ライフサイエンスコーパス: stop codon

1 of messenger RNA (mRNA) without an in-frame stop codon.

2 rial ribosomes reach the end of mRNA with no stop codon.

3 corporation of a pseudoexon with a premature stop codon.

4 e, to be integrated just upstream to the Alb stop codon.

5 andard amino acid encoded by UGA, normally a stop codon.

6 nylated at the editing site and thus lacks a stop codon.

7 at detecting and destroying mRNAs lacking a stop codon.

8 e (Sec), which is encoded by an in-frame UGA stop codon.

9 oteins with C-terminal extensions beyond the stop codon.

10 ion in the STAG3 gene leading to a premature stop codon.

11 ting select transcripts beyond the canonical stop codon.

12 uced from a gene that does not contain a UAG stop codon.

13 , with 11 unique amino acids and a premature stop codon.

14 the retained intron introducing a premature stop codon.

15 40, a translation frameshift and a premature stop codon.

16 s are released upon encountering a bona fide stop codon.

17 that was predicted to result in a premature stop codon.

18 ibosome occupancy at or just before the mRNA stop codon.

19 he zipcode protein in a region distal to the stop codon.

20 at target these mRNAs at sites closer to the stop codon.

21 ve translation start sites downstream of the stop codon.

22 don does not differ from that of a canonical stop codon.

23 genetic variant that introduces a premature stop codon.

24 at target these mRNAs at sites distal to the stop codon.

25 ions that ultimately resulted in a gain of a stop codon.

26 nonsense frame-shift and the emergence of a stop codon.

27 that does not operate as the canonical opal stop codon.

28 nes by changing single nucleotides to create stop codons.

29 ogrammed with pseudouridylated and canonical stop codons.

30 the target gene is disrupted by a series of stop codons.

31 ow NMD discriminates between PTCs and normal stop codons.

32 s from mutated genes with premature in-frame stop codons.

33 release factor (eRF1) to recognize all three stop codons.

34 that m(6)A is distributed predominantly near stop codons.

35 09, as critical for recognition of the three stop codons.

36 ressed, and 23% are interrupted by premature stop codons.

37 promotes programmed readthrough on all three stop codons.

38 active in suppression of their corresponding stop codons.

39 ising diversity of natural AAs at reassigned stop codons.

40 t exons than in next-to-last exons harboring stop codons.

41 reference for location of m(6)A sites around stop codons.

42 ion level of the genes ending with different stop codons.

43 topes encoded downstream of the PTC or other stop codons.

44 hift single-base deletions forming premature stop codons.

45 odon without increasing readthrough of other stop codons.

46 es derived from read-through of conventional stop codons.

47 empowers yeast ribosomes to read-through UGA stop codons.

48 nome gene is inactivated by tandem premature stop codons.

49 n selectively depleted of TFs that recognize stop codons.

50 dogene containing frame shifts and premature stop codons.

51 RF in bacteria, capable of reading all three stop codons.

52 er rat thyroid cells stably transfected with stop codons.

53 ATG codon and ends +188 bp downstream of the stop codon, +20 bp downstream of the polyadenylation sig

54 ide polymorphism that introduces a premature stop codon, a fraction of African descendents express fu

55 decay (NMD), the process wherein a premature stop codon affects both translation and mRNA decay.

56 less stable than the same mRNA containing a stop codon, against the general belief in nonstop decay

57 tes RF2 to mediate peptide release without a stop codon, allowing stalled ribosomes to be recycled.

58 AUG-initiating codon was replaced with a UAG stop codon along with a U112A mutation to maintain a uOR

59 ncing or assembly error that gain or abolish stop codons also complicates ORF-based prediction of lnc

60 presentation varies with the sequence of the stop codon and +1 nucleotide.

61 n-deficient strains, sequencing identified 2 stop codon and 3 IS481 locations disrupting the prn gene

62 (DGKalphaDelta10) and generates a premature stop codon and a truncated protein was identified as bei

63 One mutation resulted in a premature stop codon and absent protein, while the second mutation

64 UGA appears not to function as a stop codon and is in equilibrium with the canonical GGN

65 tion in the GL4 gene resulted in a premature stop codon and led to small seeds and loss of seed shatt

66 The resulting frameshift causes a premature STOP codon and loss of major higher molecular weight Sha

67 frameshift mutation that led to a premature stop codon and premature chain termination, whereas the

68 owed a mutation that resulted in a premature stop codon and protein truncation leading to complete lo

69 A. thaliana is enriched not only around the stop codon and within 3'-untranslated regions, but also

70 adation by 3'hExo and intermediates near the stop codon and within the coding region.

71 genes, in which only 1.3% of genes contained stop codons and 4.3% of genes were not expressed in male

72 Our data also show ribosome accumulation at stop codons and in the 3' UTR, suggesting a global defec

73 iminished, 80S ribosomes accumulated both at stop codons and in the adjoining 3'UTRs of most mRNAs.

74 ine incorporation occurs in response to opal stop codons and is dependent on the presence of a seleno

75 ay (NMD) of transcripts containing premature stop codons and related to the ATM and ATR kinases which

76 ns that cause premature STOP codons, loss of STOP codons and single nucleotide polymorphisms, and sho

77 ed truncated PrP Y145X (where X represents a stop codon) and Q160X mutants converted spontaneously in

78 n the same reading frame, separated by a UAG stop codon, and termination codon readthrough is require

79 tation in the Mc4r gene produces a premature stop codon, and the mutant SIM1 protein lacks transcript

80 in talpid(2) C2CD3 that produces a premature stop codon, and thus a truncated protein, as the likely

81 ations were predicted to introduce premature stop codons, and one was predicted to result in read thr

82 n deletions, frameshift mutations, premature stop codons, and transcriptional evidence of decay in th

83 For example, mRNAs lacking a stop codon are degraded by the exosome in association wi

84 In this compacted mRNA conformation, stop codons are favoured by a hydrogen-bonding network f

85 Stop codons are recognized by class I release factors (R

86 In bacteria, stop codons are recognized by two similar class 1 releas

87 Expressed genes, some with premature stop codons, are interspersed with nonexpressed genes, g

88 translation termination is triggered when a stop codon arrives at the ribosomal A site.

89 t also directing the PTR by decoding the UGA stop codon as serine.

90 PTBP1 can thus mark specific stop codons as genuine, preserving both the ability of N

91 eletion in exon 3 that generates a premature stop codon at codon 313 (L313X).

92 ent CLCNKB mutation that creates a premature stop codon at Trp-610.

93 tion cycle because a mutant virus containing stop codons at the amino terminus of ORF2 does not react

94 An LR mutant virus with stop codons at the amino terminus of ORF2 does not react

95 An LR mutant virus containing stop codons at the amino terminus of ORF2 does not react

96 NA so that it stacks on the second and third stop codon bases.

97 focused 16 to 17 nucleotides upstream of the stop codon because of ribosomal pausing during translati

98 The efficiency of competition for the stop codon between release factors (eRFs) and near-cogna

99 ifferent amino acids in response to an amber stop codon by utilizing switchable designer transfer RNA

100 natural amino acids through suppression of a stop codon can be limited by truncation due to competiti

101 Early stop codons can be introduced in approximately 17,000 hu

102 the intracellular TM3-4 loop by a premature stop codon, can be complemented by co-expression of the

103 ino acid substitution (G299V) or a premature stop codon causing strong virulence attenuation in mice.

104 fic UAG codon relative to UAA, the universal stop codon, compared with the wild type (WT).

105 ease or decrease translational accuracy in a stop codon context-dependent manner.

106 ated the readthrough propensity (RTP) of all stop codon contexts of the human genome by a new regress

107 Signals both 5' and 3' of the OPRL1 stop codon contribute to this high level of readthrough.

108 sites located within 150 bp of the start and stop codons converting more frequently than sites locate

109 g the sequence changes that create start and stop codons, correct frameshifts and for many of the mRN

110 cted by PTBP1 and that PTBP1 enrichment near stop codons correlates with 3'UTR length and resistance

111 Using a newly developed program called "stop codon counter," the frequencies of the three classi

112 TGA were analyzed, and a publicly available stop codon database was built.

113 s mutation in exon 5, leading to a premature stop codon deleting most of the cytoplasmic tail of LAT,

114 cture reveals that recognition of a modified stop codon does not differ from that of a canonical stop

115 that in addition to canonical termination on stop codons, eukaryotic release factors contribute to co

116 resistant strain that generates a premature stop codon expected to yield a truncated ABCC2 protein.

117 ameshift mutation results in the loss of the stop codon, extending the coding protein by 81 amino aci

118 tant, in which residue G204 is replaced by a stop codon, features a partial reduction in Gbeta1gamma2

119 a "takeoff codon" immediately upstream of a stop codon followed by a hairpin, which causes peptidyl-

120 ture translation termination on out of frame stop codons following ribosome sliding.

121 e 3' end of an mRNA without terminating at a stop codon, forming a nonstop translation complex.

122 , 282 effects (non-synonymous, synonymous or stop codon gained) were located in exonic regions (13.04

123 identified, one of them encoding a premature stop codon generating a non-functional truncated protein

124 onical stop codon to a conserved, downstream stop codon, generating VEGF-Ax ("x" for extended), a nov

125 Stop-codon-generating mutations in TcNTR-1 were associat

126 referring (P) rats are homozygous for a Grm2 stop codon (Grm2 *407) that leads to largely uncompensat

127 al class I release factors (RFs) in decoding stop codons has evolved beyond a simple tripeptide antic

128 No similar functional prion, skipping a stop codon, has been found in Escherichia coli, a fact p

129 assigned the translation function of the UAG stop codon; however, reassigning sense codons poses a gr

130 ding signatures that extend beyond annotated stop codons identified potential stop codon readthrough

131 tes, the rate of translation elongation, and stop codon identity.

132 tion-specific serotonin 2B (5-HT2B) receptor stop codon (ie, HTR2B Q20*) was reported to segregate wi

133 n the food strain that generates a premature stop codon in a global activator (gacA), encoding the re

134 in which read through of a pseudouridylated stop codon in bacteria results from increased decoding b

135 ic receptor 3 (GRM3) gene gained a premature stop codon in BMD cells, and silencing GRM3 in TMD cells

136 ylalanine (VSF, 3), in response to the amber stop codon in Escherichia coli.

137 ducted on 60 subjects, revealing a premature stop codon in exon 3 at S2377X (rs12568784) and X2392S (

138 plice variants, the most common results in a stop codon in intron 1 and a much truncated, non-functio

139 encoding p.Ser293* resulting in a premature stop codon in one family and a missense mutation encodin

140 s in CELF6 identified an inherited premature stop codon in one of the probands.

141 t terminate at, or close to, the native qapR stop codon in order for translation of PA5507 to occur.

142 ext, we generated a recombinant MHV68 with a stop codon in ORF46/UNG (DeltaUNG) that led to loss of U

143 identified by linkage analysis: a homozygous stop codon in PI3-kinase p110delta (PIK3CD) and a homozy

144 o cause alternative splicing and a premature stop codon in sweet quinoa strains.

145 oss of function due to the introduction of a stop codon in the 5' region of the BRCA1 transcript.

146 mRNA channel and substitutes for the absent stop codon in the A site by specifically recruiting rele

147 linked to a substitution causing a premature stop codon in the DMRT3 gene (DMRT3_Ser301STOP) [1].

148 within a single IR1 repeat unit, including a stop codon in the EBNA-LP gene.

149 es the reading frame and creates a premature stop codon in the first PPR domain.

150 ed that they were homozygous for a premature stop codon in the gene encoding nitric oxide synthase 1.

151 One variant, which introduces a stop codon in the GHR gene, is relatively frequent in Sa

152 Repair of the premature stop codon in the invasive sclA allele restored the abil

153 2R-encoding regions, we observed a premature stop codon in the mouse CB2R gene that truncated 13 amin

154 y release factors (RFs) 1 or 2 recognizing a stop codon in the ribosomal A site and releasing the pep

155 ter and, in presence of tamoxifen, removes a stop codon in the Rosa26(DTA/+) allele and induces dipht

156 invasive serotype M3 GAS possess a premature stop codon in the sclA gene truncating the protein.

157 tro translation of mRNAs containing an amber-stop codon in the signal peptide in the presence of the

158 and of human L1 loci containing at least one stop codon in their ORF1 sequence.

159 canonical termination, RF1 and RF2 recognize stop codons in a similar manner, and RF3 accelerates the

160 Pseudouridylation of stop codons in eukaryotic and bacterial cells results in

161 d1 mutant allele lines introducing premature stop codons in exon 1, as well as obtained an abcd1 alle

162 ble and regulatable suppression of all three stop codons in H. volcanii.

163 utations that allow them to decode premature stop codons in metabolic marker gene mRNAs, that can be

164 ding editing of 69PUK1-like pseudogenes with stop codons in ORFs.PUK1orthologs and other pseudogenes

165 ortion of the repertoire exhibited premature stop codons in some elderly subjects, indicating that ag

166 ning eRF1 interacting with each of the three stop codons in the A-site.

167 disorder are missense mutations or premature stop codons in the coding region of the lactase-phlorizi

168 demonstrate that introduction of equivalent stop codons in the full-length human L1 sequence leads t

169 Unusually, the top 3 hits all contained stop codons in the randomized region of the library, res

170 Release factors recognize stop codons in the ribosomal A-site to mediate release o

171 on skipping are designed to bypass premature stop codons in the target RNA and restore reading frame

172 wed the translational footprint of premature stop codons in Ttn, TTNtv-position-independent nonsense-

173 e able to formulate a new model in which the stop codon interacts with eRF1 through the P1 pocket.

174 Expression of pure repeats, but not stop codon-interrupted "RNA-only" repeats in Drosophila

175 plasmid maintenance, we introduced premature stop codons into the pgp genes.

176 Furthermore, the premature stop codon introduced by the CHADL frameshift mutation r

177 Despite the two in-frame stop codons introduced by splicing between exons 2 and 4

178 During this process, the stop codon is decoded as a sense codon by a near-cognate

179 If a stop codon is not encountered, translation continues int

180 on of nad5 losing both translation start and stop codons is enriched in the mutant.

181 omes translating on messenger RNAs that lack stop codons is one of the co-translational quality contr

182 readthrough--suppression of termination at a stop codon--is exploited in the replication cycles of se

183 facilitate gene inactivation by induction of STOP codons (iSTOP), we provide access to a database of

184 nue with translation through a premature UAG stop codon located in a beta-galactosidase reporter.

185 otein size (due to underlying changes in the stop codon location) or the DNA-binding forkhead domain

186 red sequence variations that cause premature STOP codons, loss of STOP codons and single nucleotide p

187 An ORF2 stop codon mutant, an ORF2 nuclear localization mutant,

188 d a nonsense mutation leading to a premature stop codon mutation (R533X).

189 that SDHB mRNAs in hypoxic monocytes gain a stop codon mutation by APOBEC3A-mediated C-to-U RNA edit

190 A premature stop codon mutation c.157C>T (p.Gln53*) cosegregating wi

191 Patient P1 has a stop codon mutation in one of the MTF genes and an S209L

192 We show that a stop codon mutation in Sqle, encoding squalene epoxidase

193 e sequencing revealed a homozygous premature stop codon mutation in the gene encoding MYSM1.

194 egulator genes in which multiple independent stop codon mutations have convergently led to culture ad

195 P amyloidosis are striking features of human stop codon mutations in the PrP gene (PRNP), associated

196 eletions provoking frameshifts and premature stop codons (NM_000760.3:c.948_963del, NP_000751.1:p.Gly

197 trates are aberrant products of mRNA lacking stop codons [nonstop translation products (NSPs)].

198 The 5' UTR variant mutates the stop codon of a small upstream open reading frame that,

199 The modulation was enriched near the stop codon of mRNAs, including genes related to neuronal

200 d-type AAV2 genome that is found between the stop codon of the cap gene, which encodes proteins that

201 A second mutation was introduced at stop codon of the IL-1R1 gene to allow tracking of the r

202 y, a 2A-GFP reporter was inserted before the stop codon of the MYF5 gene using homologous recombinati

203 equence duplication that initiates after the stop codon of the ORF, leaving the protein product of th

204 may be due to ribosome migration through the stop codon or 3'UTR mRNA binding to ribosomes on the cod

205 al event because there was no evidence for a stop codon or alternative splicing event.

206 (NS), 42% synonymous and 1% gain or loss of stop codon or splice site variant] in 16 751 genes with

207 in which translation of D10 was prevented by stop codons or activity of D10 was abrogated by catalyti

208 s such as messenger RNAs harboring premature stop-codons or short upstream open reading frame (uORFs)

209 y promoter defects, introduction of in-frame stop codon, or the lack of a polyadenylation signal.

210 e molecular basis of eRF1 discrimination for stop codons over sense codons is not known.

211 that resulted in a frameshift and premature stop codon (p.Ala174Profs( *)35).

212 or a change from cysteine 537 to a premature stop codon (p.Cys537Stop).

213 stitution (c.565G>T) introducing a premature stop codon (p.Glu189*).

214 This deletion led to a premature stop codon (p.T519X) with truncation of the last 12 amin

215 n carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed 7 kg

216 that skips exon 9, resulting in a premature stop codon predicted to encode a truncated protein.

217 When bound near a stop codon, PTBP1 blocks the NMD protein UPF1 from bindi

218 portion of these mutations lead to premature stop codons (PTCs) and are predicted to predispose mRNA

219 Drug-induced readthrough over premature stop codons (PTCs) is a potentially attractive therapy f

220 degrading transcripts that contain premature stop codons (PTCs) to mitigate their potentially harmful

221 e (C64T) at codon 22, leading to a premature stop codon (R22X) in the albino robust capuchin monkey.

222 ole-genome sequencing identified a premature stop codon, R255X, in the MYBPHL gene encoding MyBP-HL (

223 nslation termination factor, which increases stop codon read-through allowing ribosomes to translate

224 Overexpression of Sup35 decreases stop codon read-through and rescues oxidant tolerance co

225 rmination in which the maximal efficiency of stop codon read-through depends on the interaction betwe

226 s in dystrophin are specifically targeted by stop codon read-through drugs, whereas out-of-frame dele

227 f-reactivity to cryptic epitopes revealed by stop codon read-through therapies and potentially other

228 in eukaryotic and bacterial cells results in stop-codon read through.

229 Programmed stop codon readthrough is a post-transcription regulator

230 Stop codon readthrough is essential to diverse viruses,

231 rmalized reporter system, we discovered that stop codon readthrough is heterogeneous among single cel

232 Stop codon readthrough is used extensively by viruses to

233 d annotated stop codons identified potential stop codon readthrough of four mammalian genes.

234 retroviruses use ribosomal frameshifting or stop codon readthrough to regulate expression of their r

235 chaperones, substrate reduction therapy, or stop codon readthrough).

236 gene rescue, including alternative splicing, stop codon readthrough, alternative translation initiati

237 Four displayed efficient stop codon readthrough, and these have UGA immediately f

238 nally, we also uncover multiple instances of stop-codon readthrough that are conserved between specie

239 lenocysteine (Sec or U) is encoded by UGA, a stop codon reassigned by a Sec-specific elongation facto

240 trillion base pairs of metagenomic data for stop codon reassignment events, we detected recoding in

241 We observed extensive opal and amber stop codon reassignments in bacteriophages and of opal i

242 provide a molecular framework for eukaryotic stop codon recognition and have implications for future

243 Efficient stop codon recognition and peptidyl-tRNA hydrolysis are

244 and provides insights into the mechanisms of stop codon recognition and triggering of eRF3's GTPase a

245 highly conserved sequence motifs that couple stop codon recognition at the ribosomal A site to peptid

246 termination fidelity is achieved by linking stop codon recognition by RF1 to the change in conformat

247 for deciphering the principles for specific stop codon recognition by RFs identified Arg-213 as a cr

248 Our work highlights the notion that stop codon recognition involves complex interactions wit

249 TP hydrolysis stage of factor attachment and stop codon recognition.

250 Changes to synIII include TAG/TAA stop-codon replacements, deletion of subtelomeric region

251 One of the genes with premature-stop-codons requiring A-to-I editing to encode full-leng

252 nduce translational readthrough of premature stop codons resulting in the production of full-length p

253 (SCA6), whereas MPc splices to an immediate stop codon, resulting in a shorter cytoplasmic tail.

254 utionary analysis of the presence/absence of stop codons, revealing that ASP does impose significant

255 decoding of the third/wobble position of the stop codon set in the unfavorable termination context, t

256 Most RS-exons contain a premature stop codon such that their inclusion can decrease mRNA s

257 A similar conformation of RF2 may occur on stop codons, suggesting a general mechanism for release-

258 of some ORF2 constructs containing premature stop codons supported low levels of Alu retrotranspositi

259 The ongoing maturation of stop codon suppression and related technologies for unna

260 ter," the frequencies of the three classical stop codons TAA, TAG, and TGA were analyzed, and a publi

261 ense mutation in the FAM136A gene leads to a stop codon that disrupts the FAM136A protein product.

262 e substitution, which results in a premature stop codon that generates a truncated form of the ZDHHC1

263 ing to a frameshift mutation and a premature stop codon that renders a truncated protein prone to deg

264 A full 26% of genes in ST1 have stop codons that are created on the mRNA level by a nove

265 of mammalian IAVs frequently have premature stop codons that are expected to cause truncations of th

266 ways: for example, by introducing premature stop codons that either lead to the production of trunca

267 LRR-encoding exons and contains an in-frame stop codon, the alternative transcript is predicted to e

268 represented nonsense mutations resulting in stop codons, three of these in a single ApiAP2 transcrip

269 translating ribosomes traverse the canonical stop codon to a conserved, downstream stop codon, genera

270 A somatic second-site mutation reverting the stop codon to a missense mutation (p.Cys150Leu) was dete

271 ing release factor RF2, which normally binds stop codons to catalyze peptide release.

272 eliminate frameshift mutations and premature stop codons to compute the substitution rates (Ka, Ks an

273 translation machinery and can suppress amber stop codons to incorporate selenocysteine with high effi

274 mic (main) ORF1 by converting three in-frame stop codons to nonstop codons, a uORF-ORF1 fusion protei

275 normally terminates translation on all three stop codons, to provide a substantial increase in unnatu

276 sarium graminearum, we found that two tandem stop codons, UA(1831)GUA(1834)G, in its kinase domain we

277 ncounters one of three universally conserved stop codons: UAA, UAG or UGA.

278 genomes encode an operon that reassigns the stop codon UAG to pyrrolysine (Pyl), a genetic code vari

279 o found tRNA(Sec) species that recognize the stop codons UAG and UAA, and ten sense codons.

280 acid incorporation in response to the amber stop codon (UAG) in mammalian cells is commonly consider

281 ding of a release factor to one of the three stop codons (UGA, UAA or UAG) results in the termination

282 , which are incorporated via recoding of the stop codon, UGA.

283 Using three model bacteria with different stop codon usage (Escherichia coli, Mycobacterium smegma

284 We present a comprehensive analysis of stop codon usage in bacteria by analyzing over eight mil

285 Bacteria decode stop codons using two separate release factors with diff

286 ation is performed by eRF1, which recognizes stop codons via its N-terminal domain.

287 eam open reading frames, the over-reading of stop codons via ribosomal frameshifting, the existence o

288 the mouse coding sequence from the start to stop codon was replaced with the corresponding human gen

289 downstream AUGs if mRNA regions flanking the stop codon were unstructured.

290 Non-standard nad4 and cox3 stop codons were composed of single T nucleotides and li

291 Stop codons were detected in 19.3% of patients (intrapat

292 ell recognition were not observed, premature stop codons were observed in 7% and 56% of tax sequences

293 t net loss of an exon introduces a premature stop codon, which, in turn, leads to the generation of a

294 *557Gluext*46 resulted in replacement of the stop codon with 46 additional codons at the C-terminus.

295 We found that introduction of a premature stop codon within qapR eliminates transcriptional autore

296 d from the primary unspliced transcript to a stop codon within the intron unique to HSV-2 gamma34.5.

297 ype (WT) K1, a deleted K1 ORF (KSHVDeltaK1), stop codons within the K1 ORF (KSHV-K15xSTOP), or a reve

298 However, mutations leading to premature stop codons within the L1 ORF2 sequence may yield trunca

299 ng four codons (CAA, CAG, CGA, and TGG) into STOP codons without DSB formation.

300 scherichia coli enhances translation of UAG (Stop) codons, yet may also extended protein synthesis at