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1 ence factors, including the potent cytolysin streptolysin S.
2 ion of a small peptide toxin by GAS known as streptolysin S.
3 to the promoter region of the gene encoding streptolysin S.
4 cular insight into the chemical structure of streptolysin S.
5 ag promoter, which directs the expression of streptolysin S, a hemolysin that can damage the membrane
6 hat resembled the biosynthetic machinery for streptolysin S, a key virulence factor from group A Stre
8 lting strain, JRS470, produced no detectable streptolysin S and showed a drastic reduction in cell su
9 ption of ska (encoding streptokinase), sagA (streptolysin S), and speMF (mitogenic factor) but did no
11 ificantly reduced the haemolytic activity of streptolysin S, and dramatically reduced the pathology i
13 s necessary and sufficient for production of streptolysin S, another GAS virulence factor, is also ne
15 a genetic locus immediately upstream of the streptolysin S biosynthetic operon in several GAS genome
19 sing high-resolution live cell imaging, that streptolysin S induces a dramatic osmotic change in red
21 ergrational mutagenesis demonstrate that the streptolysin S-like gene cluster from Clostridium sp. is
22 s provide key insights into the mechanism of streptolysin S-mediated haemolysis and have implications
23 otypes: decreased beta-hemolysis mediated by streptolysin S, reduction in the activity of a secreted
24 ated hasABC operon, streptokinase (ska), and streptolysin S (sagA) during growth in the presence of 1
26 acid capsule synthesis and exotoxins, e.g., streptolysin S (SLS) and pyrogenic exotoxin B (SpeB).
27 ranscription of sagA, a gene associated with streptolysin S (SLS) and speB, the gene encoding pyrogen
29 et-activating factor acetylhydrolase Sse and streptolysin S (SLS) have synergistic contributions to i
30 ugh the toxicity of streptolysin O (SLO) and streptolysin S (SLS) in purified group A streptococci (G
34 Notably, the entire sag operon necessary for streptolysin S (SLS) production was under CcpA-mediated
35 ually all group A streptococci (GAS) produce streptolysin S (SLS), a cytolytic toxin that is responsi
36 nt phosphotransferase system (PTS) exhibited Streptolysin S (SLS)-mediated hemolysis during exponenti
41 ficient in expression of the cytolytic toxin streptolysin S (SLS-) and evaluated events that occur du
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