ライフサイエンスコーパス: stop

1 agonist responsiveness as synthesis of RGS2 stops.

2 e population level occurs after treatment is stopped.

3 were negative, the antibiotic treatment was stopped.

4 which was reversed when SPDEF expression was stopped.

5 ement execution but also during rapid action-stopping.

6 s recruit a fronto-basal-ganglia network for stopping.

7 elecoxib (Cel)-containing comparisons, which stopped accrual early at interim analysis on the basis o

8 Stopping actions did not engage this pathway.

9 s in arm 1 received tapered corticosteroids, stopped after day 10, whereas patients in arm 2 received

10 atment duration was scheduled for 1 year and stopped after observation of a primary end point.

11 ich corresponded to a custom-programmed hard-stop alert tool in the Epic hospital information system,

12 eotide polymorphism were more likely to have stopped all other treatment as well (OR, 0.45; 95% CI, 0

13 otal of 19.8% of women younger than 35 years stopped all protocol-assigned endocrine therapy early.

14 ated by regional back-projection and rupture-stop analysis.

15 Different onset asynchronies between stop and change cues were implemented (0 and 300 ms) in

16 thy controls when there was no delay between stop and change stimulus, while there was no difference

17 unstable suggests that the production of non-stop and intronic mRNA isoforms may represent a form of

18 serine, alanine and cysteine in response to stop and sense codons, depending on the identity element

19 The anti-Programmed cells Death-1 was stopped and a topical corticosteroid treatment was admin

20 eatment (day 36), and 30 d after GOS feeding stopped and consumption of dairy products was encouraged

21 d safety monitoring board, randomisation was stopped and immediate vaccination was also offered to ch

22 liver failure were excluded, all drugs were stopped and the imaging studies performed were positive

23 evidence for motor inhibition during action stopping and action preparation, focusing on studies tha

24 e investigated the role of gamma during fast stopping and recorded scalp electroencephalogram and loc

25 t present it is difficult to tell where sign stops and gesture begins, we suggest that sign should no

26 y of ALS drug discovery is fraught with many stops and starts.

27 (the restrain of actions in preparation for stopping) and reactive (outright stopping) inhibition.

28 rvature preference, receptive field (RF) end-stopping, and RF eccentricity in the ventral stream.

29 speedy elongation, resulting in a repetitive stop-and-go growth dynamics.

30 The ciliomotor circuitry thus constitutes a stop-and-go pacemaker system for the whole-body coordina

31 ement within chromatin is consistent with a 'stop-and-go' or 'hopping' motion.

32 last menstrual period and did not switch or stop ART in pregnancy were considered to be ART exposed

33 PrEP Participant A stopped ART and remained aviremic for 7.4 months, reboun

34 Proton pump inhibitors were stopped at least 7 days before the study and H2 receptor

35 of subsequent distant recurrence if therapy stops at 5 years could help determine whether to extend

36 e rainbow trapping, by taking advantage of a stop-band for surface waves, but also selective mode con

37 he entire visible spectrum and wide spectral stop-band widths (full-width at half-maximum >80 nm), wh

38 ls we identify all angle all mode normalized stop bands exceeding 100%, which is larger than what is

39 e optimized results show that large phononic stop bands for bulk wave propagation can be achieved at

40 At 31 months, enrollment in the trial was stopped because of the results of a prespecified interim

41 markers can be used to monitor the effect of stopping bisphosphonate therapy (eg, to identify a thres

42 As the stopping boundary for overall survival was crossed, this

43 I], 0.12 to 0.49; P<0.0001 [the prespecified stopping boundary]).

44 the spatial spread of the pushed wave can be stopped by making gene drives uniquely vulnerable ("sens

45 , chlorpyrifos, in agriculture were recently stopped by the Environmental Protection Agency under fal

46 This process can be stopped by therapeutic complement inhibition in most pat

47 ined free of HIV rebound over a decade after stopping cART.

48 specific QOL influence a woman's decision to stop chemoprevention therapy.

49 livery, informing the decision to proceed or stop clinical evaluation of a targeted treatment within

50 stitution (c.565G>T) introducing a premature stop codon (p.Glu189*).

51 e (C64T) at codon 22, leading to a premature stop codon (R22X) in the albino robust capuchin monkey.

52 n-deficient strains, sequencing identified 2 stop codon and 3 IS481 locations disrupting the prn gene

53 One mutation resulted in a premature stop codon and absent protein, while the second mutation

54 tion in the GL4 gene resulted in a premature stop codon and led to small seeds and loss of seed shatt

55 owed a mutation that resulted in a premature stop codon and protein truncation leading to complete lo

56 ino acid substitution (G299V) or a premature stop codon causing strong virulence attenuation in mice.

57 ic receptor 3 (GRM3) gene gained a premature stop codon in BMD cells, and silencing GRM3 in TMD cells

58 identified by linkage analysis: a homozygous stop codon in PI3-kinase p110delta (PIK3CD) and a homozy

59 within a single IR1 repeat unit, including a stop codon in the EBNA-LP gene.

60 and of human L1 loci containing at least one stop codon in their ORF1 sequence.

61 Furthermore, the premature stop codon introduced by the CHADL frameshift mutation r

62 nue with translation through a premature UAG stop codon located in a beta-galactosidase reporter.

63 that SDHB mRNAs in hypoxic monocytes gain a stop codon mutation by APOBEC3A-mediated C-to-U RNA edit

64 e sequencing revealed a homozygous premature stop codon mutation in the gene encoding MYSM1.

65 d-type AAV2 genome that is found between the stop codon of the cap gene, which encodes proteins that

66 nslation termination factor, which increases stop codon read-through allowing ribosomes to translate

67 Overexpression of Sup35 decreases stop codon read-through and rescues oxidant tolerance co

68 rmalized reporter system, we discovered that stop codon readthrough is heterogeneous among single cel

69 chaperones, substrate reduction therapy, or stop codon readthrough).

70 for deciphering the principles for specific stop codon recognition by RFs identified Arg-213 as a cr

71 Our work highlights the notion that stop codon recognition involves complex interactions wit

72 *557Gluext*46 resulted in replacement of the stop codon with 46 additional codons at the C-terminus.

73 that was predicted to result in a premature stop codon.

74 at target these mRNAs at sites distal to the stop codon.

75 Stop-codon-generating mutations in TcNTR-1 were associat

76 facilitate gene inactivation by induction of STOP codons (iSTOP), we provide access to a database of

77 Drug-induced readthrough over premature stop codons (PTCs) is a potentially attractive therapy f

78 Our data also show ribosome accumulation at stop codons and in the 3' UTR, suggesting a global defec

79 ay (NMD) of transcripts containing premature stop codons and related to the ATM and ATR kinases which

80 ns that cause premature STOP codons, loss of STOP codons and single nucleotide polymorphisms, and sho

81 tion cycle because a mutant virus containing stop codons at the amino terminus of ORF2 does not react

82 Early stop codons can be introduced in approximately 17,000 hu

83 al class I release factors (RFs) in decoding stop codons has evolved beyond a simple tripeptide antic

84 d1 mutant allele lines introducing premature stop codons in exon 1, as well as obtained an abcd1 alle

85 ortion of the repertoire exhibited premature stop codons in some elderly subjects, indicating that ag

86 demonstrate that introduction of equivalent stop codons in the full-length human L1 sequence leads t

87 wed the translational footprint of premature stop codons in Ttn, TTNtv-position-independent nonsense-

88 on of nad5 losing both translation start and stop codons is enriched in the mutant.

89 ing release factor RF2, which normally binds stop codons to catalyze peptide release.

90 ell recognition were not observed, premature stop codons were observed in 7% and 56% of tax sequences

91 ng four codons (CAA, CAG, CGA, and TGG) into STOP codons without DSB formation.

92 ations were predicted to introduce premature stop codons, and one was predicted to result in read thr

93 red sequence variations that cause premature STOP codons, loss of STOP codons and single nucleotide p

94 nes by changing single nucleotides to create stop codons.

95 empowers yeast ribosomes to read-through UGA stop codons.

96 RF in bacteria, capable of reading all three stop codons.

97 the target gene is disrupted by a series of stop codons.

98 at steady state for adults after starting or stopping consumption of PFOA-contaminated water.

99 When others stop cracking nuts, young monkeys sustain the uncommon a

100 terim analysis met the prespecified futility stopping criteria in the intention-to-treat population.

101 We incorporated early stopping criteria on the basis of predefined toxicity th

102 The prespecified stopping criteria were met after the enrollment of 90 of

103 o continue (the CTX arm) or discontinue (the STOP-CTX arm) were examined for malaria parasites by qua

104 rasite prevalence increased over time in the STOP-CTX arm, compared with the CTX arm, with values of

105 y of infection, >1) were only present in the STOP-CTX arm.

106 metimes withhold responses to a Go stimulus (stop cue) and change hands to respond to an alternative

107 tin treatment and 7 days after treatment had stopped (day 14).

108 ematological relapses, and the treatment was stopped December 26, 2016.

109 these committed emissions, we estimate that stopping deforestation and allowing secondary forests to

110 Inspired by the light stop design and dark-field detection of microscopes, thi

111 Achieving one-stop diagnosis and treatment for all people with TB will

112 regardless of the strategy applied, outright stopping displayed indistinguishable brain activation pa

113 ong the Cu-rich domains to the extent of the stopping distance of the helium ions.

114 those transcripts when the CD8(+) Teff cells stopped dividing just before the contraction phase.

115 Because planarians stop "doing it" at the slightest disturbance, this remai

116 onitoring period, but this decline slowed or stopped during 2003-2011.

117 m analysis was planned to allow the study to stop early for efficacy.

118 Study treatment was stopped early after an independent data monitoring commi

119 Accrual stopped early in 2012 for squamous patients because OS f

120 Recruitment was stopped early in the arms containing SQ109 since prespec

121 The trial was stopped early on the recommendation of the data monitori

122 06 participants, 84% completed follow-up, 7% stopped early, and 9% were lost to follow-up; 9% discont

123 The trial was stopped early, on the recommendation of the data and saf

124 eases in aminotransferases and the study was stopped early.

125 strained by low-level properties such as end-stopping, eccentricity, and the shape of the preferred i

126 evidence in humans (males and females) that stopping episodic retrieval to suppress an unpleasant im

127 y sensitized drives in two dimensions can be stopped, even by imperfect barriers perforated by a seri

128 wever, it eventually finds such a state, and stops evolving.

129 A dose of 4 mL/Kg increases transient stop-flow arm arterial-venous equilibrium pressure and r

130 Only 4 mL/Kg increases transient stop-flow arm arterial-venous equilibrium pressure beyon

131 flow pumps integrated with a very low volume stop-flow injector and mixing tee.

132 Stopped-flow and rapid-quench flow experiments of HadA w

133 reactivity are investigated by double-mixing stopped-flow experiments for both complexes.

134 Stopped-flow experiments revealed a approximately 2.7-fo

135 Stopped-flow experiments then demonstrated that the chan

136 In stopped-flow experiments, we observed that cYY binding t

137 In this study, using a stopped-flow fluorescence method, we examined the kineti

138 By means of NMR, stopped-flow IR, and quenched-flow techniques, the kinet

139 nt (17)O NMR spectroscopy, electrochemistry, stopped-flow kinetic analyses, and EPR measurements were

140 As shown through stopped-flow kinetic experiments, electron transfer capa

141 second-order rate constants, measured using stopped-flow kinetic techniques, spanned 4 orders of mag

142 side-chain groups in bulk measurements using stopped-flow kinetics and NMR spectroscopy.

143 In this latter case, stopped-flow light scattering analysis reveals the trans

144 Stopped-flow measurements suggest that initial PROPPIN-m

145 eir ECD spectra have been recorded online by stopped-flow measurements.

146 Fluorescence stopped-flow methods were used to record the kinetics of

147 luorescent nucleotides without using a rapid stopped-flow or quench-flow instrument and the generally

148 n into DrDps2 was investigated by static and stopped-flow SAXS measurements, revealing dynamic struct

149 Using stopped-flow spectrofluorimetry, association rate consta

150 Stopped-flow spectroscopic data revealed that transfer o

151 Stopped-flow spectroscopy results indicated rapid initia

152 Here, we present the first multimixing stopped-flow study on a fully functional truncated varia

153 An additional modification leads to a stopped-flow system very efficient for instance for 2D N

154 We used spectroscopic and stopped-flow techniques to further investigate how the c

155 Stopped-flow UV-visible absorption and freeze-quench Mos

156 the conjugation of absorption spectroscopy, stopped-flow, NMR, and X-ray crystallography.

157 sts have debated whether supercooled liquids stop flowing below a glass transition temperature [Formu

158 e the study and H2 receptor antagonists were stopped for at least 24 hours before.

159 The trial was stopped for futility after 506 patients were enrolled.

160 lso been identified that actin provides rest stops for Cx43 forward trafficking and that Cx43 has a 2

161 le velocities near the Bragg peak, where the stopping force reaches its maximum.

162 Finding massive galaxies that stopped forming stars in the early Universe presents an

163 plate, waves gradually slow down and finally stop forward propagating.

164 ually exclusive with other loss-of-function (stop/frameshift) variants.

165 In addition, a nonsense RB1 mutation (Lys-->STOP) from 1 child was also identified from the AH sampl

166 sublethal to lethal NP doses, which besides stopping fungal growth, can potentially accumulate in th

167 members and five healthy members revealed a stop gain mutation in CNGA2 (OMIM 300338) (chrX:150,911,

168 ird family was identified with an N-terminal stop gain variant predicted to be degraded by the NMD-pa

169 ymous variant in SEMA6D together with a rare stop-gain in SYNPR.

170 mined by growth rate and the mechanisms that stop growth at the end of juvenile growth.

171 STOP has also informed the development of other public h

172 e consistent with both Dietary Approaches to Stop Hypertension (DASH) and dietary portfolio principle

173 We evaluated the Dietary Approaches to Stop Hypertension (DASH), the alternate Mediterranean di

174 overweight or obese, a Dietary Approaches to Stop Hypertension (DASH)-style based nutrition counselli

175 I, 0.82-1.13); for the Dietary Approaches to Stop Hypertension score the hazard ratio in men was 0.75

176 score [aMED], and the Dietary Approaches to Stop Hypertension score) and colorectal cancer risk in t

177 lites within the DASH (Dietary Approaches to Stop Hypertension Trial)-Sodium Trial to further our und

178 eduction and the DASH (Dietary Approaches to Stop Hypertension) diet, a diet rich in fruits, vegetabl

179 pattern such as DASH (Dietary Approaches to Stop Hypertension) or the Mediterranean diet as emphasiz

180 We report the final results of the Stop Imatinib (STIM1) study with a long follow-up.

181 Therapy was stopped in 2 cases (12%) due to gastrointestinal intoler

182 d be ruled out and asthma medications safely stopped in randomly selected adults with physician-diagn

183 d preset boundaries, nutrient enrichment was stopped in the experimental lake.

184 aration for stopping) and reactive (outright stopping) inhibition.

185 ific inhibition of their activity that fully stopped iron-coupled AOM.

186 ion, the neural network involved in outright stopping is ubiquitous and independent of strategy, whil

187 sed, the neural network involved in outright stopping is ubiquitous.

188 obial therapy for intra-abdominal infection (STOP-IT), and results suggest global superiority of shor

189 NZ) behavior while simultaneously sustaining stopped light energy bands which contain multiple points

190 at produce an altered reading frame, such as stop-lost variants and small insertions and deletions (I

191 Transcripts affected by stop-lost variants introduce a median of 15 amino acids,

192 CRISPR-STOP-mediated targeted screening demonstrates comparable

193 We show that the CRISPR-STOP method is an efficient and less deleterious alterna

194 deplete symbionts, block embryogenesis, and stop microfilariae production.

195 wer-demanding duty cycles required for start-stop microhybrid vehicles.

196 ressor Bgcn is required for spermatogonia to stop mitosis and transition to meiotic prophase and the

197 ising therapeutic approach to simultaneously stop multiple cancer-driving pathways in HCC.

198 nt of Foxp3(+) Tregs in vivo at the start or stop of therapy impaired immune tolerance, highlighting

199 thesized to play a central role in the rapid stopping of movement in reaction to a stop signal.

200 turnally migrating Swainson's Thrushes often stop on the northern Gulf of Mexico coast before flying

201 ort-term PPIs should subsequently attempt to stop or reduce them.

202 d since treatment after the onset can hardly stop or reverse the disease progress.

203 There are currently no drugs that can stop or slow the progression of the disease.

204 Most patients stopped or used no opioids owing to adequate pain contro

205 Stopping or pausing in response to threats, conflicting

206 us (STN) is activated by scenarios involving stopping or pausing, yet evidence that the STN causally

207 et evidence that the STN causally implements stops or pauses is lacking.

208 ors found or excluded), treatment (modified, stopped, or modality shifted), or follow-up modified.

209 Topical corticosteroids could be tapered, stopped, or restarted on the basis of disease activity.

210 energetic costs, trans-Gulf migrants should stop over when they encounter crosswinds or headwinds, a

211 a collapse of B. graminis haustoria, thereby stopping P. flocculosa growth, as barley plants show hig

212 ewing (MI) and feedback of urine cotinine to stop passive smoking (PS) in children at risk for asthma

213 aging, clinicians must decide if they should stop, pause, or continue treatment.

214 d a set of reads with well-defined start and stop positions, in a length range of 16 to 22 nucleotide

215 10 keV/u, and validated against established stopping power data.

216 ) and wide bandgaps (>1.9 eV), showing great stopping power for hard radiation and high intrinsic ele

217 directly with the surrounding matter so the stopping power is minimal.

218 r-ionic forces, which translate into nuclear stopping power well above the adiabatic prediction.

219 The study was stopped prematurely for safety reasons after 16 patients

220 ed the greatest declines, whereas those that stop primarily in other regions had slowly declining or

221 iameter to understand the intrinsic particle stopping process within the material.

222 This article describes the STOP program and how it has contributed to polio eradica

223 he international Stop Transmission of Polio (STOP) program began supporting the Global Polio Eradicat

224 In 1999, the Stop Transmission of Polio (STOP) program was developed and initiated by the CDC, in

225 olio eradication efforts, including national STOP programs.

226 9 participants receiving FIX at study entry stopped prophylaxis.

227 program is probably an effective strategy to stop PS in children.

228 tcome measure was the percentage of families stopping PS (parental report verified and unverified wit

229 d in pumping at half the pacing frequency or stopped pumping altogether, possibly due to UNC-68 leaki

230 ational types of proactive policing, such as stop, question, and frisk.

231 elucidate the mechanisms of reactivation and stop reactivation in its tracks.

232 might differentially involve attention- and stopping-related processes that might be implemented by

233 th 2(*-) and 2(2-) and result in a slow-fast-stop rotation mode for 2-2(*-)-2(2-).

234 in the placebo group (chi(2)=7.8, p=0.0053, stopping rule not reached).

235 A floxed-stop sequence was inserted between the promoter and the

236 ng the microtubule-stabilizing protein Short stop (Shot).

237 phase of the study, participants with longer stop signal reaction time (SSRT) reported greater amphet

238 ealthy volunteers (n=63) first completed the stop signal task, a behavioral measure of inhibitory con

239 key electrophysiology in a context-dependent stop signal task, we found a functional double dissociat

240 rapid stopping of movement in reaction to a stop signal.

241 ontrols, performed a modified version of the stop-signal paradigm, which required participants to inh

242 ping (paced by a metronome) in response to a stop-signal sound, which was timed such that successful

243 ts of both sexes during a stimulus-selective stop-signal task and performed strategy-dependent functi

244 indings position Cdc42 (go-signal) and RhoA (stop-signal) at the centre of a molecular checkpoint dow

245 nal imaging responses to three paradigms-the stop-signal, monetary incentive delay, and faces tasks-w

246 recoding of highly specific UGA codons from stop signals to Sec.

247 tion-related processes in stimulus-selective stopping.SIGNIFICANCE STATEMENT Dissociating inhibition

248 H-strand transcripts beyond their canonical stop site and that TOP1MT acts as a topological barrier

249 e usage of alternate transcription start- or stop sites allows a single gene to produce multiple tran

250 ll visual areas, we found a tendency for end-stopped sites to prefer curved over straight contours.

251 Data come from 1,826 participants attending Stop Smoking Services (SSS) across England in 2012/13.

252 the go process (dependent discriminate then stop strategy).

253 to 4000 mg of peanut protein 12 weeks after stopping study drug.

254 cm) compared with the TB immediately before stopping sunitinib.

255 proportion of participants in the egg group stopped taking the study powder because of a confirmed a

256 ere still significant at least 5 years after stopping tamoxifen therapy (RR per year of use, 0.85; 95

257 nsomnia and impulsiveness as measured by the STOP task.

258 Urgent action is needed to stop the cCMV's epidemic, particularly in this populatio

259 fully will provide translational insights to stop the growing incidence of nephrolithiasis.

260 h at least stable disease, and only 1 had to stop the therapy after only 4 cycles of treatment owing

261 ools and approaches to detect leprosy and to stop the transmission of Mycobacterium leprae, the causa

262 ents who will not benefit from erlotinib and stop the treatment at this time.

263 To stop the tuberculosis epidemic, it is critical that we i

264 At 30 months, patients stopped the study drug and were observed for 3 months.

265 The sponsor stopped the trial after a prespecified interim analysis.

266 atment and give a good result in the form of stopping the growth of the tumor with simultaneous retai

267 Stopping the reaction with acetic acid and a centrifugat

268 cART is effective in stopping the retroviral replication cycle, but not in in

269 data and safety monitoring board recommended stopping the study for futility when 894 (median age, 63

270 ariety of ways, being nuclear and electronic stopping the two avenues in which dissipation is usually

271 The detachment of Vps34 stops the production of PtdIns(3)P, allowing for the tur

272 ive resources than controls when required to stop their response (reactive inhibition).

273 ine or subsequent dasatinib or nilotinib who stopped therapy after at least 3 years of TKI treatment

274 reatment experienced virologic relapse after stopping therapy.

275 to be investigated and put into practice to stop this downward trend.

276 ble if the blood supply for the organ is not stopped, thus resulting in optimal transplant outcomes.

277 monstrated that loss of MR4.5 3 months after stopping TKI was predictive of failure to maintain MMR l

278 lanned for an oesophagogastric resection was stopped towards the end of the trial.

279 2% when OJ was consumed after the volunteers stopped training for 7 d.

280 The National Stop Transmission of Polio (NSTOP) program was collabora

281 In 2009, the international Stop Transmission of Polio (STOP) program began supporti

282 In 1999, the Stop Transmission of Polio (STOP) program was developed

283 it is likely that effective interventions to stop transmission will require a combination of approach

284 endent degradation of Miro1 and consequently stops transport.

285 RR], 3.5; 95% CI, 2.3 to 5.1) and for having stopped treatment (RR, 3.4; 95% CI, 2.1 to 6.0), self-de

286 y analyses were done, excluding patients who stopped treatment for reasons of disease progression and

287 How hippocampal GABA contributes to stopping unwanted thoughts is unknown.

288 The trial was stopped upon predefined interim analysis after 30 patien

289 able flexibility for decisions about when to stop use of OPV in the context of uncertainty about whet

290 orld, and eliminating that risk will require stopping use of all oral polio vaccines (OPVs) once all

291 Significantly more children undergoing PPT stopped using laxatives (adjusted odds ratio, 6.5; 95% c

292 k of death from cancer compared to those who stopped using the drug at their diagnosis.

293 tal delay was milder in 4 of 6 patients with stop variants and in a patient with a variant in the S2

294 th Sudan Expanded Program on Immunization by STOP volunteers, implementing partners, and non-governme

295 scrimination process of the critical signal (stop vs attentional capture signal) may interact with th

296 extensively studied in the context of action stopping, where a planned movement needs to be abruptly

297 most strongly when the tap was successfully stopped, whereas phase-based connectivity between the co

298 cal LED epifluorescence sensor using a light stop with an arc-shaped aperture for enhancing the flexi

299 Stopping work because of the heat was also associated wi

300 sound, which was timed such that successful stopping would occur only in 50% of all trials.