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1 hibitors (CaCl2 omission being paradoxically stimulatory).
2 in this context is antagonistic rather than stimulatory.
3 tip growth with SA being inhibitory and MeSA stimulatory.
4 clusters are formed and DC are rendered less stimulatory.
5 , TIM-3 expression has also been shown to be stimulatory.
6 (-/-) DC display augmented allogeneic T cell stimulatory ability, expanding IFN-gamma(+) and IL-17(+)
7 of frameshifting is achieved by the combined stimulatory action of a "slippery" sequence, an mRNA pse
8 y cell signaling pathway that determines the stimulatory action of ethanol and identifies HSP-16.48 a
9 of cAMP signaling in the kidney by a direct stimulatory action of protein kinase A on the plasma mem
11 ng end of polymeric compounds, to the coffee stimulatory activity in cells mediating innate and acqui
12 ink between alpha-helical propensity and the stimulatory activity of ADs has fundamental practical an
16 observed a strong correlation between the PP-stimulatory activity of STN1 variants and their abilitie
17 kDa membranes, has previously shown in vitro stimulatory activity on BALB/c mice spleen B lymphocytes
18 king the signaling domain, and hence the IFN stimulatory activity, displaces viral proteins and suppr
19 h Staphylococcus sciuri, which has high Nod2-stimulatory activity, was sufficient to promote robust C
26 CD8 T cells exhibit a diminished response to stimulatory Ag, but an enhanced response to weak agonist
27 s the possible use of gamma irradiation as a stimulatory agent to raise the nutritive value and antio
30 this review, we will focus on the role of co-stimulatory and co-inhibitory pathways in two systemic (
31 or component of which is a large array of co-stimulatory and co-inhibitory pathways that modulate the
34 anging reorganization of the relations among stimulatory and inhibitory inputs and autonomic outputs,
35 sults from changes in the regulation of both stimulatory and inhibitory intra-adrenal signaling pathw
36 lthy immune system results from a balance of stimulatory and inhibitory pathways that allow effective
37 Hcm1 functions as a rheostat that integrates stimulatory and inhibitory signals to control cell proli
41 ructure 3' of the frameshift site has weaker stimulatory and polyamine sensitizing effects on framesh
42 , the fusion proteins showed stronger T cell-stimulatory and reduced IgE-binding capacity and induced
43 er as complex as AUD, maintenance of alcohol stimulatory and rewarding effects may play an important
44 12- to 20-bp) dsDNA (Y-form DNA) were highly stimulatory and specifically enhanced the enzymatic acti
45 IT cell in complex with MR1 bound to the non-stimulatory and stimulatory compounds showed distinct li
46 t-6, culture filtrate protein-10, and PPD as stimulatory antigens were undertaken, and cytokine respo
49 r-activated pDC acquired naive CD4(+) T-cell stimulatory capacity and promoted a regulatory Th2 respo
50 their interaction results in reduced T cell stimulatory capacity and secretion of inhibitory cytokin
51 be quantitative approaches used to infer the stimulatory capacity of a given pathogen nucleic acid sp
55 e maturation, cytokine secretion, and T-cell stimulatory capacity of reverse transmigrating (RT) and
57 olerogenic DCs and partially restored T cell stimulatory capacity, demonstrating their dependence on
59 place to regulate this self-reactivity, and stimulatory CD1-lipid complexes appear to be tightly con
62 therapy, IYIY-I2-BODIPY can act as an immune-stimulatory chemotherapeutic agent with potential applic
63 ex with MR1 bound to the non-stimulatory and stimulatory compounds showed distinct ligand orientation
66 ing the CD74-MIF interaction under IFN-gamma-stimulatory conditions would be an effective therapeutic
68 ion, suggesting the importance of the immune-stimulatory context for the induction of this B cell phe
69 an unexpected role of SUMO-1 and SAFB in the stimulatory coupling of promoter binding, transcription
71 1,849 cytokine pairs, we identified the most stimulatory cytokine combinations capable of inducing IF
72 In this regard, NFAT5 upregulated the Th1-stimulatory cytokine IL-12 in classically activated macr
73 nant chimeric protein composed of the T-cell-stimulatory cytokine IL15, the sushi domain of IL15Ralph
74 temic immune activation with elevated immune-stimulatory cytokines and reduced transforming growth fa
76 n of TLR7 leads to the production of several stimulatory cytokines, including type I interferons (IFN
78 ifted by about 6 months, and we suggest that stimulatory day lengths and the proliferation of nesting
79 activation of the STING-dependent interferon-stimulatory DNA (ISD) pathway, which is essential for an
80 of the stimulator of IFN genes-dependent IFN-stimulatory DNA (ISD) pathway, which is essential for an
81 nsive clinical use, the attributes of CAR co-stimulatory domains that impact persistence and resistan
82 .g., Staphylococcus and Pseudomonas) and low stimulatory (e.g., Prevotella and Streptococcus) bacteri
85 ings mediate a Type 1/Type 17-related immune-stimulatory effect in the airways of asymptomatic neonat
87 E10A activity, but they severely disrupt the stimulatory effect mediated by cAMP binding to the GAF-B
88 (-1) nickel(II) and cobalt(II), and also the stimulatory effect of 5 mg L(-1) nickel(II), and cobalt(
92 C (N521C or N521A) significantly reduced the stimulatory effect of bile acids on ENaC, suggesting tha
93 RK channel activation, tempers the locomotor stimulatory effect of cocaine while also modulating the
97 o the culture in FBS appeared to inhibit the stimulatory effect of FBS on ILY, MsgA, and NanA, althou
98 findings suggested that LCB counteracted the stimulatory effect of H2O2 on secretion and expression o
101 n in vitro, and IP deficiency diminished the stimulatory effect of indomethacin on STAT6-independent
102 Although GnIH significantly suppressed the stimulatory effect of kisspeptin on GnRH release in hypo
106 ATP into a peripheral nerve might mimic the stimulatory effect of nerve injury on the regenerative s
107 petitive inhibitor that acts by blocking the stimulatory effect of nucleosomes on the ATPase activity
108 of human and rat mesangial cells confirmed a stimulatory effect of PDGF-B on DbpA transcript numbers
109 ion, the molecular mechanisms underlying the stimulatory effect of platelets on leukocyte transendoth
113 tion site as well as characterization of the stimulatory effect of Tat on P-TEFb catalytic efficiency
115 he contrary, GnIH effectively eliminated the stimulatory effect of VIP on p38 and ERK phosphorylation
118 nolasiban treatment alone has no significant stimulatory effect on both the myometrium and amnion.
122 sions via its 3'-5' exonuclease activity and stimulatory effect on DNA ligation during BER in a hairp
123 ISRIB-mediated inhibition of the ISR and its stimulatory effect on eIF2B GEF activity toward its subs
125 sion) in concert with its well-characterized stimulatory effect on lateral root growth (horizontal di
128 bition of miR-155 in endothelial cells had a stimulatory effect on proliferation and angiogenic tube
129 This function of IsdH may have an overall stimulatory effect on S. aureus heme acquisition and gro
140 nsmitters appear to have both inhibitory and stimulatory effects in the course of vascular disease de
141 response, which is characterized by low-dose stimulatory effects of a wide range of agents that are t
143 rs for the major sheddases indicate that the stimulatory effects of calcyon on NRG1 cleavage and shed
145 l positive regulator of EAAT1, mediating the stimulatory effects of EGF, whereas YY1 is a negative re
146 efficient mRNAs preferentially depend on the stimulatory effects of eIF4G-dependent closed-loop assem
148 ular and molecular mechanisms regulating the stimulatory effects of FGF2 on odontoblast differentiati
149 nflammatory macrophages, as suggested by the stimulatory effects of heterologously expressed guanine
150 nding of the molecular mechanisms behind the stimulatory effects of IL-10 during allergic inflammatio
151 a-mediated proinflammatory responses and the stimulatory effects of IL-1beta on house dust mite (HDM)
152 egative feedback mechanism to counteract the stimulatory effects of insulin on OB production of Glu-O
154 a positive regulator of AKT1, mediating the stimulatory effects of rs2494737 increasing endometrial
155 sCD48 bound to SEB and down-regulated SEB stimulatory effects on eosinophils as assessed by EPO an
157 We conclude that, in female rats, leptin's stimulatory effects on SNA are differentially enhanced b
158 ified the receptors that mediate glutamate's stimulatory effects on the counterregulatory responses,
160 Comparison of the HAX-1 deletion-induced stimulatory effects with those elicited by PLN ablation
163 Recoding sites and a downstream recoding stimulatory element (RSE) mediate expected levels of rec
165 coding sites, along with downstream recoding stimulatory elements (RSEs), have long been studied in r
166 bserved depend on the presence of cis-acting stimulatory elements located 5' and 3' of the frameshift
167 switches were constructed by coupling -1 PRF stimulatory elements to RNA aptamers using rational desi
169 ng and OPN promoter activity via an upstream stimulatory factor (USF)-activated cognate inhibited by
170 , whereas for rs8076131, changes in upstream stimulatory factor 1 and 2 transcription factor binding
172 negative strains, suggesting that at least 1 stimulatory factor is susceptible to SpeB proteolytic de
173 tected through association with the cleavage stimulatory factor TFIIS, which enables rapid recovery f
175 Thus, these exosomes may be important immune-stimulatory factors in allergic immune responses and imp
176 eparation of venoms unexpectedly showed that stimulatory factors partition into protein-containing fr
177 9.361 injection also decreased expression of stimulatory Fcgamma receptors, especially FcgammaRIII, a
179 , binds more avidly to an inhibitory than to stimulatory FcRs, and has limited ability to aggregate p
180 n platform, benefiting from intrinsic immuno-stimulatory features while retaining excellent safety pr
181 o largely reverse the inhibitory (FKBP51) or stimulatory (FKBP52) effects of these co-chaperones on t
182 support a substantially revised model for co-stimulatory function in the primary GC response, with cr
187 partly identical to the alpha-subunit of the stimulatory G protein (Gsalpha), but the cellular action
188 ich is catalyzed by the alpha-subunit of the stimulatory G protein (Gsalpha), controls renin synthesi
190 ction mutations of GNAL, a gene encoding the stimulatory G-protein Galphaolf, which is critical for a
191 oded protein, Galphaolf, an adenylyl-cyclase-stimulatory G-protein highly enriched in striatal projec
192 sing expression of inhibitory (Galphai2) and stimulatory (GalphasL) G-protein subunits produced minor
194 We further found that LepRb(POA) neurons are stimulatory glutamatergic neurons, contrary to prevalent
195 re about coexpression of both inhibitory and stimulatory immune checkpoints on individual cells withi
196 iderable extent by activating complement and stimulatory immunoglobulin crystallizable fragment recep
197 a (rTnfalpha) and PGF2alpha recapitulate the stimulatory in vitro effects of salmon Lh (sLh) on contr
198 both necessary and sufficient to mediate the stimulatory influence of the flora on myeloid cell longe
199 ies show that AVP exerts a potent and direct stimulatory influence upon the electrical activity and [
200 of the lung milieu, converting an effective stimulatory influenza-reactive environment into a suppre
201 heir cellular origin, they can induce immune stimulatory-, inhibitory-, or tolerance-inducing effects
202 Cyclins/DNA synthesis rates were linked to stimulatory/inhibitory factors in the culture medium, wh
205 in increased expression of important T-cell stimulatory ligands (Dll4, Il7, and Vegf) by thymic epit
208 e arthritis and were treated with either the stimulatory mAb to LAIR-1 or a hamster IgG control.
209 maR-independent agonistic activity to immune-stimulatory mAbs such as anti-CD40, -4-1BB, and -CD28.
211 ther cell population was positive for the co-stimulatory markers CD40, CD80 and CD86, but both demons
212 moted BMDC maturation and upregulation of co-stimulatory markers, including CD40, CD86, and MHC-II, a
215 ion that contained concentrations within the stimulatory micromolar range in contrast to previously r
216 dependent depletion of surface MHCII, the co-stimulatory molecule B7.2, and suppression of T cell act
217 oduction, showed robust expression of the co-stimulatory molecule CD40L, and promoted the development
218 significantly higher MHC class II and the co-stimulatory molecule CD80 compared to Tetherin KO DCs.
219 otypically mature as they up-regulate the co-stimulatory molecule CD86 from intracellular storages to
222 -regulated the expression of the negative co-stimulatory molecule PD-L1, and this can be prevented fo
223 a4beta1 (CD49d) which, as well as being a co-stimulatory molecule, is required for CLL cells to under
225 sed to a diverse range of potentially immune-stimulatory molecules including semi-allogeneic antigens
226 r histocompatibility complex class II and co-stimulatory molecules on antigen-presenting cells (APCs)
227 ressed significantly higher levels of the co-stimulatory molecules OX40 (37.2% of FOXP3+ cell populat
228 everal pathways of regulation of ILC2s by co-stimulatory molecules such as ICOS, regulatory T cells a
229 are members of the extended B7 family of co-stimulatory molecules, have diverse functions in the imm
230 ass II family, cytokines, chemokines, and co-stimulatory molecules, was significantly altered in tumo
232 enhanced migration and permeability of tumor-stimulatory myeloid cells, and suppressed EC-mediated st
233 h that this is a consequence of blocking the stimulatory, non-covalent, binding of ubiquitin to the b
235 Natural killer T cells (NKT cells) have stimulatory or inhibitory effects on the immune response
236 ding and ultraviolet radiation, resulting in stimulatory or inhibitory signals via plasma membrane nu
238 ted by the semaphorin Sema7a, interacting in stimulatory or inhibitory ways with its beta1 integrin o
239 that crosstalk between co-inhibitory and co-stimulatory pathways in pathogen-specific CD4 T cells ca
242 tive immaturity, and challenge the view that stimulatory peptides are the ultimate gatekeepers of pub
243 de alphaMSH for POMC-neurons, and two growth-stimulatory peptides, growth hormone-releasing hormone (
244 ription factor HSF-1 played in determining a stimulatory phenotype of Caenorhabditis elegans in respo
245 tably, the sensitivity of Or47b neurons to a stimulatory pheromone, palmitoleic acid, is low in young
247 ced regulatory volume decrease (RVI) via the stimulatory phosphorylation of NKCC1 (Thr(203)/Thr(207)/
248 ddition to the well-documented T202 and Y204 stimulatory phosphorylation sites in the activation T-lo
249 rt rate (HR), blood pressure, and subjective stimulatory, pleasurable and aversive responses were mon
250 d heart rate and blood pressure, and induced stimulatory, pleasurable, and aversive subjective effect
251 that a self-peptide with low (but not high) stimulatory potency promotes thymic Treg formation and c
253 ction might create conditions that allow the stimulatory presentation of self peptides themselves and
255 as triggers of innate immune responses, the stimulatory properties of bacterial RNA and its role dur
256 OVs is increasingly focused on their immune stimulatory properties, which may work synergistically w
257 adrenergic receptor (B2AR) activates Galpha stimulatory protein (Galphas) on the endosome exclusivel
258 the alpha subunit Galphas of heterotrimeric stimulatory protein Gs exhibits structural features impl
260 valuated were the aversive, pleasurable, and stimulatory ratings of nicotine's effects, cardiovascula
261 g, we identified an immune cell-specific, co-stimulatory receptor B7.2 (CD86) as a co-receptor of lym
263 munoglobulin and ITIM domain (TIGIT), the co-stimulatory receptor CD226 and their ligand PVR are alte
266 gG2b mAb that binds both FcgammaRIIB and the stimulatory receptor FcgammaRIII), by actively immunizin
267 se of CD8(+) effector T cells expressing the stimulatory receptor Klrk1/NKG2D, a decrease in CD4(+) C
268 get T cells through Ag presentation, killing stimulatory receptor Ly49s6 and coreceptor CD8alphaalpha
269 odents exhibit atypical expression of the co-stimulatory receptor OX40 on CD4 T cells and that therap
270 DCs, we found that CD28, a prototypic T cell stimulatory receptor, was highly expressed in pDCs.
271 ity, upregulates the expression of T-cell co-stimulatory receptors, with the inducible co-stimulator
276 intercellular adhesion molecule 1, and (3) a stimulatory role for thrombin, the thrombospondin-1/CD36
277 ia to test the hypothesis that calcium has a stimulatory role in skeletal muscle mitochondria not app
278 suggest that SEVI may not play a significant stimulatory role in the efficiency of male-to-female sex
280 onasal sensory neurons (VSNs) sample various stimulatory semiochemicals dissolved in the intraluminal
282 es (ICs) in human CD4(+) T-cells produced co-stimulatory signal like CD28 that triggered IFN-gamma pr
283 ) T-cells phosphorylate Syk and provide a co-stimulatory signal to CD4(+) T-cells in the absence of C
285 human cells, promoting the expression of co-stimulatory signals and the secretion of pro-inflammator
286 functionality in some patients if sufficient stimulatory signals are delivered, which might open up o
287 the pre-TCR, beta-selection also requires co-stimulatory signals from Notch receptors - key cell fate
288 nscription slippage for gene expression, the stimulatory structure provides parallels with programmed
297 R has opposing effects on BCC carcinogenesis-stimulatory via mutagenesis and inhibitory via productio
298 R and Gs (guanine nucleotide binding protein stimulatory) were reduced, whereas left ventricular and
299 tagonistic effects on mitochondrial editing: stimulatory, which requires a catalytic glutamate for mo
300 TSPX, truncation of which renders TSPX to be stimulatory while its transposition to the C-terminus of
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