ライフサイエンスコーパス: streptococcal

1 Here we show that streptococcal 4-aminobenzoate/para-amino benzoic acid (p

2 . pyogenes virulence factor, which we termed streptococcal 5'-nucleotidase A (S5nA).

3 donii and in Escherichia coli expressing the streptococcal accessory Sec system.

4 standing of the predominant features of oral streptococcal adaptive immune repertoires.

5 he beta-sandwich domain seen in the parental streptococcal adhesin, but flanking sequences at both N-

6 otein Epf from S. pyogenes serotype M49 is a streptococcal adhesin.

7 sin, Fap1, demonstrating that BapA1 is a new streptococcal adhesin.

8 cosylation of a family of serine-rich repeat streptococcal adhesins.

9 a mutant deficient in the production of the streptococcal ADP-ribosyltransferase SpyA generates lesi

10 Although a streptococcal aldolase, LacD.1, has been adapted to viru

11 Although streptococcal and Bacillus UGLs were active on unsaturat

12 In comparison with structures of streptococcal and Bacillus UGLs, a pocket-like structure

13 SC-derived mAb 24.3.1 was found to recognize streptococcal and brain Ags.

14 biotic used as the last resort treatment for streptococcal and staphylococcal bacteria including meth

15 lecular-weight serine-rich proteins found in streptococcal and staphylococcal species and possesses t

16 soriasis activity has been linked to group A streptococcal and viral infections.

17 Affinity purification of the anti-streptococcal antibodies present within pooled immunoglo

18 The streptococcal antigen I/II (AgI/II)-family polypeptides

19 ion of the minor fimbrial antigen (Mfa) with streptococcal antigen I/II (e.g., SspB) facilitates colo

20 icate that the Mfa1-interacting interface of streptococcal antigen I/II encompasses both the KKVQDLLK

21 interaction involves the association of the streptococcal antigen I/II with the minor fimbrial antig

22 algorithms used a rapid and specific group A streptococcal antigen test to screen throat specimens, f

23 ecent advances have been made in identifying streptococcal antigens that may play a pathogenic role i

24 In monoculture, streptococcal arginine biosynthesis was inefficient and

25 erful lysin with potential for treating most streptococcal associated infections.

26 IgG from SC and a related subset of streptococcal-associated behavioral disorders called "pe

27 Streptococcal attachment to and entry into epithelial ce

28 The theme of molecular mimicry in streptococcal autoimmune sequelae is the recognition of

29 pathogenesis of rheumatic fever and group A streptococcal autoimmune sequelae of the heart valve and

30 AE reports for viridans group streptococcal bacteremia, a targeted toxicity on AAML053

31 he third Ig-binding domain of protein G from streptococcal bacteria (GB3).

32 Streptococcal bacteria use peptide signals as a means of

33 colonized much less efficiently in vitro on streptococcal biofilms than on Actinomyces naeslundii bi

34 latelets directly enhances the resistance of streptococcal biofilms to clindamycin.

35 lonization of S. mutans BM71 on the existing streptococcal biofilms.

36 ults of routine throat cultures on selective streptococcal blood agar plates.

37 We analyzed 58 recent oral streptococcal bloodstream isolates, and we obtained clin

38 wo conserved group A streptococci (GAS) Ags, streptococcal C5a peptidase and immunogenic secreted pro

39 Autoantibodies against the group A streptococcal carbohydrate epitope GlcNAc and cardiac my

40 GAS-induced IL-17A significantly influences streptococcal carriage and alters local inflammatory res

41 During the chronic phase of streptococcal cell wall-induced arthritis in rats, compo

42 oinflammation associated with an established streptococcal CNS infection when delivered therapeutical

43 utbreak investigation implicated measles and streptococcal co-infections in most deaths, and also cha

44 The streptococcal coaggregation regulator (ScaR) of Streptoc

45 The streptococcal collagen-like (Scl) proteins are widely pr

46 ce factors deployed by streptococci includes streptococcal collagen-like (Scl) proteins.

47 Streptococcal collagen-like protein 1 (Scl-1) is one of

48 urring polymorphism in the gene encoding the streptococcal collagen-like protein A (SclA) in GAS carr

49 , we characterize an interaction between the streptococcal collagen-like protein Scl1.6 of M6-type gr

50 direct interactions between the cell surface streptococcal collagen-like protein-1 (Scl1) and the hum

51 We recently reported that the streptococcal collagen-like protein-1, Scl1, selectively

52 ot affect triple helix stability of the Scl (Streptococcal collagen-like) protein.

53 Prior treatment with estradiol prolonged streptococcal colonization and was associated with reduc

54 asal vaccine are necessary for prevention of streptococcal colonization.

55 S. bovis groups of species, even though many streptococcal competence genes and the competence regula

56 their viruses in humans, we analysed 13 977 streptococcal CRISPR sequences and compared them with 2

57 oexist at the same time, which suggests that streptococcal CRISPR/Cas systems are under constant pres

58 combining J8-DT with an inactive form of the streptococcal CXC protease, S. pyogenes cell envelope pr

59 lic replacement of the chromosomally encoded streptococcal cysteine protease (speB) in the MGAS5005 D

60 Streptococcal cysteine protease (SpeB), the major secret

61 Expression of SpeB, a streptococcal cysteine protease, is critical for this pr

62 staphylococcal cytolysin alpha-toxin and the streptococcal cytolysin streptolysin O enhanced penetrat

63 Viridans group streptococcal detection using PHIS microbiology data had

64 The streptococcal determinant camG encodes a lipoprotein wit

65 accounted for 34 of the 254 cases of group B streptococcal disease (13.4%).

66 ths); however, 74.4% of the cases of group B streptococcal disease (189 of 254) occurred in term infa

67 Early-onset group B streptococcal disease (EOGBS) occurs in neonates (days 0

68 in which the newborn had early-onset group B streptococcal disease (i.e., disease in infants <7 days

69 The incidence of invasive group B streptococcal disease among infants from birth through 6

70 f 254 births in which the infant had group B streptococcal disease and 7437 births in which the infan

71 There were 14,573 cases of invasive group B streptococcal disease during 1999-2005, including 1348 d

72 Severe group A streptococcal disease including acute poststreptococcal

73 Group B streptococcal disease is one of the most common infectio

74 babies younger than 7 days) invasive group B streptococcal disease is rectovaginal colonisation of th

75 ever, its importance for the pathogenesis of streptococcal disease is unknown.

76 ad a higher incidence of early-onset group B streptococcal disease than did term infants (0.73 vs. 0.

77 The overall incidence of early-onset group B streptococcal disease was 0.32 cases per 1000 live birth

78 rth through 6 days, the incidence of group B streptococcal disease was lower in 2003-2005 relative to

79 al of 61.4% of the term infants with group B streptococcal disease were born to women who had tested

80 I, III, V) could prevent most global group B streptococcal disease.

81 (day 0-6) and late-onset (day 7-89) group B streptococcal disease.

82 induce complete protection against invasive streptococcal disease.

83 ethod facilitating the prevention of group B streptococcal disease.

84 -based system that monitors invasive group B streptococcal disease.

85 vent additional cases of early-onset group B streptococcal disease.

86 ibitors to be used in prevention of invasive streptococcal disease.

87 ing an extracellular DNase virulence factor (streptococcal DNase D2, SdaD2) and subsequently acquired

88 The incidence of oral streptococcal endocarditis did not increase (unadjusted:

89 e in staphylolytic activity conferred on the streptococcal endopeptidase domain, and surprisingly the

90 heavy-chain glycan on asparagine 297 by the streptococcal enzyme endo-beta-N-acetylglucosaminidase (

91 ronal cell in Sydenham chorea share a common streptococcal epitope GlcNAc and target intracellular bi

92 oantibodies that target the dominant group A streptococcal epitope of the group A carbohydrate, N-ace

93 expression of the CovRS-controlled secreted streptococcal esterase (SsE).

94 A") protects mice from lethal challenge with streptococcal exotoxin A, as well as from lethal GAS bac

95 We named this protease SepM for streptococcal extracellular protease required for mutaci

96 esults of this study reveal a novel secreted streptococcal factor that, in the absence of SpeB, can t

97 vasive disease have been described, specific streptococcal factors and host properties influencing as

98 tify a putative fibronectin binding protein, streptococcal fibronectin binding protein A (SfbA).

99 To explore the level and extent of streptococcal fomite contamination that children might b

100 Group A streptococcal (GAS) infection induces the production of

101 AIP) began surveillance for invasive group A streptococcal (GAS) infections in Alaska in 2000 as part

102 Surveillance of group A streptococcal (GAS) infections was undertaken as a major

103 s (NSAIDs) contribute to more severe group A streptococcal (GAS) infections, yet a beneficial role fo

104 endations regarding the diagnosis of group A streptococcal (GAS) pharyngitis in adults.

105 Group A streptococcal (GAS) pharyngitis is a particularly import

106 g or treating adults at low risk for group A streptococcal (GAS) pharyngitis.

107 Invasive group A streptococcal (GAS) strains often have genetic differenc

108 on of streptokinase (SK), a critical group A streptococcal (GAS) virulence factor, were identified th

109 Survivors of infant group B streptococcal (GBS) disease are at risk of neurodevelopm

110 Further reduction in the group B streptococcal (GBS) disease burden in neonates in the Un

111 rain to injury; however, the role of group B streptococcal (GBS) disease has not been reviewed.

112 amining the epidemiology of invasive group B streptococcal (GBS) disease have been undertaken.

113 eighth in a series on the burden of group B streptococcal (GBS) disease, aims to estimate the percen

114 axis (IAP) prevents most early-onset group B streptococcal (GBS) disease.

115 All streptococcal genomes encode the alternative sigma facto

116 riginally isolated from a case of acute post-streptococcal glomerulonephritis, is unusually competent

117 des, which are mostly glucans synthesized by streptococcal glucosyltransferases (Gtfs), provide bindi

118 cation schemes within members of the "mitis" streptococcal group.

119 esis was essential for coaggregation-induced streptococcal growth.

120 reptococcus gordonii as a model organism for streptococcal H(2)O(2) production, H(2)O(2)-dependent eD

121 to play a role limited to the penetration of streptococcal HA capsules, facilitating bacterial lysoge

122 As determined by apo Streptococcal haem-associated protein, Hb had the lower

123 We evaluate the streptococcal hemoprotein receptor (Shr), a conserved st

124 alysis, we identified the FH receptor as the streptococcal histidine triad (SHT) surface protein.

125 -rich glycoprotein (HRG), and the name sHIP (streptococcal histidine-rich glycoprotein-interacting pr

126 hese results, plus the suspected role of the streptococcal homologue in certain diseases such as acut

127 ith robust activity and an extended-spectrum streptococcal host range against most streptococcal spec

128 ts into the role of complex carbohydrates in streptococcal host-pathogen interaction.

129 een mitral valve prolapse and viridans group streptococcal IE in a population-based cohort from Olmst

130 sociated with an increased incidence of oral streptococcal IE.

131 Thus, tissue deposition of streptococcal IgA-binding M proteins may contribute to t

132 ulin (IVIG) in treatment of invasive group A streptococcal (iGAS) infection, and the need for prophyl

133 rotease distinct from previous characterized streptococcal immunoglobulin degrading proteases of the

134 and is the main neurologic manifestation of streptococcal-induced rheumatic fever.

135 e neuropsychiatric disorders associated with streptococcal infection (PANDAS).

136 Streptococcal infection has been linked with the develop

137 tic shock; for 16 (50%) women with a group A streptococcal infection there was <2 h-and for 24 (75%)

138 e neuropsychiatric disorders associated with streptococcal infection)].

139 icularly with confirmed or suspected group A streptococcal infection, should be regarded as an obstet

140 During group B streptococcal infection, the alpha C protein (ACP) on th

141 ion of bacterial adaptations during systemic streptococcal infection.

142 of CpsY-dependent regulation during systemic streptococcal infection.

143 ppressed transcription of these genes during streptococcal infection.

144 nique susceptibility of the human species to streptococcal infection.

145 lines focus solely on group A beta-hemolytic streptococcal infection.

146 such as rheumatic heart disease and invasive streptococcal infection.

147 ate of varicella-associated invasive group A streptococcal infections (IGASI).

148 ted with increased risks, although less than streptococcal infections for OCD and any mental disorder

149 H binding in vivo (i.e., for pathogenesis of streptococcal infections), we used our recent finding th

150 describe a mechanism that underpins epidemic streptococcal infections, which have affected many milli

151 s M protein (emm), C5a peptidase (scpA), and streptococcal inhibitor of complement (sic) by directly

152 eptide synthetase (NRPS) system carried by a streptococcal integrative conjugative element (ICE), ICE

153 ture design of small molecular inhibitors of streptococcal invasion.

154 A total of 155 nonduplicate streptococcal isolates (50 group A, 48 group B, 28 group

155 Fifty-six alpha-hemolytic streptococcal isolates were identified using MALDI Bioty

156 ative Cpl-7 cell wall binding domains of the streptococcal LambdaSa2 endolysin were replaced by staph

157 ructure revealed a strong resemblance to the streptococcal laminin-binding proteins Lbp and Lmb.

158 ionships between plasminogen-binding group A streptococcal M (PAM) protein and SK2b have been reveale

159 en (Pg)/plasmin receptor, Pg-binding group A streptococcal M protein (PAM), and the human Pg activato

160 d the presence of T cells crossreactive with streptococcal M protein and cardiac myosin.

161 The streptococcal M protein that is used as the substrate fo

162 that respond to peptide sequences common to streptococcal M proteins and skin keratins have been det

163 previously shown that IgA-binding regions of streptococcal M proteins colocalize with IgA in mesangia

164 rldwide, regardless of the infecting group A streptococcal M serotype.

165 due internal peptide (VEK-30) from a group A streptococcal M-like protein, the dynamic properties of

166 plasminogen (human Pg (hPg)) binding Group A streptococcal M-protein (PAM) as its major cell surface

167 cal properties of the complex formed between streptococcal M1 and human fibrinogen.

168 e structure and biosynthesis of streptide, a streptococcal macrocyclic peptide.

169 ortant mechanistic implications for the anti-streptococcal macrophage response and sepsis pathogenesi

170 ed membrane protein which is anchored to the streptococcal membrane by an N-terminal transmembrane se

171 with peptide affinity tags is located in the streptococcal membrane.

172 with BBB endothelium and the pathogenesis of streptococcal meningitis.

173 lood-brain barrier and in the development of streptococcal meningitis.

174 ioning to favour carbon sources generated by streptococcal metabolism.

175 hanism of resistance involves sensing of the streptococcal metabolite hydrogen peroxide by A. actinom

176 for IL-17A in contributing to the control of streptococcal mucosal colonization and provide new insig

177 mparable to those for the well-characterized streptococcal natural transformation systems.

178 coli strains through induction of different Streptococcal (p)ppGpp synthetase fragments.

179 ntified a limited level of homology to other streptococcal PAs, including streptokinase; however, Pad

180 eals the potential of PCR/ESI-MS to detect a streptococcal pathogen not captured by conventional cult

181 tools for the understanding of Scl-mediated streptococcal pathogenesis and important structural insi

182 Recently, however, genome-wide screens of streptococcal pathogenesis have identified genes encodin

183 We conclude that SpyA contributes to streptococcal pathogenesis in the mouse subcutaneous inf

184 prompt a reevaluation of the role of SPN in streptococcal pathogenesis.

185 Streptococcal pathogens have evolved to express exoglyco

186 Many streptococcal pathogens require a polysaccharide capsule

187 own as pili, have been recently described in streptococcal pathogens, including GBS.

188 Streptococcal pathogens, such as the group B streptococc

189 gous to CiaR/CiaH, which is present in other streptococcal pathogens.

190 d in stools was highly suggestive of group A streptococcal perianal infection (probability 83.3%).

191 patients with symptoms suggestive of group A streptococcal pharyngitis (for example, persistent fever

192 uncommon at baseline and changed little for streptococcal pharyngitis (intervention, from 4.4% to 3.

193 acute enteritis, 9; Helicobacter pylori, 1; Streptococcal pharyngitis 1; and posttransplant lymphoma

194 Streptococcal pharyngitis is still a major infectious di

195 or adult and pediatric patients with group A streptococcal pharyngitis.

196 with antibiotics only if they have confirmed streptococcal pharyngitis.

197 um-positive pharyngitis clinically resembles streptococcal pharyngitis.

198 19179 with acute otitis media; 6746, group A streptococcal pharyngitis; and 4234, acute sinusitis), 4

199 (1100 with acute otitis media; 705, group A streptococcal pharyngitis; and 667, acute sinusitis), 86

200 The type PI-1 streptococcal pilus is a complex, well studied structure

201 ment of Cpa to target receptors and thus the streptococcal pilus to host cells.

202 is is the largest series to our knowledge of streptococcal PJI managed by DAIR, showing a worse progn

203 Eligible patients had a streptococcal PJI that was managed with DAIR.

204 Nephritis-associated streptococcal plasmin receptor and streptococcal pyrogen

205 The characteristics of a streptococcal plasminogen activator (PA) displaying spec

206 characterised a parallel epidemic of primary streptococcal pneumonia in soldiers without measles.

207 cial for the prevention of diseases, such as streptococcal pneumonia, that are devastating in older p

208 nthesized by conjugation of type III group B streptococcal polysaccharide (GBSIII) to ovalbumin (OVA)

209 le to locus diversification or to changes in streptococcal population structure, yet the composition

210 more frequently than group A beta-hemolytic streptococcal-positive pharyngitis in a student populati

211 ings on the immunoglobulin-binding domain of streptococcal protein G (GB1), these experimental result

212 turally very similar proteins, including the streptococcal protein G and the peptostreptococcal prote

213 ed using the albumin-binding domain (ABD) of streptococcal protein G as a stable protein scaffold.

214 t of the immunoglobulin binding domain B1 of streptococcal protein G, which in its native conformatio

215 ccal hemoprotein receptor (Shr), a conserved streptococcal protein, as a vaccine candidate against GA

216 ected transcript levels of the gene encoding streptococcal proteinase B, a major RopB-regulated virul

217 These streptococcal proteins form a structurally distinct subc

218 which we previously demonstrated between the streptococcal proteins Shp and HtsA, may apply in genera

219 ng mechanism of BBK32 and previously studied streptococcal proteins suggests that the binding and ass

220 that CP outcompetes staphylococcal MntC and streptococcal PsaA for Mn(II).

221 a proteinaceous type II TA cassette from the streptococcal pSM19035 plasmid is a member of the epsilo

222 mmunization against the Vbeta8-targeting SAg streptococcal pyrogenic exotoxin A (SpeA), or active imm

223 mages the mucosa to allow for penetration of streptococcal pyrogenic exotoxin A and possibly viable s

224 the phage encoding the SpeA1 variant of the streptococcal pyrogenic exotoxin A superantigen.

225 etration of toxic shock syndrome toxin-1 and streptococcal pyrogenic exotoxin A, respectively, across

226 A secreted cysteine protease known as streptococcal pyrogenic exotoxin B (SpeB) is a key virul

227 Streptococcal pyrogenic exotoxin B (SpeB) is a protease

228 Streptococcal pyrogenic exotoxin B (SpeB) is an extracel

229 on expression of the extracellular protease, streptococcal pyrogenic exotoxin B (SpeB), capsular hyal

230 ssociated streptococcal plasmin receptor and streptococcal pyrogenic exotoxin B are currently conside

231 s encoding streptococcal superantigen (ssa), streptococcal pyrogenic exotoxins (speC, speH, and speI)

232 equently, we determined that pneumolysin and streptococcal pyruvate oxidase-derived H2O2 production w

233 We found a high sensitivity of a group A streptococcal rapid diagnostic testing (98%) but relativ

234 eract with fibulin-1 and that SOF is a major streptococcal receptor for fibulin-1 but not the only re

235 Eleven strep-EURO and seven other streptococcal reference centers received a panel of 20 c

236 We conclude that VP1 is a novel streptococcal regulatory peptide that controls biofilm d

237 analyzed CRISPR sequences with corresponding streptococcal repeats in order to improve our understand

238 Although streptococcal SAgs are known virulence factors in scarle

239 To determine whether the streptococcal secreted esterase (Sse), an antigen that p

240 oid cells, has to be adapted with respect to streptococcal sensing, handling, and response.

241 In a streptococcal sepsis model, this constrained cytokine pr

242 e of HLA-II allelic variations in modulating streptococcal sepsis outcomes and suggest the presence o

243 ed a moribund patient who had beta-hemolytic streptococcal sepsis.

244 Human plasma HDL are the target of streptococcal serum opacity factor (SOF), a virulence fa

245 ibbling mechanism that is similar to that of streptococcal serum opacity factor, which also selective

246 ein that may function as a type of conserved streptococcal shape, elongation, division, and sporulati

247 GAS) freshly isolated from individuals with streptococcal sore throat or invasive ("flesh-eating") i

248 the genomes of strains causing pharyngitis (streptococcal "sore throat").

249 nsporter complex in four different sensitive streptococcal species and demonstrated that it can confe

250 ore, we draw parallels with other pathogenic streptococcal species and provide future research perspe

251 All streptococcal species contain the master regulator SigX

252 ral genetic transformation; however, not all streptococcal species have been shown to be naturally co

253 uinis is also the most common viridans group streptococcal species implicated in infective endocardit

254 cci occurs when a lectin-like adhesin on one streptococcal species recognizes a receptor polysacchari

255 voir for many potential pathogens, including streptococcal species that cause endocarditis.

256 ectrum streptococcal host range against most streptococcal species, including S. pyogenes, S. agalact

257 ial sex pheromone system in a commensal oral streptococcal species, which may have implications for i

258 in vitro phenotypes of its homologs in other streptococcal species.

259 nents (PlyCA and PlyCB) that is specific for streptococcal species.

260 shing between atypical pneumococci and other streptococcal species.

261 ) were identified in four different pyogenic streptococcal species.

262 oproteins as virulence determinants in other streptococcal species.

263 e the differential expression of arcA in two streptococcal species.

264 ve, the most common being Staphylococcal and Streptococcal species.

265 treptococcus oralis, the choline-independent streptococcal strain that served as the DNA donor in the

266 Genome sequencing of an additional 1,125 streptococcal strains and virulence studies revealed tha

267 caused by multidrug-resistant neisserial or streptococcal strains.

268 The streptococcal studies showed much higher MIC/MBC results

269 e oxidative stress-adaptive responses by the streptococcal subfamily of PerR.

270 dherence and subsequent biofilm formation on streptococcal substrates.

271 ND.1 to PhiM23ND.4, harboring genes encoding streptococcal superantigen (ssa), streptococcal pyrogeni

272 ndrome (TSS) is caused by staphylococcal and streptococcal superantigens (SAgs) that provoke a swift

273 eptococcus sepsis by modulating responses to streptococcal superantigens (Strep-SAgs).

274 Here we show that the streptococcal surface protein SfbI mediates covalent int

275 In particular, streptococcal surface proteins have been implicated as p

276 Isolation of the streptococcal surface proteins recognised by pooled huma

277 by virtue of repetitive sequences-designated streptococcal surface repeats.

278 Individuals with a positive streptococcal test result had an increased risk of any m

279 21 girls and 547922 boys), 638265 received a streptococcal test, 349982 of whom had positive test res

280 < .001), compared with individuals without a streptococcal test.

281 on on individuals with the registration of a streptococcal test.

282 cebo arm due to ineligibility arising from a streptococcal throat infection and one in the lumacaftor

283 DAS hypothesis found that individuals with a streptococcal throat infection had elevated risks of men

284 l disorder and OCD was more elevated after a streptococcal throat infection than after a nonstreptoco

285 specifically OCD and tic disorders, after a streptococcal throat infection.

286 type of psoriasis is usually associated with streptococcal throat infections and mainly occurs in HLA

287 of chronic psoriasis can be associated with streptococcal throat infections, and T cells that respon

288 ith protection from erysipelas (n = 278) and streptococcal tonsillitis (n = 209) compared with contro

289 from patients with flares associated with a streptococcal tonsillitis and with the HLA-Cw6 allele (c

290 can Heart Association regarding treatment of streptococcal tonsillo-pharyngitis were revised.

291 For antibiotic treatment of streptococcal tonsillopharyngitis the recommendations fo

292 Streptococcal toxic shock syndrome (STSS) and necrotizin

293 a patient with necrotizing fasciitis (NF) or streptococcal toxic shock syndrome (STSS).

294 severe invasive disease in humans, including streptococcal toxic shock syndrome and necrotizing fasci

295 Eighty-four cases of severe iGAS infection (streptococcal toxic shock syndrome, necrotizing fasciiti

296 t case of S. suis arthroplasty infection and streptococcal toxic shock-like syndrome due to an nonenc

297 sults have bearing on the pathophysiology of streptococcal toxic shock.

298 ted upon endolysosomal processing of group B streptococcal type III polysaccharide coupled to a carri

299 Previously reported streptococcal virulence genes, such as mga, hasA, amrA,

300 ign of future studies of M protein function, streptococcal virulence, epidemiological surveillance, a