cells respond to the effective stiffness of local matrix attachment points.

199 tography, and apply it to characterizing the stiffness of mouse aortas.

200 ical structures, with an average compressive stiffness of O(1) kPa (0.49 +/- 0.04 kPa stress at 30% c

201 rbation effect by PGPC correspond to greater stiffness of PGPC-treated endothelial cells observed by

202 f growth cone forces applied to beads at low stiffness of restraint revealed switching between two st

203 In this paper, the stiffness of single adherent cells are optomechanically

204 In this study, we measured the stiffness of skeletal muscle myofibrils in rigor.

205 Reducing the effective stiffness of the cell membrane by disrupting the actin c

206 l clock is regulated by the mechano-chemical stiffness of the cellular microenvironment in primary ce

207 ed the greatest remineralizing effect on the stiffness of the completely demineralized dentin matrice

208 se material that should be important for the stiffness of the dendrite.

209 The stiffness of the DNA layer is measured through changes o

210 How mechanical stimuli such as stiffness of the extracellular matrix (ECM) contribute t

211 their localization is promoted by increasing stiffness of the extracellular matrix.

212 terize spatiotemporal changes of the elastic stiffness of the injured rat neocortex and spinal cord a

213 Aspects such as pore size or stiffness of the matrix influence the selection of the m

214 to various activating antibodies and bending stiffness of the micropipette.

215 l pore to estimate the variation with tissue stiffness of the mutation rate in tumors.

216 tion grade and MR elastography-derived shear stiffness of the nucleus pulposus and annulus fibrosus r

217 Second, the local stiffness of the organ of Corti complex felt by individu

218 ssociation between the bone failure load and stiffness of the peripheral skeleton and dietary protein

219 Cells actively probe and respond to the stiffness of their surroundings.

220 osis was associated with reductions in liver stiffness on magnetic resonance elastography, collagen c

221 ies of both phases, demonstrating mechanical stiffness on par with the highest-performing known nanom

222 cells are mechanosensitive but the effect of stiffness on their functions is still debated.

223 ne size, spontaneous curvature, and membrane stiffness on vesiculation and vesicle size distribution

224 odels, we investigated the effects of matrix stiffness on vessel growth and integrity during angiogen

225 predicts, and experiments confirm, that the stiffness optimum of U251 glioma cell migration, morphol

226 t a cell migration simulator that predicts a stiffness optimum that can be shifted by altering the nu

227 tal stiffness, and many cell types exhibit a stiffness optimum, at which migration is maximal.

228 ing is sensitive to cell adhesion but not to stiffness or cell size.

229 suggest that therapeutically targeting tumor stiffness or the endothelial cell response to tumor stif

230 gnificant difference in the odds of arterial stiffness (OR, 1.07; 95% CI, 0.63-1.84; P = .80) and hyp

231 response is not mediated by hypoxia, matrix stiffness, or bulk matrix density, but rather by matrix

232 ollagen sources for stromal contributions to stiffness, organization and ultrastructure via atomic fo

233 platform as an in vitro system with tunable stiffness over a range relevant for recapitulating mecha

234 ns were observed for worst joint pain, joint stiffness, pain interference, and functioning.

235 he observed 25% increase in interplanar bond stiffness, primarily enhances the high-temperature creep

236 Importantly, DAPF showed stiffness properties that are well suited to spinal cord

237 zed starches, single and dual, had increased stiffness, providing a higher tensile strength and lower

238 yocardial performance index (MPI) and aortic stiffness (pulse wave velocity; PWV) were evaluated befo

239 a 64% decrease in E/A, and increased aortic stiffness (PWV: 6.36 +/- 0.47 vs.4.89 +/- 0.41, OSED vs.

240 cillation and, importantly, broadens the ECM stiffness range over which FAs can accurately adapt to t

241 depends crucially on the flagellar/cell wall stiffness ratio.

242 ith increases in nuclear tension and nuclear stiffness resulting from increases in myosin-II and lami

243 , increased RV contractility, and reduced RV stiffness, RV hypertrophy, RV fibrosis, RV inflammation,

244 ients was calculated to detect 50% change in stiffness scores.

245 al mechanism of a reversible single-molecule stiffness sensor.

246 ials that are able to reversibly alter their stiffness, shape, porosity, density, or hardness upon re

247 ints yield a strikingly broad range of local stiffnesses, spanning roughly two decades.

248 ization of a mechanically unstable, negative stiffness state of a martensitic alloy by its coherent i

249 nal MR elastography was performed, and shear stiffness, storage modulus, shear loss modulus, and damp

250 The unique combination of great stiffness, strength, and extensibility makes spider majo

251 of desirable mechanical properties including stiffness, strength, toughness, damping, fatigue resista

252 -infected Zambian adults with elevated liver stiffness suggestive of significant fibrosis/cirrhosis d

253 r variations and other mutations with tissue stiffness suggests that genomic changes are occurring by

254 wo to three orders of magnitude increases in stiffness, tensile strength, and tensile toughness compa

255 , and lodging stems with enhanced mechanical stiffness that is possibly due to decreased stem thickne

256 al model, we are able to identify a critical stiffness that is required by the matrix to break interc

257 Matrix stiffness that is sensed by a cell or measured by a pure

258 ysiological or pathological changes to titin stiffness therefore affect contractility.

259 polymers with different levels of mechanical stiffness; therefore they can be fabricated by using the

260 ure guard cells display a radial gradient of stiffness, this is not present in immature guard cells,

261 with graded nanotopographies and mechanical stiffness, thus parsing the role of specific biophysical

262 Comparing pediatric liver stiffness to adult baseline values to detect pediatric l

263 anical coupling that tunes the cell internal stiffness to match that of its soft, physiological-like

264 ic pressure, cell-cell adhesion and cortical stiffness to mitotic rounding.

265 Yet, they display amazing stiffness, toughness, strength, and deformability attrib

266 nging the binding probabilities and myosin's stiffness under a constant force results in a mechanical

267 Notably, matrix stiffness up-regulates matrix metalloproteinase (MMP) ac

268 er fat in Europids or on predictors of liver stiffness using these methods.

269 Conclusion Liver stiffness values are lower and vary less with frequency

270 cells discriminate between the wide range of stiffness values found in the body and adapt their respo

271 rmation, exceptional specific stiffness, and stiffness values that span over an order of magnitude.

272 ytoskeletal contractility on lower substrate stiffness values.

273 Stiffness varied less with frequency in children and ado

274 We measured stiffness via AFM nanoindentation with a spherical inden

275 roach of local, randomized tailoring of bond stiffness via microalloying enhances creep performance o

276 six-fold increase in stiffness from expected stiffness-volume relationships calculated from extant sp

277 an age of 13.1 +/- 2.4 years, median hepatic stiffness was 2.35 kPa.

278 The decrease in myofibril passive stiffness was a common feature in all hearts with DCM-as

279 Liver shear stiffness was assessed in vivo by using US elastography

280 Assessment of aortic stiffness was evaluated by measuring pulse wave velocity

281 Liver stiffness was evaluated semiannually from 2006 to 2014 u

282 During stretching, the myofibril stiffness was independent of both displacement and speed

283 Liver stiffness was measured at 11.3 years.

284 Passive stiffness was reduced about 38% in all the DCM mutant sa

285 Cell stiffness was validated as a sorting parameter as nonvia

286 axon plasma membrane determines its overall stiffness, we introduced a coarse-grain molecular dynami

287 othelial cell behavior in response to matrix stiffness, we measured endothelial cell barrier function

288 ephropathies characterized by altered tissue stiffness, we show that gelatin-mTG substrates with Youn

289 To measure islet stiffness, we used atomic force microscopy (AFM) and dev

290 itatively assess how vancomycin affects cell stiffness, we used optical traps to bend unflagellated m

291 ealizations of such membranes have a bending stiffness well in excess of experimentally achievable te

292 resonance elastography measurements of liver stiffness were also performed.

293 kers (glutathione and cystine), and arterial stiffness were evaluated.

294 The inclusion of NDs increased the network stiffness, which in turn augmented the traction forces g

295 nts have increased apparent ascending aortic stiffness, which was strongly associated with the degree

296 rt potentials confirm the expected ultra-low stiffness while maintaining full strength.

297 nulus fibrosus MR elastography-derived shear stiffness with increasing Pfirrmann degeneration grade (

298 We observe increased stiffness with proximity to the heart, as well as region

299 creases in radius, protein accessibility and stiffness, without disrupting local structural heterogen

300 nd intraoperator analyses for proximal femur stiffness, yield strain, yield load, ultimate strain, ul