ライフサイエンスコーパス: streptolysin O

1 od of plasma membrane permeabilization using streptolysin O.

2 ng secreted toxins NAD(+)-glycohydrolase and streptolysin O.

3 i) reversible membrane permeabilization with streptolysin O.

4 tory effect of an unrelated cytolytic toxin, streptolysin O.

5 equired expression of the pore-forming toxin streptolysin O.

6 ing enhanced by the effects of M protein and streptolysin O.

7 e Dynasore also protected HeLa cells against streptolysin O.

8 sed for the homologous member of the family, streptolysin O.

9 ludes listeriolysin O, perfringolysin O, and streptolysin O.

10 ed wild-type amounts of type 3 M protein and streptolysin O.

11 ly permeabilised with the pore-forming toxin streptolysin O.

12 y permeabilized with the pore-forming toxin, streptolysin-O.

13 mmalian cells has been achieved by employing Streptolysin O, a bacterial enzyme which forms temporary

14 ne response to SCPA correlated with the anti-streptolysin O and anti-DNase B responses.

15 lored various methods including TAT peptide, Streptolysin O and microporation for delivering NeutrAvi

16 kidney (PK-15) cells were permeabilized with streptolysin-O and incubated with a library of 125I-labe

17 and permeabilization of cultured acini with streptolysin-O and insertion of GDP beta S or antibodies

18 Permeabilization by streptolysin-O and introduction of guanosine thiodiphosp

19 was similar to mga, i.e., slo (which encodes streptolysin O) and plr (encoding the plasmin receptor/g

20 hils, that this activity was attributable to streptolysin O, and that platelet/neutrophil complex for

21 by collagenase digestion, permeablized with streptolysin O, and the release of Ca2+ from internal st

22 ced into the cells via permeabilization with streptolysin-O, and cellular uptake was confirmed by flu

23 requires NF-kappaB and the virulence factor streptolysin O, but proceeds independently of P2X7R and

24 Streptolysin O damaged and killed the cells quickly, all

25 ion of toxic shock syndrome toxin-1, whereas streptolysin O directly damages the mucosa to allow for

26 e pores are produced by perfringolysin O and streptolysin O during insertion (and not small pores tha

27 alpha-toxin and the streptococcal cytolysin streptolysin O enhanced penetration of toxic shock syndr

28 While reports have linked sloR function to streptolysin O expression, transport experiments with ra

29 Permeabilization with streptolysin O for 10 minutes permitted the loss of free

30 A similar analysis conducted on streptolysin O from Streptococcus pyogenes revealed that

31 alpha-hemolysin from Staphylococcus aureus, streptolysin O from Streptococcus pyogenes, and anthroly

32 t NAD-glycohydrolase is translocated through streptolysin O-generated pores into a host cell.

33 ization of plasma membranes by detergents or streptolysin-O in hepatocytes, thymocytes, and P19, Jurk

34 tion of antibodies to HlpA and antibodies to streptolysin O, indicating that the histone-like protein

35 In MIN6 beta-cells permeabilized by streptolysin O, insulin release was stimulated by elevat

36 When delivered with streptolysin O into living human epithelial cancer cells

37 ected host cell via the pore-forming protein streptolysin O is unknown.

38 omosomal region encoding secreted NADase and streptolysin O, is the key driver of increased toxin pro

39 efect was preserved by permeabilization with streptolysin-O, it was determined that Lec35p is not dir

40 Mast cells permeabilized with streptolysin-O leak soluble (cytosol) proteins over a pe

41 e genes encoding streptokinase, CAMP factor, streptolysin O, M protein (more abundant in the CvfA(-)

42 Streptolysin-O-mediated guanosine 5'-3-O-(thio)triphosph

43 or) but did not affect transcription of slo (streptolysin O), mga (multiple gene regulator of GAS), e

44 Streptolysin-O permeabilization was used to introduce an

45 phate via the recording patch pipette or via streptolysin-O permeabilization.

46 an antagonist of Gq/11, was introduced into streptolysin-O permeabilized acini to bypass the plasma

47 When streptolysin-O permeabilized CHO cells were incubated wi

48 concentration ([Ca2+]i) from both intact and streptolysin-O permeabilized isolated nerve endings of t

49 sopressin (AVP) secretion in both intact and streptolysin-O permeabilized nerve endings.

50 We have developed a novel assay system using Streptolysin-O permeabilized neutrophils that recapitula

51 ify this, we measured resting Ca2+ sparks in streptolysin-O permeabilized ventricular myocytes from w

52 in or addition of Ca2+-containing buffers to streptolysin O-permeabilized cells induced exocytosis of

53 um) of isolated microsomes, Ca2+ uptake into streptolysin O-permeabilized cells, and analysis of SERC

54 In streptolysin O-permeabilized cells, guanosine 5'-O- (2-t

55 t vastly different transport capabilities in streptolysin O-permeabilized cells, in accordance with t

56 secretion when introduced after docking into streptolysin O-permeabilized cells; so does a Rab3A-22A

57 pendent manner, both in vitro and in vivo in streptolysin O-permeabilized chromaffin cells.

58 bility of inducers to elicit exocytosis when streptolysin O-permeabilized human sperm were loaded wit

59 y of SCAMP2, potently inhibits exocytosis in streptolysin O-permeabilized mast cells.

60 dent fashion, as shown using both intact and streptolysin O-permeabilized parasites.

61 tron microscopy and proteolytic digestion of streptolysin O-permeabilized parasitized erythrocytes.

62 Using a streptolysin O-permeabilized platelet exocytosis assay,

63 d in alpha-granule secretion, we developed a streptolysin O-permeabilized platelet model of alpha-gra

64 Streptolysin O-permeabilized platelets released alpha-gr

65 Streptolysin O-permeabilized platelets synthesized PtdIn

66 Exposure of streptolysin O-permeabilized platelets to antihuman cell

67 Incubation of streptolysin O-permeabilized platelets with an antibody

68 Incubation of streptolysin O-permeabilized platelets with phosphatidyl

69 -2, rVAMP-3, and rVAMP-8 were incubated with streptolysin O-permeabilized platelets.

70 ed Ca2+-induced alpha-granule secretion from streptolysin O-permeabilized platelets.

71 In streptolysin O-permeabilized PMNs, PLD was directly acti

72 ant CRHSP-28 (rCRHSP-28) was introduced into streptolysin-O-permeabilized acinar cells, and amylase s

73 late Ca(2+)-stimulated secretory activity in streptolysin-O-permeabilized acinar cells.

74 In streptolysin-O-permeabilized acini of transgenic mice, a

75 2+) uptake into the endoplasmic reticulum of streptolysin-O-permeabilized cells by sarco/endoplasmic

76 tion of function-blocking Sec8 antibodies to streptolysin-O-permeabilized cells revealed exocyst requ

77 tentiated InsP(3)-evoked Ca(2+) release from streptolysin-O-permeabilized cells.

78 with the slow leak rate of the protein from streptolysin-O-permeabilized cells.

79 ing in vitro also inhibits acid secretion in streptolysin-O-permeabilized gastric glands.

80 In streptolysin-O-permeabilized MDCK cells, Sec8 antibodies

81 the presence of the ionophore A23187 and in streptolysin-O-permeabilized semi-intact cells.

82 Streptolysin O-permeable pancreatic acini were used to s

83 were introduced to HL-60 cells by use of the streptolysin O pore-forming peptide.

84 by TLR2 and TLR4 ligands in the presence of streptolysin O required Myd88/Trif, whereas that induced

85 ided that cells are first permeabilized with Streptolysin-O (SL-O), and (2) chimeric methylphosphonod

86 ith CLI reduced extracellular DNase Sda1 and streptolysin O (SLO) activity in vivo, whereas subinhibi

87 articipate in CMT, the pore-forming molecule streptolysin O (SLO) and an effector protein with the ch

88 Two such proteins, streptolysin O (SLO) and NAD(+)-glycohydrolase (NADase),

89 Two such products, streptolysin O (SLO) and NAD+-glycohydrolase, appear to

90 Although the toxicity of streptolysin O (SLO) and streptolysin S (SLS) in purifie

91 NADase (SPN) and streptolysin O (SLO) are two toxins that play important

92 tudies identified the pore-forming cytolysin streptolysin O (SLO) as necessary and sufficient for the

93 including the SpeB cysteine protease and the streptolysin O (SLO) cytolysin, but not SIC, a protein t

94 rearrangement in the upstream region of the streptolysin O (slo) gene of Streptococcus pyogenes whic

95 ssumes that the NAD-glycohydrolase (nga) and streptolysin O (slo) genes that code for these products

96 Streptolysin O (SLO) is a cholesterol-dependent cytolysi

97 cell lines using cationic lipid systems and streptolysin O (SLO) is used to effect their delivery.

98 duction of the cholesterol-binding cytotoxin streptolysin O (SLO) prevented internalization of GAS in

99 ed the abundance of streptolysin S (SLS) and streptolysin O (SLO) production between clinically domin

100 er permeabilization with the bacterial toxin streptolysin O (SLO) requires endocytosis via a novel pa

101 utilizes the cholesterol-dependent cytolysin Streptolysin O (SLO) to translocate the NAD(+) -glycohyd

102 utilizes the cholesterol-dependent cytolysin Streptolysin O (SLO) to translocate the NAD(+) glycohydr

103 athogen Streptococcus pyogenes that utilizes streptolysin O (SLO), a cholesterol-dependent cytolysin.

104 rulence factor that is present among most is streptolysin O (Slo), a protein with well-characterized

105 f the archetypical member of the CDC family, streptolysin O (SLO), a virulence factor from Streptococ

106 bronectin-binding proteins (sfbI and fbp54), streptolysin O (slo), hyaluronic acid capsule (hasA), st

107 rol-binding CDCs, perfringolysin O (PFO) and streptolysin O (SLO), were found to exhibit strikingly d

108 easuring the properties of Ca2+ signaling in streptolysin O (SLO)-permeabilized cells were used to st

109 Ca2+ signalling after permeabilization with streptolysin O (SLO).

110 haride and/or large amounts of the cytotoxin streptolysin O (SLO).

111 eted cytotoxins S. pyogenes NADase (SPN) and streptolysin O (SLO).

112 ular toxins NAD+-glycohydrolase (NADase) and streptolysin O (SLO).

113 ion of the secreted pore-forming haemolysin, streptolysin O (SLO).

114 using either cells gently permeabilized with streptolysin-O (SLO) or microsomes from homogenized cell

115 her streptococcal cell wall antigen (SCW) or streptolysin-O (SLO) to augment lung injury in rats.

116 In streptolysin-O (SLO)-perforated rat brain cortical synap

117 g the immunity factor IFS and the cytolysin (streptolysin O [SLO]), were more abundant in the mutant

118 between patient groups with nonfilarial Ag (streptolysin O)-stimulated supernatant (LP = 0.160 relat

119 dies recognizing specific domains of apoB in streptolysin-O (STP-O)- and saponin-permeabilized HepG2

120 n of other extracellular products, including streptolysin O, streptokinase, and DNase, was not affect

121 Anti-streptolysin-O titres were elevated in 65% of patients.

122 were used in cultured acini permeabilized by streptolysin-O to determine the role of the G proteins i

123 Streptolysin O treatment of infected human macrophages i

124 A when delivered into P815 target cells with streptolysin O, whereas transfection of target cells wit

125 Examples include the pore-forming cytotoxin streptolysin O, which oligomerises to form large pores i