ライフサイエンスコーパス: store-operated

1 ition to form a Ca(2+)-selective pore during store-operated activation and that Orai3 forms a dimeric

2 proteins or STIM2 overexpression results in store-operated activation of Imin channels, whereas STIM

3 terminal truncations than Orai1 in retaining store-operated activation.

4 itch the regulation of Imin channels between store-operated and store-independent modes.

5 ncy, and examine the roles of the endogenous store-operated and store-independent Orai channels (CRAC

6 To assess the relative contributions of store-operated and voltage-gated Ca(2+) channels to this

7 ization with Orai1, the predominant membrane store operated Ca(2+) channel that cooperates with the e

8 tion in the expression of a component of the store operated Ca(2+) channel, TRPC1 blocks MTI-101 indu

9 Store operated Ca(2+) entry (SOCE) via the Ca(2+) releas

10 g extracellular Ca(2+) with EGTA or blocking store operated Ca(2+) entry with SKF96365 also attenuate

11 IM1) and the Ca(2+) channel Orai1 as well as store operated Ca(2+) entry.

12 Store-operated Ca(2)(+) entry (SOCE) in skeletal muscle

13 blastoma cell line, we found that endogenous store-operated Ca(2)(+) entry (SOCE), which is critical

14 d CIF production and the opening of multiple store-operated Ca(2+) (SOC) channels.

15 he activation of the highly Ca(2+) selective store-operated Ca(2+) (SOC) entry current mediated by th

16 Store-operated Ca(2+) (SOC) entry is one of the major me

17 d in CD4(+) T cells, where it acted as a non-store-operated Ca(2+) channel and contributed to T cell

18 Here we demonstrate that a store-operated Ca(2+) channel subunit, Orai1, is require

19 Orai1 is a pore subunit of a store-operated Ca(2+) channel that is a major molecular

20 our results demonstrate the pivotal role of store-operated Ca(2+) channel-mediated Ca(2+) influx in

21 r stromal interaction molecule 1 (STIM1) and store-operated Ca(2+) channels (e.g., the Orai1 channel)

22 rease in extracellular Ca(2+) influx through store-operated Ca(2+) channels (SOC).

23 es have also determined the relevant role of store-operated Ca(2+) channels (SOCC) in vascular tone r

24 channels regulated by golli, we studied the store-operated Ca(2+) channels (SOCCs) in OPCs and acute

25 Stimulating the activity of store-operated Ca(2+) channels (SOCCs) to trigger a Ca(2

26 Store-operated Ca(2+) channels (SOCs) are voltage-indepe

27 Ca(2+) influx by store-operated Ca(2+) channels (SOCs) mediates all Ca(2+

28 Therefore, our data support the concept that store-operated Ca(2+) channels in hPECs and prostate can

29 mechanism for delivering Ca(2+) entering via store-operated Ca(2+) channels to specific target sites,

30 4P was suppressed when Ca(2+) influx through store-operated Ca(2+) channels was inhibited.

31 tive stores followed by Ca(2+) entry through store-operated Ca(2+) channels, and the latter selective

32 c fluxes in SANCs, including activation of a store-operated Ca(2+) current, a reduction in L-type Ca(

33 (2+) leads to overactivation of the neuronal store-operated Ca(2+) entry (nSOC) pathway in YAC128 MSN

34 STIM1) is an ER Ca(2+) sensor that activates store-operated Ca(2+) entry (SOCE) and also functions in

35 mal interaction molecule 1 (STIM1) regulates store-operated Ca(2+) entry (SOCE) and other ion channel

36 sis were dependent on TRPC4 channel-mediated store-operated Ca(2+) entry (SOCE) and sequential activa

37 Since influx of Ca(2+) may occur through store-operated Ca(2+) entry (SOCE) as well as voltage- a

38 ially regulates activation of STIM1-mediated store-operated Ca(2+) entry (SOCE) between cervical canc

39 Orai1, a store-operated Ca(2+) entry (SOCE) channel, was previous

40 Store-operated Ca(2+) entry (SOCE) channels are importan

41 Moreover, knockdown of two key store-operated Ca(2+) entry (SOCE) components, Orai1 and

42 Store-operated Ca(2+) entry (SOCE) encoded by Orai1 prot

43 Here we examined the contribution of the store-operated Ca(2+) entry (SOCE) for the pathogenesis

44 Store-operated Ca(2+) entry (SOCE) has emerged as an imp

45 Store-operated Ca(2+) entry (SOCE) in cells of the immun

46 The events leading to the activation of store-operated Ca(2+) entry (SOCE) involve Ca(2+) deplet

47 Store-operated Ca(2+) entry (SOCE) is a Ca(2+)-entry pro

48 Store-operated Ca(2+) entry (SOCE) is a major Ca(2+) inf

49 Store-operated Ca(2+) entry (SOCE) is a universal Ca(2+)

50 on depletion of intracellular Ca(2+) stores, store-operated Ca(2+) entry (SOCE) is activated.

51 Store-operated Ca(2+) entry (SOCE) is an essential proce

52 ra-2 and Mag-Fluo4) levels are decreased and store-operated Ca(2+) entry (SOCE) is inhibited, whereas

53 Store-operated Ca(2+) entry (SOCE) is the main Ca(2+) in

54 Store-operated Ca(2+) entry (SOCE) is the predominant Ca

55 In T cells, store-operated Ca(2+) entry (SOCe) is the primary Ca(2+)

56 on enhances extracellular Ca(2+) entry via a store-operated Ca(2+) entry (SOCE) mechanism in skeletal

57 i and fluid secretion and is mediated by the store-operated Ca(2+) entry (SOCE) mechanism.

58 al stem/progenitor cells (NSCs/NPCs) exhibit store-operated Ca(2+) entry (SOCE) mediated by Ca(2+) re

59 y been reported to play an important role in store-operated Ca(2+) entry (SOCE) mediated by ORAI and

60 Store-operated Ca(2+) entry (SOCE) mediates the increase

61 ER Ca(2+) level is in part monitored by the store-operated Ca(2+) entry (SOCE) system, an adaptive m

62 s, KO cells presented a notable reduction of store-operated Ca(2+) entry (SOCE) that was rescued by e

63 Store-operated Ca(2+) entry (SOCE) through Ca(2+) releas

64 Store-operated Ca(2+) entry (SOCE) through Ca(2+) releas

65 Store-operated Ca(2+) entry (SOCE) through Ca(2+) releas

66 Store-operated Ca(2+) entry (SOCE) through Ca(2+) releas

67 Store-operated Ca(2+) entry (SOCE) through sarcolemmal C

68 +) sensor STIM1 is crucial for activation of store-operated Ca(2+) entry (SOCE) through transient rec

69 fibrosis, 17beta-estradiol (E2) may inhibit store-operated Ca(2+) entry (SOCE) to impinge upon airwa

70 (ER) store, organizes as puncta that trigger store-operated Ca(2+) entry (SOCE) via plasmalemmal Ca(2

71 In the presence of store-operated Ca(2+) entry (SOCE) via plasmalemmal Ca(2

72 Store-operated Ca(2+) entry (SOCE) was blocked by the SO

73 This store-operated Ca(2+) entry (SOCE) was observed in appro

74 First, we discovered that RASSF4 regulates store-operated Ca(2+) entry (SOCE), a fundamental Ca(2+)

75 Store-operated Ca(2+) entry (SOCE), a ubiquitous mechani

76 +) levels, agonist-induced Ca(2+) increases, store-operated Ca(2+) entry (SOCE), and store-operated c

77 AT1) expression together with an increase in store-operated Ca(2+) entry (SOCE), SOCE-dependent nucle

78 hosphate (IP(3))-mediated Ca(2+) release and store-operated Ca(2+) entry (SOCE), the transient recept

79 dulated intracellular Ca(2+) release but not store-operated Ca(2+) entry (SOCE), whereas neutrophil N

80 ORAI1 is an essential pore subunit of store-operated Ca(2+) entry (SOCE), which is a major Ca(

81 ted Ca(2+) channel subunit, Orai1, underlies store-operated Ca(2+) entry (SOCE).

82 d CD95 into a cluster, eliciting a polarized store-operated Ca(2+) entry (SOCE).

83 mal interacting molecule 1 (STIM1) regulates store-operated Ca(2+) entry (SOCE).

84 Ca(2+) channel Orai1 at ER-PM junctions for store-operated Ca(2+) entry (SOCE).

85 lasma membrane (PM) Orai1 channels mediating store-operated Ca(2+) entry (SOCE).

86 Ca(2+) entry across the plasma membrane via store-operated Ca(2+) entry (SOCE).

87 at [Ca(2+)]ER can regulate Ca(2+) influx via store-operated Ca(2+) entry (SOCE).

88 n identified as the main determinants of the store-operated Ca(2+) entry (SOCE).

89 against prolonged lowering of [Ca(2+)](i) by store-operated Ca(2+) entry (SOCE).

90 intrinsic role for STC2 in the regulation of store-operated Ca(2+) entry (SOCE).

91 M2 by siRNA or inhibition by G418 suppresses store-operated Ca(2+) entry and agonist-mediated Ca(2+)

92 et-derived growth factor activates canonical store-operated Ca(2+) entry and Ca(2+) release-activated

93 ession of Orai1 in the oocytes also modified store-operated Ca(2+) entry and had an inhibitory effect

94 Store-operated Ca(2+) entry and its major determinants a

95 These dysfunctions stem from alterations in store-operated Ca(2+) entry and sarcoplasmic endoplasmic

96 Our data suggest that store-operated Ca(2+) entry and STIM1 are involved in th

97 i1, acute hypoxic conditions rapidly blocked store-operated Ca(2+) entry and the Orai1-mediated Ca(2+

98 We show that hGAAP increased store-operated Ca(2+) entry and thereby the activity of

99 R-resident regulatory protein STIM1 triggers store-operated Ca(2+) entry by direct interaction with t

100 of the pore-forming subunit Orai1, the major store-operated Ca(2+) entry channel in platelets.

101 The presence of the store-operated Ca(2+) entry channel Orai1 and its functi

102 ently of Ca(2+) entry through the ubiquitous store-operated Ca(2+) entry channel Orai1, global Ca(2+)

103 l channel 4 (TRPC4) comprises an endothelial store-operated Ca(2+) entry channel, and TRPC4 inactivat

104 Store-operated Ca(2+) entry depends critically on physic

105 Inhibition of store-operated Ca(2+) entry had no effect on ICSI-induce

106 Orai1-encoded store-operated Ca(2+) entry has recently emerged as an i

107 ped by GlaxoSmithKline, GSK-7975A, inhibited store-operated Ca(2+) entry in a concentration-dependent

108 Additionally, we found no store-operated Ca(2+) entry in control or STIM1 overexpr

109 nflux from the extracellular medium, such as store-operated Ca(2+) entry in fibroblasts and membrane

110 suggest new therapies aiming at attenuating store-operated Ca(2+) entry in the treatment of patients

111 Store-operated Ca(2+) entry is a widely encountered mech

112 The STIM1-ORAI1 pathway of store-operated Ca(2+) entry is an essential component of

113 Store-operated Ca(2+) entry is important for cell migrat

114 that with increasing agonist concentrations, store-operated Ca(2+) entry is mediated initially by end

115 Our findings show that store-operated Ca(2+) entry is needed to sustain cytopla

116 educed in the presence of MARCKS-ED SA4, but store-operated Ca(2+) entry is not inhibited.

117 Store-operated Ca(2+) entry mediated by STIM1 and ORAI1

118 Store-operated Ca(2+) entry occurs through the binding o

119 Store-operated Ca(2+) entry over the plasma membrane is

120 Orai1 and a functional store-operated Ca(2+) entry pathway are required to main

121 Ca(2+) influx occurs via the store-operated Ca(2+) entry pathway, involving stromal i

122 e 1 (STIM1) and Orai1, the components of the store-operated Ca(2+) entry pathway, to generate cells w

123 Intracellular Ca(2+) imaging revealed that store-operated Ca(2+) entry played a prominent role in S

124 Our findings indicate that store-operated Ca(2+) entry regulates SGK1 expression in

125 identified as a Ca(2+) sensor that regulates store-operated Ca(2+) entry through activation of the po

126 rative Ca(2+) release, they are sustained by store-operated Ca(2+) entry through Ca(2+) release-activ

127 ult cardiac myocytes arguably do not require store-operated Ca(2+) entry to regulate sarcoplasmic ret

128 Furthermore, Ca(2+) influx through the store-operated Ca(2+) entry triggered strong, whereas ER

129 Store-operated Ca(2+) entry was not detected in these ce

130 Store-operated Ca(2+) entry was similarly increased by o

131 ctivated calcium modulator (ORAI) 1-mediated store-operated Ca(2+) entry were found to regulate LPS-i

132 ak and that these actions are independent of store-operated Ca(2+) entry, a process that is absent in

133 brane junctions where STIM1, which regulates store-operated Ca(2+) entry, accumulates after depletion

134 activity of Orai1, the pore forming unit of store-operated Ca(2+) entry, and thus influences Ca(2+)-

135 STIM1) and Orai1 channels, key components of store-operated Ca(2+) entry, are selectively expressed i

136 s exploit host signaling pathways, including store-operated Ca(2+) entry, autophagy, and inflammasome

137 Store-operated Ca(2+) entry, essential for the adaptive

138 erface with mitochondria; but also originate store-operated Ca(2+) entry-induced transcellular Ca(2+)

139 ease from intracellular stores and driven by store-operated Ca(2+) entry.

140 dent contacts, however, are not required for store-operated Ca(2+) entry.

141 where it activates Orai1 channels, providing store-operated Ca(2+) entry.

142 ous septin proteins as crucial regulators of store-operated Ca(2+) entry.

143 e intracellular stores, a mechanism known as store-operated Ca(2+) entry.

144 ating the requirement for TRPC4 in mediating store-operated Ca(2+) entry.

145 ng on the roles of STIM and ORAI proteins in store-operated Ca(2+) entry.

146 2+) uptake occurs through a process known as store-operated Ca(2+) entry.

147 oplasm but only transverse tubules supported store-operated Ca(2+) entry.

148 t type I fiber content but not through acute store-operated Ca(2+) entry.

149 The molecular components of store-operated Ca(2+) influx channels (SOCs) in prolifer

150 ed direct evidence that TRPC1 is involved in store-operated Ca(2+) influx in OPCs and that it is modu

151 adjust in parallel the concentrations of the store-operated Ca(2+) influx mediator stromal interactio

152 Quercetin also rapidly inhibits store-operated Ca(2+) influx stimulated by thapsigargin.

153 ER-plasma membrane (PM) junctions to trigger store-operated Ca(2+) influx.

154 x, Ca(2+)-induced Ca(2+)-release (CICR), and store-operated Ca(2+) influx.

155 a(2+)](i) increases and delayed the onset of store-operated Ca(2+) influx.

156 n immune cells, calcium entry occurs through store-operated Ca(2+) release-activated Ca(2+) (CRAC) ch

157 Signaling through the store-operated Ca(2+) release-activated Ca(2+) (CRAC) ch

158 Store-operated Ca(2+) release-activated Ca(2+) (CRAC) ch

159 ated, highly calcium-selective channels: the store-operated Ca(2+) release-activated Ca(2+) (CRAC) ch

160 In store-operated Ca(2+) release-activated Ca(2+) (CRAC) ch

161 Store-operated Ca(2+) release-activated Ca(2+) (CRAC) ch

162 o-exist endogenously in many cell types: the store-operated Ca(2+) release-activated CRAC channels an

163 crosstalk mechanism between type I IFNs and store-operated Ca(2+) signaling pathways mediated at lea

164 Store-operated Ca(2+) signaling represents a major signa

165 d PARK14 disease locus (Pla2g6 gene) and the store-operated Ca(2+) signalling pathway.

166 chondrial, and lysosomal Ca(2+) pools and in store-operated Ca(2+) uptake in JNCL cells.

167 4 can interact with STIM1 to form functional store-operated Ca(2+)-entry channels, which are essentia

168 from the endoplasmic reticulum activates the store-operated Ca(2+)-influx pathway that is necessary f

169 sine kinases mobilizes Ca(2+) influx through store-operated Ca(2+)-release-activated Ca(2+) (CRAC) ch

170 equired entry of extracellular Ca(2+)through store-operated Ca(2+)channels.

171 We demonstrate that sigma1Rs inhibit store-operated Ca(2+)entry (SOCE), a major Ca(2+)influx

172 itates slow Ca(2+)-dependent inactivation of store-operated Ca(2+)entry (SOCE).

173 The store-operated Ca(2+)entry-associated regulatory factor

174 cking either Nox2 or Stim1 failed to trigger store-operated Ca2+ entry (SOCe) and NFAT nuclear accumu

175 Application of the store-operated Ca2+ entry (SOCE) blockers BTP2 (10 mum)

176 c Ca2+ activity ([Ca2+](i)), accomplished by store-operated Ca2+ entry (SOCE) involving the pore-form

177 ellular Ca2+ concentrations are regulated by store-operated Ca2+ entry (SOCE) through Ca2+ release-ac

178 (CRAC) channel genes ORAI1 and STIM1 abolish store-operated Ca2+ entry (SOCE), and patients with thes

179 A common mechanism for Ca2+ influx is store-operated Ca2+ entry (SOCE).

180 plays an essential role in the activation of store-operated Ca2+ entry (SOCE).

181 Although lowering Stim1 levels reduces store-operated Ca2+ entry and inhibits intestinal epithe

182 Store operated calcium entry (SOCE) is thought to primar

183 Store-operated calcium (Ca(2+)) entry (SOCE) mediated by

184 synaptotoxic enhancement of STIM2-dependent store-operated calcium (SOC) entry.

185 TRPM7 is not a store-operated calcium channel.

186 Store-operated calcium channels (SOCs) are calcium-selec

187 , the model shows that calcium entry through store-operated calcium channels is critical for calcium

188 ceptors (TCRs) followed by calcium entry via store-operated calcium channels.

189 e have previously demonstrated that neuronal store-operated calcium entry (nSOC) in hippocampal neuro

190 d in an increase in cell proliferation rate, store-operated calcium entry (SOCE) amplitude, cationic

191 um-dependent signaling pathways initiated by store-operated calcium entry (SOCE) are known to regulat

192 In the present study, we report store-operated calcium entry (SOCE) as a novel target of

193 Our previous studies implied store-operated calcium entry (SOCE) as the major pathway

194 Store-operated calcium entry (SOCE) by calcium release a

195 ion of ATLs alters ER morphology and affects store-operated calcium entry (SOCE) by decreasing STIM1

196 s, we propose a model wherein STIM1-mediated store-operated calcium entry (SOCE) governs the Ca(2+) s

197 e measured resting intracellular calcium and store-operated calcium entry (SOCE) in fast- and slow-tw

198 M1-deficient murine neutrophils show loss of store-operated calcium entry (SOCE) in response to both

199 Store-operated calcium entry (SOCE) is a major Ca(2+) si

200 Store-operated calcium entry (SOCE) is an important Ca(2

201 Store-operated calcium entry (SOCE) is involved in vario

202 Store-operated calcium entry (SOCE) is the mechanism by

203 Store-operated calcium entry (SOCE) is the predominant C

204 Transcriptional regulation by Store-operated Calcium Entry (SOCE) is well studied in n

205 By inhibiting store-operated calcium entry (SOCE) or voltage-gated Ca(

206 The store-operated calcium entry (SOCE) pathway is an import

207 Despite recent advances in understanding store-operated calcium entry (SOCE) regulation, the fund

208 4-mediated depletion of ER calcium activates store-operated calcium entry (SOCE) through activation o

209 her major source of [Ca(2+)]cyt elevation is store-operated calcium entry (SOCE) through plasmalemmal

210 more, pharmacological studies suggested that store-operated calcium entry (SOCE), a calcium refilling

211 ic Ca(2+) concentrations in GC cells through store-operated calcium entry (SOCE), and then mediated C

212 Sustained Ca(2+) signaling, known as store-operated calcium entry (SOCE), occurs downstream o

213 ly conserved Calcium influx pathway known as store-operated calcium entry (SOCE).

214 1) is a Ca(2+) sensor protein that initiates store-operated calcium entry (SOCE).

215 This mechanism is called store-operated calcium entry (SOCE).

216 hannel that has been considered as a part of store-operated calcium entry (SOCE).

217 lar calcium and the subsequent activation of store-operated calcium entry (SOCE).

218 eptor potential melastatin 7 (TRPM7) reduces store-operated calcium entry (SOCE).

219 by blocking mitochondrial calcium uptake and store-operated calcium entry (SOCE).

220 temporally correlated with the occurrence of store-operated calcium entry (SOCE).

221 such as excitation-contraction coupling and store-operated calcium entry (SOCE).

222 During store-operated calcium entry activation, calcium depleti

223 ctive target mRNA and proteins and abrogated store-operated calcium entry and I(CRAC) in VSMC; contro

224 on of extracellular calcium or inhibition of store-operated calcium entry blocked DIR, but the L-type

225 This protein, TMEM20 (POST), does not affect store-operated calcium entry but does reduce plasma memb

226 Interestingly, the store-operated calcium entry channel inhibitor (SK&F9636

227 ndoplasmic reticulum calcium release-induced store-operated calcium entry contributes to intracellula

228 oint mutation in STIM1 completely abolishing store-operated calcium entry in T cells.

229 Calcium flux through store-operated calcium entry is a central regulator of i

230 A unique mechanism called store-operated calcium entry is activated when ER calciu

231 of an additional level in the regulation of store-operated calcium entry pathways.

232 identify the molecular mechanism underlying store-operated calcium entry that replenishes ER stores

233 Store-operated calcium entry was also reduced in periphe

234 Store-operated calcium entry was indistinguishable betwe

235 represent the primary pathway for so-called "store-operated calcium entry" - the cellular entry of ca

236 M1) deficiency is a rare genetic disorder of store-operated calcium entry, associated with a complex

237 ai proteins constitute the core machinery of store-operated calcium entry.

238 nd 2 (STIM1 and STIM2) are key modulators of store-operated calcium entry.

239 ulum calcium activates STIM1/Orai1-dependent store-operated calcium entry.

240 e result of an acute loss of Orai1-dependent store-operated calcium entry.

241 Our results indicate that the P2Y6/store-operated calcium entry/IL-8 axis is involved in MS

242 om spines depends on STIM2-mediated neuronal store-operated calcium influx (nSOC) and continuous acti

243 The two key components of the store-operated calcium release-activated calcium channel

244 These events include release of store-operated calcium that facilitates the activation o

245 , which is sustained by Ca(2+) entry through store-operated calcium-release-activated calcium (CRAC)

246 d ER Ca(2+) store release, possibly engaging Store Operated cAMP Signaling (SOcAMPS) and activating C

247 se linked to the inappropriate activation of store-operated cAMP production.

248 did not observe any involvement of TRPC1 in store-operated cation influx.

249 STIM1 and STIM2 and their different roles in store-operated channel activation are indicative of an a

250 enhancement of SOCE activities sensitive to store-operated channel inhibitors (SKF-96365 and BTP2) a

251 sed diastolic [Ca(2+)]i, which is blunted by store-operated channel inhibitors.

252 linked to SOCE, without TRPM7 representing a store-operated channel itself.

253 , we show that pharmacological inhibition of store operated channels or reduction in the expression o

254 In other cell types store-operated channels (SOC) have been shown to contrib

255 asmic reticulum (SR) Ca(2+) stores activates store-operated channels (SOCs) composed of canonical tra

256 or potential channel 1 (TRPC1) protein-based store-operated channels (SOCs) mediates Ca(2+) entry pat

257 or potential channel 1 (TRPC1) protein-based store-operated channels (SOCs) mediates Ca(2+) entry pat

258 POINTS: Depletion of Ca(2+) stores activates store-operated channels (SOCs), which mediate Ca(2+) ent

259 Depletion of Ca(2+) stores activates store-operated channels (SOCs), which mediate Ca(2+) ent

260 Both the store-operated channels and the store-independent arachi

261 critically dependent on Ca(2+) entry through store-operated channels but do not depend strongly on Ca

262 ltage-gated channels are less important than store-operated channels in the control of airway smooth

263 nnel, in regulating Ca(2+) entry through the store-operated channels mouse transient receptor potenti

264 alcium sensor that initiates the assembly of store-operated channels, and the calcium-independent pho

265 endoplasmic reticulum (ER) Ca(2+) sensor for store-operated channels.

266 TIM2 differ in the ability to activate these store-operated channels; Imin channels are regulated by

267 s signalling power; Ca(2+) microdomains near store-operated CRAC channels in the plasma membrane and

268 ur findings demonstrate that Ca2+ influx via store-operated CRAC channels is essential for CaCC activ

269 ent potassium channels (K(ATP)) or an inward store-operated current (SOC).

270 ses, store-operated Ca(2+) entry (SOCE), and store-operated currents (ISOC) are largely enhanced in t

271 On the other hand, many cell types display store-operated currents different from CRAC.

272 contribute to enhanced SOCE and differential store-operated currents in tumor cells, whereas ORAI2 an

273 e-activated Ca(2+) (CRAC) channel, mediating store-operated currents.

274 effect of NCLX activity on Ca(2+) influx via store-operated entry.

275 Inhibition of store-operated gating by 2-APB was accompanied by the su

276 sing direct activation, 2-APB also regulates store-operated gating of Orai3 channels, causing potenti

277 aracterized by exquisite Ca(2+) selectivity, store-operated gating, and distinct pore properties and

278 Last, store-operated influx, evoked by ER depletion, was remov

279 that the Orai3 subtype, in addition to being store-operated, is also activated in a store-independent

280 tores in the endoplasmic reticulum through a store-operated mechanism.

281 clear whether STIM2 is capable of regulating store-operated non-CRAC channels.

282 hypothesis that pharmacological blockade of store-operated or Ca(2+) release-activated Ca(2+) channe

283 of calcium release from SGs that involves SG store-operated Orai channels activated by their regulato

284 y, these structural requisites were found in store-operated Orai channels.

285 be activated by Ca(2+) nanodomains near open store-operated Orai1 and voltage-gated Ca(2+) channels i

286 lular Ca(2+) that accompanies the opening of store-operated Orai1/CRAC channels.

287 (shRNA) and absent in TRPC1(-/-) cells, and store-operated PKC phosphorylation of TRPC1 was inhibite

288 Store-operated PKC phosphorylation of TRPC1 was reduced

289 SOCs, and U73122 and GF109203X also reduced store-operated PKC-dependent phosphorylation of TRPC1 pr

290 patients reveals a significant deficiency in store-operated PLA2g6-dependent Ca(2+) signalling, which

291 PLCbeta1 with small hairpin RNA reduced both store-operated PLC activity and stimulation of TRPC1 SOC

292 Moreover, store-operated PLCbeta1 activity measured with the fluor

293 Here, we show that the store-operated response in Muller cells, radial glia tha

294 By characterizing the properties of store-operated signaling pathways in Muller cells, these

295 in VSMCs, and a novel role for STIM1, where store-operated STIM1-TRPC1 interactions stimulate Galpha

296 VSMCs, and a novel role for STIM1, in which store-operated STIM1-TRPC1 interactions stimulate PLCbet

297 Store-operated TRPC1 channel activity was inhibited by T

298 Store-operated TRPC1 channel and PLCbeta1 activities wer

299 Store-operated TRPC1 channels were identified by their e

300 this is achieved and the respective roles of store-operated versus store-independent Ca(2+) entry pat