ライフサイエンスコーパス: stratum corneum

1 within the uppermost layer of the epidermis (stratum corneum).

2 ses appear to be free to act only within the stratum corneum.

3 h comprise approximately 50% of the lipid in stratum corneum.

4 eramides, an integral lipid component of the stratum corneum.

5 mained bound to a thiol-rich band within the stratum corneum.

6 by complete absence of a granular layer and stratum corneum.

7 s for the 5-fold thickening of the Abca12-/- stratum corneum.

8 d stratum granulosum, and a non-keratinizing stratum corneum.

9 elope of corneocytes in the outer layer, the stratum corneum.

10 also disrupted, producing a poorly developed stratum corneum.

11 istinct stages: spinous, granular layer, and stratum corneum.

12 could sustain 0.6N that is enough to pierce stratum corneum.

13 s of these agents on the lipid matrix of the stratum corneum.

14 ophil-rich microabscesses formed beneath the stratum corneum.

15 ocytes and in the intercellular space of the stratum corneum.

16 esence of abundant lipase activity in asebia stratum corneum.

17 ilar to that previously recorded from intact stratum corneum.

18 the recovery of the barrier function of the stratum corneum.

19 volume that can rival the volume of the dry stratum corneum.

20 meable barrier of cornified cell layers, the stratum corneum.

21 rant profilaggrin-processing products in the stratum corneum.

22 stratum corneum was 85% lower than in normal stratum corneum.

23 scopically disrupt the lipid bilayers of the stratum corneum.

24 rficial layers of the epidermis, beneath the stratum corneum.

25 atio of acidic to neutral regions within the stratum corneum.

26 ratum granulosum, and declining again in the stratum corneum.

27 nits that aggregate keratin filaments in the stratum corneum.

28 is, and then over a few days migrated to the stratum corneum.

29 and an accumulation of lipid droplets in the stratum corneum.

30 tained uniformly, but not corneocytes in the stratum corneum.

31 ty barrier, by altering the structure of the stratum corneum.

32 the penetration efficacy of the nanogel into stratum corneum.

33 nt a better way to deliver siRNAs across the stratum corneum.

34 rugs can effectively permeate through intact stratum corneum.

35 rily distributed into, or on the top of, the stratum corneum.

36 ity results in increased water loss from the stratum corneum.

37 ncluding the intracellular components of the stratum corneum.

38 inated by the heterogeneous structure of the stratum corneum.

39 mide structures could be elucidated in human stratum corneum.

40 ntracellular space of the corneocytes in mid-stratum corneum (25 microm diameter) approaches neutrali

41 Skin grafting experiments confirmed the stratum corneum abnormalities and normal BrdU uptake.

42 The data definitively show that the stratum corneum acid mantle results from the presence of

43 of interventions with partial removal of the stratum corneum after curettage and microdermabrasion an

44 heir estimated saturation doses in the upper stratum corneum allows one to distinguish between diffus

45 Such barrier function of the stratum corneum also hampers the use of common adjuvants

46 After minimal injury to the stratum corneum alterations in the calcium concentration

47 face between a macroscopic sample of porcine stratum corneum and an adherent deformable elastomer sub

48 ton syndrome, which causes detachment of the stratum corneum and chronic inflammation.

49 tion can effectively carry siRNA through the stratum corneum and deposit it at the lower epidermis/up

50 The stratum corneum and DNA repair do not completely protect

51 ely, a low permeability of siRNA through the stratum corneum and epidermis has significantly limited

52 lation has been shown to efficiently disrupt stratum corneum and facilitate transcutaneous drug deliv

53 hough immunostaining was associated with the stratum corneum and fluorescein isothiocyanate-labeled o

54 d skin substitute was healed by day 3, and a stratum corneum and fully stratified epithelium were re-

55 and a ripple-like pattern in the junction of stratum corneum and granular layers.

56 t (1) both SRB and RBHE penetrate beyond the stratum corneum and into the viable epidermis only in di

57 Mutant mice exhibit fragile stratum corneum and perinatal death due to dehydration.

58 lved in the physical barrier function of the stratum corneum and provide innate cutaneous host defens

59 e large anionic molecules must penetrate the stratum corneum and reach the living epidermis and dermi

60 to the cornified envelope) is present in the stratum corneum and retains the ability to form covalent

61 the observed deficit in the adhesion of the stratum corneum and the severely compromised epidermal b

62 lid microneedles, providing microporation of stratum corneum and therefore enhancement of topical dru

63 normalities in both skin barrier structures (stratum corneum and tight junctions), a robust T(H)2 res

64 elivery system that can permeate through the stratum corneum and viable epidermis and efficiently dep

65 on, an accumulation of lipid droplets in the stratum corneum, and a water barrier defect.

66 ecreased intercellular lipid lamellae in the stratum corneum, and aberrant keratinocyte differentiati

67 f water ("cisternae") present throughout the stratum corneum, and at 24 h these cisternae substantial

68 wave emission, microjet penetration into the stratum corneum, and impact of microjet on the stratum c

69 otease activity, prevented detachment of the stratum corneum, and improved the barrier function of th

70 l epidermal changes, primarily involving the stratum corneum, and increased epidermal thickness were

71 on through the external barrier of the skin, stratum corneum, and secure exposure to the viable skin

72 ratum corneum, and impact of microjet on the stratum corneum are considered.

73 epidermis in Drosophila (cuticle) and mice (stratum corneum) are structurally unrelated.

74 within the polymer matrix, breach the skin's stratum corneum barrier and dissolve upon contact with s

75 e a proteolytic cascade that is required for stratum corneum barrier functionality.

76 on due to their ability to bypass the skin's stratum corneum barrier in a minimally-invasive fashion

77 olgi network, that deliver the precursors of stratum corneum barrier lipids to the extracellular comp

78 o NIR dye and shown to penetrate through the stratum corneum barrier when topically applied to mouse

79 We show that on breakdown of the epidermal stratum corneum barrier, type 2 and type 17 inflammatory

80 rs, and differentiation to form an effective stratum corneum barrier.

81 work in mouse skin on breakdown of epidermal stratum corneum barrier.

82 rrier function is compromised because of the stratum corneum becoming spontaneously detached in the n

83 th a decrease in the free thiol layer in the stratum corneum, but not in the nucleated epidermis.

84 ular layer and thinning of the epidermis and stratum corneum by 50%.

85 ansverse diffusivities of these compounds in stratum corneum by factors ranging from 250 to over 2000

86 delivered to the extracellular spaces of the stratum corneum by the secretion of lamellar bodies.

87 Disruption of the stratum corneum, by acetone application on the skin of h

88 Physical disruption of the stratum corneum can improve the efficiency of delivery.

89 e sweat glands, since increased hydration in stratum corneum causes it to become softer.

90 of stratum corneum swelling, and identifies stratum corneum cell layers that swell less.

91 Both the number of stratum corneum cell layers was reduced and the processi

92 iciency caused striking malformations of the stratum corneum, characterized by dysmorphic and pleomor

93 In the normal epidermis, the stratum corneum chymotryptic enzyme (SCCE) thought to pl

94 ing enzymes are potential substrates for the stratum corneum chymotryptic enzyme (SCCE), protein extr

95 neum tryptic enzyme (SCTE, kallikrein 5) and stratum corneum chymotryptic protease (SCCE, kallikrein

96 ompromises permeability barrier homeostasis, stratum corneum cohesion, wound healing, and epidermal i

97 Ceramides in mammalian stratum corneum comprise a heterogeneous mixture of mole

98 Stratum corneum comprises corneocytes, derived from oute

99 f contact allergy, nickel sensitization, and stratum corneum defects.

100 hione and, following penetration through the stratum corneum, depleted thiols in the viable epidermis

101 ation, cornified envelope morphogenesis, and stratum corneum desquamation.

102 -related peptidases that are associated with stratum corneum detachment was either low or undetectabl

103 -alpha plays a physiologic role during fetal stratum corneum development.

104 y and provides free amino acids in the outer stratum corneum, did not account for the relative humidi

105 confirmed that a well-tolerated regimen for stratum corneum disruption before vaccine patch applicat

106 e-induced immunity and that the magnitude of stratum corneum disruption correlates with the immune re

107 These rhythms persist during stratum corneum disruption with and without CS applicati

108 gic side-effects is related to the degree of stratum corneum disruption.

109 normal skin, moved through the extracellular stratum corneum domains.

110 in desquamation by cleaving proteins of the stratum corneum (e.g., corneodesmosin and plakoglobin).

111 Injury to the stratum corneum elicits an epidermal hyperproliferative

112 assessed in culture media and extracts from stratum corneum, epidermis and dermis after 24h, and the

113 Even though stratum corneum exhibits structural features across mult

114 This concept is probed using excised human stratum corneum exposed to aqueous solutions of radiolab

115 define the in vivo swelling behavior of the stratum corneum: exposure to water for 4 or 24 h results

116 The stratum corneum extracellular matrix (ECM) is enriched i

117 n of the epidermis, including defects of the stratum corneum, extracellular lipid composition and cel

118 suggests that psoriasin, purified from human stratum corneum extracts, selectively kills Escherichia

119 maintain epidermal thickness, contributes to stratum corneum formation and may eliminate pre-malignan

120 In PPAR-alpha-/- mice we observed delayed stratum corneum formation between day 18.5 of gestation

121 rted that both epidermal differentiation and stratum corneum formation in utero are stimulated by pha

122 ologic role in epidermal differentiation and stratum corneum formation in utero.

123 pidermis-specific polyprotein, profilaggrin, stratum corneum formation, and acquisition of epidermal

124 inocytes is required for epidermal turnover, stratum corneum formation, and removal of ultraviolet-da

125 encoding filaggrin, a protein essential for stratum corneum formation, these data point to an innate

126 Get-1(-/-) mice with striking impairment of stratum corneum formation.

127 inal differentiation protein expression, and stratum corneum formation.

128 Serum antibody reactive with human stratum corneum found in patients with psoriatic arthrit

129 f filaggrin were quantified in tape-stripped stratum corneum from 31 atopic dermatitis patients and u

130 mall numbers of bacteria which penetrate the stratum corneum from everyday activities.

131 f keratinocyte SerpinB2 is protection of the stratum corneum from proteolysis via inhibition of uroki

132 tratum corneum neutralization alone provokes stratum corneum functional abnormalities, including aber

133 lowing secretion of lamellar bodies into the stratum corneum, glucosylceramides are metabolized to ce

134 t trypsin-like serine protease (TLSP) in the stratum corneum, have been implicated in the pathogenesi

135 tracellular metabolites, which contribute to stratum corneum hydration and pH.

136 We assessed here whether sebum influences stratum corneum hydration or permeability barrier functi

137 sters, triglycerides) did not restore normal stratum corneum hydration to asebia skin, topical glycer

138 on from triglyceride in sebaceous glands for stratum corneum hydration was demonstrated further by (i

139 e hydrolysis in sebaceous glands, normalized stratum corneum hydration, and the glycerol content of a

140 erplasia, inflammation, and decreased (>50%) stratum corneum hydration, associated with a reduction i

141 permeability barrier homeostasis and reduced stratum corneum hydration, we hypothesized here that epi

142 d-derived glycerol is a major contributor to stratum corneum hydration.

143 th ionic and uncharged, partition into human stratum corneum immersed in aqueous solutions to an exte

144 s that crisscross the cornified cells of the stratum corneum imparting structural integrity, and defe

145 by reduced glycerol content in epidermis and stratum corneum in AQP3-knockout mice, and correction of

146 pidermal water loss, increased overt loss of stratum corneum in inflammatory lesions, and impaired st

147 lasers) have been shown to permeabilize the stratum corneum in vivo and facilitate the transport of

148 The average pH of the stratum corneum increases with depth because of a decrea

149 oy, in contrast to BMV, restores compromised stratum corneum integrity and barrier function.

150 rmeability barrier homeostasis and decreased stratum corneum integrity/cohesion, as well as the mecha

151 cutaneous permeability barrier function and stratum corneum integrity/cohesion, as well as the respo

152 taneous permeability barrier homeostasis and stratum corneum integrity/cohesion, but these approaches

153 bnormalities in both barrier homeostasis and stratum corneum integrity/cohesion.

154 ase inhibitors with the superbase normalized stratum corneum integrity/cohesion.

155 Three modes of bubble-stratum corneum interactions including shock wave emissi

156 er exposure leads to extensive disruption of stratum corneum intercellular lipid lamellae.

157 he disruptive effect of overhydration on the stratum corneum intercellular space, identifies large an

158 ws a strong signal at the stratum granulosum/stratum corneum interface.

159 lar body content marker, acid lipase, to the stratum corneum interstices.

160 Keratinization of the stratum corneum involves a highly choreographed sequence

161 served after tape-stripping, indicating that stratum corneum is a major source of UVA-induced oxidati

162 The study suggests the stratum corneum is a more chaotic structure than previou

163 nderstanding of the mechanical properties of stratum corneum is based on the assumption that its thic

164 ation depth of the evanescent field into the stratum corneum is comparable with the thickness of a la

165 The stratum corneum is composed of protein-enriched corneocy

166 lux between the follicle and the surrounding stratum corneum is involved.

167 anisotropic brick-and-mortar geometry of the stratum corneum is obtained using the commercial finite

168 The barrier function of the stratum corneum is provided by patterned lipid lamellae

169 The permeabilization of the stratum corneum is transient and its barrier function re

170 The skin barrier (stratum corneum) is a major factor for determining the n

171 ed that the viable epidermis, underlying the stratum corneum, is included as a potentially important

172 brosidase activity at the stratum granulosum-stratum corneum junction and a modest decrease in both i

173 ence of expression at the stratum granulosum/stratum corneum junction.

174 ression of terminal differentiation markers (stratum corneum, K10, and loricrin).

175 The stratum corneum layer and Ki67 in keratinocytes of the e

176 xplain the lack of restoration of functional stratum corneum layers observed after BM treatment.

177 e expansion of the lacunar spaces within the stratum corneum leading to the formation of transient ch

178 trastructural analyses demonstrated abnormal stratum corneum lipid architecture in AD and IV HEEs, in

179 n expansion of the lacunar spaces within the stratum corneum lipid bilayers but no changes in the org

180 interactions of cavitation bubbles with the stratum corneum lipid bilayers.

181 oordinately drive both the generation of the stratum corneum lipid-enriched extracellular matrix and

182 aditional dermal absorption models treat the stratum corneum lipids as a homogenous medium through wh

183 d irregular distribution patterns within the stratum corneum lipids as observed in experimental data.

184 These studies demonstrate unequivocally that stratum corneum neutralization alone provokes stratum co

185 To study the consequences of stratum corneum neutralization, independent of hydration

186 ed changes in skin properties and CCBAs from stratum corneum of healthy human subjects, providing a m

187 c transport and distribution of water of the stratum corneum of infants and compare it to those of ad

188 The results suggest that although the stratum corneum of infants may appear intact shortly aft

189 The stratum corneum of lesional but also clinically unaffect

190 found in both interfollicular and follicular stratum corneum of lesional KP, which correlated ultrast

191 om the stratum basale, stratum spinosum, and stratum corneum of lesions from the transgenic mice usin

192 o compromised chelation of the metals in the stratum corneum of patients with atopic dermatitis.

193 igo, Staphylococcus aureus spreads under the stratum corneum of skin by elaboration of exfoliative to

194 strated notable topographical changes in the stratum corneum of skin permeated with CYnLIP that were

195 laggrin is a major structural protein in the stratum corneum of the epidermis.

196 limited by their poor permeation across the stratum corneum of the skin and low penetration into the

197 y due to the transport barriers posed by the stratum corneum of the skin and the biofilm.

198 ic junctions made between the keratin of the stratum corneum of the skin and the glass surface.

199 The impact of the complex structure of the stratum corneum on transdermal penetration is not yet fu

200 showed that it shrunk the corneocytes in the stratum corneum (p<0.001) and the imaging of the skin ha

201 ng the integrity and barrier function of the stratum corneum, particularly during times of skin infla

202 er breakdown, attributed to the elevation of stratum corneum pH.

203 ns) is pH dependent over the pH range of the stratum corneum (pH 4.5 to pH 7.2).

204 using a vertical diffusion holder, with the stratum corneum placed between two electrode-containing

205 The lipid matrix of the skin's stratum corneum plays a key role in the barrier function

206 tabolism or in the protein components of the stratum corneum produce scaly or ichthyotic skin with ab

207 In the stratum corneum proteases degrade the inhibitor, freeing

208 er hand, correlated with the denaturation of stratum corneum proteins, making it feasible to use prot

209 ) contains multiple conserved genes encoding stratum-corneum proteins.

210 any layers of these specialized cells in the stratum corneum provide a tough and resilient framework

211 The origin of the acidic pH of the stratum corneum remains conjectural, however.

212 The stratum corneum resistance was measured using a vertical

213 Since stratum corneum (SC) acidification in adults is required

214 essential endogenous pathway responsible for stratum corneum (SC) acidification.

215 2-15 months) are linked instead to defective stratum corneum (SC) acidity.

216 Neutralization of stratum corneum (SC) adversely impacts key epidermal fun

217 s limited by their low absorption across the stratum corneum (SC) and into viable cells of skin.

218 e skin is often dependent upon breaching the stratum corneum (SC) and targeting cells within defined

219 Stratum corneum (SC) and viable epidermal thickness meas

220 rmal units has been proposed on the basis of stratum corneum (SC) architecture, proliferation kinetic

221 er abnormality was associated with decreased stratum corneum (SC) ceramide content and impaired lamel

222 At birth, human stratum corneum (SC) displays a near-neutral surface pH,

223 enotype, we assessed epidermal structure and stratum corneum (SC) function in a previously genotyped

224 e assessed the mechanisms by which PS alters stratum corneum (SC) function.

225 transporter aquaporin-3 (AQP3) have reduced stratum corneum (SC) hydration and skin elasticity, and

226 We studied the role of AQP3 in stratum corneum (SC) hydration by comparative measuremen

227 Although stratum corneum (SC) hydration has been primarily of con

228 y approximately 2-fold, suggesting defective stratum corneum (SC) hydration.

229 Basal permeability barrier function and stratum corneum (SC) integrity were abnormal, but barrie

230 produces nonlamellar phase separation in the stratum corneum (SC) interstices, explaining the barrier

231 The stratum corneum (SC) is an effective permeability barrie

232 h quantity and spatial distribution of human stratum corneum (SC) lipids from samples collected in vi

233 Filaggrin (FLG) mutations result in reduced stratum corneum (SC) natural moisturizing factor (NMF) c

234 The reduced pH of the stratum corneum (SC) of darkly pigmented skin could acco

235 Abundant lacunae of unprocessed lipids in stratum corneum (SC) of FAK(K5 KO) mice and delayed barr

236 showed recently that short-term increases in stratum corneum (SC) pH are accompanied by minor alterat

237 At birth, neonatal stratum corneum (SC) pH is close to neutral but acidifie

238 ifferences in epidermal function, we studied stratum corneum (SC) pH, permeability barrier homeostasi

239 alternative, but the barrier of skin's outer stratum corneum (SC) prevents delivery of most drugs.

240 ous abnormalities were not evident, and both stratum corneum (SC) skin hydration and surface pH were

241 We collected stratum corneum (SC) specimens from the volar forearms o

242 of the outermost layer of the epidermis, the stratum corneum (SC), are not understood.

243 izational details of epidermis, specifically stratum corneum (SC), during sonophoresis are beyond the

244 The outermost epidermal layer, the stratum corneum (SC), exhibits an acidic surface pH, whe

245 In neonatal rat stratum corneum (SC), pH declines from pH 6.8 at birth t

246 The outermost region of the epidermis, the stratum corneum (SC), provides an essential barrier to w

247 st versus fifth stripping ("outer" vs. "mid"-stratum corneum (SC), respectively) from nine normal adu

248 Intercellular lipids of the stratum corneum (SC), the outer layer of the epidermis,

249 solvents on the outermost layer of skin, the stratum corneum (SC), using polarization transfer solid-

250 e goal of epidermal ontogenesis is to form a stratum corneum (SC), which is required for post-natal p

251 s (pH 5.0-5.5) over 5-6 days in neonatal rat stratum corneum (SC).

252 of the outermost layer of the epidermis, the stratum corneum (SC).

253 signaling from serine proteases (SP) in the stratum corneum (SC).

254 ve cutaneous functions largely reside in the stratum corneum (SC).

255 LTRs and spanned the entire thickness of the stratum corneum (SC).

256 wed an abnormally-compacted outer epidermis [stratum corneum (SC)], while electron microscopy reveale

257 e outermost skin barrier (referred to as the stratum corneum, SC) and subsequent catalytic generation

258 The intercellular lipid matrix of the skin's stratum corneum serves to protect the body against desic

259 The stratum corneum showed parakeratotsis.

260 Ultrastructure of the stratum corneum showed premature loss of cohesion of cor

261 ation of the secreted lamellar bodies at the stratum corneum-stratum granulosum boundary.

262 he mechanical effects of these events on the stratum corneum structure, the relationship between the

263 including permeability barrier homeostasis, stratum corneum surface pH, and water-holding capacity,

264 crom) are acquired every 1.7 microm from the stratum corneum surface to the first viable layer (strat

265 sternal structures, defines the magnitude of stratum corneum swelling, and identifies stratum corneum

266 is to produce the protective, semi-permeable stratum corneum that permits terrestrial life.

267 ubstantially reduced drug diffusivity in the stratum corneum (the outermost epidermal layer), dominan

268 corresponding to a depth of 2-3 mum, of the stratum corneum (the outermost, 15-20 mum skin layer).

269 tion and allow S. aureus to spread under the stratum corneum, the main barrier of the skin, explainin

270 sed to effectively deliver siRNA through the stratum corneum, the major challenge is that this approa

271 Stratum corneum, the outermost layer of skin, allows tra

272 tive function of the skin is mediated by the stratum corneum, the outermost layer of the skin, which

273 We study the drying of stratum corneum, the skin's outermost layer and an essen

274 Retinoids cause dyshesion and thinning of stratum corneum, thereby reducing hyperkeratosis that li

275 orneum in inflammatory lesions, and impaired stratum corneum thickening after phorbol ester treatment

276 markers (filaggrin and loricrin), increased stratum corneum thickness, and significantly reduced T-c

277 h results in a 3- or 4-fold expansion of the stratum corneum thickness, respectively.

278 es had larger values consistently for infant stratum corneum throughout the first year of life and sh

279 ations, reacts with amino acids in the outer stratum corneum to form a mixture of high molecular weig

280 Both exposure of stratum corneum to neutral pH buffers and blockade of ac

281 g abnormality associated with an increase in stratum corneum tryptic enzyme (SCTE) in the epidermis.

282 estern blot, and siRNA, the serine proteases stratum corneum tryptic enzyme (SCTE, kallikrein 5) and

283 Located in the stratum corneum, urocanic acid is a major epidermal chro

284 get their effects to skin's barrier layer of stratum corneum using microneedles, thermal ablation, mi

285 ydration, and the glycerol content of asebia stratum corneum was 85% lower than in normal stratum cor

286 The interaction of water with the stratum corneum was assessed by measuring capacitance, t

287 The skin barrier was defective and the stratum corneum was detached through desmosomal cleavage

288 In the current study, the stratum corneum was disrupted using an electrocardiogram

289 glyceride content of both asebia and control stratum corneum was low, consistent with high rates of t

290 dities, indicating that the structure of the stratum corneum was not a major factor.

291 AQP3-knockout mice have reduced stratum corneum water content and elasticity compared wi

292 on found in the extracellular matrix of skin stratum corneum, were analyzed by X-ray diffraction meth

293 tioning-limited solute diffusion through the stratum corneum, where the lipid structure is represente

294 ected within the extracellular matrix of the stratum corneum, whereas the intracellular space of the

295 epidermal epithelium leading to a defective stratum corneum, which allows enhanced allergen penetrat

296 s vaccination is the barrier function of the stratum corneum, which must be overcome either by abrasi

297 uantity of ultra long-chain ceramides in the stratum corneum, which play a key role in maintaining th

298 kin revealed hyperkeratosis and a disordered stratum corneum with an accumulation of neutral lipid dr

299 se from a pathogen that is restricted to the stratum corneum, with little or no tissue reaction.

300 paired skin barrier function and a defective stratum corneum, with SerpinB2(-/-) mice showing increas

301 pended in water, facilitate adherence to the stratum corneum without subsequent intra-epidermal or fo