ライフサイエンスコーパス: strategy to overcome

1 n-RAF activities is an effective therapeutic strategy to overcome acquired-resistance to vemurafenib.

2 a rational base for the development of novel strategies to overcome antiangiogenic resistance in the

3 l show whether necroptosis is truly a better strategy to overcome apoptosis resistance and provide th

4 nction ARVs, and furthermore, they provide a strategy to overcome ARV function in the clinic.

5 programs at 21 medical schools, the various strategies to overcome barriers in training physicians i

6 ach highlights the potential of mobilization strategies to overcome barriers to successful engraftmen

7 y identification of barriers to tool use and strategies to overcome barriers.

8 y have led to the development of therapeutic strategies to overcome castration resistance.

9 at addressing this shortfall by identifying strategies to overcome challenges, developing the tools

10 cquired chemoresistance to TMZ and potential strategies to overcome chemoresistance are, therefore, c

11 lowing the development of improved treatment strategies to overcome chemoresistance.

12 herapeutic efficacy, thereby providing a new strategy to overcome chemoresistance and to improve the

13 the ERCC1-XPF complex as a novel therapeutic strategy to overcome chemoresistance.

14 d to these phenotypes, but optimal treatment strategies to overcome chemotherapeutic resistance and e

15 unction, therefore, presents a promising new strategy to overcome chemotherapy resistance in breast c

16 P11B expression could serve as a therapeutic strategy to overcome cisplatin resistance.

17 Strategies to overcome clinical inertia must focus on me

18 nza, and suggest that additional therapeutic strategies to overcome defective antibacterial immunity

19 a prophylactic, potent, and safe therapeutic strategy to overcome DFP toxicity.

20 A strategy to overcome disease-causing nonsense mutations

21 Therefore, new combination strategies to overcome drug resistance in patients with

22 tacle for long-term remission, and effective strategies to overcome drug resistance would have signif

23 In this study, we have provided four strategies to overcome drug resistance.

24 ettes promise to yield novel, more-effective strategies to overcome drug resistance.

25 itors, which also can be used to develop new strategies to overcome drug-resistant mRCC.

26 Such approach could be seen as a promising strategy to overcome drug resistance and enhance the eff

27 of autoreactive B cells and represents a new strategy to overcome drug resistance in human ALL.

28 B-cell selection represents a promising new strategy to overcome drug resistance in human ALL.

29 al inhibition of GLI1, revealing a potential strategy to overcome drug resistance in some patients.

30 andidate target to develop novel therapeutic strategy to overcome drug resistance.

31 Strategies to overcome EGFR T790M-mediated drug resistan

32 in breast cancer drug development, including strategies to overcome endocrine and human epidermal gro

33 st antidonor T cells and suggest a practical strategy to overcome engraftment barriers in primed indi

34 Therefore, strategies to overcome epigenetic modifications underlyi

35 nsure that the goal of the National HIV/AIDS Strategy to overcome health disparities becomes a realit

36 e possibility that bacteria may have evolved strategies to overcome host cell apoptosis was explored

37 t pathogens utilize many universal offensive strategies to overcome host defenses, irrespective of th

38 different clones may have adopted different strategies to overcome host responses and cause severe p

39 indicate that influenza virus has evolved a strategy to overcome host innate immunity by downregulat

40 t CLL cells may provide novel drug treatment strategies to overcome ibrutinib resistance mediated by

41 ether these data provide a novel therapeutic strategy to overcome imatinib mesylate resistance, espec

42 ntial targets for development of therapeutic strategies to overcome immune evasion.

43 s with a mesenchymal phenotype and suggest a strategy to overcome immune evasion through induction of

44 tion may represent an attractive therapeutic strategy to overcome immune tolerance in breast cancer.

45 eted CAR T cells and explored cell-intrinsic strategies to overcome inhibition of CAR T cells.

46 e present a non-competitive active transport strategy to overcome intestinal barriers in the form of

47 have shown that viruses have evolved a novel strategy to overcome intestinal mucinous barriers agains

48 However, bacteria have evolved strategies to overcome iron starvation, for example, by

49 r this translational discrepancy and suggest strategies to overcome it with the next generation of PA

50 nst viruses, and many viruses have developed strategies to overcome its antiviral effects.

51 protocols to silence immune checkpoints as a strategy to overcome locally active immune escape pathwa

52 ial for the clinical use of this therapeutic strategy to overcome MDR.

53 ed small molecule combinations are potential strategies to overcome mutation-mediated resistance.

54 Potential new strategies to overcome off-target nanomaterial accumulat

55 resistance to develop effective therapeutic strategies to overcome or prevent drug resistance.

56 sible EGFR inhibitors and reveal alternative strategies to overcome or prevent the development of res

57 Here, we explored strategies to overcome original antigenic sin responses

58 al DNA complexes, and viruses will require a strategy to overcome particle binding and clearance by c

59 opulation through vaccination is a promising strategy to overcome pathogen epitope variability and to

60 Additionally, we explore potential strategies to overcome PI resistance.

61 is study, we define a targeted combinatorial strategy to overcome PLX4032/vemurafenib resistance in m

62 g SIRT1 represents an attractive therapeutic strategy to overcome primary resistance in defined subse

63 Novel therapeutic strategies to overcome proteasome inhibitor resistance a

64 fore, essential to develop novel therapeutic strategies to overcome radioresistance and improve radio

65 To investigate therapeutic strategies to overcome resistance to anastrozole treatme

66 his JOCSynopsis, we summarize small molecule strategies to overcome resistance to beta-lactam antibio

67 ications related to the development of novel strategies to overcome resistance to tolerance.

68 on therapy, and prophylaxis were explored as strategies to overcome resistance.

69 elop better diagnostic tools and therapeutic strategies to overcome resistance.

70 stant OSCC cells, which could be a promising strategy to overcome resistance to anti-EGFR therapy.

71 pathways simultaneously may be an attractive strategy to overcome resistance to antiangiogenesis ther

72 e use of antiangiogenesis drugs may be a new strategy to overcome resistance to antiangiogenesis ther

73 Therefore, a combination strategy to overcome resistance to EGFR mono-targeted th

74 broad range of tumor cell lines to provide a strategy to overcome resistance to kinase inhibitor ther

75 F, thereby revealing a potential therapeutic strategy to overcome resistance to RAF inhibition in a s

76 ous lung tumors, thus providing an effective strategy to overcome resistance.

77 or their upstream regulators is a promising strategy to overcome rituximab resistance.

78 hibition of the PI3K/Akt/mTOR pathway is one strategy to overcome SCLC resistance mediated by ECM.

79 These findings provide a strategy to overcome several key limitations of CED that

80 nct to iDA cell therapy, it presents a novel strategy to overcome some current caveats of cell replac

81 n of this pathway may represent an efficient strategy to overcome stromal-mediated chemotherapy refra

82 imiting bnAb production to be elucidated and strategies to overcome such limitations to be evaluated.

83 Strategies to overcome such resistance are currently und

84 TNFalpha-induced apoptosis and corresponding strategies to overcome such resistance.

85 and autoimmunity and for the development of strategies to overcome T cell tolerance in situations su

86 iming and the effector phases and provides a strategy to overcome T(reg) cell-mediated suppression in

87 cond-generation EGFR TKI may be an effective strategy to overcome T790M-mediated drug resistance.

88 level of CCNE2 and that it could be a novel strategy to overcome TAM resistance in breast cancer pat

89 SynthEx utilizes a "synthetic-normal" strategy to overcome technical and financial issues.

90 s of compounds conferring cryotolerance, and strategies to overcome temperature-dependent barriers to

91 e in this regard has been the development of strategies to overcome the "crystallization problem", wh

92 Strategies to overcome the apparent irreversible hair ce

93 at AOM consortia use specialized biochemical strategies to overcome the challenges of metal availabil

94 Limitations and strategies to overcome the challenges of paper biosensor

95 tries of siRNA formulations are enabling new strategies to overcome the core obstacles to delivery wh

96 I also discuss viral strategies to overcome the deleterious effects of cell d

97 nal tract, noroviruses have developed unique strategies to overcome the host defense system.

98 Viruses have developed distinct strategies to overcome the host defense system.

99 ew toward how such information could lead to strategies to overcome the lower immunogenicity of vacci

100 ansgenic mouse lung tumor models to evaluate strategies to overcome the most common EGFR TKI resistan

101 iciencies have led to a plethora of creative strategies to overcome the physical, chemical, and biolo

102 We anticipate that CyG will provide new strategies to overcome the pitfall of present day albumi

103 ience will require devising and implementing strategies to overcome the political, administrative, fi

104 learn from the sector in general and discuss strategies to overcome the present limitations.

105 all partial grafts, which mandates effective strategies to overcome the problems regarding insufficie

106 for gene therapy with viral vectors, unless strategies to overcome the rapid in vivo elimination of

107 Strategies to overcome the restoration of BCR-ABL signal

108 d males of many species to develop different strategies to overcome the sperm of competing males.

109 y have led to the development of therapeutic strategies to overcome the state of 'castration resistan

110 New strategies to overcome the thymic atrophy of aging are n

111 content and codon usage, and suggest simple strategies to overcome the transgene expression problem

112 Pathogens have evolved different strategies to overcome the various barriers that they en

113 Stat3-targeted therapy is a new therapeutic strategy to overcome the acquired resistance to vemurafe

114 ion of this pathway might represent a useful strategy to overcome the cell-inherent resistance to can

115 Drug combinations are a promising strategy to overcome the compensatory mechanisms and unw

116 that particle size reduction is a pragmatic strategy to overcome the current limitation of mannitol

117 Finally, our results call for a strategy to overcome the financial and technical barrier

118 esents a novel single-agent immunomodulatory strategy to overcome the immune responses against transg

119 eted photosensitizer and red light) may be a strategy to overcome the limitations inherent in photody

120 proach may represent a potential therapeutic strategy to overcome the limitations of anti-VEGFR monot

121 ogenic expression of antigens is a promising strategy to overcome the limited long-term efficacy of a

122 This nano-antibiotic represents a strategy to overcome the mucus barrier, increase local d

123 One strategy to overcome the obstacle of polymorphism is to

124 Thus, ATR inhibition is a unique strategy to overcome the PARPi resistance of BRCA-defici

125 Cellular immunotherapy may provide a strategy to overcome the poor prognosis of metastatic an

126 ity of a multiple-site interaction, may be a strategy to overcome the problems for drug design associ

127 ic structure description of Cu(Z) provides a strategy to overcome the reaction barrier of N(2)O reduc

128 A novel strategy to overcome the resistance is to target the apo

129 A widely used chemical genetic strategy to overcome the specificity challenge exploits

130 ct serotypes may be an effective and general strategy to overcome the suppressive effects of pre-exis

131 ake solid tumors difficult to treat, as well strategies to overcome them and enhance drug penetration

132 rugiperda (Sf9) insect cell line and devised strategies to overcome them by overexpression of the enz

133 systems, primary physiological barriers and strategies to overcome them, and advances in preclinical

134 defects been elucidated, but two successful strategies to overcome them, namely adoptive immunothera

135 the study of neurological disease and offer strategies to overcome them.

136 ing such an approach in a wider context, and strategies to overcome them.

137 (each 1 mg/kg/h), suggesting a need for new strategies to overcome them.

138 diovascular disease and to discuss potential strategies to overcome them.

139 on revealed mechanisms of escape and enabled strategies to overcome them.

140 ecific to antiangiogenic therapy and develop strategies to overcome them.

141 thodically review these barriers and suggest strategies to overcome them.

142 (each 1 mg/kg/h), suggesting a need for new strategies to overcome them.-Carter, J.

143 Strategies to overcome these barriers are as follows: in

144 mit realization of this vision, and possible strategies to overcome these barriers that can improve c

145 New strategies to overcome these barriers will be needed if

146 Strategies to overcome these challenges include drug del

147 gating the genetic basis of PAD and possible strategies to overcome these challenges; and (3) discuss

148 ation and spread, but viruses have developed strategies to overcome these defenses.

149 Strategies to overcome these hurdles are also reviewed,

150 Unfortunately, clinical strategies to overcome these lag far behind.

151 Strategies to overcome these limitations are being pursu

152 or engineered phages could provide effective strategies to overcome these obstacles.

153 ences in MTXPG accumulation and point to new strategies to overcome these potential causes of treatme

154 is study, we demonstrate genetic engineering strategies to overcome these shortcomings by integrating

155 made, often resulting in low "hit rates." A strategy to overcome these approximations is to rescore

156 n of multiple epitopes was investigated as a strategy to overcome these barriers.

157 Here we describe a strategy to overcome these challenges, CISMR (CRISPR-med

158 discuss the potential of targeting HIFs as a strategy to overcome these instances of AA therapy resis

159 Here we report a general strategy to overcome these limitations and achieve solut

160 notransplantation of porcine islets may be a strategy to overcome these supply problems.

161 Strategies to overcome this antigen-driven, cell-intrins

162 epitope variants have both been proposed as strategies to overcome this challenge.

163 e to drug resistance, as well as therapeutic strategies to overcome this clinically.

164 designing the most appropriate and effective strategies to overcome this important and frequently und

165 e goal of guiding development of therapeutic strategies to overcome this limitation.

166 ms will play a significant role in informing strategies to overcome this meaningful limitation.

167 Strategies to overcome this resistance will be discussed

168 One strategy to overcome this barrier is to use latency-reve

169 As a strategy to overcome this barrier, the use of stealth co

170 We have devised a pooled adapter strategy to overcome this bias, and validated the method

171 Recently, we demonstrated a general strategy to overcome this challenge by incorporating a b

172 One recent strategy to overcome this challenge relies on protein-ba

173 -deazaxanthine (c7X) has been suggested as a strategy to overcome this effect.

174 Here we demonstrate a strategy to overcome this hurdle by avoiding the gaseous

175 This work proposes a data processing strategy to overcome this instrumental limitation and in

176 with both an opportunity to understand and a strategy to overcome this leading cause of human morbidi

177 'Therapeutic cloning' is a strategy to overcome this limitation by generating nucle

178 ose and demonstrate a microstructural design strategy to overcome this limitation by matching the mic

179 One strategy to overcome this limitation is to target novel

180 One strategy to overcome this limitation is to use tetrahedr

181 One strategy to overcome this obstacle is to remove the meth

182 Here we test a unique signaling-based strategy to overcome this obstacle.

183 One strategy to overcome this problem is to use systems that

184 tors used by pathogens represents a powerful strategy to overcome this problem, because extensive alt

185 Here we present a strategy to overcome this problem, employing a Gal4-indu

186 al Ontologies (OBO) consortium is pursuing a strategy to overcome this problem.

187 One strategy to overcome this resistance is to inhibit other

188 ce to ABT-737, these results suggest a novel strategy to overcome this resistance.

189 Thus, we have tested a potential strategy to overcome TM cell-driven rejection by targeti

190 finity/T-cell functional avidity, and pursue strategies to overcome tolerance and immunosuppression.

191 Stat3 inhibition may represent a therapeutic strategy to overcome tolerance to tumor antigens and eli

192 at targeting HOTAIR function may represent a strategy to overcome TRAIL resistance in pancreatic canc

193 poptosis, suggesting a potential therapeutic strategy to overcome TRAIL resistance.

194 fficacy, thus constituting a novel candidate strategy to overcome trastuzumab resistance and improve

195 t blocking this loop may provide alternative strategy to overcome trastuzumab resistance.

196 g the potential clinical application of this strategy to overcome trastuzumab resistance.

197 tive breast cancers, potentially useful as a strategy to overcome trastuzumab resistance.

198 One of the promising strategies to overcome tumor multidrug resistance (MDR)

199 ecifically in tumor cells, and provide a new strategy to overcome tumor chemoresistance.

200 These data suggest strategies to overcome VP35 inhibition of DC function.

201 sis of xenograft rejection and in developing strategies to overcome xenograft rejection.