ライフサイエンスコーパス: strategy to

1 The application of this strategy to a (15) N2 -diazirine-containing choline deri

2 s needed for better screening and preventive strategies to abrogate these toxic effects and improve p

3 Moreover, the general applicability of this strategy to access dihydroxylated biphenyls is demonstra

4 st in developing alternative and sustainable strategies to achieve textile functionality that do not

5 form of the chemokine may not be the optimal strategy to achieve disease control.

6 e and time, cortex uses a similar processing strategy to achieve higher-level and increasingly invari

7 e and time, the visual system uses a similar strategy to achieve increasingly invariant representatio

8 Our strategy to achieve this goal is based on the spatial se

9 nductor with antireflection layer is general strategy to achieve this including crystalline silicon (

10 st inhibition of PLD4 as a novel therapeutic strategy to activate protease-mediated degradation of ex

11 ion as well as the prevention of and control strategies to address anemia.

12 One promising strategy to address this challenge is the systematic bac

13 A strategy to address this problem is the development of c

14 develop novel therapeutic and/or preventive strategies to ameliorate pain in SCD.

15 Accordingly, strategies to antagonize the antiapoptotic Bcl-2 protein

16 luation impossible and require metareasoning strategies to apportion cognitive resources adaptively.

17 use many different criteria and peer review strategies to assess grant proposals.

18 eumococcal disease (IPD) calls for alternate strategies to assess this.

19 Herein, a mass spectrometry (MS)-assisted strategy to assign the methyl resonances of methionine r

20 tor I receptor (IGF-IR) is a new therapeutic strategy to attenuate the underlying autoimmune pathogen

21 onoclonal antibodies delivery as a potential strategy to augment the host immune response to prevent

22 Searching for strategies to avoid racemization, a new class of light-d

23 osts, which consequently evolve a variety of strategies to avoid, eliminate, or tolerate infection.

24 However, for blood-based strategies to be useful, the quantity of biomarker shed

25 ntrol kinase activity, providing insight for strategies to better regulate kinase activity.

26 populations where PEM is endemic may be one strategy to boost vaccination-promoted immunity and impr

27 ost may provide a more effective vaccination strategy to broaden the antibody responses to emerging v

28 reflect on our clinical practice and discuss strategies to build a successful split program using an

29 we highlight new findings and compare these strategies to cell division mechanisms elucidated in mod

30 Online ECG monitoring education and strategies to change practice can lead to improved nurse

31 The predominant strategy to characterize Fe plaque using dithionite-citr

32 This provides a fundamentally different strategy to circumvent multiple mechanisms of kinase inh

33 bute towards development of phytoremediation strategies to clean up TNT from polluted military sites.

34 ort replication and have therefore developed strategies to co-opt cellular processes to optimize infe

35 basis for rationally designed immunotherapy strategies to combat Alzheimer's and related neurodegene

36 icine will be to discover new antibiotics or strategies to combat multidrug resistant bacteria, espec

37 rsion of FAPs into adipocytes, pointing to a strategy to combat fatty degeneration of skeletal muscle

38 groups is the mainstay of the public health strategy to combat influenza.

39 rease their microscopic surface area offer a strategy to combatting the loss in signal associated wit

40 ed pericardial drug delivery could provide a strategy to concentrate therapeutics within a unique, ca

41 w aging promotes CVD in order to develop new strategies to confront this challenge.

42 use genetic tethering and disulfide bonding strategies to construct HslU pseudohexamers containing m

43 Herein we report a new strategy to construct CTFs (CTF-HUSTs) via a polycondens

44 tion, which may contribute to further design strategies to control greenhouse gas emissions from agri

45 ntigenicity for the development of antiviral strategies to control human bocavirus infections.IMPORTA

46 mechanisms is critical to the development of strategies to control microbiological communities that i

47 argeting VEGF signaling may serve as a novel strategy to control CNS leukemia in patients, replacing

48 may constitute an alternative or additional strategy to conventional tumor-directed chemotherapy.

49 resses susceptibility test methods and other strategies to counter antibiotic resistance of C. diffic

50 Strategies to counter sustained catabolism have therapeu

51 nol, and pretreatment of caffeine might be a strategy to counter the hypnotic effects of ethanol.

52 sfully evade the host, the virus has evolved strategies to counteract antiviral responses, including

53 Selective CP blockade may be a promising strategy to counteract rejection.

54 others, the software offers several tracking strategies to cover a wide range of different model orga

55 tes that Synechococcus has distinct adaptive strategies to deal with Cu toxicity at both the clade an

56 and tree cover may hold promise as proactive strategies to decrease urban violence.

57 Here, we used a pharmacogenetic strategy to decrease mediodorsal thalamic activity in ad

58 A strategy to deliver a well-defined persulfide species in

59 We apply this strategy to demonstrate differential mRNA trafficking be

60 ng in ASFs and explored a combined targeting strategy to deplete senescent cholangiocytes and ASFs fr

61 d metal stress in bacteria could be a useful strategy to design new approaches to antibacterial thera

62 We provide a strategy to design ratiometric sensors that display dram

63 We present the first comparison of two strategies to detect DNA using a giant magnetoresistive

64 e used an unbiased D-amino acid substitution strategy to determine structure-assembly relationships o

65 role in neuropathy, highlighting a potential strategy to develop a neurovirulence-attenuated vaccine

66 Until recently, the only strategy to develop drugs regulating GPCR activity was t

67 Self-assembled bilayers offer a promising strategy to directly harness photon upconversion via tri

68 ssibility of using an untargeted metabolomic strategy to discriminate between common and durum wheat

69 protein degradation systems as an additional strategy to disrupt protein homeostasis.

70 bility spectrometry (IM-MS(2)) and lead to a strategy to distinguish alpha- and beta-linkages within

71 nient (17)O nuclear magnetic resonance (NMR) strategy to distinguish oxide nanocrystals exposing diff

72 dralenes is reported, representing a general strategy to diversely substituted higher homologues of t

73 ckpoint therapy prompts exploration of other strategies to downregulate PD-1 for cancer therapy.

74 roduce the molecular mechanism and different strategies to edit genes using the CRISPR-Cas9 system.

75 une response is crucial to identifying novel strategies to effectively address highly pathogenic and

76 Within this context, we discuss vaccination strategies to elicit broad and potent immune responses b

77 nhibitor, ganciclovir, represents a possible strategy to eliminate latently infected cells without in

78 ere we apply integrative functional genomics strategies to elucidate global HCV-miRNA interactions.

79 report here a general and scalable synthetic strategy to embed 2,2'-bipyridine units into the backbon

80 rtheless, definition of clinical development strategies to enable sound regulatory assessment, with a

81 to this goal is development of a new linking strategy to enable intersheet association mediated by si

82 We then present strategies to engineer BphP-based NIR fluorescent protei

83 Here, we demonstrate a novel strategy to engineer pre-vascularized, cell-laden hydrog

84 nuation of 1,2-DCA and to design appropriate strategies to enhance biodegradation.

85 Strategies to enhance respiration and initiate oxidative

86 diacylglycerol (DAG), successful engineering strategies to enhance TAG levels have focused on the con

87 cking mini-antibody (mini-body; HDPDL1) as a strategy to enhance CAR T-cell killing.

88 f pretargeting fusion protein cocktails as a strategy to enhance nanoparticle delivery to a diverse a

89 ombination with other agents is an effective strategy to enhance Taxol cytotoxicity.

90 may therefore represent a clinically useful strategy to enhance the activity of Bcl-2 inhibitors.

91 Overall, our study provided a promising strategy to enhance the stability of LDL-based nanogels

92 etic antibodies and may serve as a universal strategy to enhance the success rates of Fabs as structu

93 Government's strong commitment to long-term strategies to ensure access to delivery care in health f

94 develop latency reversal and viral clearance strategies to eradicate established HIV infection.

95 Strategies to eradicate latent infection can only be eva

96 Tumors use several strategies to evade the host immune response, including

97 We applied three different strategies to evaluate the distribution of CNVs in the T

98 A strategy to expand anti-Stokes shifting from the far-red

99 the mouse testis has adopted a regenerative strategy to expand stem cell activity by incorporating a

100 Our findings demonstrate an effective strategy to explore selective inhibitors for helicases,

101 The established platform not only provides strategies to fabricate ECM-like interfaces for medical

102 elop an electrochemical sacrificial-template strategy to fabricate hollow Co3 O4 microtube arrays wit

103 eres with triblock copolymers is a promising strategy to fabricate mixed-matrix membranes.

104 propose the use of a continuous-flow sorting strategy to facilitate future coupling to next generatio

105 gesting that targeting HIF-1alpha could be a strategy to foster iTreg differentiation in an inflammat

106 NDEx is presented in the context of a novel strategy to foster network-oriented communities of inter

107 A metal and solvent free strategy to functionalize aryl methyl ethers through dir

108 ations of BPs, but also propose an efficient strategy to further improve the biocompatibility of BPs.

109 The types of defects and controllable strategies to generate defects in electrocatalysts are p

110 asing availability of phylogenomic datasets, strategies to generate genome-scale data from organisms

111 bacterial pathogens have developed versatile strategies to generate niches inside the eukaryotic cell

112 We explored two strategies to generate suitable pLAIVs.

113 so developed a lentiviral vector and cloning strategy to generate high-complexity pooled dual-knockou

114 Here, we developed a novel and simple strategy to greatly enhance the potency of the existing

115 A strategy to halt dissolution of particle-coated air bubb

116 cessary for the development of translational strategies to harness this process for neuronal repair.

117 al, and there is a need to develop exogenous strategies to help regenerate the thymus.

118 ties, stress testing represents a reasonable strategy to help better risk stratify asymptomatic patie

119 -carbohydrate snack, may be a simple dietary strategy to help manage total cholesterol and LDL choles

120 into a conjugated backbone is an attractive strategy to high performance semiconducting polymers.

121 We used two broad-spectrum detection strategies to identify pathogens in test-negative childr

122 llel dense-module search and cross-selection strategy to identify an asthma-associated gene module.

123 We applied a systematic review-based strategy to identify and integrate evidence from epidemi

124 opulation-based linkage analysis is a useful strategy to identify complex trait variants.

125 d to develop a high-throughput and efficient strategy to identify the E3-substrate interaction.

126 vestigate in silico, a possible experimental strategy to illuminate the interplay between 3D chromati

127 have selected two such lineage-based design strategies to illustrate how such in-depth analysis can

128 ment and pave the way to the exploitation of strategies to impact liver infection by the malaria para

129 ngal treatment options and discuss promising strategies to impede the evolution of drug resistance.

130 online ECG monitoring education program and strategies to implement and sustain change in practice.

131 nd habit strength are modifiable targets for strategies to improve adherence in psoriasis.

132 lity of PCR testing, indicating the need for strategies to improve aetiological diagnosis in children

133 Strategies to improve CD4 reconstitution can improve HCT

134 rovide a valuable target for new research on strategies to improve health.

135 l origins of this low efficiency can provide strategies to improve it.

136 isease is important for developing effective strategies to improve outcomes.

137 a necessary step toward developing effective strategies to improve the patient-reported and clinicall

138 ing of decellularized vessels provides a new strategy to improve re-endothelialization of vascular gr

139 ation of down-shifting materials is a viable strategy to improve the efficiency of Silicon solar cell

140 e norms and standards of care is a potential strategy to improve the treatment of women during childb

141 elopment efforts have focused on identifying strategies to increase SMN expression.

142 ourage the development of effective pro-drug strategies to increase the intracellular levels of itaco

143 alter arthropod sex ratios and reproductive strategies to increase the proportion of the infected ma

144 (ie, nonmedical exemptions) may be a useful strategy to increase immunization rates and prevent outb

145 s primary care providers can be an effective strategy to increase the primary care capacity.

146 her affinity ligands may represent a general strategy to increase their therapeutic index.

147 d a Cre recombinase-mediated chromosome loss strategy to individually delete mouse chromosomes 9, 10,

148 and will aid in optimization of immunization strategies to induce V2 apex bnAb responses.

149 The simplest and so far most promising strategy to induce enantioselectivity to solid metal cat

150 -coated surface modification is an effective strategy to induce long-term MK2i release as well as hem

151 Using genetic or pharmacological strategies to inhibit CCL5 or CCR2, we demonstrated that

152 r this observed behavior and propose control strategies to inhibit discordant alternans.

153 Strategies to inhibit extracellular signal-regulated kin

154 ive infection in humans, DENV uses different strategies to inhibit or avoid the host innate immune sy

155 dren with brain tumours, and discuss various strategies to integrate these advances to drive further

156 The absence of a straightforward strategy to interface native d-DNA with its enantiomer l

157 minoazidation reaction provides an efficient strategy to introduce azide, one of the most useful chem

158 oving the food environment need multifaceted strategies to invoke clinically meaningful change in BMI

159 endocarditis and outlines current and future strategies to limit its impact.

160 Strategies to limit the emergence and spread of MDROs in

161 ves is vital in developing effective control strategies to limit the spread of the disease.

162 promoting plasmid loss would be an effective strategy to limit conjugation-assisted persistence of an

163 Intramolecular H-bonding represents a useful strategy to limit internal water rotational motion and i

164 m in vivo represents a promising therapeutic strategy to limit salivary gland inflammation and improv

165 s cholera, phage prophylaxis could provide a strategy to limit the impact of bacterial disease on hum

166 hat PFT-mu may offer a tractable therapeutic strategy to limit this common side-effect of many types

167 To overcome these barriers, we developed a strategy to macroencapsulate islets from different sourc

168 hanism by which animals adjust their dietary strategy to maintain protein homeostasis.

169 tension generation, as a previously unknown strategy to maintain stemness in 3D.

170 inhibits NEMO polyubiquitination as a clever strategy to manipulate the host cell environment to the

171 eems to be an age-independent domain-general strategy to master cognitive challenges.

172 encourage efficient planting and maintenance strategies to maximize pollination and establish resilie

173 Additional dietary strategies to maximize these benefits are required.

174 ultivars through increasing biomass is a key strategy to meet rising global food demands.

175 rmalization procedures and examine different strategies to minimize intra- and interplate nuisance ef

176 this information storage system and optimize strategies to minimize those limitations.

177 ions and could represent a novel therapeutic strategy to minimize the detrimental clinical outcomes o

178 acterial cause of foodborne illness, possess strategies to mitigate the toxic components of bile.

179 ons with a higher level of awareness and use strategies to mitigate this risk.

180 thways in T cells is likely to provide a new strategy to modify inflammation in a variety of disease

181 amics and demonstrated that this is a viable strategy to modify mosquito populations.

182 ide in the identification of pharmacological strategies to modulate FZD receptor function.

183 We address strategies to modulate the DLBCL microenvironment, inclu

184 hich illustrates the general utility of this strategy to modulate the stability and biological activi

185 Here we investigate a novel strategy to normalize medial frontal brain activity by s

186 those flexibilities can be a possible design strategy to obtain regular synthetic cages with full con

187 he fertilizer nutrients through an abatement strategy to offset these issues by providing the fertili

188 y 3 validated bleeding scales (Global Use of Strategies to Open Occluded Coronary Arteries [GUSTO], T

189 hogenesis, emerging targeted treatments, and strategies to optimize clinical trials to efficiently an

190 tailed discussion about the commonly adopted strategies to optimize individual TE properties is prese

191 Thus, our study provides a novel therapeutic strategy to optimize MK-1775 treatment efficiency in lun

192 d to these phenotypes, but optimal treatment strategies to overcome chemotherapeutic resistance and e

193 These findings provide a strategy to overcome several key limitations of CED that

194 Thus, ATR inhibition is a unique strategy to overcome the PARPi resistance of BRCA-defici

195 discuss the potential of targeting HIFs as a strategy to overcome these instances of AA therapy resis

196 One strategy to overcome this barrier is to use latency-reve

197 One strategy to overcome this obstacle is to remove the meth

198 Here we adapt a single-molecule strategy to perform single-molecule recovery after photo

199 rk protection systems represents a promising strategy to potentiate cancer chemotherapy.

200 Plasmodium has therefore evolved strategies to prepare for transmission, including transl

201 tion represents a straightforward and viable strategy to preserve conduit function and possibly impro

202 ese networks are increasingly used to inform strategies to prevent and control the spread of hospital

203 Effective strategies to prevent and treat AD remain elusive despit

204 ovide the basis for the development of novel strategies to prevent C. jejuni colonization of food-pro

205 R is a promising option for future treatment strategies to prevent cancer metastasis in breast cancer

206 g of its development and potentially lead to strategies to prevent ototoxic effects.

207 The second-level approach ideally involves strategies to prevent progression of disease, in additio

208 refore, may contribute to the development of strategies to prevent TDP-43 aggregation and to uncover

209 argeting of GPX4 may represent a therapeutic strategy to prevent acquired drug resistance.

210 inhibitor formation and suggest a potential strategy to prevent anti-FVIII alloantibody formation in

211 Targeting CCR1 may represent a novel strategy to prevent dissemination and overt relapse in m

212 iome, particularly in early life, might be a strategy to prevent or treat asthma, although the result

213 uation of bNAbs.IMPORTANCE bNAbs represent a strategy to prevent or treat infection by a wide range o

214 are a practical and widespread evolutionary strategy to prevent the formation of nonphysiological co

215 c microangiopathy is essential but, the best strategy to prevent these episodes remains unclear.

216 re extends the use of bioorthogonal labeling strategies to problems of clinical relevance.

217 Current strategies to produce homogeneous antibody-drug conjugat

218 nsplantation in children and improvements in strategies to prolong graft survival could substantially

219 This study provides a strategy to promote human beta-cell maturation and ident

220 E STATEMENT To date, there is no therapeutic strategy to promote synaptic recovery in the injured bra

221 tion of a chemogenomics platform to identify strategies to protect neuronal cells from mutant hunting

222 AMPT activity as a promising new therapeutic strategy to protect against anticancer drug-induced peri

223 Strategies to rapidly remove nephrotoxic serum-free ligh

224 s provides it with an effective evolutionary strategy to rapidly increase copy numbers of genomes per

225 A strategy to reach these architectures via direct difunct

226 multifaceted national effort employed novel strategies to recruit a diverse cohort, and collected bi

227 one focus of research to develop innovative strategies to recruit and redirect cytotoxic effector ce

228 cus in future research to optimize treatment strategies to reduce a negative impact on the quality of

229 Much effort is underway to develop strategies to reduce Abeta concentration or inhibit aggr

230 ign and development of novel olfactory-based strategies to reduce both the biting nuisance and diseas

231 Control strategies to reduce human schistosomiasis have evolved

232 Plants use iron-withholding strategies to reduce pathogen virulence or to locally in

233 Strategies to reduce shocks could result in cost savings

234 Strategies to reduce SIP signaling and increase retentio

235 Strategies to reduce the daily risk of bleeding and thro

236 d network structures, and propose mitigation strategies to reduce the severity of damages caused by s

237 Strategies to reduce triglyceride levels, by increasing

238 regulatory T (Treg) cells offers a promising strategy to reduce damage to an allograft by the recipie

239 ase C (PKC) modulators, provides a promising strategy to reduce if not eradicate the viral reservoir.

240 single neurons and provided a normalization strategy to reduce method-specific differences related t

241 erative transfusion practices are a possible strategy to reduce sepsis rates and improve survival aft

242 f senescent cells may be a novel therapeutic strategy to reduce steatosis.

243 of obesity may be an important public health strategy to reduce the incidence of childhood epilepsy.

244 CAP could be a key strategy to reduce the treatment gap for alcohol use dis

245 sting question: Is there an optimal feedback strategy to regulate the synthesis of a protein to ensur

246 e sought to develop a flow cytometric gating strategy to reliably identify blood IgG4(+) B cells to s

247 ic activation of EAAT2 represents a valuable strategy to relieve neuropathic pain, we synthesized nov

248 some differentiated cells utilize conserved strategies to remodel microtubules, there is considerabl

249 iver stiffness cutoffs as a test replacement strategy (to replace liver biopsy) in making key decisio

250 Strategies to resolve replication blocks are critical fo

251 al organic nitrate therapies, an alternative strategy to restore NO-cGMP signaling is via inorganic n

252 ate latent plasticity as a novel therapeutic strategy to restore synaptic strength.

253 We have developed a strategy to rewire the endogenous cellular regulatory ne

254 describe a rapid, inexpensive, and portable strategy to robustly re-identify human DNA called 'MinIO

255 We designed our strategy to select against re-targeting the 'knockout-fi

256 Thus, this nano-delivery strategy to selectively target tumors and prevent the pa

257 hese include a novel hybrid data acquisition strategy to sequence cross-links at both MS2 and MS3 lev

258 work suggests that people use two different strategies to solve the explore-exploit dilemma: directe

259 Viruses have evolved numerous strategies to specifically interfere with IFN production

260 ntervention program is probably an effective strategy to stop PS in children.

261 Present treatment strategies to stratify exacerbation risk in patients wit

262 t advances in computational and experimental strategies to study the diverse functional and phenotypi

263 These data identify a natural control strategy to suppress alpha-syn aggregation and suggest p

264 In summary, we report a strategy to suppress the KRAS oncogene in pancreatic can

265 Strategies to sustainably manage wild meat hunting in bo

266 We herein demonstrate a strategy to synthesize a high-performance polymer accept

267 As with all zeolites, strategies to tailor them for specific applications incl

268 gical, immunohistochemical, and chemogenetic strategies to target and manipulate CeA activity selecti

269 n of lipophilic cations, synthetic chemistry strategies to target compounds to mitochondria, mitochon

270 sis, our findings suggest that pharmacologic strategies to target FKBP65 and LH2 may have complementa

271 valuate innovative culture change models and strategies to target these barriers.

272 tion mechanism of TNFalpha and the basis for strategies to target TNFalpha activity.

273 es that involve ROS modulation in cells as a strategy to target cancer and bacteria.

274 Use of the same strategy to target human ANGPTL3 reduced levels of ather

275 of PDHK4 could represent a novel therapeutic strategy to target KRAS mutant colorectal and lung cance

276 may present a novel and molecularly defined strategy to target mutant p53 in pancreatic cancer.

277 of DDR, and identify a potential therapeutic strategy to target SETD2-mutant leukemias.

278 dings provide a proof-of-principle, rational strategy to target the MYB "addiction" of Ph(+) ALL.Sign

279 Because killer cells use a multipronged strategy to target vital pathways, bacteria may not easi

280 s of AMPDs, through nanoparticle preparative strategies, to the most recent applications in cancer an

281 and underscores the need for more selective strategies to therapeutically target NF-kappaB.

282 manure has been recommended as an effective strategy to to mitigate climate change.

283 ve encouraged the development of therapeutic strategies to treat and prevent telomere-associated dise

284 evelopment of T cell-based immunotherapeutic strategies to treat blinding recurrent herpes infection

285 d as key targets to aid development of novel strategies to treat chronic infection by exploiting biof

286 avenues to help design chronopharmacological strategies to treat major depressive disorder.

287 l targets provides a paradigm for developing strategies to treat respiratory distress in SMA.

288 Antivascular therapy represents a proven strategy to treat angiogenesis.

289 This study paves way for a combinatorial strategy to treat as well as prevent adverse effects of

290 pies to target the CBP/p300 bromodomain as a strategy to treat castration-resistant prostate cancer.

291 express regenerative paracrine factors is a strategy to treat vasculopathies and to promote tissue r

292 However, the absence of strategies to tune their thermal half-lives by modular m

293 We applied this strategy to two essential E. coli enzymes: the branched-

294 an innovative computational drug- discovery strategy to uncover drugs that are routinely used for ot

295 ycle and/or pathogenesis represents a useful strategy to uncover new drug targets.

296 ere we apply a multilayered chemical biology strategy to unravel the mode of action of this putative

297 rk provides a proof of concept for a general strategy to use nanohoops and their derivatives as a new

298 Here, we report a strategy to visualize DNA-Pt with high resolution, takin

299 on how depolarization can be exploited as a strategy to visualize GNR diffusion and distribution in

300 on using a flow-enabled self-assembly (FESA) strategy to yield large-area periodic cracks (i.e., micr